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821. 2-Year GLOBE trial results: telbivudine Is superior to lamivudine in patients with chronic hepatitis B.
作者: Yun-Fan Liaw.;Edward Gane.;Nancy Leung.;Stefan Zeuzem.;Yuming Wang.;Ching Lung Lai.;E Jenny Heathcote.;Michael Manns.;Natalie Bzowej.;Junqi Niu.;Steven-Huy Han.;Seong Gyu Hwang.;Yilmaz Cakaloglu.;Myron J Tong.;George Papatheodoridis.;Yagang Chen.;Nathaniel A Brown.;Efsevia Albanis.;Karin Galil.;Nikolai V Naoumov.; .
来源: Gastroenterology. 2009年136卷2期486-95页
The GLOBE trial has compared the efficacy and safety of telbivudine versus lamivudine treatment over 2 years in patients with chronic hepatitis B.
822. Narrow-band versus white-light high definition television endoscopic imaging for screening colonoscopy: a prospective randomized trial.
作者: Andreas Adler.;Jens Aschenbeck.;Timur Yenerim.;Michael Mayr.;Alireza Aminalai.;Rolf Drossel.;Andreas Schröder.;Matthias Scheel.;Bertram Wiedenmann.;Thomas Rösch.
来源: Gastroenterology. 2009年136卷2期410-6.e1; quiz 715页
Narrow-band imaging (NBI) has been implemented in gastrointestinal endoscopy to improve the contrast of endoluminal pathologic structures, one of the aims being to increase colonic adenoma detection. Previous studies from referral centers have yielded variable and conflicting results with regard to improvement in adenoma detection rates by using NBI. The present large randomized trial was designed to finally settle this issue.
823. Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis.
作者: Heather M Patton.;Joel E Lavine.;Mark L Van Natta.;Jeffrey B Schwimmer.;David Kleiner.;Jean Molleston.; .
来源: Gastroenterology. 2008年135卷6期1961-1971.e2页
Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease in American children. Noninvasive means to discriminate between NAFLD and nonalcoholic steatohepatitis (NASH) might diminish the requirement for liver biopsy or predict those at increased risk for progression.
824. Squamous overgrowth is not a safety concern for photodynamic therapy for Barrett's esophagus with high-grade dysplasia.
作者: Mary P Bronner.;Bergein F Overholt.;Shari L Taylor.;Rodger C Haggitt.;Kenneth K Wang.;J Steven Burdick.;Charles J Lightdale.;Michael Kimmey.;Hector R Nava.;Michael V Sivak.;Norman Nishioka.;Hugh Barr.;Marcia I Canto.;Norman Marcon.;Marcos Pedrosa.;Michael Grace.;Michelle Depot.; .
来源: Gastroenterology. 2009年136卷1期56-64; quiz 351-2页
Photodynamic therapy with porfimer sodium combined with acid suppression (PHOPDT) is used to treat patients with Barrett's esophagus (BE) with high-grade dysplasia (HGD). A 5-year phase 3 trial was conducted to determine the extent of squamous overgrowth of BE with HGD after PHOPDT.
825. Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer.
作者: James J Farrell.;Hany Elsaleh.;Miguel Garcia.;Raymond Lai.;Ali Ammar.;William F Regine.;Ross Abrams.;A Bowen Benson.;John Macdonald.;Carol E Cass.;Adam P Dicker.;John R Mackey.
来源: Gastroenterology. 2009年136卷1期187-95页
The human equilibrative nucleoside transporter (hENT1) protein transports gemcitabine into cells. Small retrospective studies in pancreatic cancer suggest that levels of hENT1 protein or messenger RNA may have prognostic value. We studied the predictive value of hENT1 levels in a cohort of pancreatic adenocarcinoma patients from the large prospective randomized adjuvant treatment trial RTOG9704.
826. A randomized controlled trial of antioxidant supplementation for pain relief in patients with chronic pancreatitis.
作者: Payal Bhardwaj.;Pramod Kumar Garg.;Subir Kumar Maulik.;Anoop Saraya.;Rakesh Kumar Tandon.;Subrat Kumar Acharya.
来源: Gastroenterology. 2009年136卷1期149-159.e2页
Oxidative stress has been implicated in the pathophysiology of chronic pancreatitis (CP). We evaluated the effects of antioxidant supplementation on pain relief, oxidative stress, and antioxidant status in patients with CP.
827. Oral budesonide for maintenance treatment of collagenous colitis: a randomized, double-blind, placebo-controlled trial.
