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41. Impact of Coronary Artery Disease on Cardiovascular Outcomes Differs Between Men and Women With Severe Aortic Stenosis.
作者: Kayla Brown.;Ke Xu.;Rebecca T Hahn.;Philippe Pibarot.;Jonathon Leipsic.;Ying Ma.;Marie-Annick Clavel.;Sammy Elmariah.;Neil J Weissman.;Federico M Asch.;Omar Khalique.;Martin B Leon.;Paul Cremer.;Brian R Lindman.;Maria C Alu.;Pamela S Douglas.;Melissa A Daubert.
来源: Circ Cardiovasc Interv. 2025年e014999页
There is heterogeneity in coronary artery disease (CAD) severity among individuals with severe aortic stenosis (AS), but whether this differentially influences prognosis is unknown.
42. Mechanisms Underlying Sinus Node Dysfunction in a Rat Model of Genetic Atrial Cardiomyopathy.
作者: Edouard Marcoux.;Martin Mackasey.;Deanna Sosnowski.;Patrice Naud.;Louis R Villeneuve.;Martin G Sirois.;Jean-Claude Tardif.;T Alexander Quinn.;Stanley Nattel.
来源: Circ Arrhythm Electrophysiol. 2025年18卷6期e013180页
Sinoatrial node (SAN) dysfunction is commonly associated with atrial dysrhythmia (tachy-brady syndrome) and is a particularly important feature of inherited atrial cardiomyopathies leading to artificial pacemaker implantation. Essential MYL4 (myosin light chain-4) is an atrial-selective protein that associates with the myosin light chain and participates importantly in cardiacmuscle contraction. MYL4 gene variants encoding dysfunctional versions of MYL4 cause familial atrial cardiomyopathy with a high incidence of early SAN dysfunction (SND) and pacemaker requirement. In this study, we used a rat line, genetically modified to express an E11K gene mutation responsible for familial atrial cardiomyopathy, to address the mechanisms underlying SND.
43. Disruption of cTnT-Mediated Sarcomere-Mitochondrial Communication Results in Dilated Cardiomyopathy.
作者: Lingqun Ye.;Junwei Liu.;Wei Lei.;Baoqiang Ni.;Xinglong Han.;Yan Zhang.;Yong Wang.;Kaili Hao.;Yuanhui Peng.;Hongchun Wu.;Miao Yu.;Huadong Li.;Zhen-Ao Zhao.;Zhenya Shen.;Jianyi Zhang.;Shijun Hu.
来源: Circulation. 2025年
Dilated cardiomyopathy (DCM) is substantially influenced by genetic factors. Sarcomere function is intricately associated with other organelles, particularly the reciprocal regulation between sarcomeres and mitochondria. Mitochondrial stress dysregulation is linked to DCM progression, yet mechanisms remain unclear. In this study, we investigated the effects of cTnT (cardiac troponin T) dysregulation on sarcomere-mitochondrial communication in DCM.
44. Development and Validation of Polygenic Risk Scores for Blood Pressure Traits in Continental African Populations.
作者: Ebuka Onyenobi.;Michael Zhong.;Opeyemi Soremekun.;Abram Kamiza.;Romuald Boua.;Tinashe Chikowore.; .;Segun Fatumo.;Ananyo Choudhury.;Scott Hazelhurst.;Clement Adebamowo.;Michèle Ramsay.;Bamidele Tayo.;Jennifer S Albrecht.;Timothy D O'Connor.;Yuji Zhang.;Braxton D Mitchell.;Sally N Adebamowo.
来源: Circ Genom Precis Med. 2025年18卷3期e005048页
Most polygenic risk scores (PRS) have been developed in European populations, frequently leading to limited transferability across diverse ancestry populations. This study aimed to develop and evaluate PRS for blood pressure (BP) traits in continental African populations and investigate how African genetic diversity influences PRS performance.
