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41. The relationships between depression, inflammation and self-reported disease activity in IBD and their impact on healthcare usage.
作者: Natasha Seaton.;Vari Wileman.;Christine Norton.;Joanna Hudson.;Valeria Mondelli.;Rona Moss-Morris.
来源: BMC Gastroenterol. 2025年25卷1期140页
Depression is common in people living with Inflammatory Bowel Disease (IBD). Depression rates increase with active disease and are linked to poorer clinical outcomes. Previous studies investigating the relationship between contemporaneous IBD disease activity and depression are often poorly controlled, use small samples and/or rely on self-reported measures of disease activity. Depression and self-reported disease activity (SRDA) are linked to increased healthcare usage, however, objective inflammation is rarely statistically controlled. The primary aim was to understand how self-reported disease activity and inflammation are related to depression. Secondary aims included assessing the relative influence of self-reported disease activity, inflammation and depression on healthcare usage.
42. The Impact of Hepatitis B Surface Antigen Reduction via Small Interfering RNA Treatment on Natural and Vaccine (BRII-179)-Induced Hepatitis B Virus-Specific Humoral and Cellular Immune Responses.
作者: Yun Ji.;Nina Le Bert.;Grace Lai-Hung Wong.;Mark W Douglas.;Ariel Lee.;Chong Zhu.;Bing Wang.;Jianxiang Lv.;Dong Li.;Ying Tan.;Haiyan Ma.;Jieliang Chen.;Xiaofei Chen.;Qing Zhu.;Man-Fung Yuen.;Antonio Bertoletti.
来源: Gastroenterology. 2025年169卷1期136-149页
The impact of hepatitis B surface antigen (HBsAg) reduction from small interfering RNA (siRNA) treatments on hepatitis B virus (HBV)-specific immunity of individuals with chronic hepatitis B (CHB) has not been adequately analyzed in humans. We conducted a phase 2a study treating CHB participants with nine 4-weekly doses of HBV-targeted siRNA elebsiran (BRII-835), either alone (n = 10) or in combination with a virus-like particle-based therapeutic vaccine (BRII-179) containing Pre-S1, Pre-S2, and S antigens, coadministered with (n = 39) or without (n = 41) interferon alfa.
43. Operation sequence of bidirectional endoscopy with topical anesthesia affected colonoscopy performance: a randomized controlled trial.
The operation sequence of bidirectional endoscopy with topical anesthesia varies among endoscopists, which interferes with clinical procedure. The study aimed to investigate the influence of different operation sequences on the outcomes of quality indicators and improve bidirectional endoscopy performance.
44. Electroacupuncture Reduces Duration of Postoperative Ileus After Laparoscopic Gastrectomy for Gastric Cancer: A Multicenter Randomized Trial.
作者: Lixia Pei.;Gang Wang.;Sihao Yang.;Shuxin Zhou.;Tianshu Xu.;Jia Zhou.;Wei Zhang.;Kaixin Lu.;Linyan Hu.;Yang Wang.;Ke Wang.;Dongfang You.;Yaqian Wu.;Li Li.;Jing Guo.;Jianhua Sun.
来源: Gastroenterology. 2025年169卷1期73-84页
Electroacupuncture (EA) may reduce the duration of postoperative ileus (POI) after laparoscopic gastrectomy for gastric cancer, although evidence is limited. We investigated the efficacy of EA in reducing POI duration and enhancing gastrointestinal (GI) recovery in patients undergoing laparoscopic surgery for gastric cancer.
45. Pilot feasibility study to determine the utility of direct access and quantitative magnetic resonance cholangiopancreatography (MRCP) in the assessment of suspected acute biliary or ductal gallstone presentations.
作者: Alex Novak.;Anita Acharya.;Sally Beer.;Alexis Espinosa.;Giles Bond Smith.;Cyrene Saga.;Jane Andrews.;Adam Bailey.;Zahir Soonawalla.;Helen Bungay.;Michael Pavlides.
来源: BMC Gastroenterol. 2025年25卷1期72页
Patients with suspected acute gallstone disease typically undergo abdominal ultrasound. MRCP is often used for patients with abnormal LFTs, potentially making ultrasound unnecessary for this group. Despite high inter-reader variability in MRCP interpretation, new AI technologies may automate and standardize detection and measurement.
46. Therapeutic effects of reduced glutathione on liver function, fibrosis, and HBV DNA clearance in chronic hepatitis B patients.
To evaluate the therapeutic impact of reduced glutathione combined with entecavir on liver function, fibrosis, and HBV-DNA clearance in chronic hepatitis B patients.
47. Collagen turnover biomarkers to predict outcome of patients with biliary cancer.
作者: Leonard Kaps.;Muhammed A Genc.;Markus Moehler.;Stephan Grabbe.;Jörn M Schattenberg.;Detlef Schuppan.;Rasmus Sund Pedersen.;Morten A Karsdal.;Philipp Mildenberger.;Annett Maderer.;Nicholas Willumsen.
来源: BMC Gastroenterol. 2025年25卷1期53页
The collagen-rich tumor stroma plays a crucial role in biliary tract cancer (BTC). Collagen biomarkers of type I collagen (reC1M), type III collagen (PRO-C3), type IV collagen (C4G), type VIII collagen (PRO-C8), type XI collagen (PRO-C11), type XVII collagen (PRO-C17) and type VIII collagen (TUM) may be used as potential non-invasive biomarkers.
48. A Novel, IBS-Specific IgG ELISA-Based Elimination Diet in Irritable Bowel Syndrome: A Randomized, Sham-Controlled Trial.