作者: Stephan Miehlke.;Ahmed Madisch.;Birgit Bethke.;Andrea Morgner.;Eberhard Kuhlisch.;Christine Henker.;Gerfried Vogel.;Matthias Andersen.;Eberhard Meier.;Gustavo Baretton.;Manfred Stolte.
来源: Gastroenterology. 2008年135卷5期1510-6页
Oral budesonide effectively induces clinical remission in patients with collagenous colitis, a debilitating illness characterized by chronic watery/loose diarrhea, but there is a high rate of relapse after treatment cessation.
828. A randomized, double-blinded, placebo-controlled multicenter trial of etanercept in the treatment of alcoholic hepatitis.
作者: Nicholas C Boetticher.;Craig J Peine.;Paul Kwo.;Gary A Abrams.;Tushar Patel.;Bashar Aqel.;Lisa Boardman.;Gregory J Gores.;William S Harmsen.;Craig J McClain.;Patrick S Kamath.;Vijay H Shah.
来源: Gastroenterology. 2008年135卷6期1953-60页
Alcoholic hepatitis is a cause of major morbidity and mortality that lacks effective therapies. Both experimental and clinical evidence indicate that the multifunctional cytokine tumor necrosis factor-alpha (TNF-alpha) contributes to pathogenesis and clinical sequelae of alcoholic hepatitis. A pilot study demonstrated that the TNF-alpha-neutralizing molecule etanercept could be an effective treatment for patients with alcoholic hepatitis.
829. Effects of adalimumab therapy on incidence of hospitalization and surgery in Crohn's disease: results from the CHARM study.
作者: Brian G Feagan.;Remo Panaccione.;William J Sandborn.;Geert R D'Haens.;Stefan Schreiber.;Paul J Rutgeerts.;Edward V Loftus.;Kathleen G Lomax.;Andrew P Yu.;Eric Q Wu.;Jingdong Chao.;Parvez Mulani.
来源: Gastroenterology. 2008年135卷5期1493-9页
We determined the effects of adalimumab maintenance treatment on the risks of hospitalization and surgery in Crohn's disease (CD).
830. Lower gastrointestinal events in a double-blind trial of the cyclo-oxygenase-2 selective inhibitor etoricoxib and the traditional nonsteroidal anti-inflammatory drug diclofenac.
作者: Loren Laine.;Sean P Curtis.;Michael Langman.;Dennis M Jensen.;Byron Cryer.;Amarjot Kaur.;Christopher P Cannon.
来源: Gastroenterology. 2008年135卷5期1517-25页
Nonsteroidal anti-inflammatory drugs (NSAIDs) cause lower gastrointestinal (GI) clinical events such as bleeding. Cyclo-oxygenase (COX)-2 selective inhibitors decrease upper GI events, but no prospective trial has prespecified assessment of lower GI clinical events.
831. Causal relationship of Helicobacter pylori with iron-deficiency anemia or failure of iron supplementation in children.
作者: Shafiqul A Sarker.;Hasan Mahmud.;Lena Davidsson.;Nur H Alam.;Tahmeed Ahmed.;Nurul Alam.;Mohammed A Salam.;Christoph Beglinger.;Niklaus Gyr.;George J Fuchs.
来源: Gastroenterology. 2008年135卷5期1534-42页
We investigated Helicobacter pylori (H pylori)-infection as a cause of iron deficiency (ID) and iron-deficiency anemia (IDA) or treatment failure of iron supplementation.
832. Silibinin is a potent antiviral agent in patients with chronic hepatitis C not responding to pegylated interferon/ribavirin therapy.
作者: Peter Ferenci.;Thomas-Matthias Scherzer.;Heidrun Kerschner.;Karoline Rutter.;Sandra Beinhardt.;Harald Hofer.;Maximilian Schöniger-Hekele.;Heidemarie Holzmann.;Petra Steindl-Munda.
来源: Gastroenterology. 2008年135卷5期1561-7页
Oral Silibinin (SIL) is widely used for treatment of hepatitis C, but its efficacy is unclear. Substantially higher doses can be administered intravenously (IV).
833. Haemodynamic effects of plasma-expansion with hyperoncotic albumin in cirrhotic patients with renal failure: a prospective interventional study.
作者: Andreas Umgelter.;Katrin Wagner.;Wolfgang Reindl.;Nils Nurtsch.;Wolfgang Huber.;Roland M Schmid.
来源: BMC Gastroenterol. 2008年8卷39页
Patients with advanced cirrhosis of the liver typically display circulatory disturbance. Haemodynamic management may be critical for avoiding and treating functional renal failure in such patients. This study investigated the effects of plasma expansion with hyperoncotic albumin solution and the role of static haemodynamic parameters in predicting volume responsiveness in patients with advanced cirrhosis.
