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61. The Community-Level Interventions for Pre-eclampsia (CLIP) cluster randomised trials in Mozambique, Pakistan, and India: an individual participant-level meta-analysis.
作者: Peter von Dadelszen.;Zulfiqar A Bhutta.;Sumedha Sharma.;Jeffrey Bone.;Joel Singer.;Hubert Wong.;Mrutyunjaya B Bellad.;Shivaprasad S Goudar.;Tang Lee.;Jing Li.;Ashalata A Mallapur.;Khátia Munguambe.;Beth A Payne.;Rahat N Qureshi.;Charfudin Sacoor.;Esperança Sevene.;Marianne Vidler.;Laura A Magee.; .
来源: Lancet. 2020年396卷10250期553-563页
To overcome the three delays in triage, transport and treatment that underlie adverse pregnancy outcomes, we aimed to reduce all-cause adverse outcomes with community-level interventions targeting women with pregnancy hypertension in three low-income countries.
62. Mortality in adults with multidrug-resistant tuberculosis and HIV by antiretroviral therapy and tuberculosis drug use: an individual patient data meta-analysis.
作者: Gregory P Bisson.;Mayara Bastos.;Jonathon R Campbell.;Didi Bang.;James C Brust.;Petros Isaakidis.;Christoph Lange.;Dick Menzies.;Giovanni B Migliori.;Jean W Pape.;Domingo Palmero.;Parvaneh Baghaei.;Payam Tabarsi.;Piret Viiklepp.;Stalz Vilbrun.;Jonathan Walsh.;Suzanne M Marks.
来源: Lancet. 2020年396卷10248期402-411页
HIV-infection is associated with increased mortality during multidrug-resistant tuberculosis treatment, but the extent to which the use of antiretroviral therapy (ART) and anti-tuberculosis medications modify this risk are unclear. Our objective was to evaluate how use of these treatments altered mortality risk in HIV-positive adults with multidrug-resistant tuberculosis.
63. Physical distancing, face masks, and eye protection to prevent person-to-person transmission of SARS-CoV-2 and COVID-19: a systematic review and meta-analysis.
作者: Derek K Chu.;Elie A Akl.;Stephanie Duda.;Karla Solo.;Sally Yaacoub.;Holger J Schünemann.; .
来源: Lancet. 2020年395卷10242期1973-1987页
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19 and is spread person-to-person through close contact. We aimed to investigate the effects of physical distance, face masks, and eye protection on virus transmission in health-care and non-health-care (eg, community) settings.
64. Regulatory cell therapy in kidney transplantation (The ONE Study): a harmonised design and analysis of seven non-randomised, single-arm, phase 1/2A trials.
作者: Birgit Sawitzki.;Paul N Harden.;Petra Reinke.;Aurélie Moreau.;James A Hutchinson.;David S Game.;Qizhi Tang.;Eva C Guinan.;Manuela Battaglia.;William J Burlingham.;Ian S D Roberts.;Mathias Streitz.;Régis Josien.;Carsten A Böger.;Cristiano Scottà.;James F Markmann.;Joanna L Hester.;Karsten Juerchott.;Cecile Braudeau.;Ben James.;Laura Contreras-Ruiz.;Jeroen B van der Net.;Tobias Bergler.;Rossana Caldara.;William Petchey.;Matthias Edinger.;Nathalie Dupas.;Michael Kapinsky.;Ingrid Mutzbauer.;Natalie M Otto.;Robert Öllinger.;Maria P Hernandez-Fuentes.;Fadi Issa.;Norbert Ahrens.;Christoph Meyenberg.;Sandra Karitzky.;Ulrich Kunzendorf.;Stuart J Knechtle.;Josep Grinyó.;Peter J Morris.;Leslie Brent.;Andrew Bushell.;Laurence A Turka.;Jeffrey A Bluestone.;Robert I Lechler.;Hans J Schlitt.;Maria C Cuturi.;Stephan Schlickeiser.;Peter J Friend.;Tewfik Miloud.;Alexander Scheffold.;Antonio Secchi.;Kerry Crisalli.;Sang-Mo Kang.;Rachel Hilton.;Bernhard Banas.;Gilles Blancho.;Hans-Dieter Volk.;Giovanna Lombardi.;Kathryn J Wood.;Edward K Geissler.
