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共有 806 条符合本次的查询结果, 用时 1.7654143 秒

761. Cyclosporin A and iloprost treatment of systemic sclerosis: clinical results and interleukin-6 serum changes after 12 months of therapy.

作者: G Filaci.;M Cutolo.;M Scudeletti.;C Castagneto.;L Derchi.;R Gianrossi.;F Ropolo.;P Zentilin.;A Sulli.;G Murdaca.;M Ghio.;F Indiveri.;F Puppo.
来源: Rheumatology (Oxford). 1999年38卷10期992-6页
The main aim was to analyse the long-term therapeutic effects on systemic sclerosis (SSc) patients of treatment with either (i) iloprost alone or (ii) low-dose oral cyclosporin A (CyA) associated with iloprost. A secondary aim was to analyse interleukin-6 (IL-6) serum levels in SSc patients before and after 1 yr of treatment.

762. Steroid injection for heel pain: evidence of short-term effectiveness. A randomized controlled trial.

作者: F Crawford.;D Atkins.;P Young.;J Edwards.
来源: Rheumatology (Oxford). 1999年38卷10期974-7页
To compare the effectiveness of a steroid injection (25 mg/ml prednisolone acetate) with a local anaesthetic control in the treatment of heel pain and to determine any advantage for patients' comfort of using a posterior tibial nerve block to anesthetize the heel prior to infiltration.

763. The effects of dothiepin on subjects with rheumatoid arthritis and depression.

作者: G Ash.;C M Dickens.;F H Creed.;M I Jayson.;B Tomenson.
来源: Rheumatology (Oxford). 1999年38卷10期959-67页
The relative importance of direct analgesic and antidepressant effects of antidepressant drugs in rheumatoid arthritis (RA) is not clear.

764. Defining disease activity in ankylosing spondylitis: is a combination of variables (Bath Ankylosing Spondylitis Disease Activity Index) an appropriate instrument?

作者: A Calin.;J P Nakache.;A Gueguen.;H Zeidler.;H Mielants.;M Dougados.
来源: Rheumatology (Oxford). 1999年38卷9期878-82页
Disease activity has been defined using a self-administered instrument, focusing on fatigue, axial pain, peripheral pain, enthesopathy and morning stiffness [Bath Ankylosing Spondylitis Disease Activity Index (BASDAI)]. This validated instrument is simple and takes 40 s to complete, but whether the index is an accurate expression of the component parts, or whether additional weighting would enhance its efficacy, is unclear.

765. The effect of acupuncture on patients with rheumatoid arthritis: a randomized, placebo-controlled cross-over study.

作者: J David.;S Townsend.;R Sathanathan.;S Kriss.;C J Doré.
来源: Rheumatology (Oxford). 1999年38卷9期864-9页
Acupuncture is commonly used by patients with chronic painful musculoskeletal disorders. There are, however, few well-designed studies of its efficacy. This paper describes a randomized placebo-controlled cross-over design to evaluate acupuncture as a useful treatment adjunct in the management of patients with rheumatoid arthritis (RA).

766. Zidovudine in primary Sjögren's syndrome.

作者: S D Steinfeld.;P Demols.;J P Van Vooren.;E Cogan.;T Appelboom.
来源: Rheumatology (Oxford). 1999年38卷9期814-7页
To evaluate the efficacy of the administration of zidovudine (AZT), an antiretroviral drug, in patients with primary Sjögren's syndrome (SS).

767. Haematopoietic stem cell transplantation for active systemic lupus erythematosus.

作者: A Traynor.;R K Burt.
来源: Rheumatology (Oxford). 1999年38卷8期767-72页
For patients with systemic lupus erythematosus (SLE) who are at risk of disease-related mortality, we have initiated a protocol of intensive immunosuppression and haematopoietic stem cell support. The first patient enrolled in this study was in the midst of a lupus flare manifest by nephritis and rapidly declining renal function, uncontrolled hypertension, immune-mediated cytopenias, and serositis characterized by a large pericardial effusion and abdominal pain. Antinuclear antibody (ANA), anti-double-stranded (ds) DNA and complement were abnormal. This patient is now more than 1 yr post-stem cell transplant and is taking no immunosuppressive medication. Her serologies are normal, effusions have resolved, blood pressure is normal and renal function is markedly improved. The clinical and serological course of this patient is summarized here.

