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601. Long-term use of sildenafil in inoperable chronic thromboembolic pulmonary hypertension.
作者: Jay Suntharalingam.;Carmen M Treacy.;Natalie J Doughty.;Kimberley Goldsmith.;Elaine Soon.;Mark R Toshner.;Karen K Sheares.;Rodney Hughes.;Nicholas W Morrell.;Joanna Pepke-Zaba.
来源: Chest. 2008年134卷2期229-236页
There are currently no licensed medical therapies for inoperable chronic thromboembolic pulmonary hypertension (CTEPH).
602. Modifying track layout from straight to circular has a modest effect on the 6-min walk distance.
作者: Vishal Bansal.;Kylie Hill.;Thomas E Dolmage.;Dina Brooks.;Lynda J Woon.;Roger S Goldstein.
来源: Chest. 2008年133卷5期1155-60页
The protocol used for the 6-min walk test (6MWT) influences its results. The only study to examine the effect of modifying track layout performed a retrospective analysis and concluded that institutions using continuous tracks yield greater distances than those using straight tracks. Agreement between the distances measured on different tracks could not be examined. We evaluated the effect of modifying track layout on walk distance and examined the agreement and repeatability of distances measured on different tracks.
603. Double-blind, randomized trial of dexmethylphenidate hydrochloride for the treatment of sarcoidosis-associated fatigue.
Fatigue is a common complaint in patients with sarcoidosis. We studied the effectiveness of dexmethylphenidate hydrochloride (d-MPH) in treating sarcoidosis-associated fatigue.
604. Increased systemic inflammation is a risk factor for COPD exacerbations.
作者: Karin H Groenewegen.;Dirkje S Postma.;Wim C J Hop.;Pascal L M L Wielders.;Noel J J Schlösser.;Emiel F M Wouters.; .
来源: Chest. 2008年133卷2期350-7页
COPD is characterized by episodic increases in respiratory symptoms, so-called exacerbations. COPD exacerbations are associated with an increase in local and systemic inflammation. Data of a previously published study in a well-characterized COPD cohort were analyzed to define predictive factors of acute exacerbations, particularly focusing on systemic inflammation.
605. Donepezil improves obstructive sleep apnea in Alzheimer disease: a double-blind, placebo-controlled study.
作者: Walter Moraes.;Dalva Poyares.;Lucia Sukys-Claudino.;Christian Guilleminault.;Sergio Tufik.
来源: Chest. 2008年133卷3期677-83页
There is an association between Alzheimer disease and sleep-disordered breathing. Donepezil is the drug most frequently used to treat cognitive symptoms in Alzheimer disease. This study evaluates the effects of donepezil on obstructive sleep apnea in patients with Alzheimer disease.
606. Family member satisfaction with end-of-life decision making in the ICU.
作者: Cynthia J Gries.;J Randall Curtis.;Richard J Wall.;Ruth A Engelberg.
来源: Chest. 2008年133卷3期704-12页
Families of ICU patients may be at risk for increased psychological morbidity due to end-of-life decision making. The identification of chart-based quality indicators of palliative care that predict family satisfaction with decision making may help to guide interventions to improve decision making and family outcomes.
607. Sildenafil improves health-related quality of life in patients with pulmonary arterial hypertension.
作者: Joanna Pepke-Zaba.;Claire Gilbert.;Lorraine Collings.;Martin C J Brown.
来源: Chest. 2008年133卷1期183-9页
Sildenafil inhibits phosphodiesterase-5, enhancing cyclic guanosine monophosphate- mediated relaxation of pulmonary vasculature and is effective in treating patients with pulmonary arterial hypertension (PAH).
608. Effects of montelukast treatment and withdrawal on fractional exhaled nitric oxide and lung function in children with asthma.
作者: Paolo Montuschi.;Chiara Mondino.;Pierluigi Koch.;Giovanni Ciabattoni.;Peter J Barnes.;Giuseppe Baviera.
