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64. Diminished SUV3 expression and its functional implications in the IFN-enriched monocyte subset of childhood Sjögren's Disease.
作者: Jimin Yoon.;Daesong Jang.;Myung-Chul Kim.;Joon Paek.;Rehae Miller.;Beatriz Veronese.;Rudy Alvarado.;Akaluck Thatayatikom.;Yoosik Kim.;Seunghee Cha.
来源: Rheumatology (Oxford). 2025年
This study investigates the molecular and functional implications of reduced Suv3-like RNA helicase (SUV3) expression in the interferon (IFN)-enriched subset of monocytes from childhood Sjögren's disease (cSjD). SUV3 is known to unwind double-stranded RNAs (dsRNAs) for homeostatic RNA decay within mitochondria.
65. Real-world care patterns and specialist encounters of patients with systemic autoimmune rheumatic disease-related interstitial lung disease in the United States: a retrospective administrative claims database analysis.
作者: Joseph Yang.;Michael A Head.;Kevin D Schott.;Hiangkiat Tan.;Rachel Djaraher.;Christopher L Crowe.;Mark Napier.;Kenneth Kossack.;Amy L Olson.;Elana J Bernstein.
来源: Rheumatology (Oxford). 2025年
We aimed to describe the demographics, clinical characteristics, and care patterns of patients with systemic autoimmune rheumatic diseases (SARD) prior to their interstitial lung disease (ILD) diagnosis.
66. Recruitment rate comparison between a virtual tele-research cohort and a traditional center-based cohort in idiopathic inflammatory myopathy.
作者: Siamak Moghadam-Kia.;Anushka Aggarwal.;Swamy Venuturupalli.;Shiri Keret.;Nantakarn Pongtarakulpanit.;Mark Riley.;Shalini Mahajan.;Daphne Scaramangas-Plumley.;Aarat Patel.;Joe Kelley.;Eleni Tiniakou.;Chester V Oddis.;Rohit Aggarwal.;MyPacer Study Group.
来源: Rheumatology (Oxford). 2025年
Idiopathic inflammatory myopathy (IIM, myositis) faces recruitment and retention challenges in clinical studies due to disease rarity, geographical barriers, and logistic difficulties. This study aimed to compare recruitment, enrolment, retention, and data completion between a decentralized telemedicine-based research cohort (TRC); and a traditional center-based cohort (CBC) in IIM.
67. A novel approach to refractory idiopathic inflammatory myopathy: CD19 CAR T-cell therapy-case report and literature review.
作者: Isabell Haase.;Johanna Richter.;Marie-Therese Holzer.;Boris Fehse.;Nikolas Ruffer.;Johan Seibel.;Susanna C Berger.;Nico Gagelmann.;Dominic Borie.;Francis Ayuk.;Ina Kötter.;Martin Krusche.;Nicolaus Kröger.
来源: Rheumatology (Oxford). 2025年
To explore efficacy and safety of CD19-directed Chimeric Antigen Receptor (CAR) T cell therapy in a patient with Jo1-Antisynthetase-syndrome (ASyS) refractory to multiple immunosuppressants, including anti-CD38 therapy, and review published cases on CAR T cell therapy in idiopathic inflammatory myopathies (IIM).
68. Arterial cardiovascular outcomes and venous thromboembolism in patients with primary Sjögren's syndrome: A Danish cohort study.
作者: Pierre Loiseau.;Aurélie Mailhac.;Pierre Duhaut.;Reimar W Thomsen.
来源: Rheumatology (Oxford). 2025年
To evaluate whether atherosclerotic cardiovascular disease outcomes, venous thromboembolism, heart failure, and cardiovascular mortality are elevated in patients with primary Sjögren's syndrome (pSS) compared with a matched cohort from the general population.
69. The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index exhibits an L-shaped association with all-cause mortality in rheumatoid arthritis patients: a retrospective cohort study.
作者: Jialin Zhang.;Yanhua Lin.;Jingyan Zeng.;Guihu Luo.;Pan Liao.;Qianyun Chen.;Han Zhong.;Simei Liang.;Cailiu Zhou.;Bin Yang.;Xing Li.
