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41. The impact of pancreatic duct stent placement on the clinically relevant postoperative pancreatic fistula rate for high-risk anastomoses: a systematic review and meta-analysis.
作者: Yuran Dai.;Xiaozhi Lu.;Lei Jiang.;Zipeng Lu.;Kuirong Jiang.;Yi Miao.;Jishu Wei.
来源: BMC Gastroenterol. 2025年25卷1期116页
To evaluate the impact of pancreatic duct stent outcomes on the prognosis of postoperative pancreatic fistula in patients with high-risk anastomoses.
42. Risk of stroke in patients with inflammatory bowel disease: a systematic review and meta-analysis.
作者: Chao Luo.;Lingpei Liu.;Di Zhu.;Zuanmin Ge.;Yuehua Chen.;Feng Chen.
来源: BMC Gastroenterol. 2025年25卷1期114页
Current studies suggest a potential link between inflammatory bowel disease (IBD), comprising Crohn's disease (CD) and ulcerative colitis (UC), and cardiovascular diseases, such as stroke. This study aimed to assess the risk of stroke in IBD patients compared to general population.
43. Systematic review and meta-analysis: no evidence that low-dose non-steroidal anti-inflammatory drugs (NSAIDs) reduce the risk of pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP).
Currently, many studies focus on the use of high-dose NSAIDs, showing significant effectiveness in preventing post-ERCP pancreatitis after surgery. However, some studies suggest that low-dose NSAIDs can also have certain effects. Nevertheless, after using propensity score matching to balance potential biases, the results do not seem ideal and fail to demonstrate clear effectiveness.
44. Short- and long-term outcomes of neoadjuvant chemotherapy compared with neoadjuvant chemoradiotherapy for locally advanced rectal cancer: an updated meta-analysis.
作者: Yue Guo.;Zhifeng Guo.;Jiaojiao Zhang.;Guowu Qian.;Wangquan Ji.;Linlin Song.;Zhe Guo.;Zhuo Han.
来源: BMC Gastroenterol. 2025年25卷1期87页
Neoadjuvant chemoradiotherapy (NACRT) is the standard treatment regimen for locally advanced rectal cancer (LARC) but has unavoidable radiation toxicity. With the advent of more optimized chemotherapy regimens, neoadjuvant chemotherapy (NAC) is sometimes offered as an alternative to NACRT. The purpose of this meta-analysis was to compare the short- and long-term outcomes of NAC and NACRT for LARC patients.
45. Health-related quality of life in pediatric patients with intestinal failure without neurodevelopmental delay: a systematic review and meta-analysis.
作者: Francesco Milo.;Deny Menghini.;Teresa Capriati.;Lorenzo Norsa.;Francesco Proli.;Giovanni Boroni.;Maria Immacolata Spagnuolo.;Giovanna Verlato.;Antonella Lezo.;Claudio Romano.;Stefano Vicari.;Antonella Diamanti.
来源: BMC Gastroenterol. 2025年25卷1期80页
Intestinal failure (IF) is a broad term encompassing various conditions that hinder the body's ability to absorb nutrients for growth and maintenance. These conditions can significantly affect child's well-being, leading to physical limitations, psychological distress, and social isolation. We aimed to evaluate the available data on health-related quality of life (HRQoL) in pediatric patients with IF and without neurodevelopmental delay.
46. Global prevalence of Fusobacterium nucleatum and Bacteroides fragilis in patients with colorectal cancer: an overview of case reports/case series and meta-analysis of prevalence studies.
作者: Fatemeh Sameni.;Parisa Abedi Elkhichi.;Ali Dadashi.;Mohammad Sadeghi.;Mehdi Goudarzi.;Maedeh Pourali Eshkalak.;Masoud Dadashi.
来源: BMC Gastroenterol. 2025年25卷1期71页
Colorectal cancer (CRC) is the second deadliest carcinoma across the globe and has been known as a multi-factor induced-disease. Emerging research have demonstrated that bacterial colonization may contribute to the initiation and promotion of the CRC. The presence of Fusobacterium nucleatum (F. nucleatum) and Bacteroides fragilis (B. fragilis) in the gut is associated with the development of CRC. In this study, the prevalence of F. nucleatum and B. fragilis among CRC patients has been assessed worldwide through a systematic review and meta-analysis.
47. Efficacy analysis of folic acid in chronic atrophic gastritis with Helicobacter pylori infection: a systematic review and meta-analysis.
Current data indicate that supplements such as folic acid play a significant role in treating chronic atrophic gastritis (CAG). However, no meta-analysis article evaluates its efficacy comprehensively. Therefore, we conducted a meta-analysis to compare the effectiveness and safety of folic acid in the treatment of CAG with Helicobacter pylori (H. pylori) infection.
