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601. Optimized nonbismuth quadruple therapies cure most patients with Helicobacter pylori infection in populations with high rates of antibiotic resistance.
作者: Javier Molina-Infante.;Marco Romano.;Miguel Fernandez-Bermejo.;Alessandro Federico.;Antonietta G Gravina.;Liliana Pozzati.;Elena Garcia-Abadia.;Gema Vinagre-Rodriguez.;Carmen Martinez-Alcala.;Moises Hernandez-Alonso.;Agnese Miranda.;Maria Rosaria Iovene.;Carmen Pazos-Pacheco.;Javier P Gisbert.
来源: Gastroenterology. 2013年145卷1期121-128.e1页
Strategies to eradicate Helicobacter pylori infection could be improved by suppressing acid and extending the duration of therapy (optimization). We compared the efficacy of 2 different optimized nonbismuth quadruple regimens in areas of high resistance to antimicrobial agents.
602. Association of a probiotic to a Helicobacter pylori eradication regimen does not increase efficacy or decreases the adverse effects of the treatment: a prospective, randomized, double-blind, placebo-controlled study.
作者: Tomás Navarro-Rodriguez.;Fernando Marcuz Silva.;Ricardo Correa Barbuti.;Rejane Mattar.;Joaquim Prado Moraes-Filho.;Maricê Nogueira de Oliveira.;Cristina S Bogsan.;Décio Chinzon.;Jaime Natan Eisig.
来源: BMC Gastroenterol. 2013年13卷56页
The treatment for the eradication of Helicobacter pylori (H. pylori) is complex; full effectiveness is rarely achieved and it has many adverse effects. In developing countries, increased resistance to antibiotics and its cost make eradication more difficult. Probiotics can reduce adverse effects and improve the infection treatment efficacy.If the first-line therapy fails a second-line treatment using tetracycline, furazolidone and proton-pump inhibitors has been effective and low cost in Brazil; however it implies in a lot of adverse effects. The aim of this study was to minimize the adverse effects and increase the eradication rate applying the association of a probiotic compound to second-line therapy regimen.
603. Safety and efficacy of long-term esomeprazole 20 mg in Japanese patients with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs.
作者: Kentaro Sugano.;Yoshikazu Kinoshita.;Hiroto Miwa.;Tsutomu Takeuchi.; .
来源: BMC Gastroenterol. 2013年13卷54页
Non-steroidal anti-inflammatory drugs (NSAIDs) are an effective and common treatment for chronic pain disorders, but long-term use is associated with risk of potentially life-threatening gastrointestinal adverse events (AEs). The proton pump inhibitor esomeprazole has been found to be effective for gastroprotection in NSAID users, but few long-term studies have been conducted in Japan.
604. The role of centralized reading of endoscopy in a randomized controlled trial of mesalamine for ulcerative colitis.
作者: Brian G Feagan.;William J Sandborn.;Geert D'Haens.;Suresh Pola.;John W D McDonald.;Paul Rutgeerts.;Pia Munkholm.;Ulrich Mittmann.;Debra King.;Cindy J Wong.;Guangyong Zou.;Allan Donner.;Lisa M Shackelton.;Denise Gilgen.;Sigrid Nelson.;Margaret K Vandervoort.;Marianne Fahmy.;Edward V Loftus.;Remo Panaccione.;Simon P Travis.;Gert A Van Assche.;Séverine Vermeire.;Barrett G Levesque.
来源: Gastroenterology. 2013年145卷1期149-157.e2页
Interobserver differences in endoscopic assessments contribute to variations in rates of response to placebo in ulcerative colitis (UC) trials. We investigated whether centralized review of images could reduce these variations.
605. Early surgery versus optimal current step-up practice for chronic pancreatitis (ESCAPE): design and rationale of a randomized trial.
作者: Usama Ahmed Ali.;Yama Issa.;Marco J Bruno.;Harry van Goor.;Hjalmar van Santvoort.;Olivier R C Busch.;Cornelis H C Dejong.;Vincent B Nieuwenhuijs.;Casper H van Eijck.;Hendrik M van Dullemen.;Paul Fockens.;Peter D Siersema.;Dirk J Gouma.;Jeanin E van Hooft.;Yolande Keulemans.;Jan W Poley.;Robin Timmer.;Marc G Besselink.;Frank P Vleggaar.;Oliver H Wilder-Smith.;Hein G Gooszen.;Marcel G W Dijkgraaf.;Marja A Boermeester.; .
