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641. A randomized trial of two types of nurse-assisted home care for patients with COPD.
作者: David Coultas.;Jenn Frederick.;Bethany Barnett.;Gaumita Singh.;Peter Wludyka.
来源: Chest. 2005年128卷4期2017-24页
Whereas pulmonary rehabilitation reduces symptoms and improves the quality of life of patients with COPD and is recommended in management guidelines, few patients have access to rehabilitation services. The purpose of this study was to investigate the effectiveness of increasing access to selected components of pulmonary rehabilitation by providing nurse-assisted home care that was composed of patient education, efforts to improve patient self-management skills, and enhanced follow-up.
642. Five-day telithromycin once daily is as effective as 10-day clarithromycin twice daily for the treatment of acute exacerbations of chronic bronchitis and is associated with reduced health-care resource utilization.
作者: Charles Fogarty.;Ronelle de Wet.;Lionel Mandell.;Joanne Chang.;Manickam Rangaraju.;Roomi Nusrat.
来源: Chest. 2005年128卷4期1980-8页
To demonstrate equivalence in the clinical efficacy of telithromycin vs clarithromycin treatment of outpatients with acute exacerbations of chronic bronchitis (AECB), and to compare the tolerability and respiratory-related health-care resource utilization associated with these treatment regimens.
643. Glycopyrrolate causes prolonged bronchoprotection and bronchodilatation in patients with asthma.
作者: Trevor T Hansel.;Helen Neighbour.;Edward M Erin.;Andrew J Tan.;Rachel C Tennant.;Joachim G Maus.;Peter J Barnes.
来源: Chest. 2005年128卷4期1974-9页
Inhaled anticholinergic drugs are effective bronchodilators in the treatment of COPD, and tiotropium bromide has recently been introduced as a once-daily bronchodilator for use as a maintenance treatment. Racemic glycopyrrolate is an anticholinergic drug that has been used orally to control gastric acidity, parenterally as an antisialogogue and to reverse neuromuscular blockade, and has been studied by inhalation for asthma and COPD.
644. Formoterol attenuates neutrophilic airway inflammation in asthma.
作者: Kittipong Maneechotesuwan.;Sarah Essilfie-Quaye.;Sally Meah.;Claire Kelly.;Sergei A Kharitonov.;Ian M Adcock.;Peter J Barnes.
来源: Chest. 2005年128卷4期1936-42页
Airway neutrophil levels are increased in patients with severe asthma and during asthma exacerbations. Long-acting beta2-agonists (LABAs), such as formoterol, reduce the number of asthma exacerbations. While beta2-agonists may affect neutrophil function in vitro, it is uncertain whether they have effects on neutrophilic inflammation in asthmatic patients in vivo.
645. Breaking the access barrier: evaluating an asthma center's efforts to provide education to children with asthma in schools.
作者: Lisa Cicutto.;Sue Murphy.;Debbie Coutts.;Janet O'Rourke.;Gail Lang.;Cori Chapman.;Pamela Coates.
来源: Chest. 2005年128卷4期1928-35页
To evaluate an asthma education program for children with asthma that is delivered in their school by certified asthma educators from a local hospital-based asthma center.
646. Fluticasone propionate nasal spray is superior to montelukast for allergic rhinitis while neither affects overall asthma control.
作者: Robert A Nathan.;Steven W Yancey.;Kelli Waitkus-Edwards.;Barbara A Prillaman.;John L Stauffer.;Edward Philpot.;Paul M Dorinsky.;Harold S Nelson.
来源: Chest. 2005年128卷4期1910-20页
Asthma and allergic rhinitis are both highly prevalent diseases and often coexist in patients.
647. Effects of aerosolized adenosine 5'-triphosphate vs adenosine 5'-monophosphate on dyspnea and airway caliber in healthy nonsmokers and patients with asthma.
作者: Ozen K Basoglu.;Amir Pelleg.;Sarah Essilfie-Quaye.;Caterina Brindicci.;Peter J Barnes.;Sergei A Kharitonov.
来源: Chest. 2005年128卷4期1905-9页
Extracellular adenosine 5'-triphosphate (ATP) causes neurogenic bronchoconstriction, inflammation, and coughs, and may play a mechanistic role in obstructive airway diseases. The aims of this study were to determine the effects of inhaled ATP on airway function, and to compare these effects with those of adenosine 5'-monophosphate (AMP).
648. Nebulized lidocaine for flexible bronchoscopy: a randomized, double-blind, placebo-controlled trial.
作者: Daiana Stolz.;Prashant N Chhajed.;Jörg Leuppi.;Eric Pflimlin.;Michael Tamm.
来源: Chest. 2005年128卷3期1756-60页
Topical anesthesia for flexible bronchoscopy can be administered via transcricoid injection, nebulizer, or directly through the bronchoscope in a "spray as you go" fashion. We performed a prospective, randomized, double-blind, placebo-controlled trial to evaluate whether nebulized lidocaine provides additional benefit and reduces the total anesthetic dose required during bronchoscopy.
649. The effect of thoracic epidural analgesia on the occurrence of late postoperative hypoxemia in patients undergoing elective coronary bypass surgery: a randomized controlled trial.
