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41. Effect of Azithromycin on Asthma Remission in Adults With Persistent Uncontrolled Asthma: A Secondary Analysis of a Randomized, Double-Anonymized, Placebo-Controlled Trial.
作者: Dennis Thomas.;Vanessa M McDonald.;Sean Stevens.;Melissa Baraket.;Sandra Hodge.;Alan James.;Christine Jenkins.;Guy B Marks.;Matthew Peters.;Paul N Reynolds.;John W Upham.;Ian A Yang.;Peter G Gibson.
来源: Chest. 2024年166卷2期262-270页
Asthma remission is a potential treatment goal.
42. CT Imaging Assessment of Response to Treatment in Allergic Bronchopulmonary Aspergillosis in Adults With Bronchial Asthma.
作者: Cendrine Godet.;Anne-Laure Brun.;Francis Couturaud.;François Laurent.;Jean-Pierre Frat.;Sylvain Marchand-Adam.;Frédéric Gagnadoux.;Elodie Blanchard.;Camille Taillé.;Bruno Philippe.;Sandrine Hirschi.;Claire Andréjak.;Arnaud Bourdin.;Cécile Chenivesse.;Stéphane Dominique.;Gilles Mangiapan.;Marlène Murris-Espin.;Frédéric Rivière.;Gilles Garcia.;François-Xavier Blanc.;François Goupil.;Anne Bergeron.;Thomas Flament.;Pascaline Priou.;Hervé Mal.;Joe de Keizer.;Stéphanie Ragot.;Jacques Cadranel.; .
来源: Chest. 2024年165卷6期1307-1318页
One of the major challenges in managing allergic bronchopulmonary aspergillosis remains consistent and reproducible assessment of response to treatment.
43. Automatic Mechanical Ventilation vs Manual Bag Ventilation During CPR: A Pilot Randomized Controlled Trial.
作者: Jonghwan Shin.;Hui Jai Lee.;Kwang Nam Jin.;Jung Ho Shin.;Kyoung Min You.;Stephen Gyung Won Lee.;Jin Hee Jung.;Kyoung Jun Song.;Jieun Pak.;Tae Yun Park.;Chang Je Park.;Gi Tak Bae.
来源: Chest. 2024年166卷2期311-320页
There is insufficient evidence supporting the theory that mechanical ventilation can replace the manual ventilation method during CPR.
44. The Association Between Malnutrition and High Protein Treatment on Outcomes in Critically Ill Patients: A Post Hoc Analysis of the EFFORT Protein Randomized Trial.
作者: Charles Chin Han Lew.;Zheng-Yii Lee.;Andrew G Day.;Xuran Jiang.;Danielle Bear.;Gordon L Jensen.;Pauline Y Ng.;Lauren Tweel.;Angela Parillo.;Daren K Heyland.;Charlene Compher.
来源: Chest. 2024年165卷6期1380-1391页
Preexisting malnutrition in critically ill patients is associated with adverse clinical outcomes. Malnutrition can be diagnosed with the Global Leadership Initiative on Malnutrition using parameters such as weight loss, muscle wasting, and BMI. International critical care nutrition guidelines recommend high protein treatment to improve clinical outcomes in critically ill patients diagnosed with preexisting malnutrition. However, this recommendation is based on expert opinion.
45. High vs Low PEEP in Patients With ARDS Exhibiting Intense Inspiratory Effort During Assisted Ventilation: A Randomized Crossover Trial.
作者: Giuseppe Bello.;Valentina Giammatteo.;Alessandra Bisanti.;Luca Delle Cese.;Tommaso Rosà.;Luca S Menga.;Luca Montini.;Teresa Michi.;Giorgia Spinazzola.;Gennaro De Pascale.;Mariano Alberto Pennisi.;Roberta Ribeiro De Santis Santiago.;Lorenzo Berra.;Massimo Antonelli.;Domenico Luca Grieco.
来源: Chest. 2024年165卷6期1392-1405页
Positive end-expiratory pressure (PEEP) can potentially modulate inspiratory effort (ΔPes), which is the major determinant of self-inflicted lung injury.
46. Physiologic Effects of Reconnection to the Ventilator for 1 Hour Following a Successful Spontaneous Breathing Trial.
作者: Rémi Coudroy.;Alice Lejars.;Maeva Rodriguez.;Jean-Pierre Frat.;Christophe Rault.;François Arrivé.;Sylvain Le Pape.;Arnaud W Thille.
