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681. The prone 12 o'clock position reduces ileal intubation time during colonoscopy compared to the left lateral 6 o'clock (standard) position.
作者: Arjuna P De Silva.;Ravindu S Kumarasena.;Suramya D Perera Keragala.;Udaya Kalubowila.;Madunil Niriella.;Anuradha S Dassanayake.;Arunasalam Pathmeswaran.;H Janaka de Silva.
来源: BMC Gastroenterol. 2011年11卷89页
Ileal intubation is the gold standard for a complete colonoscopy. However, despite evidence of clinical benefit ileoscopy is not always attempted due to perceived technical difficulty. Our aim was to compare time taken for ileal intubation using a new position-the prone 12 o'clock position (PP) with the standard method (left lateral 6 o'clock position-LLP).
682. Pharmacogenetic trial of a cannabinoid agonist shows reduced fasting colonic motility in patients with nonconstipated irritable bowel syndrome.
作者: Banny S Wong.;Michael Camilleri.;Irene Busciglio.;Paula Carlson.;Lawrence A Szarka.;Duane Burton.;Alan R Zinsmeister.
来源: Gastroenterology. 2011年141卷5期1638-47.e1-7页
Cannabinoid receptors are located on cholinergic neurons. Genetic variants that affect endocannabinoid metabolism are associated with colonic transit in patients with irritable bowel syndrome (IBS) with diarrhea. We compared the effects of dronabinol, a nonselective agonist of the cannabinoid receptor, with those of placebo on colonic motility and sensation in patients with IBS, and examined the effects of IBS subtype and specific genetic variants in cannabinoid mechanisms.
683. Efficacy of thalidomide for refractory gastrointestinal bleeding from vascular malformation.
作者: Zhi-Zheng Ge.;Hui-Min Chen.;Yun-Jie Gao.;Wen-Zhong Liu.;Chun-Hong Xu.;Hong-Hong Tan.;Hai-Ying Chen.;Wei Wei.;Jing-Yuan Fang.;Shu-Dong Xiao.
来源: Gastroenterology. 2011年141卷5期1629-37.e1-4页
Patients with recurrent bleeding from gastrointestinal vascular malformations are a challenge to treat. We investigated the long-term efficacy and safety of thalidomide for refractory bleeding from gastrointestinal vascular malformations in an open-label, randomized study.
684. Improved responses to pegylated interferon alfa-2b and ribavirin by individualizing treatment for 24-72 weeks.
作者: Christoph Sarrazin.;Susanne Schwendy.;Bernd Möller.;Nektarios Dikopoulos.;Peter Buggisch.;Jens Encke.;Gerlinde Teuber.;Tobias Goeser.;Robert Thimme.;Hartwig Klinker.;Wulf O Boecher.;Ewert Schulte-Frohlinde.;Renate Prinzing.;Eva Herrmann.;Stefan Zeuzem.;Thomas Berg.
来源: Gastroenterology. 2011年141卷5期1656-64页
Guidelines recommend that patients with chronic hepatitis C virus (HCV) infection be treated with pegylated interferon and ribavirin for 24, 48, or 72 weeks, based on their virologic response to treatment. We investigated the effects of treating patients for individualized durations.
685. To compare the efficacy of two kinds of Zhizhu pills in the treatment of functional dyspepsia of spleen-deficiency and qi-stagnation syndrome: a randomized group sequential comparative trial.
作者: Hongli Wu.;Zhiwei Jing.;Xudong Tang.;Xinyue Wang.;Shengsheng Zhang.;Yanan Yu.;Zhong Wang.;Hongxin Cao.;Luqi Huang.;Youhua Yu.;Yongyan Wang.
来源: BMC Gastroenterol. 2011年11卷81页
In Traditional Chinese Medicine (TCM) theory, functional dyspepsia (FD) can be divided into different syndromes according to different clinical symptoms and signs, and the most common one is spleen-deficiency and qi-stagnation syndrome that can be treated by Chinese traditional patent medicine--two kinds of Zhizhu pills, between which the primary difference in ingredients is that one contains immature orange fruit of Citrus aurantium L.(IFCA) and the other contains that of Citrus sinensis Osbeck (IFCS). The trial's objective was to compare the efficacy of two kinds of Zhizhu pills on symptom changes in patients with FD of spleen-deficiency and qi-stagnation syndrome.