来源: BMC Rheumatol. 2025年9卷1期47页
The C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index is a novel biomarker reflecting inflammation, nutrition, and immune status, and its potential clinical significance and prognostic role in patients with rheumatoid arthritis (RA) has not been reported.
71. Patient Reported Outcome Measures for Rheumatoid Arthritis Disease Activity: Rasch measurement theory to identify items and domains.
作者: Tim Pickles.;Mike Horton.;Karl Bang Christensen.;Rhiannon Phillips.;David Gillespie.;Neil Mo.;Janice Davies.;Susan Campbell.;Ernest Choy.
来源: Rheumatology (Oxford). 2025年
Disease Activity (DA) monitoring is a standard of care in Rheumatoid Arthritis (RA). There is demand for achieving this through Patient Reported Outcome Measures (PROMs). The aim of this study was to determine which items could be used to measure the construct of RA DA, by analysing legacy PROMs, using Rasch measurement theory (RMT) analyses.
72. MRI patterns of thigh muscle involvement in immune-mediated necrotizing myopathy and dermatomyositis.
作者: Anson W Wilks.;Kiana M Vakil-Gilani.;William D Rooney.;Dongseok Choi.;Daniela Ghetie.;Nizar Chahin.
来源: BMC Rheumatol. 2025年9卷1期46页
Immune-mediated necrotizing myopathy (IMNM) and dermatomyositis (DM) are characterized by weakness, hyperCKemia, associated autoantibodies, and varying extramuscular manifestations. Muscle MRI, currently subordinate to histopathology and serology in idiopathic inflammatory myopathy (IIM) classification, has an evolving role. Our study aims to define thigh muscle MRI involvement in IMNM and DM by direct comparison.
73. Transitional and CD21- PD-1+ B cells are associated with remission in early rheumatoid arthritis.
作者: Sarah McGrath.;Boel Sundbeck.;Katrin Thorarinsdottir.;Charlotte A Jonsson.;Alessandro Camponeschi.;Monica Leu Agelii.;Anna-Karin H Ekwall.;Merete Lund Hetland.;Mikkel Østergaard.;Till Uhlig.;Michael Nurmohamed.;Jon Lampa.;Dan Nordström.;Kim Hørslev-Petersen.;Bjorn Gudbjornsson.;Gerdur Gröndal.;Ronald van Vollenhoven.;Anna Rudin.;Inga-Lill Mårtensson.;Inger Gjertsson.
来源: BMC Rheumatol. 2025年9卷1期45页
Early initiation of effective treatment is associated with positive long-term prognosis for patients with rheumatoid arthritis (RA). Currently, there are no biomarkers in clinical use to predict treatment response. A predictor of treatment response may be the B-cell compartment, as this is altered in RA patients, making it a potential candidate for predicting treatment response. In this study, we sought to identify B-cell subset(s) at diagnosis that might be associated with Clinical Disease Activity Index (CDAI) remission at 24-week follow-up.
75. Predicting homozygous M694V genotype in pediatric familial Mediterranean fever: multicenter analysis and scoring system proposal.