45. Identification and Functional Assessment of Candidate Causal Cis-Regulatory Variants Underlying Electrocardiographic QT Interval GWAS Loci.
作者: Supraja Kadagandla.;Lavanya Gunamalai.;Dongwon Lee.;Ashish Kapoor.
来源: Circ Genom Precis Med. 2025年18卷3期e005032页
Identifying causal variants among tens or hundreds of associated variants at each locus in genome-wide association studies is challenging. As the vast majority of genome-wide association studies variants are noncoding, sequence variation at cis-regulatory elements (CREs) affecting transcriptional expression of specific genes is a widely accepted molecular hypothesis. Following this hypothesis, combined with the observation that open chromatin is a universal hallmark of all types of CREs, we aimed to identify candidate causal cis-regulatory variants underlying QT interval genome-wide association studies loci.
46. Genotype-Specific Outcomes of Desmosomal Cardiomyopathies.
作者: Valerio Pergola.;Alessandro Trancuccio.;Deni Kukavica.;Andrea Mazzanti.;Carlo Napolitano.;Gabriele Gaetano Scilabra.;Kenneth Steele.;Mirella Memmi.;Patrick Gambelli.;Andrea Sugamiele.;Alessia Chiara Latini.;Nicola Pisani.;Giulio Mazzotta.;Raffaella Bloise.;Massimo Morini.;Maira Marino.;Silvia G Priori.
来源: Circulation. 2025年
Desmosomal gene variants (DGVs) have been associated with a diverse spectrum of phenotypic manifestations within arrhythmogenic cardiomyopathy, but data on genotype-specific outcomes are lacking. We investigated genotype-specific arrhythmic and heart failure (HF) outcomes in DGV carriers.
47. Shorter Time to Transcatheter Aortic Valve Implantation Is Associated With Improved Outcomes in Acute Decompensated Aortic Stenosis.
作者: Michael McKenna.;Niromila Nadarajan.;Sumanto Mukhopadhyay.;Mick Ozkor.;Thomas A Treibel.;Guy Lloyd.;Sanjeev Bhattacharyya.;Anthony Mathur.;Simon Kennon.;Andreas Baumbach.;Michael J Mullen.;Kush P Patel.
来源: Circ Cardiovasc Interv. 2025年e014915页
Acute decompensated aortic stenosis is an increasingly common condition associated with a high rate of morbidity, mortality, and health care resource utilization. Among patients with acute decompensated aortic stenosis, this study aimed to assess the impact of time to transcatheter aortic valve implantation (TAVI) on outcomes, hypothesizing that longer durations are associated with worse outcomes.
48. Thoracic Aortic Disease in Patients With Heterozygous Variants Outside the Central Region of FBN2.
作者: Till Joscha Demal.;Marco Sachse.;Celia Metzlaff.;Helke Schüler.;Katalin Szöcs.;Jakob Olfe.;Veronika Stark.;Peter Frommolt.;Yskert von Kodolitsch.;Thomas S Mir.;Meike Rybczynski.;Hermann Reichenspurner.;Kerstin Kutsche.;Christian Kubisch.;Christian Detter.;Georg Rosenberger.
来源: Circ Genom Precis Med. 2025年18卷3期e004672页
Heterozygous pathogenic variants in the central region (exon 23-34) of FBN2 cause a hereditary connective tissue disorder named congenital contractural arachnodactyly, which presents with obligatory skeletal features but rarely with vascular manifestations. Scarce data exist on the association between FBN2 variants and aortic disease. This study aimed to investigate whether the location of FBN2 variants correlates with distinct clinical features, including aortic disease.
