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741. Office spirometry significantly improves early detection of COPD in general practice: the DIDASCO Study.
To determine if spirometry is essential for the early detection of COPD in general practice, compared to the screening value of a short questionnaire.
742. Predicting response to omalizumab, an anti-IgE antibody, in patients with allergic asthma.
作者: Jean Bousquet.;Sally Wenzel.;Stephen Holgate.;William Lumry.;Peter Freeman.;Howard Fox.
来源: Chest. 2004年125卷4期1378-86页
To determine baseline characteristics predictive of response to omalizumab, an anti-IgE antibody, in patients with allergic asthma.
743. Repeated dosing effects of mediator antagonists in inhaled corticosteroid-treated atopic asthmatic patients.
作者: Daniel K C Lee.;Catherine M Jackson.;Kay Haggart.;Brian J Lipworth.
来源: Chest. 2004年125卷4期1372-7页
The anti-inflammatory effects of repeated dosing with mediator antagonists as add-on therapy to that with inhaled corticosteroids (ICSs) in patients with asthma remain to be fully established.
744. Spinal prostaglandin formation and pain perception following thoracotomy: a role for cyclooxygenase-2.
Prostaglandins (PGs) generated in the spinal cord may play a major role in pain perception. Consequently, the suppression of spinal cyclooxygenase (COX) and PG formation may contribute to the analgesic effect of nonsteroidal anti-inflammatory drugs (NSAIDs) in pain following surgery. Which isoform of COX is responsible for postsurgical pain and, consequently, should be targeted, is unclear.
745. Effects of anaerobic training in children with cystic fibrosis: a randomized controlled study.
作者: Peter H C Klijn.;Annemarie Oudshoorn.;Cornelis K van der Ent.;Janjaap van der Net.;Jan L Kimpen.;Paul J M Helders.
来源: Chest. 2004年125卷4期1299-305页
Children's physical activity patterns are characterized by short-term anaerobic activities. Anaerobic exercise performance in children with cystic fibrosis (CF) has received little attention compared to aerobic performance. This study investigated the effects of anaerobic training in children with CF.
746. Symptoms, respirator use, and pulmonary function changes among New York City firefighters responding to the World Trade Center disaster.
作者: Debra M Feldman.;Sherry L Baron.;Bruce P Bernard.;Boris D Lushniak.;Gisela Banauch.;Nicole Arcentales.;Kerry J Kelly.;David J Prezant.
来源: Chest. 2004年125卷4期1256-64页
New York City firefighters responding to the World Trade Center (WTC) disaster on September 11, 2001, were exposed to numerous hazards. A medical screening program was conducted 3 weeks after the disaster on a sample of firefighters.
747. Long-term intermittent dobutamine infusion, combined with oral amiodarone for end-stage heart failure: a randomized double-blind study.
作者: John N Nanas.;Eleftheria P Tsagalou.;John Kanakakis.;Serafim N Nanas.;John V Terrovitis.;Thomas Moon.;Maria I Anastasiou-Nana.
来源: Chest. 2004年125卷4期1198-204页
To examine the effects of long-term intermittent dobutamine infusion, combined with oral amiodarone in patients with congestive heart failure (CHF) refractory to standard medical treatment.
748. Prognostic value of stress testing in patients over 75 years of age with chronic angina.
作者: Raban V Jeger.;Michael J Zellweger.;Christoph Kaiser.;Leticia Grize.;Stefan Osswald.;Peter T Buser.;Matthias E Pfisterer.; .
来源: Chest. 2004年125卷3期1124-31页
To define the prognostic value of stress testing (STRT) in patients >or= 75 years of age.
749. The relationship between single-breath diffusion capacity of the lung for nitric oxide and carbon monoxide during various exercise intensities.
作者: Gerald S Zavorsky.;Karine Badra Quiron.;Philip S Massarelli.;Larry C Lands.
来源: Chest. 2004年125卷3期1019-27页
To determine the relationship between single-breath diffusion capacity of the lung for nitric oxide (DLNO) and single-breath diffusion capacity of the lung for carbon monoxide (DLCO), and to determine the single-breath DLNO/DLCO ratios during rest and at several exercise intensities using a commercial lung diffusion system that uses electrochemical cells to analyze gases.
750. Steady-state intrapulmonary concentrations of moxifloxacin, levofloxacin, and azithromycin in older adults.
作者: Blair Capitano.;Holly M Mattoes.;Eric Shore.;Aidan O'Brien.;Sidney Braman.;Chistina Sutherland.;David P Nicolau.
来源: Chest. 2004年125卷3期965-73页
To determine the steady-state, extracellular, and intracellular pulmonary disposition of moxifloxacin (MXF), levofloxacin (LEVO), and azithromycin (AZI) relative to that of the plasma over a 24-h dosing interval.
751. Short-term and long-term outcomes of moxifloxacin compared to standard antibiotic treatment in acute exacerbations of chronic bronchitis.
作者: Robert Wilson.;Luigi Allegra.;Gérard Huchon.;Jose-Luis Izquierdo.;Paul Jones.;Tom Schaberg.;Pierre-Phillippe Sagnier.; .