作者: Eray Tunce.;Sıla Atamyıldız Uçar.;Merve Cansu Polat.;Özge Altuğ Gücenmez.;Mustafa Çakan.;Burcu Bozkaya Yücel.;Elif Arslanoğlu Aydın.;Tutku Doğan Kuzuca.;Elif Kılıç Könte.;Salih Demirhan.;Elif Küçük.;Selen Duygu Arık.;Gökçe Vatansever.;Ozan Özkaya.;Demet Tekcan.;Hülya Nalçacıoğlu.;Ayşe Tanatar.;Hatice Dilara Karakaş.;Ceyhun Açarı.;Şeyda Doğantan.;Seher Şener.;Rabia Miray Kışla Ekinci.;Pınar Garipçin.;Hülya Ercan Emreol.;Tuba Kurt.;Hatice Adıgüzel Dündar.;Ahmet Girgeç.;Ayşen Arif Tutuş.;Oya Köker.;Selahaddin Cevizbaş.;Merve Kutlar Tanıdır.;Saadet Nilay Tığrak.;Müge Sezer.;Halil Kazanasmaz.;Betül Öksel.;Raziye Burcu Taşkın.;Elif Gümüşsoy Ay.;Taner Coşkuner.;Gülcan Özomay Baykal.;Ramazan Emre Yiğit.;Şeyma Türkmen.;Kadir Ulu.;Sema Nur Taşkın.;Gülçin Otar Yener.;Ferhat Demir.;Sara Sebnem Kilic.;Metin Kaya Gürgöze.;Güzide Aksu.;Hafize Emine Sönmez.;Serkan Türkuçar.;Mukaddes Kalyoncu.;Sevcan Bakkaloğlu.;Neşe Özkayın.;Belde Kasap Demir.;Erbil Ünsal.;Selçuk Yüksel.;Ayşe Balat.;Yelda Bilginer.;Ayşenur Paç Kısaarslan.;Osman Dönmez.;Nuray Aktay Ayaz.;Kübra Öztürk.;Selcan Demir.;Esra Bağlan.;Elif Çelikel.;Özgür Kasapçopur.;Seza Özen.;Betül Sözeri.
来源: Rheumatology (Oxford). 2025年
This study aimed to evaluate the predictability of the homozygous M694V genotype in pediatric familial Mediterranean fever (FMF) patients and to develop a clinical scoring system to enhance disease management strategies.
76. Post-traumatic stress disorder and systemic lupus erythematosus: insights from a systematic review.
作者: Konstantinos Parperis.;Maria Papachristodoulou.;Chris Derk.;Savvas Psarelis.;Konstantinos Voskarides.;Andreas Chatzittofis.
来源: Rheumatology (Oxford). 2025年
Emerging evidence suggests that post-traumatic stress disorder (PTSD) may increase susceptibility to autoimmune diseases, including systemic lupus erythematosus (SLE). PTSD-related immune dysregulation is hypothesized to heighten vulnerability to autoimmunity. This systematic review sought to evaluate the relationship between PTSD and the risk of developing SLE, as well as explore potential shared genetic predispositions.
77. Chronic musculoskeletal pain among Ebola survivors in Guinea: a cross-sectional study reveals key risk factors and the need for specialized care.
作者: Yves-Marie Pers.;Anne Dubois.;Thierno Alimou Barry.;Mariama Diouldé Sall.;Laura March.;Mamadou Saliou Sow.;Alpha Kabinet Keita.;Bernard Taverne.;Jean François Étard.;Moumié Barry.;Eric Delaporte.;Abdoulaye Touré.; .
来源: Rheumatology (Oxford). 2025年
The tremendous size of the 2013-2016 West African outbreak of Ebola virus disease (EVD) resulted in a sizeable population of survivors, many reporting short-term sequelae such as arthralgia and myalgia. We aimed to examine the occurrence of chronic musculoskeletal (MS) pain among survivors.
78. Prevalence and factors associated with fatigue in patients with psoriatic arthritis: a systematic review and meta-analysis.
Fatigue is a prominent symptom in patients with psoriatic arthritis (PsA). There was a wide variety of statistics previously reported on fatigue prevalence in patients. This systematic review examined the current literature to derive the overall prevalence of fatigue and risk factors in PsA patients.
79. Effectiveness of JAK inhibitors in biologics-naïve patients with rheumatoid arthritis: a population-based study.
作者: Albert Tzu Ming Chuang.;Daniel Hsiang-Te Tsai.;Meng-Yu Weng.;Huei-Kai Huang.;Edward Chia-Cheng Lai.
来源: Rheumatology (Oxford). 2025年
We evaluated drug retention rates to compare the effectiveness of Janus kinase (JAK) inhibitors vs. tumour necrosis factor inhibitor (TNFi) biologics and non-TNFi biologics in biologics-naïve rheumatoid arthritis (RA) patients, and assessed intra-class differences among JAK inhibitors.
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