701. High Normocapnia and Better Functional Outcome in Patients Undergoing Venoarterial Extracorporeal Membrane Oxygenation After Out-of-Hospital Cardiac Arrest.
作者: Junichi Izawa.;Shunsuke Kimata.;Sho Komukai.;Masashi Okubo.;Akihiro Sakai.;Tetsuhisa Kitamura.;Yutaka Yamaguchi.
来源: Chest. 2025年167卷6期1639-1650页
The optimal target for Paco2 remains uncertain in patients undergoing venoarterial extracorporeal membrane oxygenation (VA-ECMO) after out-of-hospital cardiac arrest (OHCA).
702. Characterization of Occupational Endotoxin-Related Small Airway Disease With Longitudinal Paired Inspiratory/Expiratory CT Scans.
作者: Yuming Sun.;Jian Kang.;Feng-Ying Zhang.;Hantao Wang.;Peggy S Lai.;George R Washko.;Raul San Jose Estepar.;David C Christiani.;Yi Li.
来源: Chest. 2025年168卷1期43-55页
Although small airway disease (SAD) has been recognized as a major contributor to obstructive respiratory diseases, the association between occupational endotoxin exposure and SAD, as characterized by CT scans, requires further investigation.
703. Understanding the Determinants and Outcomes of Education in Pulmonary Rehabilitation: Moving Toward Person-Centered Care.
作者: M Aurora Mendes.;Guilherme Rodrigues.;Daisy J A Janssen.;Martijn A Spruit.;Alda Marques.
来源: Chest. 2025年167卷6期1615-1627页
Education and psychosocial support are essential components of pulmonary rehabilitation (PR). However, the delivery of education often follows a one-size-fits-all approach, with individual factors that influence learning rarely considered. Moreover, education-related outcomes are frequently overlooked in PR assessments, and their inconsistent use has limited our understanding of education's impact on people with chronic respiratory diseases. There is a clear need for practical guidance to identify key learning determinants and to define targeted education outcomes, ultimately optmizing PR and establishing quality standards.
704. Impact of Pulmonary Rehabilitation on Survival in People With Interstitial Lung Disease.
Pulmonary rehabilitation (PR) is a beneficial intervention for people with interstitial lung disease (ILD); however, the effect of PR on survival is unclear. This study compared the survival outcomes in people with ILD who were allocated to PR vs those who were allocated to control in 2 published randomized controlled trials.
705. Ventilator-Associated Pneumonia in Low- and Middle-Income vs High-Income Countries: The Role of Ventilator Bundle, Ventilation Practices, and Health Care Staffing.
作者: Marko Nemet.;Cameron G Gmehlin.;Marija Vukoja.;Yue Dong.;Ognjen Gajic.;Aysun Tekin.; .
来源: Chest. 2025年167卷6期1628-1638页
Ventilator-associated pneumonia (VAP) rates are higher in low- and middle-income countries (LMICs) than in high-income countries (HICs).
706. Video vs Direct Laryngoscopy for Tracheal Intubation After Cardiac Arrest: A Secondary Analysis of the Direct vs Video Laryngoscope Trial.
作者: Amelia L Muhs.;Kevin P Seitz.;Edward T Qian.;Brant Imhoff.;Li Wang.;Matthew E Prekker.;Brian E Driver.;Stacy A Trent.;Daniel Resnick-Ault.;Steven G Schauer.;Adit A Ginde.;Derek W Russell.;Sheetal Gandotra.;David B Page.;John P Gaillard.;Lane M Smith.;Andrew J Latimer.;Steven H Mitchell.;Nicholas J Johnson.;Shekhar A Ghamande.;Heath D White.;Kevin W Gibbs.;Jessica A Palakshappa.;Derek J Vonderhaar.;David R Janz.;Micah R Whitson.;Christopher R Barnes.;Alon Dagan.;Ari Moskowitz.;Vijay Krishnamoorthy.;James T Herbert.;Michael D April.;Aaron M Joffe.;Jeremy P Walco.;Christopher G Hughes.;Kipp Shipley.;Amelia W Maiga.;Bradley D Lloyd.;Stephanie C DeMasi.;Wesley H Self.;Todd W Rice.;Matthew W Semler.;Jonathan D Casey.; .
