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61. The efficacy of CT-P13, a biosimilar of infliximab, in inflammatory bowel diseases: a systematic review and meta-analysis.
作者: Xinyue Hu.;Xiaowei Tang.;Limin Li.;Lian Luo.;Xinsen He.;Qin Yan.;Xiaolin Zhong.
来源: BMC Gastroenterol. 2024年24卷1期406页
Since 2015, an infliximab biosimilar, CT-P13, has been approved for commercial use in many countries, easing the economic burden borne by society and patients. Many clinical trials investigating CT-P13 for the treatment of IBD have been conducted and reported that it may be a substitute for infliximab. However, the differences between the efficacy of CT-P13 and infliximab-originator require further elucidation.
62. Safety comparison of single-donor and pooled fecal microbiota transfer product preparation in ulcerative colitis: systematic review and meta-analysis.
作者: Bastien Laperrousaz.;Benoît Levast.;Mathieu Fontaine.;Stéphane Nancey.;Pierre Dechelotte.;Joël Doré.;Philippe Lehert.
来源: BMC Gastroenterol. 2024年24卷1期402页
Multiple studies have evaluated fecal microbiota transfer (FMT) in patients with ulcerative colitis (UC) using single-donor (SDN) and multidonor (MDN) products. Systematic review and meta-analysis were performed to compare the safety of SDN and MDN products.
63. Adverse Events Associated With Endoscopic Retrograde Cholangiopancreatography: Systematic Review and Meta-Analysis.
作者: Kirles Bishay.;Zhao Wu Meng.;Rishad Khan.;Mehul Gupta.;Yibing Ruan.;Marcus Vaska.;Jordan Iannuzzi.;Dylan E O'Sullivan.;Brittany Mah.;Arun C R Partridge.;Amanda M Henderson.;Howard Guo.;Sunil Samnani.;Max DeMarco.;Yuhong Yuan.;B Joseph Elmunzer.;Rajesh N Keswani.;Sachin Wani.;Zachary L Smith.;Ronald J Bridges.;Steven J Heitman.;Robert J Hilsden.;Darren R Brenner.;Grigorios I Leontiadis.;Nauzer Forbes.
来源: Gastroenterology. 2025年168卷3期568-586页
Endoscopic retrograde cholangiopancreatography (ERCP)-related adverse events (AEs) are associated with morbidity, mortality, and health care expenditure. We aimed to assess incidences and comparisons of ERCP AEs.
64. Birth characteristics and risk of colorectal cancer.
作者: Jianwen Chen.;Xu Ren.;Yalan Wang.;Chengjiang Liu.;Simei Shi.;Bo Sun.
来源: BMC Gastroenterol. 2024年24卷1期397页
There is still controversy over the association between newborns with different birth characteristics and colorectal cancer (CRC) in adulthood. We plan to use systematic reviews and meta-analysis to elucidate this relationship.
65. Risk of Clostridioides difficile infection in inflammatory bowel disease patients undergoing vedolizumab treatment: a systematic review and meta-analysis.
作者: Wei Chen.;Yuhang Liu.;Yuelun Zhang.;Hong Zhang.;Chuyan Chen.;Siying Zhu.;Yanhua Zhou.;Haiying Zhao.;Ye Zong.
来源: BMC Gastroenterol. 2024年24卷1期377页
Inflammatory bowel disease (IBD) is a chronic, relapsing condition wherein biologics have improved disease prognosis but introduced elevated infection susceptibility. Vedolizumab (VDZ) demonstrates unique safety advantages; however, a comprehensive systematic comparison regarding the risk of Clostridioides difficile infection (CDI) between vedolizumab and alternative medications remains absent.
66. Comparative Efficacy of Advanced Therapies for Management of Moderate-to-Severe Ulcerative Colitis: 2024 American Gastroenterological Association Evidence Synthesis.
作者: Ashwin N Ananthakrishnan.;M Hassan Murad.;Frank I Scott.;Manasi Agrawal.;John P Haydek.;Berkeley N Limketkai.;Edward V Loftus.;Siddharth Singh.
来源: Gastroenterology. 2024年167卷7期1460-1482页
We performed an updated systematic review and network meta-analysis to inform the 2024 American Gastroenterological Association (AGA) Clinical Guidelines on the management of moderate-to-severe ulcerative colitis (UC).
