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41. Aberrant SNHG expression predicts poor prognosis in esophageal cancer using meta-analysis and bioinformatics analysis.
作者: Ke Shi.;Li-De Huang.;Dan Li.;Wei-Min Luo.;Hua-Song Liu.;Dong-Xiao Ding.;Qiang Guo.;Yue-Feng Liu.
来源: BMC Gastroenterol. 2025年25卷1期63页
Small nucleolar RNA host gene (SNHG) family were reported involved in various biological processes and may be used as a promising prognostic marker in esophageal cancer (EC). A meta-analysis was performed to investigate the relationship between SNHG expression and prognosis of EC in this study.
42. The serum hepcidin and the hepcidin/ferritin ratio in NAFLD: a systematic review and meta-analysis.
作者: Jingmin Song.;Heqing Wang.;Xiaolian Gao.;Fen Yang.;Xinhong Zhu.;Guiyuan Qiao.;Ting Gan.;Junxiu Tao.
来源: BMC Gastroenterol. 2025年25卷1期62页
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of chronic liver diseases characterized by hepatic steatosis exceeding 5% in the absence of alcohol and other liver-damaging factors. Clinical studies have identified a potential link between abnormal iron metabolism and the high incidence of NAFLD; however, the results from clinical trials remain inconsistent. This meta-analysis aims to compare serum hepcidin levels and the hepcidin/ferritin ratio between adults with NAFLD and those without to explore their potential relationship with NAFLD.
43. Mechanistic investigation and the optimal dose based on baicalin in the treatment of ulcerative colitis-A preclinical systematic review and meta-analysis.
作者: Jinchen Chong.;Zepeng Chen.;Jiaze Ma.;Linhai He.;Yijia Zhu.;Zhihua Lu.;Zhengxi Qiu.;Chen Chen.;Yugen Chen.;Feng Jiang.
来源: BMC Gastroenterol. 2025年25卷1期50页
Ulcerative colitis (UC) is a type of inflammatory bowel disease, and current treatments often fall short, necessitating new therapeutic options. Baicalin shows therapeutic promise in UC animal models, but a systematic review is needed.
44. Prevalence of common diarrheagenic enterobacteriaceae in Iran (2000-2023): a systematic review and meta-analysis.
作者: Mozhgan Derakhshan-Sefidi.;Fereshteh Eidy.;Somayyeh Nadi-Ravandi.;Sareh Bagheri-Josheghani.;Maryam Mirfakhraei.
来源: BMC Gastroenterol. 2025年25卷1期43页
Bacterial gastroenteritis is a significant public health concern, capable of causing severe infections. Among the various pathogens involved, those belonging to the Enterobacteriaceae family are the most frequently isolated and associated with gastrointestinal disorders. This study aimed to investigate the prevalence of common diarrheagenic Enterobacteriaceae in Iran over the past two decades, from 2000 to 2023.
45. The prognostic value of systemic inflammation response index in digestive system carcinomas: a systematic review and meta-analysis.
作者: Zuo-Hu Niu.;Li Lin.;Hong-Ye Peng.;Xin-Zhuo Zheng.;Mi-Yuan Wang.;Feng-Xia Sun.;Chun-Jun Xu.
来源: BMC Gastroenterol. 2025年25卷1期34页
Digestive system carcinomas (DSC) constitute a significant proportion of solid tumors, with incidence rates rising steadily each year. The systemic inflammation response index (SIRI) has been identified as a potential prognostic marker for survival in various types DSC. This meta-analysis aimed to evaluate the prognostic value of SIRI in patients with DSC.
46. The role of exercise-based prehabilitation in enhancing surgical outcomes for patients with digestive system cancers: a meta-analysis.
作者: Shasha Xu.;Rong Yin.;Haiou Zhu.;Yin Gong.;Jing Zhu.;Changxian Li.;Qin Xu.
来源: BMC Gastroenterol. 2025年25卷1期26页
Prehabilitation is a crucial component of tumor rehabilitation that attempts to improve patients' preoperative health, although its efficacy in treating patients with cancers of the digestive system is still up for debate.
47. Investigating neutropenic enterocolitis: a systematic review of case reports and clinical insights.
作者: Samane Nematolahi.;Ali Amanati.;Hossein Molavi Vardanjani.;Mohammadreza Pourali.;Mahnaz Hosseini Bensenjan.;Farnoosh Nozari.;Mohebat Vali.;Seyed Reza Abdipour Mehrian.;Seyed Ali Nabavizadeh.;Farima Safari.
