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61. The Effects of Exercise Training in Patients With Persistent Dyspnea Following Pulmonary Embolism: A Randomized Controlled Trial.
作者: Øyvind Jervan.;Stacey Haukeland-Parker.;Jostein Gleditsch.;Mazdak Tavoly.;Frederikus A Klok.;Kjetil Steine.;Hege Hølmo Johannessen.;Martijn A Spruit.;Dan Atar.;René Holst.;Anders Erik Astrup Dahm.;Per Anton Sirnes.;Knut Stavem.;Waleed Ghanima.
来源: Chest. 2023年164卷4期981-991页
Persistent dyspnea, functional limitations, and reduced quality of life (QoL) are common following pulmonary embolism (PE). Rehabilitation is a potential treatment option, but the scientific evidence is limited.
62. Implementation of Lung Cancer Screening in Primary Care and Pulmonary Clinics: Pragmatic Clinical Trial of Electronic Health Record-Integrated Everyday Shared Decision-Making Tool and Clinician-Facing Prompts.
作者: Polina V Kukhareva.;Haojia Li.;Tanner J Caverly.;Guilherme Del Fiol.;Angela Fagerlin.;Jorie M Butler.;Rachel Hess.;Yue Zhang.;Teresa Taft.;Michael C Flynn.;Chakravarthy Reddy.;Douglas K Martin.;Isaac A Warner.;Salvador Rodriguez-Loya.;Phillip B Warner.;Kensaku Kawamoto.
来源: Chest. 2023年164卷5期1325-1338页
Although low-dose CT (LDCT) scan imaging lung cancer screening (LCS) can reduce lung cancer mortality, it remains underused. Shared decision-making (SDM) is recommended to assess the balance of benefits and harms for each patient.
63. Effects of Positive Airway Pressure Therapy on Glycemic Variability in Patients With Type 2 Diabetes and OSA: A Randomized Controlled Trial.
作者: R Nisha Aurora.;Mary R Rooney.;Dan Wang.;Elizabeth Selvin.;Naresh M Punjabi.
来源: Chest. 2023年164卷4期1057-1067页
Glycemic variability is associated with increased risk for cardiovascular disease in patients with type 2 diabetes independent of glycosylated hemoglobin A1c (HbA1c) levels. Given the conflicting evidence on the effect of positive airway pressure (PAP) therapy for OSA on HbA1c, elucidating its effect on glycemic variability has value.
64. Valaciclovir for Epstein-Barr Virus Suppression in Moderate-to-Severe COPD: A Randomized Double-Blind Placebo-Controlled Trial.
作者: Dermot A Linden.;Hong Guo-Parke.;Michael C McKelvey.;Gisli G Einarsson.;Andrew J Lee.;Derek J Fairley.;Vanessa Brown.;Gavin Lundy.;Christina Campbell.;Danielle Logan.;Margaret McFarland.;Dave Singh.;Daniel F McAuley.;Clifford C Taggart.;Joseph C Kidney.
来源: Chest. 2023年164卷3期625-636页
Epstein-Barr virus (EBV) frequently is measured at high levels in COPD using sputum quantitative polymerase chain reaction, whereas airway immunohistochemistry analysis has shown EBV detection to be common in severe disease.
65. Albuterol-Budesonide Pressurized Metered Dose Inhaler in Patients With Mild-to-Moderate Asthma: Results of the DENALI Double-Blind Randomized Controlled Trial.
作者: Bradley E Chipps.;Elliot Israel.;Richard Beasley.;Reynold A Panettieri.;Frank C Albers.;Robert Rees.;Lynn Dunsire.;Anna Danilewicz.;Eva Johnsson.;Christy Cappelletti.;Alberto Papi.