来源: Chest. 2004年125卷3期953-64页
To compare the effectiveness of oral moxifloxacin with standard antibiotic therapy in acute exacerbation of chronic bronchitis (AECB).
752. Field exercise vs laboratory eucapnic voluntary hyperventilation to identify airway hyperresponsiveness in elite cold weather athletes.
作者: Kenneth W Rundell.;Sandra D Anderson.;Barry A Spiering.;Daniel A Judelson.
来源: Chest. 2004年125卷3期909-15页
For the 2002 Winter Olympic Games, athletes were required to submit objective evidence of asthma or exercise-induced bronchoconstriction (EIB) for approval to inhale a beta(2)-agonist. Eucapnic voluntary hyperventilation (EVH) was recommended as a laboratory challenge that would identify airway hyperresponsiveness (AHR) consistent with EIB. The objective was to compare the change in FEV(1) provoked by EVH with that provoked by exercise in cold weather athletes.
753. Vitamin E and beta-carotene supplementation and hospital-treated pneumonia incidence in male smokers.
Vitamin E and beta-carotene affect various measures of immune function and accordingly might influence the predisposition of humans to infections. However, only few controlled trials have tested this hypothesis.
754. Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: a multicenter, double-blind, placebo-controlled trial.
作者: Richard B Moss.;David Rodman.;L Terry Spencer.;Moira L Aitken.;Pamela L Zeitlin.;David Waltz.;Carlos Milla.;Alan S Brody.;John P Clancy.;Bonnie Ramsey.;Nicole Hamblett.;Alison E Heald.
来源: Chest. 2004年125卷2期509-21页
The primary objective was to determine the safety and tolerability of repeated doses of aerosolized adeno-associated serotype 2 vector containing cystic fibrosis transmembrane conductance regulator (CFTR) complementary DNA (cDNA) [tgAAVCF], an adeno-associated virus (AAV) vector encoding the complete human CFTR cDNA. Secondary objectives included evaluation of pulmonary function assessed by spirometry, lung abnormalities by high-resolution CT (HRCT), airway cytokines, vector shedding, serum neutralizing antibody to AAV serotype 2 (AAV2), and gene transfer and expression in a subset of subjects undergoing bronchoscopy with bronchial brushings.
755. Prospective multicenter study of relapse following emergency department treatment of COPD exacerbation.
作者: Sunghye Kim.;Charles L Emerman.;Rita K Cydulka.;Brian H Rowe.;Sunday Clark.;Carlos A Camargo.; .
来源: Chest. 2004年125卷2期473-81页
To determine the incidence and risk factors of relapse after an emergency department (ED) visit for COPD exacerbation.
756. Methacholine challenge testing: comparison of the two American Thoracic Society-recommended methods.
作者: Catherine Wubbel.;Michael J Asmus.;Gary Stevens.;Sarah E Chesrown.;Leslie Hendeles.
来源: Chest. 2004年125卷2期453-8页
Recent American Thoracic Society guidelines recommend two different methods of methacholine challenge testing: the 2-min tidal breathing method with twofold increases in concentration, and the five-breath dosimeter method with fourfold increases. Since the tidal breathing method delivers more methacholine to the mouthpiece, we hypothesized that the provocative concentration of methacholine required to decrease FEV(1) by 20% (PC(20)) would be lower than with the dosimeter method.
757. Potassium supplementation, diet vs pills: a randomized trial in postoperative cardiac surgery patients.
作者: Wendi Norris.;Karyn S Kunzelman.;Susan Bussell.;Linda Rohweder.;Richard P Cochran.
来源: Chest. 2004年125卷2期404-9页
Cardiac surgery patients are commonly treated with diuretics, which can result in hypokalemia requiring potassium supplementation.
758. Long-term maintenance of normal sinus rhythm in patients with current symptomatic atrial fibrillation: amiodarone vs propafenone, both in low doses.
作者: George E Kochiadakis.;Nikos E Igoumenidis.;Michail I Hamilos.;Panos G Tzerakis.;Nikos C Klapsinos.;Evangelos A Zacharis.;Panos E Vardas.
来源: Chest. 2004年125卷2期377-83页
To compare the efficacy and safety of amiodarone and propafenone when used for the prevention of atrial fibrillation (AF) and maintenance of normal sinus rhythm in patients with refractory AF.
759. Conventional vs endobronchial ultrasound-guided transbronchial needle aspiration: a randomized trial.
Our group performed a randomized trial to assess whether the addition of endobronchial ultrasound (EBUS) guidance will lead to better results than standard transbronchial needle aspiration (TBNS). EBUS guidance seems to be beneficial in increasing the yield of TBNA but has not been proven to be superior to conventional procedures in a randomized trial.
760. The efficacy of premixed nitrous oxide and oxygen for fiberoptic bronchoscopy in pediatric patients: a randomized, double-blind, controlled study.
作者: Brigitte Fauroux.;Peter Onody.;Olivier Gall.;Barbara Tourniaire.;Serge Koscielny.;Annick Clément.
来源: Chest. 2004年125卷1期315-21页
s: The aim of the study was to evaluate the efficacy and safety of premixed 50% nitrous oxide and oxygen on the quality of sedation and pain control during fiberoptic bronchoscopy (FB) in children.
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