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43. Fulminant Viral Myocarditis Associated with Thogotovirus.
作者: Shuichi Osawa.;Kenji Miyazaki.;Sohtaro Mine.;Yuichiro Hirata.;Norihiko Terada.;Masayoshi Ozawa.;Kazunori Kikuchi.;Atsushi Uchida.;Kazuhito Hirose.;Yu Imakawa.;Keiko Komuro.;Noriko Nagata.;Sakurako Abe.;Yoshiaki Uchida.;Tomoko Yanaoka.;Seiya Ozono.;Tomoki Yoshikawa.;Chang-Kweng Lim.;Shuetsu Fukushi.;Aya Matsuu.;Sho Miyamoto.;Michiyo Kataoka.;Harutaka Katano.;Ken Maeda.;Hideki Ebihara.;Tadaki Suzuki.
来源: N Engl J Med. 2025年393卷9期924-926页 52. Monoclonal Antibodies in the Pathogenesis of Heparin-Induced Thrombocytopenia.
作者: Jared Treverton.;Donald M Arnold.;Daniil G Ivanov.;Nikola Ivetic.;Yi Zhang.;Hossam A Ali.;Rumi Clare.;Igor A Kaltashov.;John G Kelton.;Ishac Nazy.
来源: N Engl J Med. 2025年393卷9期879-886页
Heparin-induced thrombocytopenia (HIT) is an immune-mediated platelet disorder caused by antibodies that target complexes of platelet factor 4 (PF4) and heparin. HIT has been characterized as a polyclonal immune response; however, studies of other rare anti-PF4 disorders have identified clonally restricted antibodies.
53. One Dose versus Three Doses of Benzathine Penicillin G in Early Syphilis.
作者: Edward W Hook.;Jodie A Dionne.;Kimberly Workowski.;Candice J McNeil.;Stephanie N Taylor.;Teresa A Batteiger.;Julia C Dombrowski.;Kenneth H Mayer.;Arlene C Seña.;Matthew M Hamill.;Harold C Wiesenfeld.;Chunming Zhu.;Charlotte Perlowski.;Jorge E Mejia-Galvis.;Lori M Newman.
来源: N Engl J Med. 2025年393卷9期869-878页
Controversy persists regarding the appropriate duration of therapy with benzathine penicillin G in persons with early (i.e., primary, secondary, or early latent) syphilis (Treponema pallidum infection).
54. Home-Based Care for Hypertension in Rural South Africa.
作者: Mark J Siedner.;Nombulelo Magula.;Lusanda Mazibuko.;Nsika Sithole.;Alison Castle.;Siyabonga Nxumalo.;Thabang Manyaapelo.;Shafika Abrahams-Gessel.;Dickman Gareta.;Joanna Orne-Gliemann.;Kathy Baisley.;Max Bachmann.;Thomas A Gaziano.
来源: N Engl J Med. 2025年
Poorly controlled hypertension is a common problem worldwide, particularly in low-resource settings.
55. Targeting APOC3 with Olezarsen in Moderate Hypertriglyceridemia.
作者: Brian A Bergmark.;Nicholas A Marston.;Thomas A Prohaska.;Veronica J Alexander.;Andre Zimerman.;Filipe A Moura.;Yu Mi Kang.;Julia Weinland.;Sabina A Murphy.;Erica L Goodrich.;Shuanglu Zhang.;Dan Li.;Maciej Banach.;Erik Stroes.;Michael T Lu.;Sotirios Tsimikas.;Robert P Giugliano.;Marc S Sabatine.; .
来源: N Engl J Med. 2025年
Highly effective therapies to reduce triglyceride levels are lacking. Olezarsen is an N-acetylgalactosamine-conjugated antisense oligonucleotide that targets the messenger RNA of apolipoprotein C-III, which inhibits triglyceride clearance.
56. Ticagrelor and Aspirin or Aspirin Alone after Coronary Surgery for Acute Coronary Syndrome.
作者: Anders Jeppsson.;Stefan James.;Christian H Moller.;Carl Johan Malm.;Magnus Dalén.;Farkas Vanky.;Ivy Susanne Modrau.;Karl Andersen.;Vesa Anttila.;Gennady V Atroshchenko.;Mikael Barbu.;Mats Dreifaldt.;Ali Imad El-Akkawi.;Örjan Friberg.;Tomas Gudbjartsson.;Jarmo Gunn.;Rune Haaverstad.;Jari Halonen.;Emma C Hansson.;Jonas Holm.;Annastiina Husso.;Tatu Juvonen.;Øyvind Jakobsen.;Lena Jideus.;Emilia Johannesson.;Anna Jonsson Holmdahl.;Kristjan Jonsson.;Solveig Moss Kolseth.;Lytfi Krasniqi.;Tuomas Mäkelä.;Ari Mennander.;Lars-Erik Mohagen Krogstad.;Sulman Rafiq.;Peter Raivio.;Lars Riber.;Aminah Tahir.;Carl Thorsen.;Theis Tønnessen.;Alexander Wahba.;Igor Zindovic.;Aldina Pivodic.;Susanne J Nielsen.;David Erlinge.;Joakim Alfredsson.;Ulrik Sartipy.; .
来源: N Engl J Med. 2025年
Patients benefit from antiplatelet therapy after coronary-artery bypass grafting (CABG) for an acute coronary syndrome. Whether the addition of ticagrelor to aspirin, as compared with aspirin alone, further reduces the risk of adverse cardiovascular outcomes is unclear.
57. Apixaban for Extended Treatment of Provoked Venous Thromboembolism.
作者: Gregory Piazza.;Behnood Bikdeli.;Arvind K Pandey.;Darsiya Krishnathasan.;Candrika D Khairani.;Antoine Bejjani.;Ruth H Morrison.;Heather Hogan.;Sina Rashedi.;Mariana Pfeferman.;Junyang Lou.;John Fanikos.;Nicole Porio.;Lisa Rosenbaum.;Piotr Sobieszczyk.;Zhou Lan.;Marie Gerhard-Herman.;Umberto Campia.;Samuel Z Goldhaber.; .
来源: N Engl J Med. 2025年
The appropriate duration of anticoagulation for venous thromboembolism (VTE) in patients who have a transient provoking factor (e.g., surgery, trauma, or immobility) and concomitant enduring risk factors is uncertain.
59. Efficacy and Safety of Baxdrostat in Uncontrolled and Resistant Hypertension.
作者: John M Flack.;Michel Azizi.;Jenifer M Brown.;Jamie P Dwyer.;Jakub Fronczek.;Erika S W Jones.;Daniel S Olsson.;Shira Perl.;Hirotaka Shibata.;Ji-Guang Wang.;Ulrica Wilderäng.;Janet Wittes.;Bryan Williams.; .
来源: N Engl J Med. 2025年
Aldosterone dysregulation plays an important pathogenic role in hard-to-control hypertension. In several studies, baxdrostat, an aldosterone synthase inhibitor, reduced the seated systolic blood pressure of patients with uncontrolled or resistant hypertension.
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