来源: BMC Gastroenterol. 2013年13卷49页
In current practice, patients with chronic pancreatitis undergo surgical intervention in a late stage of the disease, when conservative treatment and endoscopic interventions have failed. Recent evidence suggests that surgical intervention early on in the disease benefits patients in terms of better pain control and preservation of pancreatic function. Therefore, we designed a randomized controlled trial to evaluate the benefits, risks and costs of early surgical intervention compared to the current stepwise practice for chronic pancreatitis.
606. A randomised controlled trial of a probiotic 'functional food' in the management of irritable bowel syndrome.
作者: Lesley M Roberts.;Deborah McCahon.;Roger Holder.;Sue Wilson.;F D Richard Hobbs.
来源: BMC Gastroenterol. 2013年13卷45页
Irritable Bowel Syndrome (IBS) is a common condition characterised by pain, distension and altered bowel habit. Evidence suggests functional foods containing probiotics improve gastrointestinal transit, however, data are limited by short follow-up periods and evaluation in selected populations.
607. Consumption of fermented milk product with probiotic modulates brain activity.
作者: Kirsten Tillisch.;Jennifer Labus.;Lisa Kilpatrick.;Zhiguo Jiang.;Jean Stains.;Bahar Ebrat.;Denis Guyonnet.;Sophie Legrain-Raspaud.;Beatrice Trotin.;Bruce Naliboff.;Emeran A Mayer.
来源: Gastroenterology. 2013年144卷7期1394-401, 1401.e1-4页
Changes in gut microbiota have been reported to alter signaling mechanisms, emotional behavior, and visceral nociceptive reflexes in rodents. However, alteration of the intestinal microbiota with antibiotics or probiotics has not been shown to produce these changes in humans. We investigated whether consumption of a fermented milk product with probiotic (FMPP) for 4 weeks by healthy women altered brain intrinsic connectivity or responses to emotional attention tasks.
608. A controlled trial of gluten-free diet in patients with irritable bowel syndrome-diarrhea: effects on bowel frequency and intestinal function.
作者: Maria I Vazquez-Roque.;Michael Camilleri.;Thomas Smyrk.;Joseph A Murray.;Eric Marietta.;Jessica O'Neill.;Paula Carlson.;Jesse Lamsam.;Denise Janzow.;Deborah Eckert.;Duane Burton.;Alan R Zinsmeister.
来源: Gastroenterology. 2013年144卷5期903-911.e3页
Patients with diarrhea-predominant irritable bowel syndrome (IBS-D) could benefit from a gluten-free diet (GFD).
609. Endoscopic large-balloon dilation alone versus endoscopic sphincterotomy plus large-balloon dilation for the treatment of large bile duct stones.
作者: Jae Chul Hwang.;Jin Hong Kim.;Sun Gyo Lim.;Soon Sun Kim.;Sung Jae Shin.;Kee Myung Lee.;Byung Moo Yoo.
来源: BMC Gastroenterol. 2013年13卷15页
Endoscopic sphincterotomy (EST) combined with large-balloon dilation (LBD) has been proposed as an alternative to manage large bile duct stones. However, recent reports indicate that LBD without EST may be safe and effective in this setting.
610. Erythromycin versus neomycin in the treatment of hepatic encephalopathy in cirrhosis: a randomized double-blind study.
作者: Fernando Gomes Romeiro.;Fabio da Silva Yamashiro.;Madileine Francely Américo.;Luciana Aparecida Corá.;Giovanni Faria Silva.;José Ricardo de Arruda Miranda.;Carlos Antonio Caramori.
来源: BMC Gastroenterol. 2013年13卷13页
Hepatic encephalopathy (HE) is a severe complication in patients with hepatic cirrhosis, which causes numerous hospital admissions and deaths. Antibiotics are the best options in HE treatment, but head-to-head comparisons between these drugs are scarce. Erythromycin combines the antimicrobial effect and prokinetic properties in the same drug, but it has never been used in HE treatment. Our aim was to evaluate the efficacy of erythromycin as an HE treatment.
611. GERD assessment including pH metry predicts a high response rate to PPI standard therapy.
作者: Arne Kandulski.;Ulrich Peitz.;Klaus Mönkemüller.;Helmut Neumann.;Jochen Weigt.;Peter Malfertheiner.