48. The serum hepcidin and the hepcidin/ferritin ratio in NAFLD: a systematic review and meta-analysis.
作者: Jingmin Song.;Heqing Wang.;Xiaolian Gao.;Fen Yang.;Xinhong Zhu.;Guiyuan Qiao.;Ting Gan.;Junxiu Tao.
来源: BMC Gastroenterol. 2025年25卷1期62页
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of chronic liver diseases characterized by hepatic steatosis exceeding 5% in the absence of alcohol and other liver-damaging factors. Clinical studies have identified a potential link between abnormal iron metabolism and the high incidence of NAFLD; however, the results from clinical trials remain inconsistent. This meta-analysis aims to compare serum hepcidin levels and the hepcidin/ferritin ratio between adults with NAFLD and those without to explore their potential relationship with NAFLD.
49. A foundation systematic review of natural language processing applied to gastroenterology & hepatology.
作者: Matthew Stammers.;Balasubramanian Ramgopal.;Abigail Owusu Nimako.;Anand Vyas.;Reza Nouraei.;Cheryl Metcalf.;James Batchelor.;Jonathan Shepherd.;Markus Gwiggner.
来源: BMC Gastroenterol. 2025年25卷1期58页
This review assesses the progress of NLP in gastroenterology to date, grades the robustness of the methodology, exposes the field to a new generation of authors, and highlights opportunities for future research.
50. Mechanistic investigation and the optimal dose based on baicalin in the treatment of ulcerative colitis-A preclinical systematic review and meta-analysis.
作者: Jinchen Chong.;Zepeng Chen.;Jiaze Ma.;Linhai He.;Yijia Zhu.;Zhihua Lu.;Zhengxi Qiu.;Chen Chen.;Yugen Chen.;Feng Jiang.
来源: BMC Gastroenterol. 2025年25卷1期50页
Ulcerative colitis (UC) is a type of inflammatory bowel disease, and current treatments often fall short, necessitating new therapeutic options. Baicalin shows therapeutic promise in UC animal models, but a systematic review is needed.
51. Prevalence of common diarrheagenic enterobacteriaceae in Iran (2000-2023): a systematic review and meta-analysis.
作者: Mozhgan Derakhshan-Sefidi.;Fereshteh Eidy.;Somayyeh Nadi-Ravandi.;Sareh Bagheri-Josheghani.;Maryam Mirfakhraei.
来源: BMC Gastroenterol. 2025年25卷1期43页
Bacterial gastroenteritis is a significant public health concern, capable of causing severe infections. Among the various pathogens involved, those belonging to the Enterobacteriaceae family are the most frequently isolated and associated with gastrointestinal disorders. This study aimed to investigate the prevalence of common diarrheagenic Enterobacteriaceae in Iran over the past two decades, from 2000 to 2023.
52. AGA Clinical Practice Guideline on the Prevention and Treatment of Hepatitis B Virus Reactivation in At-Risk Individuals.
作者: Faisal S Ali.;Mindie H Nguyen.;Ruben Hernaez.;Daniel Q Huang.;Julius Wilder.;Alejandro Piscoya.;Tracey G Simon.;Yngve Falck-Ytter.
来源: Gastroenterology. 2025年168卷2期267-284页
Hepatitis B reactivation (HBVr) can occur due to a variety of immune-modulating exposures, including multiple drug classes and disease states. Antiviral prophylaxis can be effective in mitigating the risk of HBVr. In select cases, clinical monitoring without antiviral prophylaxis is sufficient for managing the risk of HBVr. This clinical practice guideline update aims to inform frontline health care practitioners by providing evidence-based practice recommendation for the management of HBVr in at-risk individuals.
53. The prognostic value of systemic inflammation response index in digestive system carcinomas: a systematic review and meta-analysis.
作者: Zuo-Hu Niu.;Li Lin.;Hong-Ye Peng.;Xin-Zhuo Zheng.;Mi-Yuan Wang.;Feng-Xia Sun.;Chun-Jun Xu.
来源: BMC Gastroenterol. 2025年25卷1期34页
Digestive system carcinomas (DSC) constitute a significant proportion of solid tumors, with incidence rates rising steadily each year. The systemic inflammation response index (SIRI) has been identified as a potential prognostic marker for survival in various types DSC. This meta-analysis aimed to evaluate the prognostic value of SIRI in patients with DSC.
54. The role of exercise-based prehabilitation in enhancing surgical outcomes for patients with digestive system cancers: a meta-analysis.
