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61. Safety of infliximab and adalimumab in pediatric inflammatory bowel diseases: a disproportionality analysis from the FAERS database.
作者: Yanhong Deng.;Shengying Shi.;Senling Feng.;Xiangping Tan.;Yinling Wang.;Jinjin Yin.;Shaozhi Liu.;Yuanmei Gao.
来源: BMC Gastroenterol. 2025年25卷1期560页
The incidence of pediatric inflammatory bowel disease (IBD) significantly increased recently. Infliximab (IFX) and adalimumab (ADA), both TNF-α inhibitors, are the only FDA-approved treatments for pediatric IBD. Due to the unique physiological and developmental characteristics of children, postmarketing pharmacovigilance requires ongoing attention. We aimed to evaluate the safety of IFX and ADA in pediatric IBD using FAERS database data from Q1 2004 to Q1 2024.
62. Predictive factors for metabolic syndrome in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
作者: Mohammad Alnees.;Mahdi Awwad.;Duha Najajra.;Abdalaziz Darwish.;Omar Heih.;Thara Al-Ali.;Nizar Abu Hamdeh.;Ali Abdullah.;Jamal Ahmad.;Kawthar Jarrar.;Alaa Al-Ihribat.;Omar Salloum.;Qusay Abdoh.;Haitham Abu Khadija.
来源: BMC Gastroenterol. 2025年25卷1期562页
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of liver disease globally, closely associated with metabolic syndrome.
63. Association between glycated hemoglobin/high-density lipoprotein ratio and nonalcoholic fatty liver disease in a U.S. nondiabetic population: a cross-sectional study based on NHANES 2017-2020 data.
The purpose of this research was to explore the relationship between the glycated hemoglobin/high-density lipoprotein (HbA1c/HDL-C) ratio and nonalcoholic fatty liver disease (NAFLD) in non-diabetic adults in the United States.
64. Socioeconomic burden of patients hospitalized for fecal impaction: a nationwide retrospective observational study.
作者: Hiromasa Hoshi.;Akira Endo.;Kiyohide Fushimi.;Koji Morishita.
来源: BMC Gastroenterol. 2025年25卷1期563页
Fecal impaction (FI) causes serious complications and has a high mortality rate, particularly among older individuals. However, there have been few large-scale studies on FI, and understanding of FI is incomplete. In this study, we aimed to elucidate the characteristics, mortality rates, and healthcare costs of patients hospitalized for FI.
65. Investigating the shared genetic information between serum concentration levels of liver enzymes and cholelithiasis.
作者: Wenhao Tian.;Zixin Wu.;Wen Yang.;Hongyang Wang.;Qiyu Feng.
来源: BMC Gastroenterol. 2025年25卷1期564页
Liver injury is associated with cholelithiasis, with changes in liver enzyme levels potentially influencing cholelithiasis risk. This study investigates the shared genetic basis between serum levels of four liver enzymes and cholelithiasis using summary data from large-scale genome-wide association studies (GWAS).
66. Prognostic value of ALBI score for all-cause mortality in metabolic associated fatty liver disease patients: a cohort study from NHANES 2003-2018.
Metabolic Associated Fatty Liver Disease (MAFLD) is a prevalent chronic liver disorder with severe potential outcomes. While the albumin-bilirubin (ALBI) score demonstrates prognostic utility in other chronic liver diseases, its specific role and predictive performance in MAFLD patients, particularly regarding all-cause mortality, remain incompletely understood. This study aims to investigate the association between ALBI scores and all-cause mortality in individuals with MAFLD and to evaluate its prognostic potential using large-scale NHANES data.
67. Clinical relevance of transperineal ultrasound compared with anorectal manometry for the evaluation of female patients with obstructive defecation syndrome.
作者: Jingjing Li.;Yahong Xue.;Qian Chen.;Yan Ling.;Huifen Zhou.;Min Li.;Xinyi Xu.;Yusha Zeng.
来源: BMC Gastroenterol. 2025年25卷1期558页
The utility of transperineal ultrasound (TPUS) in combination with anorectal manometry (ARM) in the evaluation of women with obstructive defecation syndrome (ODS) remains unclear. We investigated the combined performance of TPUS and ARM in the evaluation of female patients with ODS, and determined the clinical utility of both modalities in the evaluation of female patients with ODS.