来源: Chest. 2024年165卷6期1406-1414页
Reconnection to the ventilator for 1 h following a successful spontaneous breathing trial (SBT) may reduce reintubation rates compared with direct extubation. However, the physiologic mechanisms leading to this effect are unclear.
47. Prophylactic Minocycline for Delirium in Critically Ill Patients: A Randomized Controlled Trial.
作者: Felipe Dal-Pizzol.;André Coelho.;Carla S Simon.;Monique Michels.;Emily Corneo.;Aline Jeremias.;Danusa Damásio.;Cristiane Ritter.
来源: Chest. 2024年165卷5期1129-1138页
Delirium is a potentially severe form of acute encephalopathy. Minocycline has neuroprotective effects in animal models of neurologic diseases; however, data from human studies remain scarce.
48. Safety and Efficacy of Clofazimine as an Alternative for Rifampicin in Mycobacterium avium Complex Pulmonary Disease Treatment: Outcomes of a Randomized Trial.
作者: Sanne M H Zweijpfenning.;Rob Aarnoutse.;Martin J Boeree.;Cecile Magis-Escurra.;Ralf Stemkens.;Bram Geurts.;Jakko van Ingen.;Wouter Hoefsloot.
来源: Chest. 2024年165卷5期1082-1092页
Results of retrospective studies have suggested clofazimine as an alternative for rifampicin in the treatment of Mycobacterium avium complex pulmonary disease (MAC-PD).
49. Comparison of Pirfenidone and Nintedanib: Post Hoc Analysis of the CleanUP-IPF Study.
作者: John S Kim.;Susan Murray.;Eric Yow.;Kevin J Anstrom.;Hyun J Kim.;Kevin R Flaherty.;Fernando J Martinez.;Imre Noth.
来源: Chest. 2024年165卷5期1163-1173页
Antifibrotics are effective in slowing FVC decline in idiopathic pulmonary fibrosis (IPF). However, whether antifibrotic type is differentially associated with FVC decline remains inconclusive.
50. Symptoms and Impaired Quality of Life After COVID-19 Hospitalization: Effect of Therapeutic Heparin in Non-ICU Patients in the Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 Acute Trial: Effect on 3-Month Symptoms and Quality of Life.
作者: Yonatan Y Greenstein.;Kinsley Hubel.;Joshua Froess.;Stephen R Wisniewski.;Vidya Venugopal.;Yu-Hsuan Lai.;Jeff S Berger.;Steven Y Chang.;Christos Colovos.;Faraaz Shah.;Lucy Z Kornblith.;Patrick R Lawler.;Manila Gaddh.;Raquel Morillo Guerrero.;William Nkemdirim.;Renato D Lopes.;Harmony R Reynolds.;Jose Seijas Amigo.;Lana Wahid.;Ajani Zahra.;Ewan C Goligher.;Ryan Zarychanski.;Eric Leifer.;David T Huang.;Matthew D Neal.;Judith S Hochman.;Mary Cushman.;Michelle N Gong.
来源: Chest. 2024年165卷4期785-799页
Therapeutic-dose heparin decreased days requiring organ support in noncritically ill patients hospitalized for COVID-19, but its impact on persistent symptoms or quality of life (QOL) is unclear.
51. Ozanimod Therapy in Patients With COVID-19 Requiring Oxygen Support: A Randomized Open-Label Pilot Trial.
作者: François Lellouche.;Pascale Blais-Lecours.;François Maltais.;Jean-François Sarrazin.;Philippe Rola.;Tuyen Nguyen.;Nathalie Châteauvert.;David Marsolais.
来源: Chest. 2024年165卷4期810-819页
Sphingosine-1-phosphate receptor ligands (SRLs) dampen immunopathologic damages in models of viral pneumonia.
52. Changes in Respiratory Mechanics With Trunk Inclination Differs Between Patients With ARDS With and Without Obesity.
Studies investigating the effect of trunk inclination on respiratory mechanics in mechanically ventilated patients with ARDS have reported postural differences in partition respiratory mechanics. Compared with more upright positions, the supine-flat position provided lower lung and chest wall elastance, allowing reduced driving pressures and end-inspiratory transpulmonary pressure. However, the effect of trunk inclination on respiratory mechanics in patients with obesity and ARDS is uncertain.
53. Modification of Endotypic Traits in OSA by the Carbonic Anhydrase Inhibitor Sulthiame.
作者: Erik Hoff.;Christian Strassberger.;Ding Zou.;Ludger Grote.;Kaj Stenlöf.;Jan Hedner.
