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41. Parasutterella excrementihominis exacerbates experimental colitis and colitis-associated colorectal cancer via pathogenic NETosis activation.
作者: Huishi Tan.;Linwen Huang.;Jun Wang.;Hongli Huang.;Zelong Lin.;Siqi Yang.;Yanqiang Shi.;Jierui Li.;Haiyan Zhang.;Yongjian Zhou.;Chongyang Huang.
来源: Gut. 2026年75卷5期920-936页
Parasutterella excrementihominis (P. excrementihominis), a Betaproteobacteria species enriched in ulcerative colitis (UC) patients, is implicated in chronic inflammation. However, its mechanistic role in UC progression and colitis-associated colorectal cancer (CAC) remains unclear.
42. Targeting cancer stem cells enhances multikinase inhibitor therapy in metabolic dysfunction-associated steatotic liver disease-related hepatocellular carcinoma.
作者: Yasi Pan.;Xiang Zhang.;Chi Chun Wong.;Huarong Chen.;Stephanie Ma.;Terence Kin-Wah Lee.;Kai Yuan.;Cong Liang.;Xingyu Zhou.;Harry Cheuk Hay Lau.;Pingmei Huang.;Danyu Chen.;Lina Wang.;Yanqiang Ding.;Qinyao Wei.;Alvin Ho Kwan Cheung.;Ka Fai To.;Jun Yu.
来源: Gut. 2025年
Metabolic dysfunction-associated steatotic liver disease-related hepatocellular carcinoma (MASLD-HCC) is an emerging malignancy with limited therapeutic options. The identity and function of cancer stem cells (CSCs) in MASLD-HCC remain poorly understood. In this study, we characterised CSCs in MASLD-HCC and investigated their contribution to MASLD-HCC tumourigenesis and therapy response.
43. Metabolomic pattern of ultraprocessed food intake and its association with colorectal cancer risk.
作者: Mengxi Du.;Xinyu Wang.;Dong Hang.;Fenglei Wang.;Yujia Lu.;Kai Wang.;Alaina M Bever.;Ana Nogal.;Danielle Haslam.;Shuji Ogino.;Jeffrey A Meyerhardt.;Liming Liang.;Qi Sun.;Curtis Huttenhower.;Andrew T Chan.;Frank B Hu.;Mingyang Song.
来源: Gut. 2025年
High ultra-processed food (UPF) intake has been linked to colorectal cancer (CRC), but underlying mechanisms remain unclear.
45. Comparison between germline and somatic loss-of-function RNF43 mutations reveals different genotype-phenotype associations and provides insights into the genetic mechanisms of colorectal tumourigenesis.
作者: Claire Palles.;Luke Freeman-Mills.;Edward Arbe-Barnes.;Nathalie Feeley.;Laura Chegwidden.;Helen Curley.;Sara Galavotti.;Connor Woolley.;Jeremy Cheadle.;Dmitri Mouradov.;Oliver Sieber.;Silvia Salatino.;Steve Thorn.;Anshita Goel.;Juan Fernandez-Tajes.;Sulochana Omwenga.;Sujata Biswas.;Timothy Maughan.;Simon J Leedham.; .; .; .; .;Viktor Hendrik Koelzer.;Lai Mun Wang.;Roland Arnold.;James Edward East.;Ian Tomlinson.
来源: Gut. 2025年
Germline RNF43 mutations cause a dominantly inherited syndrome of colorectal cancer (CRC) and serrated polyps. However, these data originate from highly selected families.
46. Tracking B cell immunity during perturbation of hepatitis B infection induced by treatment withdrawal.
作者: Sabela Lens.;Alice R Burton.;Jessica Davies.;Maelle Locatelli.;Mireia García-López.;Anna Pocurull.;Anna Jeffery-Smith.;Nikolai Novikov.;Simon P Fletcher.;Xavier Forns.;Sofía Pérez-Del-Pulgar.;Mala K Maini.
来源: Gut. 2025年
Withdrawal of prolonged nucleos(t)ide analogue (NA) treatment results in hepatitis B surface antigen (HBsAg) loss in some subjects with chronic hepatitis B (CHB), potentially revealing immune correlates of functional cure.
47. Hereditary chronic pancreatitis induced plasticity cooperates with mutant Kras in early pancreatic carcinogenesis.
作者: Tanvi Vikrant Inamdar.;Ferdinand Krannich.;Nico Hesselbarth.;Atul Verma.;Teresa Vauti.;Mariami Helena Jasaszwili.;Ghanem El Kassem.;Jasmine Hillmer.;Tom Kaune.;Michael Boettcher.;Ivonne Regel.;Heidi Griesmann.;Irene Esposito.;Markus Glaß.;Monika Hämmerle.;Patrick Michl.;Helmut Laumen.;Jonas Rosendahl.
