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61. Perceived Autonomy Support in Telerehabilitation by People With Chronic Respiratory Disease: A Mixed Methods Study.
作者: Narelle S Cox.;Joanna Y T Lee.;Christine F McDonald.;Ajay Mahal.;Jennifer A Alison.;Richard Wootton.;Catherine J Hill.;Paolo Zanaboni.;Paul O'Halloran.;Janet Bondarenko.;Heather Macdonald.;Kathryn Barker.;Hayley Crute.;Christie Mellerick.;Bruna Wageck.;Helen Boursinos.;Aroub Lahham.;Amanda Nichols.;Pawel Czupryn.;Monique Corbett.;Emma Handley.;Angela T Burge.;Anne E Holland.
来源: Chest. 2023年163卷6期1410-1424页
Autonomy-supportive health environments can assist patients in achieving behavior change and can influence adherence positively. Telerehabilitation may increase access to rehabilitation services, but creating an autonomy-supportive environment may be challenging.
62. Treatment Outcomes for Rheumatoid Arthritis-Associated Interstitial Lung Disease: A Real-World, Multisite Study of the Impact of Immunosuppression on Pulmonary Function Trajectory.
作者: Scott M Matson.;Misbah Baqir.;Teng Moua.;Michael Marll.;Jessica Kent.;Nicholas S Iannazzo.;Ryan D Boente.;John M Donatelli.;Junqiang Dai.;Francisco J Diaz.;M Kristen Demoruelle.;Mark B Hamblin.;Susan K Mathai.;Jay H Ryu.;Kristen Pope.;Christopher M Walker.;Joyce S Lee.
来源: Chest. 2023年163卷4期861-869页
Rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) is common in patients with RA and leads to significant morbidity and mortality. No randomized, placebo-controlled data are available that support the role of immunosuppression to treat RA-associated ILD, despite being widely used in clinical practice.
63. Topical Potassium Channel Blockage Improves Pharyngeal Collapsibility: A Translational, Placebo-Controlled Trial.
作者: Amal M Osman.;Sutapa Mukherjee.;Thomas J Altree.;Martina Delbeck.;Doris Gehring.;Michael Hahn.;Tina Lang.;Charles Xing.;Thomas Muller.;Gerrit Weimann.;Danny J Eckert.
来源: Chest. 2023年163卷4期953-965页
Potassium (K+) channel inhibition has been identified in animal models as a potential target to increase pharyngeal dilator muscle activity and to treat OSA. However, these findings have not yet been translated to humans.
64. Nebulized vs IV Tranexamic Acid for Hemoptysis: A Pilot Randomized Controlled Trial.
作者: Bharath Gopinath.;Prakash Ranjan Mishra.;Praveen Aggarwal.;Rakesh Nayaka.;Shivdas Rajaram Naik.;Vignan Kappagantu.;Prawal Shrimal.;Akshaya Ramaswami.;Sanjeev Bhoi.;Nayer Jamshed.;Tej Prakash Sinha.;Meera Ekka.;Akshay Kumar.
来源: Chest. 2023年163卷5期1176-1184页
Tranexamic acid (TA) is used to control bleeding in patients with hemoptysis. However, the effectiveness of the different routes of TA administration has not been studied.
65. Efzofitimod for the Treatment of Pulmonary Sarcoidosis.
作者: Daniel A Culver.;Shambhu Aryal.;Joseph Barney.;Connie C W Hsia.;W Ennis James.;Lisa A Maier.;Lucian T Marts.;Ogugua Ndili Obi.;Peter H S Sporn.;Nadera J Sweiss.;Sanjay Shukla.;Nelson Kinnersley.;Gennyne Walker.;Robert Baughman.
来源: Chest. 2023年163卷4期881-890页
Pulmonary sarcoidosis is characterized by the accumulation of immune cells that form granulomas affecting the lungs. Efzofitimod (ATYR1923), a novel immunomodulator, selectively binds neuropilin 2, which is upregulated on immune cells in response to lung inflammation.
66. Tranexamic Acid vs Adrenaline for Controlling Iatrogenic Bleeding During Flexible Bronchoscopy: A Double-Blind Randomized Controlled Trial.