来源: Chest. 2023年164卷3期585-595页
In the phase 3 MANDALA trial, as-needed albuterol-budesonide pressurized metered-dose inhaler significantly reduced severe exacerbation risk vs as-needed albuterol in patients with moderate-to-severe asthma receiving inhaled corticosteroid-containing maintenance therapy. This study (DENALI) was conducted to address the US Food and Drug Administration combination rule, which requires a combination product to demonstrate that each component contributes to its efficacy.
66. The Optimizing Lung Screening Trial (WF-20817CD): Multicenter Randomized Effectiveness Implementation Trial to Increase Tobacco Use Cessation for Individuals Undergoing Lung Screening.
作者: Kristie L Foley.;Emily V Dressler.;Kathryn E Weaver.;Erin L Sutfin.;David P Miller.;Christina Bellinger.;Carol Kittel.;Rebecca J Stone.;W Jeffrey Petty.;Stephanie R Land.;John G Spangler.;Glenn J Lesser.;Caroline Chiles.; .
来源: Chest. 2023年164卷2期531-543页
One-half of all people who undergo lung cancer screening (LCS) currently use tobacco. However, few published studies have explored how to implement effective tobacco use treatment optimally during the LCS encounter.
67. Patient-Reported Symptom and Health-Related Quality-of-Life Validation and Responsiveness During the First 6 Months of Treatment for Mycobacterium avium Complex Pulmonary Disease.
作者: Emily Henkle.;Alexandra L Quittner.;Nathan F Dieckmann.;Heather Franklin.;Amanda E Brunton.;Charles L Daley.;Kevin L Winthrop.; .
来源: Chest. 2023年164卷1期53-64页
Nontuberculous mycobacteria (NTM), predominately Mycobacterium avium complex (MAC), cause chronic pulmonary disease. Improvements in symptoms and health-related quality of life (HRQoL) are important treatment outcomes, but no validated patient-reported outcome (PRO) measure exists.
68. A Total Diet Replacement Weight Management Program for Difficult-to-Treat Asthma Associated With Obesity: A Randomized Controlled Feasibility Trial.
作者: Varun Sharma.;Helen Clare Ricketts.;Louise McCombie.;Naomi Brosnahan.;Luisa Crawford.;Lesley Slaughter.;Anna Goodfellow.;Femke Steffensen.;Duncan S Buchan.;Rekha Chaudhuri.;Michael E J Lean.;Douglas C Cowan.
来源: Chest. 2023年163卷5期1026-1037页
Obesity is often associated with uncontrolled, difficult-to-treat asthma and increased morbidity and mortality. Previous studies suggest that weight loss may improve asthma outcomes, but with heterogenous asthma populations studied and unclear consensus on the optimal method of weight management. The Counterweight-Plus Programme (CWP) for weight management is an evidence-based, dietitian-led total diet replacement (TDR) program.
69. Health-Related Quality of Life Following Robotic-Assisted or Video-Assisted Lobectomy in Patients With Non-Small Cell Lung Cancer: Results From the RVlob Randomized Clinical Trial.
作者: Runsen Jin.;Zhengyuan Zhang.;Yuyan Zheng.;Zhenyi Niu.;Siying Sun.;Yuqin Cao.;Yajie Zhang.;Abbas E Abbas.;Toni Lerut.;Jules Lin.;Hecheng Li.
来源: Chest. 2023年163卷6期1576-1588页
Robot-assisted lobectomy (RAL) is increasingly used as an alternative to video-assisted lobectomy (VAL) for resectable non-small cell lung cancer (NSCLC). However, there is little evidence of any difference in postoperative health-related quality of life (HRQoL) between these two approaches.
70. Perceived Autonomy Support in Telerehabilitation by People With Chronic Respiratory Disease: A Mixed Methods Study.
作者: Narelle S Cox.;Joanna Y T Lee.;Christine F McDonald.;Ajay Mahal.;Jennifer A Alison.;Richard Wootton.;Catherine J Hill.;Paolo Zanaboni.;Paul O'Halloran.;Janet Bondarenko.;Heather Macdonald.;Kathryn Barker.;Hayley Crute.;Christie Mellerick.;Bruna Wageck.;Helen Boursinos.;Aroub Lahham.;Amanda Nichols.;Pawel Czupryn.;Monique Corbett.;Emma Handley.;Angela T Burge.;Anne E Holland.