来源: BMC Gastroenterol. 2025年25卷1期17页
Neutropenic enterocolitis is a serious gastrointestinal complication that can develop in patients undergoing chemotherapy or other immunosuppressive treatments. It is characterized by inflammation and necrosis of the bowel, and most commonly affects the cecum and ascending colon. Although individual case reports have described the features of NE, a comprehensive synthesis of all the published cases is required.
48. Prognostic value of albumin-bilirubin grade in patients with cholangiocarcinoma: a systematic review and meta-analysis.
作者: Mahyaar Omouri-Kharashtomi.;Seyedeh Yasaman Alemohammad.;Negin Moazed.;Inas Afzali Nezhad.;Hamed Ghoshouni.
来源: BMC Gastroenterol. 2025年25卷1期19页
Cholangiocarcinoma (CCA) is a type of cancer that develops in the biliary tract. CCA accounts for 10% of primary hepatic cancers and is characterized by its aggressive nature and poor prognosis. This systematic review and meta-analysis aims to assess the prognostic value of the novel hepatic function assessment measure known as albumin-bilirubin (ALBI) grade in patients with CCA.
49. Associations between changes in the gut microbiota and liver cirrhosis: a systematic review and meta-analysis.
作者: Ye Liu.;Ziwei Chen.;Chang Li.;Tianhan Sun.;Xuanmei Luo.;Boyue Jiang.;Meilan Liu.;Qing Wang.;Tong Li.;Jianfu Cao.;Yayu Li.;Yuan Chen.;Lu Kuai.;Fei Xiao.;Hongtao Xu.;Hongyuan Cui.
来源: BMC Gastroenterol. 2025年25卷1期16页
Summaries of the relationships between the microbiota and liver cirrhosis and their conclusions are not consistent. This study describes microbial differences in patients with liver cirrhosis by performing a meta-analysis.
50. Inflammatory bowel disease increases the risk of pancreatitis: a two-sample bidirectional Mendelian randomization analysis.
Previous studies have suggested an association between inflammatory bowel disease (IBD), and pancreatitis, including acute pancreatitis (AP) and chronic pancreatitis (CP). We aimed to examine the potential causal relationship between IBD and pancreatitis using the Mendelian randomization (MR) method.
51. Human blood metabolites and gastric cancer: a Mendelian randomization analysis.
作者: Chao Zhang.;Dao Lai Huang.;Kun Zhou.;Jin Tao Cai.;Dang Liu.;Ming Hao Tan.;Guan Yu Zhu.;Xiang Hua Wu.
来源: BMC Gastroenterol. 2024年24卷1期478页
Gastric cancer (GC) remains one of the predominant malignant tumors within the digestive tract, yet its underlying biological mechanisms remain elusive. The primary objective of this study is to delineate the causal relationship between circulating metabolites and GC.
52. Efficacy of probiotic, prebiotic, and synbiotics supplements in individuals with anemia: a systematic review and meta-analysis of randomized controlled trials.
作者: Qian Hu.;Ying Liu.;Youmei Fei.;Jingping Zhang.;Shao Yin.;Hui Zou.;Fengya Zhu.
来源: BMC Gastroenterol. 2024年24卷1期472页
Anemia is a common global health problem, particularly in impoverished regions, with a high incidence rate. The condition is multifactorial, with iron deficiency being one of the most prevalent causes. Current treatment for anemia often relies on iron supplements or erythropoiesis-stimulating agents, although these therapies may show limited efficacy for some patients. Recent evidence suggests that probiotics, prebiotics, and synbiotics, as microbiome modulators, hold significant potential in the treatment of anemia. These interventions may enhance iron absorption and improve overall blood health through their impact on gut microbiota, thus providing an alternative or complementary approach to conventional treatments.
53. Efficacy and safety of PD-1 and PD-L1 inhibitors in advanced colorectal cancer: a meta-analysis of randomized controlled trials.
PD-1 and PD-L1 inhibitors have emerged as promising therapies for advanced colorectal cancer (CRC), but their efficacy and safety profiles require further evaluation. This meta-analysis aims to assess the efficacy and safety of PD-1/PD-L1 inhibitors in this patient population.
54. Fecal Hemoglobin Levels in Prior Negative Screening and Detection of Colorectal Neoplasia: A Dose-Response Meta-Analysis.
作者: Danica M N van den Berg.;Rosita van den Puttelaar.;Lucie de Jonge.;Iris Lansdorp-Vogelaar.;Esther Toes-Zoutendijk.