来源: Gut. 2026年75卷5期1003-1014页
Chronic pancreatitis (CP) is a risk factor for pancreatic cancer, with inherited cases conferring a markedly increased risk. The underlying mechanisms driving malignant transformation by CP remain poorly understood.
48. Effects of a probiotic fermented dairy product on hippocampal metabolites, structure and function: an 8-week randomised, placebo-controlled trial in healthy women.
作者: Wolfgang Marx.;Chao Suo.;Thusharika Dissanayaka.;Suzan Maleki.;Liam Nguyen.;Nikolaj Travica.;Mohammadreza Mohebbi.;Mojtaba Lotfaliany.;Murat Yucel.;Amelia J McGuinness.;Michael Berk.;Hajara Aslam.;Felice N Jacka.
来源: Gut. 2025年75卷3期
Fermented foods are a promising yet underexplored intervention for influencing brain function and mental health through the gut-brain axis.
49. Secondary bile acid production by gut bacteria promotes Western diet-associated colorectal cancer.
作者: Annika Osswald.;Esther Wortmann.;David Wylensek.;Stephanie Kuhls.;Olivia I Coleman.;Kenneth Peuker.;Anne Strigli.;Quinten R Ducarmon.;Martin Larralde.;Wei Liang.;Nicole S Treichel.;Fabian Schumacher.;Colin Volet.;Silke Matysik.;Karin Kleigrewe.;Michael Gigl.;Sascha Rohn.;Chun-Jun Guo.;Burkhard Kleuser.;Gerhard Liebisch.;Angelika Schnieke.;Jason M Ridlon.;Rizlan Bernier-Latmani.;Georg Zeller.;Sebastian Zeissig.;Dirk Haller.;Krzysztof Flisikowski.;Thomas Clavel.;Soeren Ocvirk.
来源: Gut. 2025年
Western diet and associated production of secondary bile acids (BAs) have been linked to the development of sporadic colorectal cancer (CRC). Despite observational studies showing that secondary BAs produced by 7α-dehydroxylating (7αDH+) gut bacteria are increased in CRC, a causal proof of their tumour-promoting effects is lacking.
50. PCK1 deficiency promotes MASH-HCC progression by 12-HETE-induced CD8+ T cell dysfunction.
作者: Kang Wu.;Luo Li.;Yi Liu.;Kai Wang.;Jianghong Zheng.;Huijun Liang.;Fengli Xu.;Renming Liu.;Chang Chen.;Luyi Huang.;Haijun Deng.;Xiaojian Han.;Shi Chen.;Zhirong Zhang.;Xinyu Liu.;Qiang He.;Xiaosong Li.;Aishun Jin.;Ailong Huang.;Ni Tang.
来源: Gut. 2025年
Metabolic dysfunction-associated steatohepatitis-related hepatocellular carcinoma (MASH-HCC) has been reported to be less responsive to immune checkpoint inhibitors, which may be associated with metabolic reprogramming of tumour cells and abnormal tumour microenvironment.
51. CD177+ neutrophils drive extracellular matrix remodelling and HGF-alpha release in ALPPS-induced liver regeneration.
作者: Jiayan Yan.;Ao Huang.;Shiyu Zhang.;Na Yao.;Junfeng Huang.;Zhifeng Jiang.;Jiayi Wang.;Feiyu Chen.;Qichao Yu.;Jianwen Cheng.;Senquan Zhang.;Tianyi Li.;Rongshan Gao.;Runze Miao.;Rongkui Luo.;Shaolai Zhou.;Yuan Ji.;Zheng Wang.;Dongmei Gao.;Zhenbin Ding.;Zhaoyou Tang.;Jia Fan.;Miguel A Esteban.;Hans Jürgen Schlitt.;Xinrong Yang.;Jian Zhou.
来源: Gut. 2025年
Associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) effectively induces rapid liver hypertrophy in patients with initially unresectable liver tumours, yet the immunological mechanisms remain unclear.
52. Fibroblast pentose phosphate pathway activation upon decreased circPLCE1 exacerbates intestinal fibrosis in Crohn's disease.
作者: Longyuan Zhou.;Jing Nie.;Zhiyin Feng.;Rongchang Li.;Pingxin Zhang.;Sinan Lin.;Yao Zhang.;Florian Rieder.;Changhao Chen.;Minhu Chen.;Ren Mao.
来源: Gut. 2026年75卷5期905-919页
Intestinal fibrosis, a hallmark complication of Crohn's disease (CD), frequently progresses to stricture formation and surgical intervention. Fibroblast metabolic reprogramming is important in organ fibrosis. However, its role in intestinal fibrogenesis of CD remains elusive.
