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57. Efficacy of GLP-1 receptor agonists and dual GLP-1/GIP receptor agonists in managing MALFD: a meta-analysis of randomized controlled trials.
作者: Surtika Tamilwanan.;Zoriah Aziz.;Lim Yan Rong.;Ahmad Naoras Bitar.;Raghdaa Hamdan Al Zarzour.;Salah A Alshehade.
来源: BMC Gastroenterol. 2025年25卷1期765页
Metabolic dysfunction-associated fatty liver disease (MAFLD) affects up to 30% of the global population, yet effective pharmacological treatments remain limited. This systematic review and meta-analysis evaluated the efficacy of GLP-1 receptor agonists and dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) receptor agonists in managing MAFLD.
58. Impact of PG-SGA-assessed malnutrition stratification on clinical outcomes in advanced gastrointestinal malignancies: a retrospective cohort study.
作者: Pei Zhuang.;Jun-Xuan Chen.;Bing Xia.;Xiao-Su Chen.;Xiao-Tian Chen.;Li Li.;Ting Zhu.;Shu-An Wang.;Qing-Yan Li.
来源: BMC Gastroenterol. 2025年25卷1期766页
The traditional TNM staging system fails to explain survival heterogeneity in advanced gastrointestinal cancer, while malnutrition remains an underutilized prognostic modulator. We aimed to establish the prognostic value of dynamic nutritional risk stratification using the Patient-Generated Subjective Global Assessment (PG-SGA).
59. Risk factors for surgical recurrence and the preventive effect of endoscopic balloon dilatation in postoperative patients with Crohn 's disease.
作者: Masatsugu Kojima.;Toru Miyake.;Shigeki Bamba.;Soichiro Tani.;Keiji Muramoto.;Sachiko Kaida.;Katsushi Takebayashi.;Hiromitsu Maehira.;Reiko Otake.;Haruki Mori.;Nobuhito Nitta.;Tomoharu Shimizu.;Masaji Tani.
来源: BMC Gastroenterol. 2025年25卷1期764页
Although biologics have improved Crohn's disease (CD) management, surgery is still required for severe strictures or penetrating disease. Endoscopic balloon dilatation (EBD) is widely used for postoperative strictures and provides symptom relief; however, its potential preventive effect on surgical recurrence remains unclear. In addition, prognostic factors for surgical recurrence have not been fully established.
60. Targeting Mutual Dependence of Phosphatidylinositol-3-Kinase α/δ and Small Ubiquitin-Like Modifier Signaling in Pancreatic Cancer.
作者: Hazal Köse.;Christian Schneeweis.;Philipp Putze.;Constanza Tapia Contreras.;Laura Ferreiro.;Leonie Witte.;Ilaria Deidda.;Frederik Herzberg.;Sophie Ebert.;Juraj Jakubik.;Leoni Moldaner.;Jovan Todorovic.;Isabelle Träger.;Chuanbing Zang.;Uta M Demel.;Elisabeth Hessmann.;Marieluise Kirchner.;Simone Rhein.;Jens Hoffmann.;Zuzana Tatarova.;Michael Ghadimi.;Dieter Saur.;Kai Kappert.;Philipp Mertins.;Günter Schneider.;Ulrich Keller.;Matthias Wirth.
来源: Gastroenterology. 2025年
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal cancer, with a 5-year survival rate of <13%. Despite advances in diagnostics and treatments, the standard of care for PDAC remains inadequate, and most patients develop resistance to therapy. Targeted approaches, such as Kirsten rat sarcoma (KRAS) inhibition, have shown promise in preclinical models, although clinical application remains challenged by the rapid development of resistance. The phosphatidylinositol-3-kinase (PI3K) signaling pathway is critical for PDAC development and maintenance, yet pharmacologic targeting has failed to yield significant clinical benefits.
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