来源: Chest. 2023年163卷6期1410-1424页
Autonomy-supportive health environments can assist patients in achieving behavior change and can influence adherence positively. Telerehabilitation may increase access to rehabilitation services, but creating an autonomy-supportive environment may be challenging.
71. Treatment Outcomes for Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Real-World, Multisite Study of the Impact of Immunosuppression on Pulmonary Function Trajectory.
作者: Scott M Matson.;Misbah Baqir.;Teng Moua.;Michael Marll.;Jessica Kent.;Nicholas S Iannazzo.;Ryan D Boente.;John M Donatelli.;Junqiang Dai.;Francisco J Diaz.;M Kristen Demoruelle.;Mark B Hamblin.;Susan K Mathai.;Jay H Ryu.;Kristen Pope.;Christopher M Walker.;Joyce S Lee.
来源: Chest. 2023年163卷4期861-869页
Rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) is common in patients with RA and leads to significant morbidity and mortality. No randomized, placebo-controlled data are available that support the role of immunosuppression to treat RA-associated ILD, despite being widely used in clinical practice.
72. Topical Potassium Channel Blockage Improves Pharyngeal Collapsibility: A Translational, Placebo-Controlled Trial.
作者: Amal M Osman.;Sutapa Mukherjee.;Thomas J Altree.;Martina Delbeck.;Doris Gehring.;Michael Hahn.;Tina Lang.;Charles Xing.;Thomas Muller.;Gerrit Weimann.;Danny J Eckert.
来源: Chest. 2023年163卷4期953-965页
Potassium (K+) channel inhibition has been identified in animal models as a potential target to increase pharyngeal dilator muscle activity and to treat OSA. However, these findings have not yet been translated to humans.
73. Nebulized vs IV Tranexamic Acid for Hemoptysis: A Pilot Randomized Controlled Trial.
作者: Bharath Gopinath.;Prakash Ranjan Mishra.;Praveen Aggarwal.;Rakesh Nayaka.;Shivdas Rajaram Naik.;Vignan Kappagantu.;Prawal Shrimal.;Akshaya Ramaswami.;Sanjeev Bhoi.;Nayer Jamshed.;Tej Prakash Sinha.;Meera Ekka.;Akshay Kumar.
来源: Chest. 2023年163卷5期1176-1184页
Tranexamic acid (TA) is used to control bleeding in patients with hemoptysis. However, the effectiveness of the different routes of TA administration has not been studied.
74. Efzofitimod for the Treatment of Pulmonary Sarcoidosis.
作者: Daniel A Culver.;Shambhu Aryal.;Joseph Barney.;Connie C W Hsia.;W Ennis James.;Lisa A Maier.;Lucian T Marts.;Ogugua Ndili Obi.;Peter H S Sporn.;Nadera J Sweiss.;Sanjay Shukla.;Nelson Kinnersley.;Gennyne Walker.;Robert Baughman.
来源: Chest. 2023年163卷4期881-890页
Pulmonary sarcoidosis is characterized by the accumulation of immune cells that form granulomas affecting the lungs. Efzofitimod (ATYR1923), a novel immunomodulator, selectively binds neuropilin 2, which is upregulated on immune cells in response to lung inflammation.
75. Tranexamic Acid vs Adrenaline for Controlling Iatrogenic Bleeding During Flexible Bronchoscopy: A Double-Blind Randomized Controlled Trial.
作者: Sonja Badovinac.;Goran Glodić.;Ivan Sabol.;Feđa Džubur.;Mateja Janković Makek.;Denis Baričević.;Marta Koršić.;Filip Popović.;Dražena Srdić.;Miroslav Samaržija.