686. Improvement in liver pathology of patients with β-thalassemia treated with deferasirox for at least 3 years.
作者: Yves Deugnier.;Bruno Turlin.;Martine Ropert.;M Domenica Cappellini.;John B Porter.;Vanessa Giannone.;Yiyun Zhang.;Louis Griffel.;Pierre Brissot.
来源: Gastroenterology. 2011年141卷4期1202-11, 1211.e1-3页
Most data on the effects of iron chelation therapy for patients with liver fibrosis come from small studies. We studied the effects of the oral iron chelator deferasirox on liver fibrosis and necroinflammation in a large population of patients with iron overload β-thalassemia.
687. Early mucosal healing with infliximab is associated with improved long-term clinical outcomes in ulcerative colitis.
作者: Jean Frédéric Colombel.;Paul Rutgeerts.;Walter Reinisch.;Dirk Esser.;Yanxin Wang.;Yinghua Lang.;Colleen W Marano.;Richard Strauss.;Björn J Oddens.;Brian G Feagan.;Stephen B Hanauer.;Gary R Lichtenstein.;Daniel Present.;Bruce E Sands.;William J Sandborn.
来源: Gastroenterology. 2011年141卷4期1194-201页
In the Active Ulcerative Colitis Trial (ACT)-1 and ACT-2, patients with ulcerative colitis treated with infliximab were more likely than those given placebo to have a clinical response, undergo remission, and have mucosal healing. We investigated the association between early improvement (based on endoscopy) and subsequent clinical outcome.
688. A poxvirus vaccine is safe, induces T-cell responses, and decreases viral load in patients with chronic hepatitis C.
作者: François Habersetzer.;Géraldine Honnet.;Christine Bain.;Marianne Maynard-Muet.;Vincent Leroy.;Jean-Pierre Zarski.;Cyrille Feray.;Thomas F Baumert.;Jean-Pierre Bronowicki.;Michel Doffoël.;Christian Trépo.;Delphine Agathon.;Myew-Ling Toh.;Martine Baudin.;Jean-Yves Bonnefoy.;Jean-Marc Limacher.;Geneviève Inchauspé.
来源: Gastroenterology. 2011年141卷3期890-899.e1-4页
Therapy for chronic hepatitis C (CHC) has limited efficacy, adverse effects, and high costs. Cohort and vaccine-based preclinical studies have indicated the importance of T-cell-based immunity in controlling viral infection. TG4040 is a recombinant poxvirus vaccine that expresses the hepatitis C virus (HCV) proteins NS3, NS4, and NS5B. We performed a phase I clinical trial to assess the safety, immunogenicity, and early antiviral efficacy of TG4040 in patients with CHC.
689. Neuroticism influences brain activity during the experience of visceral pain.
作者: Steven J Coen.;Michiko Kano.;Adam D Farmer.;Veena Kumari.;Vincent Giampietro.;Mick Brammer.;Steven C R Williams.;Qasim Aziz.
来源: Gastroenterology. 2011年141卷3期909-917.e1页
One particularly important individual dynamic known to influence the experience of pain is neuroticism, of which little is known about in visceral pain research. Our aim was to study the relationship between neuroticism, psychophysiologic response, and brain processing of visceral pain.
690. Rate of progression of hepatic fibrosis in patients with chronic hepatitis C: results from the HALT-C Trial.
作者: John C Hoefs.;Mitchell L Shiffman.;Zachary D Goodman.;David E Kleiner.;Jules L Dienstag.;Anne M Stoddard.; .
来源: Gastroenterology. 2011年141卷3期900-908.e1-2页
The gradual accumulation of hepatic fibrosis in chronic liver disease results in clinical complications. The rate of hepatic fibrosis score progression (RFSP) in predicting clinical outcomes was assessed by extending the 4-year Hepatitis C Antiviral Long-term Treatment Against Cirrhosis (HALT-C) Trial to include preenrollment liver biopsies.
691. FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease.
作者: Rayko Evstatiev.;Philippe Marteau.;Tariq Iqbal.;Igor L Khalif.;Jürgen Stein.;Bernd Bokemeyer.;Ivan V Chopey.;Florian S Gutzwiller.;Lise Riopel.;Christoph Gasche.; .