来源: Chest. 2007年132卷6期1876-81页
Leukotriene receptor antagonists (LTRAs) reduce fractional exhaled nitric oxide (Feno) concentrations in children with asthma, but the effect of LTRA withdrawal on Feno and lung function is unknown. We aimed to study the effect of treatment and withdrawal of montelukast, a LTRA, on airway inflammation as reflected by Feno and lung function in children with asthma.
609. Impact of cough across different chronic respiratory diseases: comparison of two cough-specific health-related quality of life questionnaires.
作者: Liam Polley.;Nurman Yaman.;Liam Heaney.;Chris Cardwell.;Eimear Murtagh.;John Ramsey.;Joseph MacMahon.;Richard W Costello.;Lorcan McGarvey.
来源: Chest. 2008年134卷2期295-302页
Cough is a prominent symptom across a range of common chronic respiratory diseases and impacts considerably on patient health status.
610. Sputum eosinophils and the response of exercise-induced bronchoconstriction to corticosteroid in asthma.
作者: MyLinh Duong.;Padmaja Subbarao.;Ellinor Adelroth.;George Obminski.;Tara Strinich.;Mark Inman.;Soren Pedersen.;Paul M O'Byrne.
来源: Chest. 2008年133卷2期404-11页
The relationship between eosinophilic airway inflammation and exercise-induced bronchoconstriction (EIB), and the response to inhaled corticosteroid (ICS) therapy was examined.
611. Aerosolized salbutamol accelerates the resolution of pulmonary edema after lung resection.
作者: Marc Licker.;Jean-Marie Tschopp.;John Robert.;Jean-Georges Frey.;John Diaper.;Christoph Ellenberger.
来源: Chest. 2008年133卷4期845-52页
Ischemia-reperfusion injuries, fluid overload, and cardiac insufficiency may all contribute to alveolar and interstitial lung edema. We hypothesized that aerosolized salbutamol would reduce extravascular lung water and improve oxygenation after lung resection by stimulating epithelial fluid clearance and cardiovascular function.
612. The efficacy and safety of combination salmeterol (50 microg)/fluticasone propionate (500 microg) inhalation twice daily via accuhaler in Chinese patients with COPD.
作者: Jin-Ping Zheng.;Lan Yang.;Ya Mei Wu.;Ping Chen.;Zhong Guang Wen.;Wen-Jie Huang.;Yi Shi.;Chang-Zheng Wang.;Shao-Guang Huang.;Tie-ying Sun.;Guang-Fa Wang.;Sheng-Dao Xiong.;Nan-Shan Zhong.
来源: Chest. 2007年132卷6期1756-63页
Few studies of the efficacy and safety of therapy with combinations of salmeterol/fluticasone propionate (SFCs) have been conducted in Chinese patients with COPD, and the benefits of combination therapy in nonsmoking patients with COPD are, to our knowledge, not known.
613. Hemodynamic parameters are prognostically important in cardiogenic shock but similar following early revascularization or initial medical stabilization: a report from the SHOCK Trial.
作者: Raban V Jeger.;April M Lowe.;Christopher E Buller.;Matthias E Pfisterer.;Vladimir Dzavik.;John G Webb.;Judith S Hochman.;Ulrich P Jorde.; .
来源: Chest. 2007年132卷6期1794-803页
In cardiogenic shock (CS), conclusive data on serial hemodynamic measurements for treatment guidance and prognosis are lacking.
614. Portable exhaled nitric oxide as a screening tool for asthma in young adults during pollen season.
作者: Konstantinos Kostikas.;Andriana I Papaioannou.;Kalliopi Tanou.;Angela Koutsokera.;Maria Papala.;Konstantinos I Gourgoulianis.
来源: Chest. 2008年133卷4期906-13页
The fraction of exhaled NO (FeNO) is valuable for the follow-up of asthmatic patients. However, its usefulness as a screening tool for asthma is not established.
615. Effects of dynamic bilevel positive airway pressure support on central sleep apnea in men with heart failure.
作者: Michael Arzt.;Roland Wensel.;Sylvia Montalvan.;Thomas Schichtl.;Stephan Schroll.;Stephan Budweiser.;Friedrich C Blumberg.;Günther A J Riegger.;Michael Pfeifer.