54. Stem-like CD8+ T cells preserve HBV-specific responses in HBV/HIV co-infection.
作者: Anucha Preechanukul.;Aljawharah Alrubayyi.;Bo Sun.;Edward Arbe-Barnes.;Jonida Kokici.;Frances Gorou.;Sarun Prasitdumrong.;Kelly A S da Costa.;Natasha Fisher-Pearson.;Noshin Hussain.;Stephanie Kucykowicz.;Indrajit Ghosh.;Fiona Burns.;Sabine Kinloch.;Pedro Simoes.;Sanjay Bhagani.;Patrick T F Kennedy.;Mala K Maini.;Rachael Bashford-Rogers.;Upkar S Gill.;Dimitra Peppa.
来源: Gut. 2025年
Chronic hepatitis B virus (HBV) infection disproportionately affects people living with HIV, who are often excluded from functional cure studies.
56. Gut microbe alleviates stress-related cancer metastasis by oleic acid degradation.
作者: Chen Liu.;Junli Gong.;Zhanhao Luo.;Peng Lai.;Shuang Guo.;Dayi Liang.;Guangyuan Chen.;Mengze Xing.;Jing Yu.;Yanchun Xie.;Danling Liu.;Wanyi Zeng.;Zhen He.;Ping Lan.
来源: Gut. 2026年75卷5期968-983页
Chronic stress is a known risk factor for cancer metastasis. However, the underlying mechanisms, particularly those involving the gut microbiota and their metabolites, remain unclear.
57. Decoding HBV-specific adaptive immunity: from natural clearance to cure.
Chronic HBV infection remains a major global health burden, with current antiviral therapies effectively suppressing viral replication but rarely achieving functional cure. Adaptive immunity is central to viral clearance but is profoundly impaired during chronic infection. Inducing and enhancing adaptive immunity through therapeutic vaccines, immune checkpoint inhibitors or T cell-based therapies represents a promising approach for HBV cure strategies. However, recent preclinical and clinical studies have demonstrated only limited efficacy, underscoring major immunological challenges. In this review, we summarise current knowledge of the correlates of viral clearance and persistence, discuss key unresolved questions and outline future research directions needed to advance immune-based HBV cure strategies.
58. Gut microbiota predict development of postdischarge diabetes mellitus in acute pancreatitis.
作者: Christoph Ammer-Herrmenau.;Richard Meier.;Kai L Antweiler.;Thomas Asendorf.;Silke Cameron.;Gabriele Capurso.;Marko Damm.;Linh Dang.;Fabian Frost.;Jacob Hamm.;Albrecht Hoffmeister.;Yana Kocheva.;Christian Meinhardt.;Lukasz Nawacki.;Vitor Nunes.;Arpad Panyko.;María Lourdes Ruiz-Rebollo.;Cesáreo Flórez-Pardo.;Veit Phillip.;Aldis Pukitis.;Diana Vaselane.;Ecaterina Rinja.;Vasile Sandru.;Arlett Schaefer.;Rahel Scholz.;Julian Seelig.;Simon Sirtl.;Volker Ellenrieder.;Albrecht Neesse.
来源: Gut. 2026年75卷2期316-325页
Postdischarge morbidity and mortality is high in acute pancreatitis (AP) and pathophysiological mechanisms remain poorly understood.
59. FOXM1 inhibition reduces IL-13-induced epithelial remodelling and inflammation in eosinophilic oesophagitis.
作者: Masaru Sasaki.;Joshua X Wang.;Ryugo Teranishi.;Takefumi Itami.;Yusen Zhou.;Kanak V Kennedy.;Ann Semeao.;Satoshi Ishikawa.;Takeo Hara.;Emily A McMillan.;Mark Mahon.;Hailey Golden.;Diya Dhakal.;Alyssa Baccarella.;Heidi Winters.;Chizoba N Umeweni.;Benjamin J Wilkins.;Tatiana A Karakasheva.;Kelly A Whelan.;Sydney M Shaffer.;Melanie A Ruffner.;Amanda B Muir.
来源: Gut. 2026年75卷5期857-871页
Eosinophilic oesophagitis (EoE) is a chronic allergic disease characterised by oesophageal epithelial remodelling, barrier dysfunction and inflammation. The transcription factor forkhead box M1 (FOXM1) has been shown to be a key regulator of epithelial proliferation and inflammation in allergic asthma.
60. Acute upper gastrointestinal bleeding in the UK: 2022 audit update.
作者: Gaurav B Nigam.;Kathryn Oakland.;Sarah Hearnshaw.;John Grasnt-Casey.;Paul Davies.;Paula Dhiman.;Shane W Goodwin.;Bhaskar Kumar.;Elizabeth Ratcliffe.;Joanna A Leithead.;Raman Uberoi.;Lise Estcourt.;Vipul Jairath.;Simon P L Travis.;Mike F Murphy.;Adrian Stanley.;Andrew Douds.; .
来源: Gut. 2026年75卷4期760-771页
Acute upper gastrointestinal bleeding (AUGIB) is a common medical emergency with evolving demographics and management strategies, particularly in medical/endoscopic therapy and transfusion strategies.
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