作者: Shasha Xu.;Rong Yin.;Haiou Zhu.;Yin Gong.;Jing Zhu.;Changxian Li.;Qin Xu.
来源: BMC Gastroenterol. 2025年25卷1期26页
Prehabilitation is a crucial component of tumor rehabilitation that attempts to improve patients' preoperative health, although its efficacy in treating patients with cancers of the digestive system is still up for debate.
55. Eradication Therapy to Prevent Gastric Cancer in Helicobacterpylori-Positive Individuals: Systematic Review and Meta-Analysis of Randomized Controlled Trials and Observational Studies.
作者: Alexander C Ford.;Yuhong Yuan.;Jin Young Park.;David Forman.;Paul Moayyedi.
来源: Gastroenterology. 2025年
Screening for, and treating, Helicobacter pylori in the general population or patients with early gastric neoplasia could reduce incidence of, and mortality from, gastric cancer. We updated a meta-analysis of randomized controlled trials (RCTs) examining this issue.
56. Investigating neutropenic enterocolitis: a systematic review of case reports and clinical insights.
作者: Samane Nematolahi.;Ali Amanati.;Hossein Molavi Vardanjani.;Mohammadreza Pourali.;Mahnaz Hosseini Bensenjan.;Farnoosh Nozari.;Mohebat Vali.;Seyed Reza Abdipour Mehrian.;Seyed Ali Nabavizadeh.;Farima Safari.
来源: BMC Gastroenterol. 2025年25卷1期17页
Neutropenic enterocolitis is a serious gastrointestinal complication that can develop in patients undergoing chemotherapy or other immunosuppressive treatments. It is characterized by inflammation and necrosis of the bowel, and most commonly affects the cecum and ascending colon. Although individual case reports have described the features of NE, a comprehensive synthesis of all the published cases is required.
57. Prognostic value of albumin-bilirubin grade in patients with cholangiocarcinoma: a systematic review and meta-analysis.
作者: Mahyaar Omouri-Kharashtomi.;Seyedeh Yasaman Alemohammad.;Negin Moazed.;Inas Afzali Nezhad.;Hamed Ghoshouni.
来源: BMC Gastroenterol. 2025年25卷1期19页
Cholangiocarcinoma (CCA) is a type of cancer that develops in the biliary tract. CCA accounts for 10% of primary hepatic cancers and is characterized by its aggressive nature and poor prognosis. This systematic review and meta-analysis aims to assess the prognostic value of the novel hepatic function assessment measure known as albumin-bilirubin (ALBI) grade in patients with CCA.
58. Associations between changes in the gut microbiota and liver cirrhosis: a systematic review and meta-analysis.
作者: Ye Liu.;Ziwei Chen.;Chang Li.;Tianhan Sun.;Xuanmei Luo.;Boyue Jiang.;Meilan Liu.;Qing Wang.;Tong Li.;Jianfu Cao.;Yayu Li.;Yuan Chen.;Lu Kuai.;Fei Xiao.;Hongtao Xu.;Hongyuan Cui.
来源: BMC Gastroenterol. 2025年25卷1期16页
Summaries of the relationships between the microbiota and liver cirrhosis and their conclusions are not consistent. This study describes microbial differences in patients with liver cirrhosis by performing a meta-analysis.
59. Efficacy of probiotic, prebiotic, and synbiotics supplements in individuals with anemia: a systematic review and meta-analysis of randomized controlled trials.
作者: Qian Hu.;Ying Liu.;Youmei Fei.;Jingping Zhang.;Shao Yin.;Hui Zou.;Fengya Zhu.
来源: BMC Gastroenterol. 2024年24卷1期472页
Anemia is a common global health problem, particularly in impoverished regions, with a high incidence rate. The condition is multifactorial, with iron deficiency being one of the most prevalent causes. Current treatment for anemia often relies on iron supplements or erythropoiesis-stimulating agents, although these therapies may show limited efficacy for some patients. Recent evidence suggests that probiotics, prebiotics, and synbiotics, as microbiome modulators, hold significant potential in the treatment of anemia. These interventions may enhance iron absorption and improve overall blood health through their impact on gut microbiota, thus providing an alternative or complementary approach to conventional treatments.
60. Efficacy and safety of PD-1 and PD-L1 inhibitors in advanced colorectal cancer: a meta-analysis of randomized controlled trials.
PD-1 and PD-L1 inhibitors have emerged as promising therapies for advanced colorectal cancer (CRC), but their efficacy and safety profiles require further evaluation. This meta-analysis aims to assess the efficacy and safety of PD-1/PD-L1 inhibitors in this patient population.
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