49. Hemodynamic Right Heart Catheterization Before Transcatheter Mitral and Tricuspid Therapies.
作者: Cosmo Godino.;Antonio Sisinni.;Luca Raone.;Francesco Maria Sparasci.;Andrea Munafò.;Alberto Margonato.;Luca Testa.;Maurizio Taramasso.;Fabien Praz.;Sami Alnasser.;Neil Fam.;Rodrigo Estevez-Loureiro.;Francesco Saia.;Francesco Bedogni.;Azeem Latib.;Claudia Baratto.;Francesca Coppi.;Marianna Adamo.;Altin Palloshi.;Gabriele Crimi.;Scott Lim.;Francesco Maisano.;Ryan J Tedford.;Sergio Caravita.
来源: Circ Heart Fail. 2025年e012489页
Recent findings emphasize the potential role of invasive hemodynamic assessment in guiding transcatheter mitral and tricuspid valve percutaneous interventions. Right heart catheterization-derived parameters offer insights into hemodynamic changes associated with valvular heart diseases, pulmonary hypertension phenotyping, and right ventricular to pulmonary artery coupling. This might improve prognostic stratification for candidates to transcatheter therapies. This review provides a clinical overview of available data regarding the utility of preoperative right heart catheterization-derived parameters in patients undergoing mitral and tricuspid percutaneous repair or replacement.
50. Proteomic Signatures for Risk Prediction of Atrial Fibrillation.
作者: Hanjin Park.;Faye L Norby.;Daehoon Kim.;Eunsun Jang.;Hee Tae Yu.;Tae-Hoon Kim.;Jae-Sun Uhm.;Jung-Hoon Sung.;Hui-Nam Pak.;Moon-Hyoung Lee.;Pil-Sung Yang.;Boyoung Joung.
来源: Circulation. 2025年
Proteomic signatures might improve disease prediction and enable targeted disease prevention and management. We explored whether a protein risk score derived from large-scale proteomics data improves risk prediction of atrial fibrillation (AF).
51. Randomized Study Comparing Angiography Guidance With Physiology Guidance After PCI: The EASY-PREDICT Study.
作者: Paola Ulacia Flores.;Tomas Cieza.;Safia Ouarrak.;Andrés Ruhl.;Siddharta Mengi.;Robert De Larochellière.;David Garcia.;Jean-Pierre Déry.;Anthony Poulin.;Éric Larose.;Bernard Noël.;Can Manh Nguyen.;Jean-Michel Paradis.;Olivier F Bertrand.
来源: Circ Cardiovasc Interv. 2025年e015165页
Physiology assessment of coronary lesion prepercutaneous coronary intervention (PCI) using hyperemic and nonhyperemic pressure ratios is useful to determine if a lesion requires treatment. Whether the physiology after PCI is superior to angiography guidance only is unknown. The study sought to investigate whether post-PCI physiology improves clinical outcomes compared with standard angiographic guidance.
52. Intracellular L-PGDS-Derived 15d-PGJ2 Inhibits CaMKII Through Lipoxidation to Alleviate Cardiac Ischemia/Reperfusion Injury.
作者: Qingmei Hu.;Junxia Zhang.;Xile Luo.;Peiyu Hu.;Jiayi Li.;Fan Li.;Zeyuan Wang.;Shuyang Zhang.;Zishan Jiao.;Yitong Liu.;Jiaxin Duanmu.;Li Jin.;Peng Xie.;Wenneng Zhu.;Wen Zheng.;Haibao Shang.;Xinli Hu.;Zhixing Chen.;Rui-Ping Xiao.;Yan Zhang.
来源: Circulation. 2025年
Myocardial ischemia/reperfusion (I/R) injury is a substantial challenge to the management of ischemic heart disease, the leading cause of mortality worldwide. Arachidonic acid (AA) is a prominent polyunsaturated fatty acid in the human body and plays an important role in various physiological and pathological conditions. AA metabolic enzymes determine AA levels; however, currently there is no comprehensive analysis of AA enzymes in cardiac I/R injury.
53. Feasibility of Computed Tomography as a Gatekeeper for Invasive Angiography Before TAVR: A Pragmatic Real-World Experience.