68. CTI as a biomarker for diarrhea in U.S. adults: insights from NHANES 2005-2010.
The C-Reactive protein-triglyceride-glucose index (CTI), a novel composite biomarker integrating inflammation and insulin resistance, has shown promise in predicting metabolic and inflammatory outcomes. However, its association with bowel dysfunction remains unexplored.
69. The development of a multimodal prediction model based on CT and MRI for the prognosis of pancreatic cancer.
作者: Zheng Dou.;Jiaxi Lin.;Chenghao Lu.;Xiaoting Ma.;Ruoxu Zhang.;Jinzhou Zhu.;Songbing Qin.;Chao Xu.;Jinli Li.
来源: BMC Gastroenterol. 2025年25卷1期557页
To develop and validate a hybrid radiomics model to predict the overall survival in pancreatic cancer patients and identify risk factors that affect patient prognosis.
70. CT assessment of total abdominal muscle area index (TAMAI) as a predictive tool for early post operative complications in laparoscopic sleeve gastrectomy: a prospective case-control study.
作者: Islam Haney Shawali.;Yara ELhefnawi.;Mohammed ElShwadfy Nageeb.;Bahaa Eldin Mahmoud.
来源: BMC Gastroenterol. 2025年25卷1期555页
In metabolic bariatric surgery (MBS) a lot of focus is made on preoperative risk assessment to enhance patient's baseline performance and improve postoperative clinical outcomes. The aim of this study is to assess pre-operative sarcopenia by computed tomography (CT) scan, as a predictive tool for early post-operative complications in candidates for MBS.
71. Doppler ultrasound and 2D shear wave ultrasound elastography for liver fibrosis evaluation in Fontan-associated liver disease.
作者: Nakarin Inmutto.;Attaporn Jantarangkoon.;Natthapong Nimitrungtawee.;Nattaporn Sriwicha.;Sarawut Kongkarnka.;Saviga Sethasathien.;Tanop Srisuwan.
来源: BMC Gastroenterol. 2025年25卷1期553页
The Fontan operation improves survival in patients with single ventricle physiology but is associated with Fontan-associated liver disease (FALD), characterized by progressive fibrosis due to prolonged elevated central venous pressure. While 2D shear wave elastography (2D-SWE) can assess fibrosis, it often overestimates stiffness in congestive conditions. Doppler ultrasound, which evaluates hepatic hemodynamics, may complement 2D-SWE for fibrosis assessment. This study evaluated the diagnostic performance of Doppler ultrasound and 2D-SWE in assessing hepatic fibrosis in Fontan patients and compared the findings with biopsy-proven fibrosis severity.
72. Association between albumin-corrected anion gap and delirium in acute pancreatitis: insights from the MIMIC-IV database.
作者: Yuanshuo Ge.;Youran Ma.;Peng Lv.;Junhao Ren.;Zhe Wang.;Cheng Zhang.
来源: BMC Gastroenterol. 2025年25卷1期554页
Delirium frequently occurs as a severe complication among patients with acute pancreatitis (AP), contributing to extended hospital stays, higher mortality rates, and lasting cognitive deficits. The pathogenesis of delirium in this setting is strongly influenced by metabolic abnormalities, including disturbances in electrolyte balance and widespread inflammation. Although the albumin-corrected anion gap (ACAG) is a recognized indicator of metabolic dysfunction, its relevance to delirium in AP patients has not been adequately investigated.
73. Percutaneous endoscopy in the management of intra-abdominal complex disorders.
作者: Li Wang.;Jiamin Qin.;Kaixiao Kun.;Xiaoxia Li.;Xinhui He.;Zhen Tang.;Honglin Chen.;Yong Yan.;Yaodan Cao.;Liming Wen.
来源: BMC Gastroenterol. 2025年25卷1期556页
Intra-abdominal complex disorders pose significant challenges to clinicians due to their intricate nature and diagnostic uncertainties. This study aims to comprehensively evaluate the feasibility, safety, and efficacy of percutaneous endoscopy in the management of such conditions.
74. Relationship between gut microbiota dysbiosis and bile acid in patients with hepatitis B-induced cirrhosis.
作者: Yannan Li.;Dan Zhang.;Tian Tian.;Jing Xie.;Xiaolin Wang.;Wenjun Deng.;Ningbo Hao.;Changzheng Li.
来源: BMC Gastroenterol. 2025年25卷1期552页
Dysbiosis of the gut microbiota is a significant factor influencing the progression of hepatitis B-related cirrhosis (HBC). Bile acid (BA) metabolism is increasingly recognized as a key participant in the liver-gut microbiota axis.