768. Autologous stem cell transplantation: a possible treatment for refractory juvenile chronic arthritis?

作者: N M Wulffraat.;W Kuis.
来源: Rheumatology (Oxford). 1999年38卷8期764-6页
In adults, autologous stem cell transplantation (ASCT) has been described recently as a possible treatment for severe autoimmune disease refractory to conventional treatment. We report here the four first children with severe forms of juvenile chronic arthritis (JCA) treated with ASCT.

769. Hyaluronic acid in the treatment of osteoarthritis of the knee.

作者: E C Huskisson.;S Donnelly.
来源: Rheumatology (Oxford). 1999年38卷7期602-7页
We examined the efficacy, safety and patient satisfaction of intra-articular hyaluronic acid (HA) in patients with osteoarthritis of the knee.

770. Bone mineral density in scleroderma.

作者: L Carbone.;F Tylavsky.;J Wan.;K McKown.;S Cheng.
来源: Rheumatology (Oxford). 1999年38卷4期371-2页

771. The effects of interferon beta treatment on arthritis.

作者: P P Tak.;B A Hart.;M C Kraan.;M Jonker.;T J Smeets.;F C Breedveld.
来源: Rheumatology (Oxford). 1999年38卷4期362-9页
To determine whether interferon beta (IFN-beta) therapy might have a beneficial effect on arthritis, we evaluated the effect of IFN-beta on collagen type II-induced arthritis (CIA) in rhesus monkeys and conducted a pilot study in patients with rheumatoid arthritis (RA).

772. A randomized trial of acupuncture as an adjunctive therapy in osteoarthritis of the knee.

作者: B M Berman.;B B Singh.;L Lao.;P Langenberg.;H Li.;V Hadhazy.;J Bareta.;M Hochberg.
来源: Rheumatology (Oxford). 1999年38卷4期346-54页
The purpose of this study was to investigate the efficacy of acupuncture as an adjunctive therapy to standard care for the relief of pain and dysfunction in elderly patients with osteoarthritis (OA) of the knee.

773. A preliminary study of ultrasound aspiration of bone erosion in early rheumatoid arthritis.

作者: D McGonagle.;W Gibbon.;P O'Connor.;D Blythe.;R Wakefield.;M Green.;D Veale.;P Emery.
来源: Rheumatology (Oxford). 1999年38卷4期329-31页
To develop a new technique to assess the primary lesion in early rheumatoid arthritis (RA).

774. Chromosomal analysis of peripheral lymphocytes of patients before and after radiation synovectomy with samarium-153 particulate hydroxyapatite.

作者: E K O'Duffy.;F J Oliver.;S J Chatters.;H Walker.;D C Lloyd.;J C Edwards.;P J Ell.
来源: Rheumatology (Oxford). 1999年38卷4期316-20页
Radiation synovectomy may be indicated for the treatment of chronic synovitis. A number of factors may affect its current use, including availability, limited evidence for its efficacy compared to intra-articular glucocorticoid, and concerns regarding the potential long-term effects of radiation exposure, particularly in younger patients. Specific chromosome-type abnormalities in peripheral lymphocytes can be useful indicators of whole-body radiation exposure. The frequency of these aberrations has been shown to increase in patients who have had radiation synovectomy using yttrium-90 by up to five times compared to baseline levels. Samarium-153 particulate hydroxyapatite (Sm-153 PHYP) is a new radiopharmaceutical currently on trial which appears to have less extra-articular leakage than yttrium-90 compounds. The aim of this study was to identify any increase in specific chromosome-type abnormalities, using published criteria, in patients following Sm-153 PHYP synovectomy of the knee. The 10 patients (five men, five women) in whom the analyses were performed had a mean age of 47 yr (range 28-70 yr).

775. Probucol improves symptoms and reduces lipoprotein oxidation susceptibility in patients with Raynaud's phenomenon.

作者: C P Denton.;T D Bunce.;M B Dorado.;Z Roberts.;H Wilson.;K Howell.;K R Bruckdorfer.;C M Black.
来源: Rheumatology (Oxford). 1999年38卷4期309-15页
Reactive oxygen species have been implicated in the pathogenesis of inflammatory and vascular disease. We have undertaken a controlled trial to evaluate probucol, a synthetic antioxidant, as a potential therapy for Raynaud's phenomenon.