来源: Chest. 2024年165卷3期704-715页
The carbonic anhydrase inhibitor sulthiame reduces OSA severity, increases overnight oxygenation, and improves sleep quality. Insights into how sulthiame modulates OSA pathophysiologic features (endotypic traits) adds to our understanding of the breathing disorder itself, as well as the effects of carbonic anhydrases in respiratory regulation.
54. Oxygen Therapy in Patients With Intermediate-Risk Acute Pulmonary Embolism: A Randomized Trial.
作者: Deisy Barrios.;Diego Durán.;Carmen Rodríguez.;Jorge Moisés.;Ana Retegui.;José Luis Lobo.;Raquel López.;Leyre Chasco.;Luis Jara-Palomares.;Alfonso Muriel.;Remedios Otero-Candelera.;Pedro Ruiz-Artacho.;Manuel Monreal.;Behnood Bikdeli.;David Jiménez.; .
来源: Chest. 2024年165卷3期673-681页
The effect of supplemental oxygen therapy in patients with intermediate-risk pulmonary embolism (PE) who do not have hypoxemia at baseline is uncertain.
55. Artificial Intelligence Improves Novices' Bronchoscopy Performance: A Randomized Controlled Trial in a Simulated Setting.
作者: Kristoffer Mazanti Cold.;Sujun Xie.;Anne Orholm Nielsen.;Paul Frost Clementsen.;Lars Konge.
来源: Chest. 2024年165卷2期405-413页
Navigating through the bronchial tree and visualizing all bronchial segments is the initial step toward learning flexible bronchoscopy. A novel bronchial segment identification system based on artificial intelligence (AI) has been developed to help guide trainees toward more effective training.
56. Effect of Intraarrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Invasive Treatment: A Post Hoc Bayesian Reanalysis of a Randomized Clinical Trial.57. Phenotypic Features of Pediatric Bronchiectasis Exacerbations Associated With Symptom Resolution After 14 Days of Oral Antibiotic Treatment.
作者: Vikas Goyal.;Stephanie T Yerkovich.;Keith Grimwood.;Julie M Marchant.;Catherine A Byrnes.;Ian Brent Masters.;Anne B Chang.
来源: Chest. 2023年164卷6期1378-1386页
Respiratory exacerbations in children and adolescents with bronchiectasis are treated with antibiotics. However, antibiotics can have variable interindividual effects when treating exacerbations.
58. Clinic vs Home Spirometry for Monitoring Lung Function in Patients With Asthma.
作者: John Oppenheimer.;Nicola A Hanania.;Rekha Chaudhuri.;Hironori Sagara.;Zelie Bailes.;Andrew Fowler.;Guy Peachey.;Emilio Pizzichini.;David Slade.
来源: Chest. 2023年164卷5期1087-1096页
Studies examining agreement between home and clinic spirometry in patients with asthma are limited, with conflicting results. Understanding the strengths and limitations of telehealth and home spirometry is particularly important considering the SARS-CoV-2 pandemic.
59. Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicle Infusion for the Treatment of Respiratory Failure From COVID-19: A Randomized, Placebo-Controlled Dosing Clinical Trial.
作者: Amy L Lightner.;Vikram Sengupta.;Sascha Qian.;John T Ransom.;Sam Suzuki.;David J Park.;Timothy I Melson.;Brian P Williams.;James J Walsh.;Mustafa Awili.
来源: Chest. 2023年164卷6期1444-1453页
Bone marrow mesenchymal stem cell (BM-MSC)-derived extracellular vesicles (ExoFlo) convey the immunomodulatory and regenerative properties of intact BM-MSCs. This study aimed to determine the safety and efficacy of ExoFlo as treatment for moderate to severe ARDS in patients with severe COVID-19.
60. The Effects of Exercise Training in Patients With Persistent Dyspnea Following Pulmonary Embolism: A Randomized Controlled Trial.
作者: Øyvind Jervan.;Stacey Haukeland-Parker.;Jostein Gleditsch.;Mazdak Tavoly.;Frederikus A Klok.;Kjetil Steine.;Hege Hølmo Johannessen.;Martijn A Spruit.;Dan Atar.;René Holst.;Anders Erik Astrup Dahm.;Per Anton Sirnes.;Knut Stavem.;Waleed Ghanima.
来源: Chest. 2023年164卷4期981-991页
Persistent dyspnea, functional limitations, and reduced quality of life (QoL) are common following pulmonary embolism (PE). Rehabilitation is a potential treatment option, but the scientific evidence is limited.
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