来源: Lancet. 2020年395卷10237期1627-1639页
Use of cell-based medicinal products (CBMPs) represents a state-of-the-art approach for reducing general immunosuppression in organ transplantation. We tested multiple regulatory CBMPs in kidney transplant trials to establish the safety of regulatory CBMPs when combined with reduced immunosuppressive treatment.
65. Monotherapy with a P2Y12 inhibitor or aspirin for secondary prevention in patients with established atherosclerosis: a systematic review and meta-analysis.
作者: Mauro Chiarito.;Jorge Sanz-Sánchez.;Francesco Cannata.;Davide Cao.;Matteo Sturla.;Cristina Panico.;Cosmo Godino.;Damiano Regazzoli.;Bernhard Reimers.;Raffaele De Caterina.;Gianluigi Condorelli.;Giuseppe Ferrante.;Giulio G Stefanini.
来源: Lancet. 2020年395卷10235期1487-1495页
Antiplatelet therapy is recommended among patients with established atherosclerosis. We compared monotherapy with a P2Y12 inhibitor versus aspirin for secondary prevention.
66. Delayed versus early initiation of renal replacement therapy for severe acute kidney injury: a systematic review and individual patient data meta-analysis of randomised clinical trials.
作者: Stéphane Gaudry.;David Hajage.;Nicolas Benichou.;Khalil Chaïbi.;Saber Barbar.;Alexander Zarbock.;Nuttha Lumlertgul.;Ron Wald.;Sean M Bagshaw.;Nattachai Srisawat.;Alain Combes.;Guillaume Geri.;Tukaram Jamale.;Agnès Dechartres.;Jean-Pierre Quenot.;Didier Dreyfuss.
来源: Lancet. 2020年395卷10235期1506-1515页
The timing of renal replacement therapy (RRT) for severe acute kidney injury is highly debated when no life-threatening complications are present. We assessed whether a strategy of delayed versus early RRT initiation affects 28-day survival in critically ill adults with severe acute kidney injury.
67. The risk of tuberculosis in children after close exposure: a systematic review and individual-participant meta-analysis.
作者: Leonardo Martinez.;Olivia Cords.;C Robert Horsburgh.;Jason R Andrews.; .
来源: Lancet. 2020年395卷10228期973-984页
Tens of millions of children are exposed to Mycobacterium tuberculosis globally every year; however, there are no contemporary estimates of the risk of developing tuberculosis in exposed children. The effectiveness of contact investigations and preventive therapy remains poorly understood.
68. Comprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis.
作者: Marc A Suchard.;Martijn J Schuemie.;Harlan M Krumholz.;Seng Chan You.;RuiJun Chen.;Nicole Pratt.;Christian G Reich.;Jon Duke.;David Madigan.;George Hripcsak.;Patrick B Ryan.
来源: Lancet. 2019年394卷10211期1816-1826页
Uncertainty remains about the optimal monotherapy for hypertension, with current guidelines recommending any primary agent among the first-line drug classes thiazide or thiazide-like diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, dihydropyridine calcium channel blockers, and non-dihydropyridine calcium channel blockers, in the absence of comorbid indications. Randomised trials have not further refined this choice.
69. Type and timing of menopausal hormone therapy and breast cancer risk: individual participant meta-analysis of the worldwide epidemiological evidence.
Published findings on breast cancer risk associated with different types of menopausal hormone therapy (MHT) are inconsistent, with limited information on long-term effects. We bring together the epidemiological evidence, published and unpublished, on these associations, and review the relevant randomised evidence.
70. The state of hypertension care in 44 low-income and middle-income countries: a cross-sectional study of nationally representative individual-level data from 1·1 million adults.
