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61. Early assessment of treatment response in primary biliary cholangitis: key to timely management.
作者: Tomas Koky.;Sylvia Drazilova.;Martin Janicko.;Dominika Toporcerova.;Jakub Gazda.;Peter Jarcuska.
来源: BMC Gastroenterol. 2025年25卷1期571页
The aim of our study was to explore predictive factors associated with compete biochemical response (CBR) in primary biliary cholangitis (PBC) patients treated with ursodeoxycholic acid (UDCA) at month 12 and at last check-up; CBR was defined as both normal bilirubin and ALP levels. We also evaluated hepatic decompensation and prognosis during UDCA treatment.
62. Global, regional, and national burden of colorectal cancer in the elderly (aged > 60 years): a comprehensive analysis across 204 countries and territories (1990-2021).
作者: Shiyin Luo.;Jichun Gong.;Youwen Zhu.;Liqun Wang.;Kun Zhang.
来源: BMC Gastroenterol. 2025年25卷1期570页
Colorectal Cancer (CRC) is highly prevalent among the elderly (Aged > 60 Years). Investigating the global epidemiological trends of colorectal cancer in elderly patients can aid in developing targeted prevention and control measures.
63. Epidemiologic and clinical profiles of colorectal cancer in Southern Egypt.
作者: Doris W Chiu.;Noha Rashad.;Nashwa Kordy.;Emad Shash.;Amr Soliman.
来源: BMC Gastroenterol. 2025年25卷1期569页
To calculate the incidence of colorectal cancer in Southern Egypt and to describe the epidemiological profiles of people with colorectal cancer in this region.
64. Serological assessment of PRO-C16 (type XVI collagen formation) reflects intestinal fibrostenotic strictures in patients with crohn's disease.
作者: Joachim H Mortensen.;M Lindholm.;L Langholm.;P Giuffrida.;D Ruane.;T Manon-Jensen.;G Mazza.;F Caprioli.;L Pastorelli.;A-C Bay-Jensen.;M Pinzani.;M A Karsdal.;A Di Sabatino.
来源: BMC Gastroenterol. 2025年25卷1期568页
Fibrostenotic stricturing disease affects 30-50% of patients with Crohn's disease (CD), leading to intestinal resection. Currently, there exists a great medical need to identify biomarkers related to fibrostenotic strictures for optimized patient management. Thus, we investigated PRO-C16 as a biomarker for intestinal fibrosis in patients with CD.
66. Canadian Association of Gastroenterology Clinical Practice Guideline for the Endoscopic Management of Nonvariceal Nonpeptic Ulcer Upper Gastrointestinal Bleeding.
作者: Alan N Barkun.;Loren Laine.;Grigorios I Leontiadis.;Ian M Gralnek.;Nicholas Carman.;Mostafa Ibrahim.;Michael Sey.;Ali A Alali.;Matthew W Carroll.;Lawrence Hookey.;Mark Borgaonkar.;David Armstrong.;James Y W Lau.;Nauzer Forbes.;Rapat Pittayanon.;Frances Tse.
来源: Gastroenterology. 2025年
Nonvariceal, nonpeptic ulcer bleeding, arising from etiologies such as malignant tumors, Mallory-Weiss tears (MWTs), Dieulafoy's lesions, and gastric antral vascular ectasia, constitutes a significant and increasing proportion of upper gastrointestinal bleeding cases. These evidence-based guidelines, developed by the Canadian Association of Gastroenterology with international collaboration, are the first to specifically address the endoscopic management of these conditions, aiming to support patients, clinicians, and others in making informed decisions.
67. Impact of timing of endoscopy on clinical outcomes in cirrhotic patients with esophageal variceal bleeding: a monocentric retrospective study from Vietnam.
In cirrhotic patients with esophageal variceal bleeding (EVB), most guidelines recommend endoscopy within 12 h. However, the optimal timing for the highest treatment efficacy remains controversial, and current studies provide inconsistent results. This study aims to evaluate the optimal timing by comparing clinical outcomes between early endoscopy (< 12 h) and delayed endoscopy (≥12 h) groups.
68. The value of fecal calprotectin measured by fluorescent immunochromatography assay in evaluating clinical and endoscopic activity in ulcerative colitis.
作者: Mingyang Xu.;Junrong Li.;Wei Qian.;Fangmei Ling.;Yidong Chen.;Shuang Li.;Yiyu Cheng.;Qi Yu.;Liangru Zhu.
来源: BMC Gastroenterol. 2025年25卷1期566页
Fecal calprotectin (FC) levels correlate with clinical or endoscopic activity in ulcerative colitis (UC), however, these values vary widely between detection methods, and optimal cut-off values remain debated. To assess the correlation between FC levels measured by fluorescent immunochromatography assay (FICA) and disease activity and to identify optimal cut-off values for predicting clinical and endoscopic activity in UC.
69. Safety of infliximab and adalimumab in pediatric inflammatory bowel diseases: a disproportionality analysis from the FAERS database.