776. A 12-month randomized controlled trial of patient education on radiographic changes and quality of life in early rheumatoid arthritis.

作者: P S Helliwell.;M O'Hara.;J Holdsworth.;A Hesselden.;T King.;P Evans.
来源: Rheumatology (Oxford). 1999年38卷4期303-8页
In rheumatoid arthritis, education programmes successfully impart knowledge but, notwithstanding issues of empowerment, this knowledge has to be translated into behavioural change to have a chance of improving disease outcome. Arguably, behavioural change must also occur early if outcomes are to be improved. For these reasons, we planned a study of patient education in early disease, with radiological damage and quality of life as the main outcome variables.

777. New arguments for a vasculitic nature of polymyalgia rheumatica using positron emission tomography.

作者: D Blockmans.;A Maes.;S Stroobants.;J Nuyts.;G Bormans.;D Knockaert.;H Bobbaers.;L Mortelmans.
来源: Rheumatology (Oxford). 1999年38卷5期444-7页
To study the possible contribution of fluorodeoxyglucose (FDG)-positron emission tomography (PET) in the diagnosis of giant cell arteritis and polymyalgia rheumatica.

778. Comparative efficacy and safety of nimesulide and diclofenac in patients with acute shoulder, and a meta-analysis of controlled studies with nimesulide.

作者: W Wober.
来源: Rheumatology (Oxford). 1999年38 Suppl 1卷33-8页
Adverse events, particularly gastrointestinal, partially offset the therapeutic value of NSAIDs. The abilities of nimesulide to inhibit COX-2 preferentially and to exert other novel anti-inflammatory actions are consistent with good efficacy and safety. This is borne out by a double-blind multicentre comparison of nimesulide and diclofenac in 122 patients with acute shoulder, and by a meta-analysis of various nimesulide trials. At the end of the 14 day double-blind study, nimesulide was at least as effective as diclofenac (investigator ratings: good/very good in 79.0% of patients given nimesulide, and 78.0% with diclofenac; patient ratings: good/very good in 82.3 and 78.0% respectively). Four patients (6.5%) dropped out in the nimesulide group (two early recovery, one lack of effect, one adverse event), compared with 13 (21.7%) in the diclofenac group, due mainly to adverse events (P=0.003). Global tolerability was judged by the investigators to be good/very good in 96.8% of the nimesulide group compared with 72.9% of those given diclofenac. Judgements by the patients were 96.8 and 78.0% respectively. Both differences are highly significant statistically. The meta-analysis demonstrates that nimesulide given for 2 weeks is far more efficacious than placebo in treating osteoarthritis, and is at least comparable to other NSAIDs The benefit-risk ratio for nimesulide was better in all individual studies since 100 mg nimesulide twice daily was about equal to placebo in safety and tolerability, especially regarding gastrointestinal adverse events.

779. Responsiveness of outcome measures in juvenile chronic arthritis. Italian Pediatric Rheumatology Study Group.

作者: N Ruperto.;A Ravelli.;F Falcini.;L Lepore.;A Buoncompagni.;V Gerloni.;M Bardare.;E Cortis.;F Zulian.;M L Sardella.;C Giovanni Strano.;M Alessio.;M G Alpigiani.;D Migliavacca.;A Pistorio.;S Viola.;A Martini.
来源: Rheumatology (Oxford). 1999年38卷2期176-80页
To examine the responsiveness of the disease activity measures more commonly used in juvenile chronic arthritis (JCA) clinical trials.

780. Changes in articular synovial lining volume measured by magnetic resonance in a randomized, double-blind, controlled trial of intra-articular samarium-153 particulate hydroxyapatite for chronic knee synovitis.

作者: G P Clunie.;I D Wilkinson.;D Lui.;M A Hall-Craggs.;M N Paley.;J C Edwards.;P J Ell.
来源: Rheumatology (Oxford). 1999年38卷2期113-7页
Magnetic resonance techniques have recently been investigated as tools with which to monitor inflammatory joint disease. Our aim was to use a contrast-enhanced T1-weighted protocol to monitor the short-term changes in knee synovial lining volume in a double-blind, randomized, controlled trial of intra-articular samarium-153 particulate hydroxyapatite (Sm-153 PHYP).
共有 806 条符合本次的查询结果, 用时 1.7654143 秒