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641. A randomized placebo-controlled trial of arthroscopic lavage versus lavage plus intra-articular corticosteroids in the management of symptomatic osteoarthritis of the knee.
作者: M D Smith.;M Wetherall.;T Darby.;A Esterman.;J Slavotinek.;P Roberts-Thomson.;M Coleman.;M J Ahern.
来源: Rheumatology (Oxford). 2003年42卷12期1477-85页
To assess the efficacy of intra-articular steroid injections following arthroscopy and joint lavage in symptomatic OA of the knee.
642. Analysis of the 5' flanking region of the interleukin 10 gene in patients with systemic sclerosis.
作者: A Crilly.;J Hamilton.;C J Clark.;A Jardine.;R Madhok.
来源: Rheumatology (Oxford). 2003年42卷11期1295-8页
Fibrosis, a feature of systemic sclerosis (SSc), is more severe in the diffuse compared with the limited disease variant. Interleukin 10 (IL-10) is an anti-inflammatory cytokine which reduces type 1 collagen mRNA levels in human fibroblasts. The 5' flanking region of the IL-10 gene is highly polymorphic, with three single base pair substitutions at position -1082(G/A), -819(C/T) and -592(C/A), which results in differential IL-10 production. The GCC/GCC genotype is associated with high IL-10 production while the ATA/ATA genotype with low production. We postulated that there would be a difference in IL-10 polymorphisms in patients with limited (lSSc) and diffuse (dSSc) disease.
643. Near-iron deficiency-induced remission of gouty arthritis.
Previous evidence supports a role for iron in the pathogenesis of gout. For example, iron, when added to media containing urate crystals, stimulated oxidative stress with subsequent complement and neutrophil activation. Conversely, iron removal inhibited these responses as well as urate-crystal-induced foot pad inflammation in rats in-vivo. The objective of the present study was to investigate whether or not iron removal may improve the outcome of gouty arthritis in humans as well.
644. Activated leucocytes express and secrete macrophage inflammatory protein-1alpha upon interaction with synovial fibroblasts of rheumatoid arthritis via a beta2-integrin/ICAM-1 mechanism.
作者: M Hanyuda.;T Kasama.;T Isozaki.;M M Matsunawa.;N Yajima.;H Miyaoka.;H Uchida.;Y Kameoka.;H Ide.;M Adachi.
来源: Rheumatology (Oxford). 2003年42卷11期1390-7页
To examine the expression and regulation of chemotactic factor, macrophage inflammatory protein-1alpha (MIP-1alpha) by fibroblast-like synoviocytes (FLS), monocytes and polymorphonuclear neutrophils (PMN) isolated from the synovial fluid (SF) of rheumatoid arthritis (RA) patients.
646. Expression of the pro-inflammatory protein S100A12 (EN-RAGE) in rheumatoid and psoriatic arthritis.
作者: D Foell.;D Kane.;B Bresnihan.;T Vogl.;W Nacken.;C Sorg.;O Fitzgerald.;J Roth.
来源: Rheumatology (Oxford). 2003年42卷11期1383-9页
Infiltration of synovial tissue by neutrophils is crucial in rheumatoid arthritis (RA), psoriatic arthritis (PsA) and seronegative arthritis (SA). Altered vascular function and endothelial activation are important in PsA. S100A12 (EN-RAGE) is secreted by activated granulocytes and binds to the receptor for advanced glycation end products, which induces nuclear factor (NF)-kappaB-dependent activation of endothelium.
647. Comparison of intra-articular triamcinolone hexacetonide and triamcinolone acetonide in oligoarticular juvenile idiopathic arthritis.
作者: F Zulian.;G Martini.;D Gobber.;C Agosto.;C Gigante.;F Zacchello.
来源: Rheumatology (Oxford). 2003年42卷10期1254-9页
To compare the efficacy and safety of intra-articular triamcinolone hexacetonide (TH) and triamcinolone acetonide (TA) in children with oligoarticular juvenile idiopathic arthritis (JIA).
648. Valdecoxib is as effective as diclofenac in the management of rheumatoid arthritis with a lower incidence of gastroduodenal ulcers: results of a 26-week trial.
To compare the efficacy and upper gastrointestinal (GI) safety of valdecoxib 20 and 40 mg daily with those of diclofenac 75 mg slow release (SR) twice daily in treating rheumatoid arthritis (RA).
649. Prognostic factors in lateral epicondylitis: a randomized trial with one-year follow-up in 266 new cases treated with minimal occupational intervention or the usual approach in general practice.
To determine whether minimal intervention by occupational specialists involving information about the disorder, encouragement to stay active and instruction in graded self-performed exercises could enhance the prognosis of lateral epicondylitis compared with the treatment usually given in general practice, to quantify workplace factors associated with the prognosis, and to consider treatments given in general practice.
650. CARD15/NOD2 analysis in rheumatoid arthritis susceptibility.
作者: I Ferreirós-Vidal.;F Barros.;J L Pablos.;A Carracedo.;J J Gómez-Reino.;A Gonzalez.
来源: Rheumatology (Oxford). 2003年42卷11期1380-2页
To determine if the mutations in the CARD15/NOD2 gene predisposing to Crohn's disease (CD) contribute also to the genetic susceptibility to rheumatoid arthritis (RA).
651. Radiographic progression in early rheumatoid arthritis: a 12-month randomized controlled study comparing the combination of cyclosporin and methotrexate with methotrexate alone.