来源: Gastroenterology. 2011年141卷3期846-853.e1-2页
Iron deficiency anemia (IDA) is common in chronic diseases and intravenous iron is an effective and recommended treatment. However, dose calculations and inconvenient administration may affect compliance and efficacy. We compared the efficacy and safety of a novel fixed-dose ferric carboxymaltose regimen (FCM) with individually calculated iron sucrose (IS) doses in patients with inflammatory bowel disease (IBD) and IDA.
692. Telaprevir alone or with peginterferon and ribavirin reduces HCV RNA in patients with chronic genotype 2 but not genotype 3 infections.
作者: Graham R Foster.;Christophe Hézode.;Jean-Pierre Bronowicki.;Giampiero Carosi.;Ola Weiland.;Lieselotte Verlinden.;Rolf van Heeswijk.;Ben van Baelen.;Gaston Picchio.;Maria Beumont.
来源: Gastroenterology. 2011年141卷3期881-889.e1页
We evaluated antiviral activity of 2 weeks therapy with telaprevir alone, peginterferon alfa-2a and ribavirin (PR), or all 3 drugs (TPR) in treatment-naïve patients with chronic hepatitis C virus (HCV) genotype 2 or 3 infections.
693. Faster recovery of gastrointestinal transit after laparoscopy and fast-track care in patients undergoing colonic surgery.
作者: Sjoerd H W van Bree.;Malaika S Vlug.;Willem A Bemelman.;Markus W Hollmann.;Dirk T Ubbink.;Aeilko H Zwinderman.;Wouter J de Jonge.;Susanne A Snoek.;Karen Bolhuis.;Esmerij P M van der Zanden.;Frans O The.;Roel J Bennink.;Guy E E Boeckxstaens.
来源: Gastroenterology. 2011年141卷3期872-880.e1-4页
Postoperative ileus is characterized by delayed gastrointestinal (GI) transit and is a major determinant of recovery after colorectal surgery. Both laparoscopic surgery and fast-track multimodal perioperative care have been reported to improve clinical recovery. However, objective measures supporting faster GI recovery are lacking. Therefore, GI transit was measured following open and laparoscopic colorectal surgery with or without fast-track care.
694. The tryptophan hydroxylase inhibitor LX1031 shows clinical benefit in patients with nonconstipating irritable bowel syndrome.
作者: Philip M Brown.;Douglas A Drossman.;Alastair J J Wood.;Gary A Cline.;Kenny S Frazier.;Jessica I Jackson.;Johanna Bronner.;Joel Freiman.;Brian Zambrowicz.;Arthur Sands.;Michael D Gershon.
来源: Gastroenterology. 2011年141卷2期507-16页
Serotonin (5-hydroxytryptamine [5-HT]) has an important role in gastrointestinal function. LX1031 is an oral, locally acting, small molecule inhibitor of tryptophan hydroxylase (TPH). Local inhibition of TPH in the gastrointestinal tract might reduce mucosal production of serotonin (5-HT) and be used to treat patients with nonconstipating irritable bowel syndrome (IBS).
695. Pregabalin reduces pain in patients with chronic pancreatitis in a randomized, controlled trial.
作者: Søren Schou Olesen.;Stefan A W Bouwense.;Oliver H G Wilder-Smith.;Harry van Goor.;Asbjørn Mohr Drewes.
来源: Gastroenterology. 2011年141卷2期536-43页
Pain is a disabling symptom for patients with chronic pancreatitis (CP) and difficult to treat. Evidence from basic science and human studies indicates that pain processing by the central nervous system is abnormal and resembles that observed in patients with neuropathic pain disorders. We investigated whether agents used to treat patients with neuropathic pain are effective in CP.
696. Durability of radiofrequency ablation in Barrett's esophagus with dysplasia.
作者: Nicholas J Shaheen.;Bergein F Overholt.;Richard E Sampliner.;Herbert C Wolfsen.;Kenneth K Wang.;David E Fleischer.;Virender K Sharma.;Glenn M Eisen.;M Brian Fennerty.;John G Hunter.;Mary P Bronner.;John R Goldblum.;Ana E Bennett.;Hiroshi Mashimo.;Richard I Rothstein.;Stuart R Gordon.;Steven A Edmundowicz.;Ryan D Madanick.;Anne F Peery.;V Raman Muthusamy.;Kenneth J Chang.;Michael B Kimmey.;Stuart J Spechler.;Ali A Siddiqui.;Rhonda F Souza.;Anthony Infantolino.;John A Dumot.;Gary W Falk.;Joseph A Galanko.;Blair A Jobe.;Robert H Hawes.;Brenda J Hoffman.;Prateek Sharma.;Amitabh Chak.;Charles J Lightdale.