作者: Pascal Geldsetzer.;Jennifer Manne-Goehler.;Maja-Emilia Marcus.;Cara Ebert.;Zhaxybay Zhumadilov.;Chea S Wesseh.;Lindiwe Tsabedze.;Adil Supiyev.;Lela Sturua.;Silver K Bahendeka.;Abla M Sibai.;Sarah Quesnel-Crooks.;Bolormaa Norov.;Kibachio J Mwangi.;Omar Mwalim.;Roy Wong-McClure.;Mary T Mayige.;Joao S Martins.;Nuno Lunet.;Demetre Labadarios.;Khem B Karki.;Gibson B Kagaruki.;Jutta M A Jorgensen.;Nahla C Hwalla.;Dismand Houinato.;Corine Houehanou.;Mohamed Msaidié.;David Guwatudde.;Mongal S Gurung.;Gladwell Gathecha.;Maria Dorobantu.;Albertino Damasceno.;Pascal Bovet.;Brice W Bicaba.;Krishna K Aryal.;Glennis Andall-Brereton.;Kokou Agoudavi.;Andrew Stokes.;Justine I Davies.;Till Bärnighausen.;Rifat Atun.;Sebastian Vollmer.;Lindsay M Jaacks.
来源: Lancet. 2019年394卷10199期652-662页
Evidence from nationally representative studies in low-income and middle-income countries (LMICs) on where in the hypertension care continuum patients are lost to care is sparse. This information, however, is essential for effective targeting of interventions by health services and monitoring progress in improving hypertension care. We aimed to determine the cascade of hypertension care in 44 LMICs-and its variation between countries and population groups-by dividing the progression in the care process, from need of care to successful treatment, into discrete stages and measuring the losses at each stage.
71. Long-term and recent trends in hypertension awareness, treatment, and control in 12 high-income countries: an analysis of 123 nationally representative surveys.
Antihypertensive medicines are effective in reducing adverse cardiovascular events. Our aim was to compare hypertension awareness, treatment, and control, and how they have changed over time, in high-income countries.
72. Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis.
作者: Maximilian Huhn.;Adriani Nikolakopoulou.;Johannes Schneider-Thoma.;Marc Krause.;Myrto Samara.;Natalie Peter.;Thomas Arndt.;Lio Bäckers.;Philipp Rothe.;Andrea Cipriani.;John Davis.;Georgia Salanti.;Stefan Leucht.
来源: Lancet. 2019年394卷10202期939-951页
Schizophrenia is one of the most common, burdensome, and costly psychiatric disorders in adults worldwide. Antipsychotic drugs are its treatment of choice, but there is controversy about which agent should be used. We aimed to compare and rank antipsychotics by quantifying information from randomised controlled trials.
73. Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis.
作者: Mélanie Drolet.;Élodie Bénard.;Norma Pérez.;Marc Brisson.; .
来源: Lancet. 2019年394卷10197期497-509页
More than 10 years have elapsed since human papillomavirus (HPV) vaccination was implemented. We did a systematic review and meta-analysis of the population-level impact of vaccinating girls and women against human papillomavirus on HPV infections, anogenital wart diagnoses, and cervical intraepithelial neoplasia grade 2+ (CIN2+) to summarise the most recent evidence about the effectiveness of HPV vaccines in real-world settings and to quantify the impact of multiple age-cohort vaccination.
74. New WHO prevalence estimates of mental disorders in conflict settings: a systematic review and meta-analysis.
作者: Fiona Charlson.;Mark van Ommeren.;Abraham Flaxman.;Joseph Cornett.;Harvey Whiteford.;Shekhar Saxena.
来源: Lancet. 2019年394卷10194期240-248页
Existing WHO estimates of the prevalence of mental disorders in emergency settings are more than a decade old and do not reflect modern methods to gather existing data and derive estimates. We sought to update WHO estimates for the prevalence of mental disorders in conflict-affected settings and calculate the burden per 1000 population.
75. Extending thrombolysis to 4·5-9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data.
作者: Bruce C V Campbell.;Henry Ma.;Peter A Ringleb.;Mark W Parsons.;Leonid Churilov.;Martin Bendszus.;Christopher R Levi.;Chung Hsu.;Timothy J Kleinig.;Marc Fatar.;Didier Leys.;Carlos Molina.;Tissa Wijeratne.;Sami Curtze.;Helen M Dewey.;P Alan Barber.;Kenneth S Butcher.;Deidre A De Silva.;Christopher F Bladin.;Nawaf Yassi.;Johannes A R Pfaff.;Gagan Sharma.;Andrew Bivard.;Patricia M Desmond.;Stefan Schwab.;Peter D Schellinger.;Bernard Yan.;Peter J Mitchell.;Joaquín Serena.;Danilo Toni.;Vincent Thijs.;Werner Hacke.;Stephen M Davis.;Geoffrey A Donnan.; .