作者: Sonja Badovinac.;Goran Glodić.;Ivan Sabol.;Feđa Džubur.;Mateja Janković Makek.;Denis Baričević.;Marta Koršić.;Filip Popović.;Dražena Srdić.;Miroslav Samaržija.
来源: Chest. 2023年163卷4期985-993页
The most commonly used topical hemostatic agents during flexible bronchoscopy (FB) are cold saline and adrenaline. Data on use of other agents such as tranexamic acid (TXA) for this purpose are limited.
67. Sleep Arousal-Related Ventricular Repolarization Lability Is Associated With Cardiovascular Mortality in Older Community-Dwelling Men.
作者: Sobhan Salari Shahrbabaki.;Dominik Linz.;Susan Redline.;Katie Stone.;Kristine Ensrud.;Mathias Baumert.
来源: Chest. 2023年163卷2期419-432页
Sleep is fragmented by brief arousals, and excessive arousal burden has been linked to increased cardiovascular (CV) risk, but mechanisms are poorly understood.
68. Multidisciplinary ICU Recovery Clinic Visits: A Qualitative Analysis of Patient-Provider Dialogues.
作者: Leanne M Boehm.;Valerie Danesh.;Tammy L Eaton.;Joanne McPeake.;Maria A Pena.;Kemberlee R Bonnet.;Joanna L Stollings.;Abigail C Jones.;David G Schlundt.;Carla M Sevin.
来源: Chest. 2023年163卷4期843-854页
Research confirms the heterogeneous nature of patient challenges during recovery from the ICU and supports the need for modifying care experiences, but few data are available to guide clinicians seeking to support patients' individual recovery trajectories.
69. High-Dose IV Hydroxocobalamin (Vitamin B12) in Septic Shock: A Double-Blind, Allocation-Concealed, Placebo-Controlled Single-Center Pilot Randomized Controlled Trial (The Intravenous Hydroxocobalamin in Septic Shock Trial).
作者: Jayshil J Patel.;Rodney Willoughby.;Jennifer Peterson.;Thomas Carver.;James Zelten.;Adrienne Markiewicz.;Kaitlin Spiegelhoff.;Lauren A Hipp.;Bethany Canales.;Aniko Szabo.;Daren K Heyland.;Christian Stoppe.;Jacek Zielonka.;Julie K Freed.
来源: Chest. 2023年163卷2期303-312页
Elevated hydrogen sulfide (H2S) contributes to vasodilatation and hypotension in septic shock, and traditional therapies do not target this pathophysiologic mechanism. High-dose IV hydroxocobalamin scavenges and prevents H2S formation, which may restore vascular tone and may accentuate recovery. No experimental human studies have tested high-dose IV hydroxocobalamin in adults with septic shock.
70. Factors Associated With Smoking Cessation Attempts in Lung Cancer Screening: A Secondary Analysis of the National Lung Screening Trial.
作者: Nina A Thomas.;Ralph Ward.;Nichole T Tanner.;Alana M Rojewski.;Benjamin Toll.;Mulugeta Gebregziabher.;Gerard A Silvestri.
来源: Chest. 2023年163卷2期433-443页
Lung cancer remains the leading cause of cancer-related mortality in the United States. The National Lung Screening Trial (NLST) demonstrated a 20% reduction in lung cancer mortality resulting from lung cancer screening (LCS) with an additive reduction from smoking abstinence. However, successful smoking cessation within LCS is variable.
71. Inhaled Treprostinil Dosage in Pulmonary Hypertension Associated With Interstitial Lung Disease and Its Effects on Clinical Outcomes.
作者: Steven D Nathan.;Chunqin Deng.;Christopher S King.;Hilary M DuBrock.;Jean Elwing.;Sudarshan Rajagopal.;Franz Rischard.;Sandeep Sahay.;Meredith Broderick.;Eric Shen.;Peter Smith.;Victor F Tapson.;Aaron B Waxman.
来源: Chest. 2023年163卷2期398-406页
Pulmonary hypertension (PH) complicates the course of many patients with fibrotic interstitial lung disease (ILD). Inhaled treprostinil (iTre) has been shown to improve functional ability and to delay clinical worsening in patients with PH resulting from ILD.