67. Placebo Rates in Crohn's Disease Randomized Clinical Trials: An Individual Patient Data Meta-Analysis.
作者: Virginia Solitano.;Malcolm Hogan.;Siddharth Singh.;Silvio Danese.;Laurent Peyrin-Biroulet.;Guangyong Zou.;Yuhong Yuan.;Bruce E Sands.;Brian G Feagan.;Parambir S Dulai.;Neeraj Narula.;Christopher Ma.;Vipul Jairath.
来源: Gastroenterology. 2025年168卷2期344-356页
Understanding placebo rates is critical for efficient clinical trial design. We assessed placebo rates and associated factors using individual patient data from Crohn's disease trials.
68. The prevalence of obesity and underweight in celiac patients at the time of diagnosis: a systematic review and meta-analysis.
作者: Farzad Maleki.;Marjan Hosseinpour.;Ali Delpisheh.;Mansour Bahardoust.;Fatemeh Hajizadeh-Sharafabad.;Mohammad Reza Pashaei.
来源: BMC Gastroenterol. 2024年24卷1期357页
This study aimed to estimate the prevalence of obesity, overweight, and underweight in celiac disease (CD) at diagnosis before starting the Gluten-free diet (GFD).
69. Efficacy and safety of direct-acting antiviral regimen for patients with hepatitis C virus genotype 2: a systematic review and meta-analysis.
Direct-acting antivirals (DAAs) show high cure rates in treating chronic hepatitis C virus (HCV). However, the effect of DAAs on patients infected with genotype 2 (GT2) is difficult to determine despite the availability of several DAA regimens.
70. Effect of factor VIII and FVIII/PC ratio on portal vein thrombosis in liver cirrhosis: a systematic review and meta‑analysis.
作者: Zhinian Wu.;Ying Xiao.;Zeqiang Qi.;Tingyu Guo.;Hua Tong.;Yadong Wang.
来源: BMC Gastroenterol. 2024年24卷1期320页
To date, there is an ongoing debate regarding the ability to predict PVT development using markers of FVIII or FVIII/PC ratio. This study presents evidence-based medical findings on the influence of FVIII activity levels and FVIII/PC values in the formation of PVT in cirrhosis.
71. Genetic estimation of causalities between educational attainment with common digestive tract diseases and the mediating pathways.
作者: Yudan Wang.;Yanping Bi.;Yilin Wang.;Fuqing Ji.;Lanhui Zhang.
来源: BMC Gastroenterol. 2024年24卷1期304页
The association between education, intelligence, and cognition with digestive tract diseases has been established. However, the specific contribution of each factor in the pathogenesis of these diseases are still uncertain.
72. Incidence and risk factors for colorectal cancer in Africa: a systematic review and meta-analysis.
作者: Nkengeh N Tazinkeng.;Ethan F Pearlstein.;Martha Manda-Mapalo.;Ayooluwatomiwa D Adekunle.;Joao Filipe G Monteiro.;Kelsey Sawyer.;Stella-Maris C Egboh.;Kanwal Bains.;Evaristus S Chukwudike.;Mouhand F Mohamed.;Comfort Asante.;Julius Ssempiira.;Akwi W Asombang.
来源: BMC Gastroenterol. 2024年24卷1期303页
Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. There is a significant burden of mortality from colorectal cancer in Africa. Due to the heterogeneity of dietary and lifestyle practices throughout Africa, our work sought to define risk factors for the development of CRC in the African continent.
73. Efficacy and safety of endoscopic nasobiliary drainage versus percutaneous transhepatic cholangial drainage in the treatment of advanced hilar cholangiocarcinoma: a systematic review and meta-analysis.
作者: Huiling Zhou.;Chunxia Liu.;Xianhuan Yu.;Mingye Su.;Jingwen Yan.;Xiangde Shi.
来源: BMC Gastroenterol. 2024年24卷1期302页
To evaluate and compare the efficacy and safety of Endoscopic Nasobiliary Drainage (ENBD) and Percutaneous Transhepatic Cholangiography Drainage (PTCD) in patients with advanced Hilar Cholangiocarcinoma (HCCA) through a meta-analysis of clinical studies.
74. Causal relationships between neuropsychiatric disorders and nonalcoholic fatty liver disease: A bidirectional Mendelian randomization study.
作者: Shisong Wang.;Hui Gao.;Pengyao Lin.;Tianchen Qian.;Lei Xu.
来源: BMC Gastroenterol. 2024年24卷1期299页
Increasing evidences suggest that nonalcoholic fatty liver disease (NAFLD) is associated with neuropsychiatric disorders. Nevertheless, whether there were causal associations between them remained vague. A causal association between neuropsychiatric disorders and NAFLD was investigated in this study.