来源: Chest. 2008年134卷1期61-6页
Treatment with continuous positive airway pressure (CPAP) improves cardiac function in chronic heart failure (CHF) patients with central sleep apnea (CSA)-Cheyne-Stokes respiration (CSR) by stabilizing ventilation, but frequently central apneas and hypopneas persist. Our objective was to test the hypothesis that flow-targeted dynamic bilevel positive airway pressure (BPAP) support (BiPAP autoSV; Respironics; Murrysville, PA) effectively suppresses CSR-CSA in CHF patients.
616. Ultrasound vs. CT in detecting chest wall invasion by tumor: a prospective study.
作者: Venkata Bandi.;William Lunn.;Armin Ernst.;Ralf Eberhardt.;Hans Hoffmann.;Felix J F Herth.
来源: Chest. 2008年133卷4期881-6页
Lung cancer is one of the leading causes of cancer-related deaths worldwide. Accurate staging is important for patient management and clinical research. The recognition of chest wall involvement preoperatively is important for staging and surgical planning. Multiple modalities are available to assess the chest wall involvement preoperatively, including CT scanning, MRI, and ultrasound (US) examination. The purpose of this study was to evaluate the sensitivity and specificity of the US examination in determining the chest wall involvement of lung cancer compared to that of CT scan and surgery.
617. Management of sleep apnea: concordance between nonreference and reference centers.
作者: Lourdes Hernández.;Marta Torrella.;Núria Roger.;Antonia Llunell.;Eugeni Ballester.;Llorenç Quinto.;Mario Serrano.;Fernando Masa.;Josep M Montserrat.
来源: Chest. 2007年132卷6期1853-7页
When a disorder is as prevalent as sleep apnea-hypopnea syndrome (SAHS), different medical levels and approaches should be involved in facilitating the diagnosis, at least, of patients with symptoms that disrupt social or working life, and of risk groups such as professional drivers. We sought to analyze the degree of concordance between management and treatment decisions for SAHS patients at sleep reference centers (RCs) and at non-RCs (NRCs).
618. Goal-directed intraoperative therapy reduces morbidity and length of hospital stay in high-risk surgical patients.
作者: Abele Donati.;Silvia Loggi.;Jean-Charles Preiser.;Giovanni Orsetti.;Cristopher Münch.;Vincenzo Gabbanelli.;Paolo Pelaia.;Paolo Pietropaoli.
来源: Chest. 2007年132卷6期1817-24页
Postoperative organ failures commonly occur after major abdominal surgery, increasing the utilization of resources and costs of care. Tissue hypoxia is a key trigger of organ dysfunction. A therapeutic strategy designed to detect and reverse tissue hypoxia, as diagnosed by an increase of oxygen extraction (O2ER) over a predefined threshold, could decrease the incidence of organ failures. The primary aim of this study was to compare the number of patients with postoperative organ failure and length of hospital stay between those randomized to conventional vs a protocolized strategy designed to maintain O2ER < 27%.
619. Effects of one-legged exercise training of patients with COPD.
Most patients with severe COPD are limited by dyspnea and are obliged to exercise at low intensity. Even those undergoing training do not usually have increased peak oxygen uptake (Vo2). One-legged exercise, at half the load of two-legged exercise, places the same metabolic demands on the targeted muscles but reduces the ventilatory load, enabling patients to increase work capacity. The purpose of this study was to determine whether one-legged exercise training would improve aerobic capacity compared with two-legged training in stable patients with COPD.
620. Initial airway management skills of senior residents: simulation training compared with traditional training.
作者: Pierre D Kory.;Lewis A Eisen.;Mari Adachi.;Vanessa A Ribaudo.;Marnie E Rosenthal.;Paul H Mayo.
来源: Chest. 2007年132卷6期1927-31页
Scenario-based training (SBT) with a computerized patient simulator (CPS) is effective in teaching physicians to manage high-risk, low-frequency events that are typical of critical care medicine. This study compares the initial airway management skills of a group of senior internal medicine residents trained using SBT with CPS during their first year of postgraduate training (PGY) with a group of senior internal medicine residents trained using the traditional experiential method.
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