72. Assessing Daily Life Physical Activity by Actigraphy in Pulmonary Arterial Hypertension: Insights From the Randomized Controlled Study With Selexipag (TRACE).
作者: Luke S Howard.;Stephan Rosenkranz.;Robert P Frantz.;Anna R Hemnes.;Thomas Pfister.;Shu-Fang Hsu Schmitz.;Hall Skåra.;Marc Humbert.;Ioana R Preston.
来源: Chest. 2023年163卷2期407-418页
Reduced daily life physical activity (DLPA) in pulmonary arterial hypertension (PAH) contributes to a poor quality of life.
73. A 30-Minute Spontaneous Breathing Trial Misses Many Children Who Go On to Fail a 120-Minute Spontaneous Breathing Trial.
作者: Kelby E Knox.;Justin C Hotz.;Christopher J L Newth.;Michael C K Khoo.;Robinder G Khemani.
来源: Chest. 2023年163卷1期115-127页
The optimal length of spontaneous breathing trials (SBTs) in children is unknown.
74. Long-term Azithromycin in Children With Bronchiectasis Unrelated to Cystic Fibrosis: Treatment Effects Over Time.
作者: Don Vicendese.;Stephanie Yerkovich.;Keith Grimwood.;Patricia C Valery.;Catherine A Byrnes.;Peter S Morris.;Shyamali C Dharmage.;Anne B Chang.
来源: Chest. 2023年163卷1期52-63页
Following evidence from randomized controlled trials, patients with bronchiectasis unrelated to cystic fibrosis receive long-term azithromycin to reduce acute respiratory exacerbations. However, the period when azithromycin is effective and which patients are likely to most benefit remain unknown.
75. Multimodal Telemonitoring for Weight Reduction in Patients With Sleep Apnea: A Randomized Controlled Trial.
作者: Kimihiko Murase.;Takuma Minami.;Satoshi Hamada.;David Gozal.;Naomi Takahashi.;Yoshinari Nakatsuka.;Hirofumi Takeyama.;Kiminobu Tanizawa.;Daisuke Endo.;Toshiki Akahoshi.;Yasutaka Moritsuchi.;Toru Tsuda.;Yoshiro Toyama.;Motoharu Ohi.;Yasuhiro Tomita.;Koji Narui.;Naho Matsuyama.;Tetsuro Ohdaira.;Takatoshi Kasai.;Tomomasa Tsuboi.;Yasuhiro Gon.;Yoshihiro Yamashiro.;Shinichi Ando.;Hiroyuki Yoshimine.;Yoshifumi Takata.;Akiomi Yoshihisa.;Koichiro Tatsumi.;Shin-Ichi Momomura.;Tomohiro Kuroda.;Satoshi Morita.;Takeo Nakayama.;Toyohiro Hirai.;Kazuo Chin.
来源: Chest. 2022年162卷6期1373-1383页
Telemonitoring the use of CPAP devices and remote feedback on device data effectively optimizes CPAP adherence in patients with OSA.
76. Effectiveness of a Long-term Home-Based Exercise Training Program in Patients With COPD After Pulmonary Rehabilitation: A Multicenter Randomized Controlled Trial.
作者: Anja Frei.;Thomas Radtke.;Kaba Dalla Lana.;Patrick Brun.;Thomas Sigrist.;Marc Spielmanns.;Swantje Beyer.;Thomas F Riegler.;Gilbert Büsching.;Sabine Spielmanns.;Ramona Kunz.;Tamara Cerini.;Julia Braun.;Yuki Tomonaga.;Miquel Serra-Burriel.;Ashley Polhemus.;Milo A Puhan.
来源: Chest. 2022年162卷6期1277-1286页
Most patients with COPD do not maintain exercise training after pulmonary rehabilitation (PR).
77. Immediate, Remote Smoking Cessation Intervention in Participants Undergoing a Targeted Lung Health Check: Quit Smoking Lung Health Intervention Trial, a Randomized Controlled Trial.
作者: Parris J Williams.;Keir E J Philip.;Navjot Kaur Gill.;Deirdre Flannery.;Sara Buttery.;Emily C Bartlett.;Anand Devaraj.;Samuel V Kemp.;Jamie Addis.;Jane Derbyshire.;Michelle Chen.;Katie Morris.;Anthony A Laverty.;Nicholas S Hopkinson.