作者: Asa Phichaphop.;Paul Sorajja.;Maurice Enriquez-Sarano.;Miho Fukui.;Atsushi Okada.;Davide Margonato.;Mohammed Abed.;Takahiro Nishihara.;Hideki Koike.;Evan Walser-Kuntz.;John R Lesser.;Victor Y Cheng.;Vinayak N Bapat.;Nadira Hamid.;João L Cavalcante.
来源: Circ Cardiovasc Interv. 2025年e015181页
Although pretranscatheter aortic valve replacement-computed tomography angiography (TAVR-CTA) has shown a good correlation with invasive coronary angiography (ICA) for ruling out obstructive coronary artery disease (CAD), its clinical effectiveness and safety as a gatekeeper for ICA pre-transcatheter aortic valve replacement (pre-TAVR) remain unclear. This study aims to determine whether routine TAVR-CTA, without premedication, could safely defer and guide the need for ICA pre-TAVR.
54. Valve-in-Valve TAVR for Degenerated Surgical Valves in Patients With Small Aortic Annuli: A Report From a Japanese Nationwide Registry.
作者: Yusuke Oba.;Hiraku Kumamaru.;Satoshi Hoshide.;Shun Kohsaka.;Kazuo Shimamura.;Yohei Ohno.;Masafumi Sato.;Hisaya Kobayashi.;Hiroshi Funayama.;Kenji Harada.;Koji Kawahito.;Kazuomi Kario.
来源: Circ Cardiovasc Interv. 2025年e015087页
Valve-in-valve transcatheter aortic valve replacement (ViV-TAVR) provides an alternative treatment for high-risk patients with failed surgical bioprosthetic aortic valves. However, limited data exist on ViV-TAVR outcomes in patients with small aortic annuli, particularly among the relatively small-statured Japanese population.
55. Antecedent Flu-Like Illness and Onset of Idiopathic Dilated Cardiomyopathy: The DCM Precision Medicine Study.
作者: Hanyu Ni.;Jinwen Cao.;Daniel D Kinnamon.;Elizabeth Jordan.;Garrie J Haas.;Mark Hofmeyer.;Evan P Kransdorf.;Jamie Diamond.;Anjali Owens.;Brian Lowes.;Douglas Stoller.;W H Wilson Tang.;Mark H Drazner.;Palak Shah.;Jane E Wilcox.;Stuart D Katz.;Javier Jimenez.;Supriya Shore.;Daniel P Judge.;Jonathan O Mead.;Jason Cowan.;Patricia K Parker.;Gordon S Huggins.;Ray E Hershberger.
来源: Circ Heart Fail. 2025年18卷5期e012602页
Previous studies have speculated that a viral infection may act as a trigger in the development of idiopathic dilated cardiomyopathy (DCM) among individuals genetically at risk. This study aims to describe the frequency of patients with DCM who reported experiencing symptoms of flu-like illness before their DCM diagnosis and to examine if this experience modified the association between genetics and DCM.
56. Marshall-Plan Ablation Strategy Versus Pulmonary Vein Isolation in Persistent AF: A Randomized Controlled Trial.
作者: Nicolas Derval.;Romain Tixier.;Josselin Duchateau.;Xavier Bouteiller.;Timothé Loock.;Arnaud Denis.;Rémi Chauvel.;Benjamin Bouyer.;Marine Arnaud.;Masaaki Yokoyama.;Christopher Kowalewski.;Cinzia Monaco.;Ciro Ascione.;Frédéric Sacher.;Mélèze Hocini.;Pierre Jaïs.;Michel Haïssaguerre.;Thomas Pambrun.
来源: Circ Arrhythm Electrophysiol. 2025年18卷5期e013427页
Beyond pulmonary vein (PV) isolation, the optimal ablation strategy for persistent atrial fibrillation (AF) remains poorly defined. The purpose of this study was to compare 2 ablation strategies in the treatment of patients with persistent AF: a comprehensive ablation strategy based on anatomic considerations versus PV isolation alone.