来源: Lancet. 2019年394卷10193期139-147页
Stroke thrombolysis with alteplase is currently recommended 0-4·5 h after stroke onset. We aimed to determine whether perfusion imaging can identify patients with salvageable brain tissue with symptoms 4·5 h or more from stroke onset or with symptoms on waking who might benefit from thrombolysis.
76. Drug-eluting or bare-metal stents for percutaneous coronary intervention: a systematic review and individual patient data meta-analysis of randomised clinical trials.
作者: Raffaele Piccolo.;Kaare H Bonaa.;Orestis Efthimiou.;Olivier Varenne.;Andrea Baldo.;Philip Urban.;Christoph Kaiser.;Wouter Remkes.;Lorenz Räber.;Adam de Belder.;Arnoud W J van 't Hof.;Goran Stankovic.;Pedro A Lemos.;Tom Wilsgaard.;Jörg Reifart.;Alfredo E Rodriguez.;Expedito E Ribeiro.;Patrick W J C Serruys.;Alex Abizaid.;Manel Sabaté.;Robert A Byrne.;Jose M de la Torre Hernandez.;William Wijns.;Peter Jüni.;Stephan Windecker.;Marco Valgimigli.; .
来源: Lancet. 2019年393卷10190期2503-2510页
New-generation drug-eluting stents (DES) have mostly been investigated in head-to-head non-inferiority trials against early-generation DES and have typically shown similar efficacy and superior safety. How the safety profile of new-generation DES compares with that of bare-metal stents (BMS) is less clear.
77. Oral immunotherapy for peanut allergy (PACE): a systematic review and meta-analysis of efficacy and safety.
作者: Derek K Chu.;Robert A Wood.;Shannon French.;Alessandro Fiocchi.;Manel Jordana.;Susan Waserman.;Jan L Brożek.;Holger J Schünemann.
来源: Lancet. 2019年393卷10187期2222-2232页
Oral immunotherapy is an emerging experimental treatment for peanut allergy, but its benefits and harms are unclear. We systematically reviewed the efficacy and safety of oral immunotherapy versus allergen avoidance or placebo (no oral immunotherapy) for peanut allergy.
78. Clinical outcomes after ABO-incompatible renal transplantation: a systematic review and meta-analysis.
作者: Florian G Scurt.;Lara Ewert.;Peter R Mertens.;Hermann Haller.;Bernhard M W Schmidt.;Christos Chatzikyrkou.
来源: Lancet. 2019年393卷10185期2059-2072页
ABO-incompatible renal transplantation (ABOi-rTx) is increasingly used to overcome organ shortage. Evidence about its non-inferiority in comparison with ABO-compatible renal transplantation (ABOc-rTx) needs to be analysed at early and late timepoints. We aimed to investigate differences in outcome after ABOi-rTX and ABOc-rTX.
79. Maternal and perinatal mortality and complications associated with caesarean section in low-income and middle-income countries: a systematic review and meta-analysis.
作者: Soha Sobhy.;David Arroyo-Manzano.;Nilaani Murugesu.;Gayathri Karthikeyan.;Vinoth Kumar.;Inderjeet Kaur.;Evita Fernandez.;Sirisha Rao Gundabattula.;Ana Pilar Betran.;Khalid Khan.;Javier Zamora.;Shakila Thangaratinam.
来源: Lancet. 2019年393卷10184期1973-1982页
Universal and timely access to a caesarean section is a key requirement for safe childbirth. We identified the burden of maternal and perinatal mortality and morbidity, and the risk factors following caesarean sections in low-income and middle-income countries (LMICs).
80. How long does a knee replacement last? A systematic review and meta-analysis of case series and national registry reports with more than 15 years of follow-up.
作者: Jonathan T Evans.;Robert W Walker.;Jonathan P Evans.;Ashley W Blom.;Adrian Sayers.;Michael R Whitehouse.
来源: Lancet. 2019年393卷10172期655-663页
Knee replacements are the mainstay of treatment for end-stage osteoarthritis and are effective. Given time, all knee replacements will fail and knowing when this failure might happen is important. We aimed to establish how long a knee replacement lasts.
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