来源: Chest. 2023年163卷2期455-463页
Lung cancer screening programs provide an opportunity to support people who smoke to quit, but the most appropriate model for delivery remains to be determined. Immediate face-to-face smoking cessation support for people undergoing screening can increase quit rates, but it is not known whether remote delivery of immediate smoking cessation counselling and pharmacotherapy in this context also is effective.
78. A Double-Blind Randomized Placebo-Controlled Phase 3 Trial of Tobramycin Inhalation Solution in Adults With Bronchiectasis With Pseudomonas aeruginosa Infection.
作者: Wei-Jie Guan.;Jin-Fu Xu.;Hong Luo.;Xing-Xiang Xu.;Yuan-Lin Song.;Wan-Li Ma.;Zong-An Liang.;Xue-Dong Liu.;Guo-Jun Zhang.;Xiao-Ju Zhang.;Rong-Kai Li.;Shu-Yang Zhu.;Yi-Jie Zhang.;Xing-Jun Cai.;Li-Ping Wei.;Dong-Bo Tian.;Hui Zhao.;Ping-Yan Chen.;Jie-Ming Qu.;Nan-Shan Zhong.; .
来源: Chest. 2023年163卷1期64-76页
Few large-scale studies have demonstrated the efficacy of tobramycin nebulization in bronchiectasis. We evaluated the efficacy and safety of nebulized tobramycin inhalation solution (TIS) in adults with bronchiectasis with Pseudomonas aeruginosa infection.
79. Ventilatory Strategy to Prevent Atelectasis During Bronchoscopy Under General Anesthesia: A Multicenter Randomized Controlled Trial (Ventilatory Strategy to Prevent Atelectasis -VESPA- Trial).
作者: Moiz Salahuddin.;Mona Sarkiss.;Ala-Eddin S Sagar.;Ioannis Vlahos.;Christopher H Chang.;Archan Shah.;Bruce F Sabath.;Julie Lin.;Juhee Song.;Teresa Moon.;Peter H Norman.;George A Eapen.;Horiana B Grosu.;David E Ost.;Carlos A Jimenez.;Gouthami Chintalapani.;Roberto F Casal.
来源: Chest. 2022年162卷6期1393-1401页
Atelectasis negatively influences peripheral bronchoscopy, increasing CT scan-body divergence, obscuring targets, and creating false-positive radial-probe endobronchial ultrasound (RP-EBUS) images.
80. Neutralizing COVID-19 Convalescent Plasma in Adults Hospitalized With COVID-19: A Blinded, Randomized, Placebo-Controlled Trial.
作者: Wesley H Self.;Allison P Wheeler.;Thomas G Stewart.;Harry Schrager.;Jason Mallada.;Christopher B Thomas.;Vince D Cataldo.;Hollis R O'Neal.;Nathan I Shapiro.;Conor Higgins.;Adit A Ginde.;Lakshmi Chauhan.;Nicholas J Johnson.;Daniel J Henning.;Stuti J Jaiswal.;Manoj J Mammen.;Estelle S Harris.;Sonal R Pannu.;Maryrose Laguio-Vila.;Wissam El Atrouni.;Marjolein de Wit.;Daanish Hoda.;Claudia S Cohn.;Carla McWilliams.;Carl Shanholtz.;Alan E Jones.;Jay S Raval.;Simon Mucha.;Tina S Ipe.;Xian Qiao.;Stephen J Schrantz.;Aarthi Shenoy.;Richard D Fremont.;Eric J Brady.;Robert H Carnahan.;James D Chappell.;James E Crowe.;Mark R Denison.;Pavlo Gilchuk.;Laura J Stevens.;Rachel E Sutton.;Isaac Thomsen.;Sandra M Yoder.;Amanda J Bistran-Hall.;Jonathan D Casey.;Christopher J Lindsell.;Li Wang.;Jill M Pulley.;Jillian P Rhoads.;Gordon R Bernard.;Todd W Rice.; .
来源: Chest. 2022年162卷5期982-994页
Convalescent plasma has been one of the most common treatments for COVID-19, but most clinical trial data to date have not supported its efficacy.
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