来源: Gastroenterology. 2025年168卷3期587-597页
Prior studies have shown that individuals with fecal hemoglobin (f-Hb) concentrations just below the positivity cutoff have an increased colorectal cancer risk compared with those with no or low f-Hb. Understanding the dose-response association between f-Hb in a prior screening round and the detection of colorectal neoplasia is crucial for tailoring risk-based screening recommendations.
55. Sex-related differences in profiles and clinical outcomes of Inflammatory bowel disease: a systematic review and meta-analysis.
作者: Dana A Salem.;Rawan El-Ijla.;Razan R AbuMusameh.;Khaled A Zakout.;Alaa Y Abu Halima.;Mohammed T Abudiab.;Yahya M Banat.;Basel F Alqeeq.;Mohammed Al-Tawil.;Khaled Matar.
来源: BMC Gastroenterol. 2024年24卷1期425页
Inflammatory bowel disease (IBD) is a chronic and idiopathic condition that includes both Crohn's disease (CD) and ulcerative colitis (UC). The impact of sex on the disease course and the clinical outcomes not fully understood. Our systematic review and meta-analysis aims to explore the differences in the clinical outcomes in IBD.
56. Efficacy and safety of Nivolumab in advanced gastric and gastroesophageal junction cancer: a meta-analysis of randomized controlled trials.
作者: Xinming Lei.;Weimin Huo.;Tian Xu.;Jianguang Xu.;Maoning Liu.;Chengjiang Liu.;Zhangyuan Gu.
来源: BMC Gastroenterol. 2024年24卷1期422页
*CoNivolumab, an immune checkpoint inhibitor, has shown promise in treating advanced unresectable gastric and gastroesophageal junction cancer. This meta-analysis aims to evaluate the efficacy and safety of Nivolumab, alone and in combination with chemotherapy, in this patient population.
57. Long-term outcomes of additional surgery versus surveillance-only clinical decision for early colorectal cancer patients after non-curative endoscopic resection: a meta-analysis.
The clinical decision-making regarding post hoc management of early colorectal cancer (CRC) patients who have undergone non-curative endoscopic resection (ER) remains a subject of debate. This systematic review and meta-analysis aims to compare the clinical outcomes between patients undergoing additional surgery and those receiving surveillance only.
58. Impact of perioperative immunonutrition on postoperative outcomes in pancreaticoduodenectomy: a systematic review and meta-analysis of randomized controlled trials.
作者: Gaofeng Zhang.;Bing Zhao.;Tengang Deng.;Xiaofei He.;Yongpin Chen.;Changtao Zhong.;Jie Chen.
来源: BMC Gastroenterol. 2024年24卷1期412页
This systematic review and meta-analysis aimed to evaluate the impact of perioperative immunonutrition on postoperative outcomes in patients undergoing pancreaticoduodenectomy (PD).
59. Advantages comparison of peritoneal drainage versus no drainage after laparoscopic appendectomy for complicated appendicitis: a meta-analysis.
作者: Hongsheng Wu.;Biling Liao.;Tiansheng Cao.;Tengfei Ji.;Yumei Luo.;Jianbin Huang.;Keqiang Ma.
来源: BMC Gastroenterol. 2024年24卷1期411页
Peritoneal drainage (PD) following laparoscopic appendectomy(LA) has long been considered beneficial for appendicitis patients, especially those with complicated appendicitis. However, recent research has raised doubts about the advantages of PD, as it not only fails to reduce postoperative complications but also prolongs the operative duration and hospital stay and incurs higher medical expenses. Given this controversy, we conducted a meta-analysis to determine whether drainage is necessary after LA for complicated appendicitis. This meta-analysis had registered in PROSPERO(ID: CRD42023472382).
60. Efficacy and safety of tanshinone IIA in combination with mesalazine in the treatment of ulcerative colitis: a Systematic review and meta-analysis.
作者: Xiao Chen.;Qiujun Zhou.;Bolin Wang.;Dandan Feng.;Ronglin Jiang.;Xi Wang.
来源: BMC Gastroenterol. 2024年24卷1期410页
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by relapsing inflammation of the colon. Tanshinone IIA, a compound derived from traditional Chinese medicine, has demonstrated anti-inflammatory properties and may enhance treatment outcomes when combined with mesalazine. This study aims to determine the overall response rate of Tanshinone IIA in combination with mesalazine for the treatment of UC.
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