75. Meta-analysis of the effectiveness of early endoscopic treatment of Acute biliary pancreatitis based on lightweight deep learning model.
Acute biliary pancreatitis (ABP) is a clinical common acute abdomen. After the first pancreatitis, relapse rate is high, which seriously affects human life and health and causes great economic burdens to family and society. According to a great many research findings, endoscopic retrograde cholangiopancreatography (ERCP) is an effective treatment method. However, whether ERCP should be performed in early stage of ABP is still controversial in clinical practice.
76. Efficacy of probiotics, prebiotics, and synbiotics on liver enzymes, lipid profiles, and inflammation in patients with non-alcoholic fatty liver disease: a systematic review and meta-analysis of randomized controlled trials.
作者: Youwen Pan.;Yafang Yang.;Jiale Wu.;Haiteng Zhou.;Chao Yang.
来源: BMC Gastroenterol. 2024年24卷1期283页
There is a contradiction in the use of microbiota-therapies, including probiotics, prebiotics, and synbiotics, to improve the condition of patients with nonalcoholic fatty liver disease (NAFLD). The aim of this review was to evaluate the effect of microbiota-therapy on liver injury, inflammation, and lipid levels in individuals with NAFLD.
77. Prevalence of autoimmune pancreatitis in pancreatic resection for suspected malignancy: a systematic review and meta-analysis.
作者: Zain A Karamya.;Attila Kovács.;Dóra Illés.;Bálint Czakó.;Alíz Fazekas.;Nelli Farkas.;Péter Hegyi.;László Czakó.
来源: BMC Gastroenterol. 2024年24卷1期278页
Autoimmune pancreatitis (AIP) is a diagnosis-challenging disease that often mimics pancreatic malignancy. Pancreatic resection is considered to be a curative treatment for pancreatic ductal adenocarcinoma (PDAC). This meta-analysis aims to study the incidence of AIP in patients who have undergone pancreatic resection for clinical manifestation of cancer.
78. Mucinous histology is a negative predictor of neoadjuvant chemoradiotherapy for locally advanced rectal adenocarcinoma.
作者: Xiangwen Tan.;Yiwei Zhang.;Xiaofeng Wu.;Qing Fang.;Yunhua Xu.;Shuxiang Li.;Jinyi Yuan.;Xiuda Peng.;Kai Fu.;Shuai Xiao.
来源: BMC Gastroenterol. 2024年24卷1期263页
Neoadjuvant chemoradiotherapy (NCRT) followed by total mesorectal excision (TME) is the standard treatment for locally advanced rectal cancer (LARC). Mucinous adenocarcinoma (MAC) is a potential poor prognosis subgroup of rectal cancer. However, the predictive value of MAC in NCRT treatment of LARC is controversial.
79. Can proximal gastrectomy with double-tract reconstruction replace total gastrectomy? a meta-analysis of randomized controlled trials and propensity score-matched studies.
作者: Guangxu Zhu.;Xuguang Jiao.;Shengjie Zhou.;Qingshun Zhu.;Lei Yu.;Qihang Sun.;Bowen Li.;Hao Fu.;Jie Huang.;Wei Lang.;Xiaomin Lang.;Shengyong Zhai.;Jinqiu Xiong.;Yanan Fu.;Chunxiao Liu.;Jianjun Qu.
来源: BMC Gastroenterol. 2024年24卷1期230页
According to the 5th edition of the Japanese Guidelines for the Treatment of Gastric Cancer, proximal gastrectomy is recommended for patients with early upper gastric cancer who can retain the distal half of the residual stomach after R0 resection. However, a large number of recent clinical studies suggest that surgical indications for proximal gastrectomy in the guidelines may be too narrow. Therefore, this meta-analysis included patients with early and advanced gastric cancer and compared short- and long-term postoperative outcomes between the two groups. At the same time, we only had high-quality clinical studies such as propensity score-matched studies and randomized controlled trials, which made our research more authentic and credible.
80. The Global Incident Gastrointestinal Cancers Attributable to Suboptimal Diets From 1990 to 2018.
作者: Yiting Li.;Xing Jia.;Caiyu Li.;Haoxin Sun.;Shaofa Nie.;Edward L Giovannucci.;Li Liu.
来源: Gastroenterology. 2024年167卷6期1141-1151页
The contribution of suboptimal diets to gastrointestinal (GI) cancer incidence globally remains unquantified, and we aimed to evaluate it.
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