来源: Chest. 2025年167卷5期1408-1415页
Airway management is a critical component of the care of patients experiencing cardiac arrest, but data from randomized trials on the use of video vs direct laryngoscopy for intubation in the setting of cardiac arrest are limited. Current American Heart Association guidelines recommend placement of an endotracheal tube either during CPR or shortly after return of spontaneous circulation, but do not provide guidance around intubation methods, including the choice of laryngoscope.
707. Factors Associated With High Intrathoracic Pressure in Patients With Obesity Undergoing Right Heart Catheterization.
作者: Gaurav Manek.;Shaoxiong Zhang.;Eduard Krishtopaytis.;Apostolos Perelas.;Ghaleb Khirfan.;Deborah Paul.;David Toth.;James E Lane.;Robert L Chatburn.;Umur Hatipoğlu.;Adriano R Tonelli.
来源: Chest. 2025年167卷6期1759-1763页 708. Low-Dose Melatonin for Prevention of Delirium in Critically Ill Patients: A Multicenter, Randomized, Placebo-Controlled Feasibility Trial.
作者: Lisa D Burry.;David R Williamson.;Michael E Detsky.;Francis Bernard.;Jennifer Foster.;Sangeeta Mehta.;Ruxandra Pinto.;Damon C Scales.;Louise Rose.
来源: Chest. 2025年167卷5期1397-1407页
Delirium is a common and serious syndrome of acute brain dysfunction associated with negative outcomes. Melatonin may have a role in delirium prevention for critically ill adults based on data from noncritically ill patient populations. Our objective was to assess the feasibility of a multicenter, randomized, placebo-controlled trial testing the hypothesis that low-dose melatonin prevents delirium in adults who are critically ill.
709. A 75-Year-Old Man With Supine Hypotension.
作者: Andres Leonardo Mora Carpio.;Madelyn Renzetti.;Martin Mutonga.;Mark D Siegel.
来源: Chest. 2025年167卷1期e9-e12页
A 75-year-old patient with autosomal dominant polycystic kidney disease (ADPKD) and hypertension was admitted to the hospital with abdominal pain secondary to a choledochal cyst resulting in biliary dilation. His hospital course was complicated by pneumonia, encephalopathy, and lower gastrointestinal bleeding (LGIB) that initially did not lead to hemodynamic compromise. To further evaluate the LGIB, a colonoscopy was performed, during which he experienced significant hypotension after being placed in the supine position and given anesthesia. The hypotension required treatment with vasoactive medications, termination of the colonoscopy, and transfer to the medical ICU for invasive hemodynamic monitoring and treatment.
710. A 23-Year-Old Man With Multilobar Consolidation.
作者: Ajay Kundu.;Nitesh Gupta.;Rohit Kumar.;Pranav Ish.;Manu Madan.;Rajnish Kaushik.;A J Mahendran.
来源: Chest. 2025年167卷1期e5-e8页
A 23-year-old man presented to the ED with a history of respiratory distress, cough, and fever for 10 days. He was evaluated in the ED, where he received a diagnosis of pulmonary edema, secondary to mitral regurgitation with mitral valve prolapse syndrome. He was treated with antibiotics and diuretics and discharged to home. Three months later, he returned to the ED with similar complaints, for which he was treated symptomatically and discharged. After 4 months, the patient once again appeared with worsening respiratory distress and cough with fever. The dyspnea was not accompanied by orthopnea, pedal edema, or palpitation. The patient was admitted to the medical ICU. He had no history of arthralgia, myalgia, skin rash, or other signs of autoimmune disease. He denied any history of smoking, work-related or occupational exposures, drug intake, or recent travel.
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