作者: A Marchesoni.;N Battafarano.;M Arreghini.;B Panni.;M Gallazzi.;S Tosi.
来源: Rheumatology (Oxford). 2003年42卷12期1545-9页
To determine whether patients with early rheumatoid arthritis (RA) treated with cyclosporin A (CsA) and methotrexate (MTX) in combination for 12 months show a lower rate of radiographic deterioration than those treated with MTX alone.
652. Acupuncture to reduce nausea during chemotherapy treatment of rheumatic diseases.
To study if acupuncture, combined with ondansetron treatment, reduces nausea and vomiting associated with cyclophosphamide infusion in patients with rheumatic diseases.
653. Carotid and femoral arterial wall mechanics in scleroderma.
作者: K-S Cheng.;A Tiwari.;A Boutin.;C P Denton.;C M Black.;R Morris.;G Hamilton.;A M Seifalian.
来源: Rheumatology (Oxford). 2003年42卷11期1299-305页
Large-vessel arterial disease is increasingly recognized as a major cause of morbidity in autoimmune rheumatic disorders. Recent evidence suggests that scleroderma (systemic sclerosis, SSc) may be linked to altered fibrillin-1 metabolism associated with a defect in chromosome 15q. If this is the case, we may expect to see changes in the arterial wall mechanics of large vessels not clinically involved in the disease process. We undertook a study to determine whether the biomechanical properties and intima-media thickness (IMT) of the elastic carotid artery and the muscular femoral artery are altered in subjects with limited (lcSSc) and diffuse (dcSSc) cutaneous SSc.
654. Immediate effects of adhesive tape on pain and disability in individuals with knee osteoarthritis.
To evaluate the effects of two knee taping techniques, therapeutic tape and neutral tape, on pain and observed disability in symptomatic generalized knee osteoarthritis (OA).
655. Three-monthly ibandronate bolus injection offers favourable tolerability and sustained efficacy advantage over two years in established corticosteroid-induced osteoporosis.
Corticosteroids are widely prescribed, although treatment-related side-effects are common. Of these adverse events (AEs), osteoporosis is considered the most serious. Currently, oral bisphosphonates are the standard treatment for corticosteroid-induced osteoporosis (CIO). However, intermittent intravenous (i.v.) therapy may have advantages, including lack of gastrointestinal AEs, improved bioavailability and increased compliance. This study investigated the efficacy and safety of 3-monthly i.v. ibandronate bolus injections in patients with established CIO. The results from a planned 2-yr interim analysis are reported.
656. Fatigue in systemic lupus erythematosus: a randomized controlled trial of exercise.
作者: C M Tench.;J McCarthy.;I McCurdie.;P D White.;D P D'Cruz.
来源: Rheumatology (Oxford). 2003年42卷9期1050-4页
To test the efficacy of a graded aerobic exercise programme in treating fatigue in systemic lupus erythematosus.
657. Radiological progression in early rheumatoid arthritis after DMARDS: a one-year follow-up study in a clinical setting.
作者: R Sanmarti.;A Gomez.;G Ercilla.;J Gratacos.;M Larrosa.;X Suris.;O Vinas.;G Salvador.;J Munoz-Gomez.;J D Canete.
来源: Rheumatology (Oxford). 2003年42卷9期1044-9页
To analyse the frequency and prognostic factors of radiographic progression in a series of Spanish patients with early rheumatoid arthritis (RA) after 1 yr of treatment with disease-modifying anti-rheumatic drugs (DMARDs).
658. Influence of therapy with chimeric monoclonal tumour necrosis factor-alpha antibodies on intracellular cytokine profiles of T lymphocytes and monocytes in rheumatoid arthritis patients.
作者: A J Schuerwegh.;J F Van Offel.;W J Stevens.;C H Bridts.;L S De Clerck.
来源: Rheumatology (Oxford). 2003年42卷4期541-8页
It has been shown that T lymphocytes and monocytes/macrophages, producing pro-inflammatory cytokines, play a pivotal role in the pathophysiology of rheumatoid arthritis (RA). In recent placebo-controlled double-blind randomized studies, chimeric (human/mouse) tumour necrosis factor-alpha (TNFalpha) antibodies (cA2) proved to be very effective in improving clinical disease activity and reducing inflammatory parameters in RA.
659. Long-term efficacy of a cognitive behavioural treatment from a randomized controlled trial for patients recently diagnosed with rheumatoid arthritis.
作者: L Sharpe.;T Sensky.;N Timberlake.;B Ryan.;S Allard.
来源: Rheumatology (Oxford). 2003年42卷3期435-41页
This study examined the long-term efficacy of a cognitive behavioural intervention for patients with recent-onset, seropositive rheumatoid arthritis (RA).
660. Clinical and psychological outcome from a randomized controlled trial of patient-initiated direct-access hospital follow-up for rheumatoid arthritis extended to 4 years.
作者: J R Kirwan.;K Mitchell.;S Hewlett.;M Hehir.;J Pollock.;D Memel.;B Bennett.
来源: Rheumatology (Oxford). 2003年42卷3期422-6页
Patients with rheumatoid arthritis (RA) are traditionally seen regularly as out-patients, irrespective of whether it is appropriate or timely to see them. A randomized controlled trial has shown that over 2 yr, seeing patients only when they or their general practitioner (GP) request a review saves time and resources and is more convenient. This study aimed to assess clinical and psychological outcomes when the trial was extended to 4 yr.
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