来源: BMC Gastroenterol. 2013年13卷12页
Inadequate response to proton pump inhibitor (PPI) therapy in patients with gastroesophageal reflux disease (GERD) is reported in up to 40%. Patients with non erosive reflux disease (NERD) have lower response rates compared to patients with erosive reflux disease (ERD); pH metry contributes to GERD diagnosis and is critical for proper diagnosis of NERD. Aim of the study was to assess the need for doubling esomeprazole standard dose (40 mg) for 4 weeks in PPI naive patients with typical reflux symptoms and diagnosis of GERD based on endoscopy and 48 hours, wireless pH metry.
612. Pre-study protocol MagPEP: a multicentre randomized controlled trial of magnesium sulphate in the prevention of post-ERCP pancreatitis.
作者: Gabriele Fluhr.;Julia Mayerle.;Eckhard Weber.;Ali Aghdassi.;Peter Simon.;Thomas Gress.;Thomas Seufferlein.;Joachim Mössner.;Andreas Stallmach.;Thomas Rösch.;Martina Müller.;Britta Siegmund.;Petra Büchner-Steudel.;Ina Zuber-Jerger.;Marcus Kantowski.;Albrecht Hoffmeister.;Jonas Rosendahl.;Thomas Linhart.;Jochen Maul.;László Czakó.;Péter Hegyi.;Matthias Kraft.;Georg Engel.;Thomas Kohlmann.;Anne Glitsch.;Tilman Pickartz.;Christoph Budde.;Claudia Nitsche.;Kirsten Storck.;Markus M Lerch.
来源: BMC Gastroenterol. 2013年13卷11页
Acute pancreatitis is the most common complication of diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP). In spite of continuing research, no pharmacologic agent capable of effectively reducing the incidence of ERCP-induced pancreatitis has found its way into clinical practise. A number of experimental studies suggest that intrapancreatic calcium concentrations play an important role in the initiation of intracellular protease activation, an initiating step in the course of acute pancreatitis. Magnesium can act as a calcium-antagonist and counteracts effects in calcium signalling. It can thereby attenuate the intracellular activation of proteolytic digestive enzymes in the pancreas and reduces the severity of experimental pancreatitis when administered either intravenously or as a food supplement.
613. Outcomes of treatment for achalasia depend on manometric subtype.
作者: Wout O Rohof.;Renato Salvador.;Vito Annese.;Stanislas Bruley des Varannes.;Stanislas Chaussade.;Mario Costantini.;J Ignasi Elizalde.;Marianne Gaudric.;André J Smout.;Jan Tack.;Olivier R Busch.;Giovanni Zaninotto.;Guy E Boeckxstaens.
来源: Gastroenterology. 2013年144卷4期718-25; quiz e13-4页
Patients with achalasia are treated with either pneumatic dilation (PD) or laparoscopic Heller myotomy (LHM), which have comparable rates of success. We evaluated whether manometric subtype was associated with response to treatment in a large population of patients treated with either PD or LHM (the European achalasia trial).
614. Efficacy of telbivudine in Taiwanese chronic hepatitis B patients compared with GLOBE extension study and predicting treatment outcome by HBV DNA kinetics at week 24.
作者: Chao Wei Hsu.;You Chen Chao.;Chuan Mo Lee.;Ting Tsung Chang.;Yi Cheng Chen.
来源: BMC Gastroenterol. 2012年12卷178页
The aims of this study were to compare results from a Taiwanese sub-study of the GLOBE 2303 telbivudine study and evaluate the HBV DNA kinetics.
615. Marginal turbid band and light blue crest, signs observed in magnifying narrow-band imaging endoscopy, are indicative of gastric intestinal metaplasia.
作者: Jin Kwang An.;Geun Am Song.;Gwang Ha Kim.;Do Youn Park.;Na Ri Shin.;Bong Eun Lee.;Hyun Young Woo.;Dong Yup Ryu.;Dong Uk Kim.;Jeong Heo.
来源: BMC Gastroenterol. 2012年12卷169页
Gastric intestinal metaplasia (IM) usually appears in flat mucosa and shows few morphologic changes, making diagnosis using conventional endoscopy unreliable. Magnifying narrow-band imaging (NBI) endoscopy enables evaluation of detailed morphological features that correspond with the underlying histology. The aim of this study was to investigate and clarify the diagnostic efficacy of magnifying NBI endoscopic findings for the prediction and diagnosis of IM.