57. Heterogeneous Dysregulation of Myosin Super-Relaxation and Energetics in Hypertrophic Cardiomyopathy.
作者: Julien Ochala.;Miao Feng.;Qian Wang.;Chahida Chaami.;Edgar Nollet.;Christopher T A Lewis.;Anthony L Hessel.;Michelle Michels.;Kenneth C Bedi.;Kenneth B Margulies.;Jose R Pinto.;Kenneth S Campbell.;Diederik W D Kuster.;Jolanda van der Velden.
来源: Circ Heart Fail. 2025年e012614页
Hypertrophic cardiomyopathy is often linked to likely pathogenic and pathogenic variants in genes encoding myofilament proteins. The exact molecular mechanisms by which these lead to cardiac dysfunction and metabolic remodeling remain incompletely understood. Hence, here, we sought to determine whether likely pathogenic and pathogenic variants in thick (MYL2) and thin (TNNI3 or TNNT2) filament genes modulate the myosin super-relaxed state, a critical molecular regulator of heart energetics.
58. 10-Year Outcomes of Deferred or Conventional Stent Implantation in Patients With STEMI (DANAMI-3-DEFER).
作者: Jasmine Melissa Marquard.;Thomas Engstrøm.;Henning Kelbæk.;Rasmus Paulin Beske.;Utsho Islam.;Dan Eik Høfsten.;Lene Holmvang.;Frants Pedersen.;Christian Juhl Terkelsen.;Evald Høj Christiansen.;Hans-Henrik Tilsted.;Charlotte Glinge.;Reza Jabbari.;Ashkan Eftekhari.;Bent Raungaard.;Peter Clemmensen.;Hans Erik Bøtker.;Lisette Okkels Jensen.;Lars Køber.;Jacob Thomsen Lønborg.
来源: Circ Cardiovasc Interv. 2025年18卷6期e015369页
Primary percutaneous coronary intervention (PCI) with stenting is recommended in ST-segment-elevation myocardial infarction. Immediate stenting may cause distal embolization, microvascular damage, and flow disturbances, leading to adverse outcomes. We report the 10-year clinical outcomes of deferred stenting versus conventional PCI in patients with ST-segment-elevation myocardial infarction.
59. Long-Term Safety and Efficacy of Renal Denervation: 24-Month Results From the SPYRAL HTN-ON MED Trial.
作者: David E Kandzari.;Felix Mahfoud.;Raymond R Townsend.;Kazuomi Kario.;Michael A Weber.;Roland E Schmieder.;Konstantinos Tsioufis.;Stuart Pocock.;Minglei Liu.;Vanessa DeBruin.;Sandeep Brar.;Michael Böhm.
来源: Circ Cardiovasc Interv. 2025年e015194页
Six-month results from the SPYRAL HTN-ON MED trial demonstrated that renal denervation (RDN) reduced office blood pressure (BP), and not 24-hour ambulatory systolic BP, compared with sham control in hypertensive patients. In this prespecified analysis of the ON MED trial, long-term changes in BP, antihypertensive drug use, and safety outcomes through 24 months are compared between RDN and sham control groups.
60. Validation of a Novel Risk Prediction Score for Sudden Cardiac Death in the Framingham Heart Study.
作者: Thien Tan Tri Tai Truyen.;Honghuang Lin.;Marco Mathias.;Harpriya Chugh.;Kyndaron Reinier.;Emelia J Benjamin.;Sumeet S Chugh.
来源: Circ Arrhythm Electrophysiol. 2025年18卷6期e013647页
We have previously reported a novel clinical risk score (risk prediction score for shockable sudden cardiac arrest [VFRisk]) for the prediction of shockable sudden cardiac arrest, discovered and validated in 2 US west coast communities. We hypothesized that VFRisk predicts sudden cardiac death (SCD) risk in the geographically distinct FHS (Framingham Heart Study).
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