75. Relationship of coffee consumption with colonic diverticulosis.
作者: Osman Cagin Buldukoglu.;Serkan Ocal.;Serdar Akca.;Galip Egemen Atar.;Ferda Akbay Harmandar.;Ayhan Hilmi Cekin.
来源: BMC Gastroenterol. 2025年25卷1期548页
Diverticulosis is the most common benign pathology of the colon. Genetics, inflammation, neuromuscular abnormalities, colonic motility and lifestyle including dietary habits play roles in disease pathogenesis. Coffee is one of the most commonly consumed beverages worldwide and exerts antiinflammatory functions in the human body as well as affecting colonic motility and neuromuscular physiology of the gastrointestinal system. Therefore, this study was planned to investigate the relationship between coffee consumption and diverticulosis.
76. Prognostic value of neutrophil-to-lymphocyte ratio in septic patients with liver cirrhosis: a cohort study.
Inflammation plays a critical role in the pathogenesis of both sepsis and cirrhosis. The neutrophil-to-lymphocyte ratio (NLR), a composite inflammatory marker, has garnered increasing attention. However, the association between NLR and the risk of mortality in patients with cirrhosis and sepsis remains unclarified.
77. Preoperative albumin-bilirubin grade combined with sarcopenia predicts long-term outcomes after laparoscopic gastrectomy for advanced gastric cancer.
作者: Shuangshuang Hou.;Yang Yu.;Nanbo Li.;Wenjing Yu.;Zhiyuan Dai.;He Li.;Lianyi Guo.;Jiajun Yin.;Ju Wu.
来源: BMC Gastroenterol. 2025年25卷1期550页
This retrospective study evaluated the predictive value of preoperative albumin–bilirubin (ALBI) grade combined with sarcopenia for the long-term prognosis of patients with advanced gastric cancer (AGC) undergoing laparoscopic radical surgery.
78. Association of alterations in transcriptomics and intestinal immune responses with Bifidobacterium longum BAA2573 in improving dextran sulfate sodium-induced colitis.
作者: Wujuan Hao.;Lan Gu.;Renmin Zhou.;Cuilan Huang.;Xuyang Wang.;Yanshan Liu.;Qiong Lin.
来源: BMC Gastroenterol. 2025年25卷1期551页
Preliminary studies have demonstrated the potential of Bifidobacterium longum (B. longum) BAA2573 in alleviating dextran sulfate sodium (DSS)-induced colitis; however, the underlying mechanisms are still unclear.
79. GastroNet-5M: A Multicenter Dataset for Developing Foundation Models in Gastrointestinal Endoscopy.
作者: Martijn R Jong.;Tim G W Boers.;Kiki N Fockens.;Jelmer B Jukema.;Carolus H J Kusters.;Tim J M Jaspers.;Rixta A H van Eijck van Heslinga.;Floor C Slooter.;Maarten R Struyvenberg.;Raf Bisschops.;Joost A van der Putten.;Peter H N de With.;Fons van der Sommen.;Albert J de Groof.;Jacques J G H M Bergman.; .
来源: Gastroenterology. 2025年
Training deep learning systems in endoscopy generally requires vast datasets of annotated images, which are often scarce and costly to obtain. Foundation models are pretrained on large, diverse datasets and can be applied across a wide range of tasks with minimal additional fine-tuning. For endoscopy, foundation models require datasets of general endoscopic images. Yet, datasets for developing such models remain limited. In this study, we present GastroNet-5M, a dataset comprising 4,820,653 endoscopic images of ∼500,000 procedures.
80. Low Fermentable Oligosaccharides, Disaccharides, Monosaccharides, and Polyols Diet Improves Colonic Barrier Function and Mast Cell Activation in Patients With Diarrhea-Predominant Irritable Bowel Syndrome: A Mechanistic Trial.
作者: Jun Gao.;Allen A Lee.;Shabnam Abtahi.;Jerrold R Turner.;Madhusudan Grover.;Alexander Schmidt.;Thomas M Schmidt.;Judy W Nee.;Johanna Iturrino.;Anthony Lembo.;William D Chey.;John W Wiley.;Prashant Singh.
来源: Gastroenterology. 2025年
A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (LFD) is the most efficacious dietary therapy for irritable bowel syndrome (IBS). However, the mechanisms by which fermentable oligosaccharides, disaccharides, monosaccharides, and polyols drive IBS pathophysiology are unclear.
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