作者: Lars Hyldborg Lundstrøm.;Eigil Nygård.;Lamia Bada Hviid.;Finn Møller Pedersen.;Jesper Ravn.;Jan Aldershvile.;Jacob Rosenberg.
来源: Chest. 2005年128卷3期1564-70页
To evaluate the effect of perioperative thoracic epidural analgesia followed by postoperative epidural analgesia compared with conventional IV anesthesia on the occurrence of late postoperative hypoxemia in patients undergoing elective coronary bypass graft (CABG) surgery.
650. Effects of 8-week, interval-based inspiratory muscle training and breathing retraining in patients with generalized myasthenia gravis.
作者: Guilherme Augusto de Freitas Fregonezi.;Vanessa Regiane Resqueti.;Rosa Güell.;Jesus Pradas.;Pere Casan.
来源: Chest. 2005年128卷3期1524-30页
To assess the effect of interval-based inspiratory muscle training (IMT) combined with breathing retraining (BR) in patients with generalized myasthenia gravis (MG) in a partial home program.
651. Omission bias and decision making in pulmonary and critical care medicine.
Pulmonary and critical care physicians routinely make complex decisions, but little is known about cognitive aspects of this process. Omission bias and status quo bias are well-described cognitive biases that can cause lay decision makers to prefer inaction that preserves the status quo even when changing the status quo through action is more likely to lead to the best outcomes. It is unknown if these biases influence trained decision makers such as pulmonologists.
652. Anticoagulant therapy for idiopathic pulmonary fibrosis.
作者: Hiroshi Kubo.;Katsutoshi Nakayama.;Masaru Yanai.;Tomoko Suzuki.;Mutsuo Yamaya.;Mika Watanabe.;Hidetada Sasaki.
来源: Chest. 2005年128卷3期1475-82页
To evaluate the effect of anticoagulant therapy on the survival of patients with idiopathic pulmonary fibrosis (IPF).
653. Lack of tachyphylaxis to methacholine at 24 h.
To examine for tachyphylaxis to methacholine at 24 h and to use these data to assess the repeatability of the provocative concentration of a substance causing a 20% fall in FEV1 (PC20) for methacholine and to obtain statistical power calculations.
654. The effect of ipratropium nasal spray on bronchial methacholine challenge.
To determine the effect ipratropium bromide nasal spray has on methacholine challenge testing for airway hyperresponsiveness.
655. Effect of respiratory muscle endurance training in patients with COPD undergoing pulmonary rehabilitation.
作者: M Jeffery Mador.;Omer Deniz.;Ajay Aggarwal.;Mary Shaffer.;Thomas J Kufel.;Christina M Spengler.
来源: Chest. 2005年128卷3期1216-24页
Respiratory muscle endurance training (hyperpnea training) has been shown to have beneficial effects in patients with COPD.
656. Can individualized rehabilitation improve functional independence in elderly patients with COPD?
作者: Louise Sewell.;Sally J Singh.;Johanna E A Williams.;Rachael Collier.;Michael D L Morgan.
来源: Chest. 2005年128卷3期1194-200页
The aims of this study were to establish whether pulmonary rehabilitation (PR) improves domestic function and daily activity levels in COPD and whether individually targeted exercise is more effective than general exercise.
657. Improvements in symptom-limited exercise performance over 8 h with once-daily tiotropium in patients with COPD.
作者: François Maltais.;Alan Hamilton.;Darcy Marciniuk.;Paul Hernandez.;Frank C Sciurba.;Kai Richter.;Steven Kesten.;Denis O'Donnell.
来源: Chest. 2005年128卷3期1168-78页
We have previously shown that tiotropium at 18 mug reduces lung hyperinflation and dyspnea during exercise and improves exercise tolerance in patients with COPD. The present study was designed to gain further insight into the duration of improvements.
658. Comparison of the short-term effects of salmeterol and formoterol on heart rate variability in adult asthmatic patients.
作者: Beyhan Eryonucu.;Kürsat Uzun.;Niyazi Güler.;Mustafa Tuncer.;Cengizhan Sezgi.
来源: Chest. 2005年128卷3期1136-9页
We investigated the effects of beta2-adrenergic agonists salmeterol and formoterol on heart rate variability (HRV) in adult asthmatic patients using time-domain measures of HRV.
659. Effects of 24 weeks of lansoprazole therapy on asthma symptoms, exacerbations, quality of life, and pulmonary function in adult asthmatic patients with acid reflux symptoms.
作者: Michael R Littner.;Felix W Leung.;E David Ballard.;Bidan Huang.;Nina K Samra.; .
来源: Chest. 2005年128卷3期1128-35页
Difficult-to-control asthma has been associated with gastroesophageal acid reflux. Acid-suppressive treatment has been inconsistent in improving asthma control.
660. Formoterol added to low-dose budesonide has no additional antiinflammatory effect in asthmatic patients.
作者: Shelley E Overbeek.;Paul G Mulder.;Sophia M Baelemans.;Henk C Hoogsteden.;Jan-Bas Prins.
来源: Chest. 2005年128卷3期1121-7页
Adding inhaled long-acting beta2-agonists to a low dose of inhaled corticosteroids (ICSs) results in better asthma control than increasing the dose of ICSs. An important, but as yet unresolved, question is whether this is due to an additional reduction of airway inflammation.
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