来源: Chest. 2023年163卷4期985-993页
The most commonly used topical hemostatic agents during flexible bronchoscopy (FB) are cold saline and adrenaline. Data on use of other agents such as tranexamic acid (TXA) for this purpose are limited.
76. Sleep Arousal-Related Ventricular Repolarization Lability Is Associated With Cardiovascular Mortality in Older Community-Dwelling Men.
作者: Sobhan Salari Shahrbabaki.;Dominik Linz.;Susan Redline.;Katie Stone.;Kristine Ensrud.;Mathias Baumert.
来源: Chest. 2023年163卷2期419-432页
Sleep is fragmented by brief arousals, and excessive arousal burden has been linked to increased cardiovascular (CV) risk, but mechanisms are poorly understood.
77. Multidisciplinary ICU Recovery Clinic Visits: A Qualitative Analysis of Patient-Provider Dialogues.
作者: Leanne M Boehm.;Valerie Danesh.;Tammy L Eaton.;Joanne McPeake.;Maria A Pena.;Kemberlee R Bonnet.;Joanna L Stollings.;Abigail C Jones.;David G Schlundt.;Carla M Sevin.
来源: Chest. 2023年163卷4期843-854页
Research confirms the heterogeneous nature of patient challenges during recovery from the ICU and supports the need for modifying care experiences, but few data are available to guide clinicians seeking to support patients' individual recovery trajectories.
78. High-Dose IV Hydroxocobalamin (Vitamin B12) in Septic Shock: A Double-Blind, Allocation-Concealed, Placebo-Controlled Single-Center Pilot Randomized Controlled Trial (The Intravenous Hydroxocobalamin in Septic Shock Trial).
作者: Jayshil J Patel.;Rodney Willoughby.;Jennifer Peterson.;Thomas Carver.;James Zelten.;Adrienne Markiewicz.;Kaitlin Spiegelhoff.;Lauren A Hipp.;Bethany Canales.;Aniko Szabo.;Daren K Heyland.;Christian Stoppe.;Jacek Zielonka.;Julie K Freed.
来源: Chest. 2023年163卷2期303-312页
Elevated hydrogen sulfide (H2S) contributes to vasodilatation and hypotension in septic shock, and traditional therapies do not target this pathophysiologic mechanism. High-dose IV hydroxocobalamin scavenges and prevents H2S formation, which may restore vascular tone and may accentuate recovery. No experimental human studies have tested high-dose IV hydroxocobalamin in adults with septic shock.
79. Factors Associated With Smoking Cessation Attempts in Lung Cancer Screening: A Secondary Analysis of the National Lung Screening Trial.
作者: Nina A Thomas.;Ralph Ward.;Nichole T Tanner.;Alana M Rojewski.;Benjamin Toll.;Mulugeta Gebregziabher.;Gerard A Silvestri.
来源: Chest. 2023年163卷2期433-443页
Lung cancer remains the leading cause of cancer-related mortality in the United States. The National Lung Screening Trial (NLST) demonstrated a 20% reduction in lung cancer mortality resulting from lung cancer screening (LCS) with an additive reduction from smoking abstinence. However, successful smoking cessation within LCS is variable.
80. Inhaled Treprostinil Dosage in Pulmonary Hypertension Associated With Interstitial Lung Disease and Its Effects on Clinical Outcomes.
作者: Steven D Nathan.;Chunqin Deng.;Christopher S King.;Hilary M DuBrock.;Jean Elwing.;Sudarshan Rajagopal.;Franz Rischard.;Sandeep Sahay.;Meredith Broderick.;Eric Shen.;Peter Smith.;Victor F Tapson.;Aaron B Waxman.
来源: Chest. 2023年163卷2期398-406页
Pulmonary hypertension (PH) complicates the course of many patients with fibrotic interstitial lung disease (ILD). Inhaled treprostinil (iTre) has been shown to improve functional ability and to delay clinical worsening in patients with PH resulting from ILD.
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