作者: Yanhong Deng.;Shengying Shi.;Senling Feng.;Xiangping Tan.;Yinling Wang.;Jinjin Yin.;Shaozhi Liu.;Yuanmei Gao.
来源: BMC Gastroenterol. 2025年25卷1期560页
The incidence of pediatric inflammatory bowel disease (IBD) significantly increased recently. Infliximab (IFX) and adalimumab (ADA), both TNF-α inhibitors, are the only FDA-approved treatments for pediatric IBD. Due to the unique physiological and developmental characteristics of children, postmarketing pharmacovigilance requires ongoing attention. We aimed to evaluate the safety of IFX and ADA in pediatric IBD using FAERS database data from Q1 2004 to Q1 2024.
70. Predictive factors for metabolic syndrome in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
作者: Mohammad Alnees.;Mahdi Awwad.;Duha Najajra.;Abdalaziz Darwish.;Omar Heih.;Thara Al-Ali.;Nizar Abu Hamdeh.;Ali Abdullah.;Jamal Ahmad.;Kawthar Jarrar.;Alaa Al-Ihribat.;Omar Salloum.;Qusay Abdoh.;Haitham Abu Khadija.
来源: BMC Gastroenterol. 2025年25卷1期562页
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of liver disease globally, closely associated with metabolic syndrome.
71. Association between glycated hemoglobin/high-density lipoprotein ratio and nonalcoholic fatty liver disease in a U.S. nondiabetic population: a cross-sectional study based on NHANES 2017-2020 data.
The purpose of this research was to explore the relationship between the glycated hemoglobin/high-density lipoprotein (HbA1c/HDL-C) ratio and nonalcoholic fatty liver disease (NAFLD) in non-diabetic adults in the United States.
72. Socioeconomic burden of patients hospitalized for fecal impaction: a nationwide retrospective observational study.
作者: Hiromasa Hoshi.;Akira Endo.;Kiyohide Fushimi.;Koji Morishita.
来源: BMC Gastroenterol. 2025年25卷1期563页
Fecal impaction (FI) causes serious complications and has a high mortality rate, particularly among older individuals. However, there have been few large-scale studies on FI, and understanding of FI is incomplete. In this study, we aimed to elucidate the characteristics, mortality rates, and healthcare costs of patients hospitalized for FI.
73. Investigating the shared genetic information between serum concentration levels of liver enzymes and cholelithiasis.
作者: Wenhao Tian.;Zixin Wu.;Wen Yang.;Hongyang Wang.;Qiyu Feng.
来源: BMC Gastroenterol. 2025年25卷1期564页
Liver injury is associated with cholelithiasis, with changes in liver enzyme levels potentially influencing cholelithiasis risk. This study investigates the shared genetic basis between serum levels of four liver enzymes and cholelithiasis using summary data from large-scale genome-wide association studies (GWAS).
74. Prognostic value of ALBI score for all-cause mortality in metabolic associated fatty liver disease patients: a cohort study from NHANES 2003-2018.
Metabolic Associated Fatty Liver Disease (MAFLD) is a prevalent chronic liver disorder with severe potential outcomes. While the albumin-bilirubin (ALBI) score demonstrates prognostic utility in other chronic liver diseases, its specific role and predictive performance in MAFLD patients, particularly regarding all-cause mortality, remain incompletely understood. This study aims to investigate the association between ALBI scores and all-cause mortality in individuals with MAFLD and to evaluate its prognostic potential using large-scale NHANES data.
78. Clinical relevance of transperineal ultrasound compared with anorectal manometry for the evaluation of female patients with obstructive defecation syndrome.
作者: Jingjing Li.;Yahong Xue.;Qian Chen.;Yan Ling.;Huifen Zhou.;Min Li.;Xinyi Xu.;Yusha Zeng.
来源: BMC Gastroenterol. 2025年25卷1期558页
The utility of transperineal ultrasound (TPUS) in combination with anorectal manometry (ARM) in the evaluation of women with obstructive defecation syndrome (ODS) remains unclear. We investigated the combined performance of TPUS and ARM in the evaluation of female patients with ODS, and determined the clinical utility of both modalities in the evaluation of female patients with ODS.
79. CTI as a biomarker for diarrhea in U.S. adults: insights from NHANES 2005-2010.
The C-Reactive protein-triglyceride-glucose index (CTI), a novel composite biomarker integrating inflammation and insulin resistance, has shown promise in predicting metabolic and inflammatory outcomes. However, its association with bowel dysfunction remains unexplored.
80. The development of a multimodal prediction model based on CT and MRI for the prognosis of pancreatic cancer.
作者: Zheng Dou.;Jiaxi Lin.;Chenghao Lu.;Xiaoting Ma.;Ruoxu Zhang.;Jinzhou Zhu.;Songbing Qin.;Chao Xu.;Jinli Li.
来源: BMC Gastroenterol. 2025年25卷1期557页
To develop and validate a hybrid radiomics model to predict the overall survival in pancreatic cancer patients and identify risk factors that affect patient prognosis.
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