834. Therapy of metronidazole with azathioprine to prevent postoperative recurrence of Crohn's disease: a controlled randomized trial.
作者: Geert R D'Haens.;Severine Vermeire.;Gert Van Assche.;Maja Noman.;Isolde Aerden.;Gust Van Olmen.;Paul Rutgeerts.
来源: Gastroenterology. 2008年135卷4期1123-9页
More than 80% of Crohn's disease (CD) patients undergoing resection suffer recurrence of their disease. Therapy with aminosalicylates, antimetabolites, or antibiotics leads to a modest reduction in the incidence of recurrence.
835. Impact of wide-angle, high-definition endoscopy in the diagnosis of colorectal neoplasia: a randomized controlled trial.
作者: Maria Pellisé.;Glòria Fernández-Esparrach.;Andrés Cárdenas.;Oriol Sendino.;Elena Ricart.;Eva Vaquero.;Antonio Z Gimeno-García.;Cristina Rodríguez de Miguel.;Michel Zabalza.;Angels Ginès.;Josep M Piqué.;Josep Llach.;Antoni Castells.
来源: Gastroenterology. 2008年135卷4期1062-8页
It is essential to optimize standard colonoscopy technique to be able to increase polyp detection. We sought to compare the performance of colonoscopy using a high-definition, wide-angle endoscope (HDE) versus a standard colonoscope (SC) for the detection of colorectal neoplasia.
836. A controlled pharmacogenetic trial of sibutramine on weight loss and body composition in obese or overweight adults.
作者: April B M Grudell.;Seth Sweetser.;Michael Camilleri.;Deborah J Eckert.;Maria I Vazquez-Roque.;Paula J Carlson.;Duane D Burton.;Autumn E Braddock.;Matthew M Clark.;Karen M Graszer.;Sarah A Kalsy.;Alan R Zinsmeister.
来源: Gastroenterology. 2008年135卷4期1142-54页
Weight loss in response to sibutramine is highly variable. We assessed the association of specific markers of polymorphisms of candidate alpha2A adrenoreceptor, 5-HT transporter, and GNbeta3 genes and weight loss with sibutramine.
837. Spectroscopic microvascular blood detection from the endoscopically normal colonic mucosa: biomarker for neoplasia risk.
作者: Hemant K Roy.;Andrew Gomes.;Vladimir Turzhitsky.;Michael J Goldberg.;Jeremy Rogers.;Sarah Ruderman.;Kim L Young.;Alex Kromine.;Randall E Brand.;Mohammed Jameel.;Parmede Vakil.;Nahla Hasabou.;Vadim Backman.
来源: Gastroenterology. 2008年135卷4期1069-78页
We previously used a novel biomedical optics technology, 4-dimensional elastically scattered light fingerprinting, to show that in experimental colon carcinogenesis the predysplastic epithelial microvascular blood content is increased markedly. To assess the potential clinical translatability of this putative field effect marker, we characterized the early increase in blood supply (EIBS) in human beings in vivo.
838. Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis.
作者: Guruprasad P Aithal.;James A Thomas.;Philip V Kaye.;Adam Lawson.;Stephen D Ryder.;Ian Spendlove.;Andrew S Austin.;Jan G Freeman.;Linda Morgan.;Jonathan Webber.
来源: Gastroenterology. 2008年135卷4期1176-84页
Nonalcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease for which there is limited therapy available. Insulin sensitizing, anti-inflammatory, and antifibrotic properties of thiazolidinediones support their use in treating NASH. We have evaluated pioglitazone in the treatment of nondiabetic patients with NASH.
839. A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease.
作者: William J Sandborn.;Brian G Feagan.;Richard N Fedorak.;Ellen Scherl.;Mark R Fleisher.;Seymour Katz.;Jewel Johanns.;Marion Blank.;Paul Rutgeerts.; .
来源: Gastroenterology. 2008年135卷4期1130-41页
Interleukin-12 and interleukin-23 are inflammatory cytokines implicated in Crohn's disease pathophysiology. Ustekinumab is a monoclonal antibody against the p40 subunit of interleukin-12/23.
840. New insight into intestinal motor function via noninvasive endoluminal image analysis.
作者: Carolina Malagelada.;Fosca De Iorio.;Fernando Azpiroz.;Anna Accarino.;Santi Segui.;Petia Radeva.;Juan-R Malagelada.
来源: Gastroenterology. 2008年135卷4期1155-62页
Evaluation of small bowel motility by intestinal manometry is invasive and requires expertise for interpretation. Our aim was to use capsule technology for evaluation of small bowel motor function based on a fully computerized image analysis program.
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