616. Comparison between the recovery time of alfentanil and fentanyl in balanced propofol sedation for gastrointestinal and colonoscopy: a prospective, randomized study.
作者: Wai-Meng Ho.;Chia-Ming Yen.;Chin-Hung Lan.;Chung-Yi Lin.;Su-Boon Yong.;Kai-Lin Hwang.;Ming-Chih Chou.
来源: BMC Gastroenterol. 2012年12卷164页
There is increasing interest in balanced propofol sedation (BPS) titrated to moderate sedation (conscious sedation) for endoscopic procedures. However, few controlled studies on BPS targeted to deep sedation for diagnostic endoscopy were found. Alfentanil, a rapid and short-acting synthetic analog of fentanyl, appears to offer clinically significant advantages over fentanyl during outpatient anesthesia.It is reasonable to hypothesize that low dose of alfentanil used in BPS might also result in more rapid recovery as compared with fentanyl.
617. Increased risk of advanced neoplasms among asymptomatic siblings of patients with colorectal cancer.
作者: Siew C Ng.;James Y W Lau.;Francis K L Chan.;Bing Yee Suen.;Wai-Keung Leung.;Yee Kit Tse.;Simon S M Ng.;Janet F Y Lee.;Ka-Fai To.;Justin C Y Wu.;Joseph J Y Sung.
来源: Gastroenterology. 2013年144卷3期544-50页
Colorectal cancer (CRC) is the second-most common cancer in Hong Kong. Relatives of patients with CRC have an increased risk of colorectal neoplasm. We assessed the prevalence of advanced neoplasms among asymptomatic siblings of patients with CRC.
618. HCV genotype 1a shows a better virological response to antiviral therapy than HCV genotype 1b.
作者: Adriano M Pellicelli.;Mario Romano.;Tommaso Stroffolini.;Ettore Mazzoni.;Fabrizio Mecenate.;Roberto Monarca.;Antonio Picardi.;Maria Elena Bonaventura.;Cristina Mastropietro.;Pascal Vignally.;Arnaldo Andreoli.;Massimo Marignani.;Cecilia D'Ambrosio.;Lucia Miglioresi.;Lorenzo Nosotti.;Olga Mitidieri.;Umberto Vespasiani Gentilucci.;Claudio Puoti.;Giuseppe Barbaro.;Angelo Barlattani.;Caterina Furlan.;Giorgio Barbarini.; .
来源: BMC Gastroenterol. 2012年12卷162页
The impact of viral subtype on the rate of sustained virological response (SVR) to antiviral therapy in patients chronically infected with hepatitis C genotype 1 subtype 1a and 1b has not been extensively investigated. The aim of this study is to determine whether the HCV genotype 1 subtypes 1a and 1b respond differently to treatment with PEGylated interferon (PEG-IFN) plus ribavirin.
619. Electroacupuncture reduces duration of postoperative ileus after laparoscopic surgery for colorectal cancer.
作者: Simon S M Ng.;Wing Wa Leung.;Tony W C Mak.;Sophie S F Hon.;Jimmy C M Li.;Cherry Y N Wong.;Kelvin K F Tsoi.;Janet F Y Lee.
来源: Gastroenterology. 2013年144卷2期307-313.e1页
We investigated the efficacy of electroacupuncture in reducing the duration of postoperative ileus and hospital stay after laparoscopic surgery for colorectal cancer.
620. The value of pancreatic stone protein in predicting acute appendicitis in patients presenting at the emergency department with abdominal pain.
作者: Christoph Tschuor.;Dimitri Aristotle Raptis.;Përparim Limani.;Thomas Bächler.;Christian Eugen Oberkofler.;Stefan Breitenstein.;Rolf Graf.
来源: BMC Gastroenterol. 2012年12卷154页
Pancreatic Stone Protein (PSP) is a protein naturally produced mainly in the pancreas and the gut. There is evidence from experimental and clinical trials that blood PSP levels rise in the presence of inflammation or infection. However, it is not known whether PSP is superior to other established blood tests (e.g. White Blood Count, Neutrophils or C - reactive protein) in predicting appendicitis in patients presenting with abdominal pain and a clinical suspicion of appendicitis at the emergency room.
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