来源: Gastroenterology. 2011年141卷2期460-8页
Radiofrequency ablation (RFA) can eradicate dysplasia and intestinal metaplasia in patients with dysplastic Barrett's esophagus (BE), and reduce rates of esophageal adenocarcinoma. We assessed long-term rates of eradication, durability of neosquamous epithelium, disease progression, and safety of RFA in patients with dysplastic BE.
697. Prediction of response to PPI therapy and factors influencing treatment outcome in patients with GORD: a prospective pragmatic trial using pantoprazole.
作者: Robert C Heading.;Hubert Mönnikes.;Anne Tholen.;Holger Schmitt.
来源: BMC Gastroenterol. 2011年11卷52页
Management of patients with gastro-oesophageal reflux disease (GORD) can be assisted by information predicting the likely response to proton pump inhibitor (PPI) treatment. The aim was to undertake a study of GORD patients designed to approximate ordinary clinical practice that would identify patient characteristics predicting symptomatic response to pantoprazole treatment.
698. Is hepatotropic contrast enhanced MR a more effective method in differential diagnosis of hemangioma than multi-phase CT and unenhanced MR?
作者: Edyta Szurowska.;Tomasz Nowicki.;Ewa Izycka-Swieszewska.;Joanna Wypych.;Anna Drobinska-Jurowiecka.;Karolina Markiet.;Arkadiusz Szarmach.;Michal Studniarek.
来源: BMC Gastroenterol. 2011年11卷43页
Cavernous hemangiomas are the most frequent neoplasms of the liver and in routine clinical practice they often need to be differentiated from malignant tumors and other benign focal lesions. The purpose of this study is to evaluate whether diagnostic accuracy of magnetic resonance imaging (MRI) of hepatic hemangiomas, showing atypical pattern on US, improves with the use of Gd-BOPTA in comparison with contrast-enhanced multi-phase computed tomography (CT).
699. A prospective, multi centre, randomized clinical study to compare the efficacy and safety of Ertapenem 3 days versus Ampicillin-Sulbactam 3 days in the treatment of localized community acquired intra-abdominal infection. (T.E.A. Study: Three days Ertapenem vs three days Ampicillin-sulbactam).
作者: Federico Coccolini.;Fausto Catena.;Luca Ansaloni.;Giorgio Ercolani.;Salomone Di Saverio.;Filippo Gazzotti.;Daniel Lazzareschi.;Antonio D Pinna.
来源: BMC Gastroenterol. 2011年11卷42页
The recommendations outlined in the latest guidelines published by the Surgical Infection Society (SIS) and the Infectious Disease Society of America (IDSA) regarding the proper duration of antibiotic therapy in patients with intra-abdominal infections are limited and non-specific. This ambiguity is due mainly to the lack of clinical trials on the topic of optimal duration of therapy. It is well known that the overuse of antibiotics has several important consequences such as increased treatment costs, reduced clinical efficacy, and above all, the increased emergence of antibiotic-resistant pathogens. Ampicillin-Sulbactam is a commonly used "first line" antibiotic for intra-abdominal infections. Ertapenem and Ampicillin-sulbactam are recommended as primary treatment agents for localized peritonitis by both the SIS and IDSA guidelines.
700. The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin.
作者: Fritz Francois.;Jatin Roper.;Neal Joseph.;Zhiheng Pei.;Aditi Chhada.;Joshua R Shak.;Asalia Z Olivares de Perez.;Guillermo I Perez-Perez.;Martin J Blaser.
来源: BMC Gastroenterol. 2011年11卷37页
Appetite and energy expenditure are regulated in part by ghrelin and leptin produced in the gastric mucosa, which may be modified by H. pylori colonization. We prospectively evaluated the effect of H. pylori eradication on meal-associated changes in serum ghrelin and leptin levels, and body weight.
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