作者: Prashant Singh.;William D Chey.;Will Takakura.;Brooks D Cash.;Brian E Lacy.;Eamonn M M Quigley.;Charles W Randall.;Anthony Lembo.
来源: Gastroenterology. 2025年168卷6期1128-1136.e4页
Personalized dietary therapies for irritable bowel syndrome (IBS) are needed and an immunoglobulin (Ig)G-antibody-based elimination diet presents a potential solution. However, existing studies have serious methodological limitations. This study aimed to assess the efficacy of an elimination diet by using a novel IBS-specific IgG assay.
49. Noncontrast Magnetic Resonance Imaging vs Ultrasonography for Hepatocellular Carcinoma Surveillance: A Randomized, Single-Center Trial.
作者: Hyungjin Rhee.;Myeong-Jin Kim.;Do Young Kim.;Chansik An.;Wonseok Kang.;Kyunghwa Han.;Yun Ho Roh.;Kwang-Hyub Han.;Sang Hoon Ahn.;Jin-Young Choi.;Jun Yong Park.;Yong Eun Chung.;Seung Up Kim.;Beom Kyung Kim.;Sunyoung Lee.;Hye Won Lee.;Jae Seung Lee.
来源: Gastroenterology. 2025年168卷6期1170-1177.e12页
This study aimed to compare ultrasonography (US) and noncontrast magnetic resonance imaging (MRI) in the surveillance of hepatic malignancy.
50. Glepaglutide, a Long-Acting Glucagon-like Peptide-2 Analogue, Reduces Parenteral Support in Patients With Short Bowel Syndrome: A Phase 3 Randomized Controlled Trial.
作者: Palle B Jeppesen.;Tim Vanuytsel.;Sukanya Subramanian.;Francisca Joly.;Geert Wanten.;Georg Lamprecht.;Marek Kunecki.;Farooq Rahman.;Thor S S Nielsen.;Mark Berner-Hansen.;Ulrich-Frank Pape.;David F Mercer.
来源: Gastroenterology. 2025年168卷4期701-713.e6页
Glepaglutide is a long-acting glucagon-like peptide (GLP)-2 analogue developed to improve intestinal absorption in patients with short bowel syndrome (SBS). The authors conducted a trial to establish the efficacy and safety of glepaglutide in reducing parenteral support (PS) needs in patients with SBS with intestinal failure.
51. Effect of an Endoscopy Screening on Upper Gastrointestinal Cancer Mortality: A Community-Based Multicenter Cluster Randomized Clinical Trial.
作者: Changfa Xia.;He Li.;Yongjie Xu.;Guizhou Guo.;Xiaodong Yu.;Wanying Wang.;Shuguang Dai.;Chunyun Dai.;Yigong Zhu.;Kun Jiang.;Zhiyi Zhang.;Junguo Hu.;Guohui Song.;Chao Chen.;Haifan Xiao.;Yanfang Chen.;Ting Song.;Shipeng Yan.;Bingbing Song.;Yutong He.;Jinyi Zhou.;Shaokai Zhang.;Wanqing Chen.
来源: Gastroenterology. 2025年168卷4期725-740页
Population-based observational studies suggest that endoscopic screening may reduce upper gastrointestinal cancer mortality. We aimed to quantify the effect of endoscopy screening.
52. Innovative strategies for the rapid restoration of intestinal function in patients undergoing abdominal surgery: use of probiotics. Pilot study of 15 patients.
作者: Elisabetta Radice.;Olexii Potapov.;Galyna Shabat.;Elisa Martello.;Giorgia Meineri.;Paolo Risso.;Francesco DI Pierro.;Francesco Olandese.
来源: Minerva Gastroenterol (Torino). 2025年71卷1期7-14页
The clinical value of probiotics in patients undergoing abdominal surgery, particularly colorectal surgery, remains uncertain despite their well-documented health benefits. This pilot randomized controlled trial aimed to assess the effects of perioperative and postoperative oral administration of two probiotics, Clostridium butyricum CBM588® and Bifidobacterium longum ES1, on immune function, systemic inflammatory response, postoperative infections, and recovery after colorectal surgery.
53. Effectiveness and safety of vonoprazan and amoxicillin dual regimen with Saccharomyces boulardii supplements on eradication of Helicobacter pylori.
作者: Jing Yu.;Chen Cui.;Kai Ma.;Peng Yang.;Yizhou Jiang.;Xiaoyong Wang.
来源: BMC Gastroenterol. 2024年24卷1期430页
Currently, Vonoprazan (VPZ) and amoxicillin dual regimen (VA-dual) has not achieved satisfied efficacy as the first-line treatment for Helicobacter pylori (H. pylori) infection in China. Thus, we aimed to determine the effect of VA-dual plus Saccharomyces boulardii (S. boulardii) on H. pylori eradication rate.
54. Survival outcomes of population-wide colonoscopy screening: reanalysis of the NordICC data.
Colonoscopy as a common screening practice to prevent colorectal cancer lacks strong evidence. NordICC, the first randomized trial of colonoscopy screening, reported no clear clinical benefit for colonoscopy in the intention-to-screen population with suggested benefit in the risk of colorectal incidence and cancer-specific mortality in the per-protocol analyses. However, although the study was designed to perform survival analysis, no survival outcomes were reported since the underlying assumption for hazard ratio was not valid. We aimed to assess whether colonoscopy screening is associated with improved survival outcomes compared with usual care.
55. The mechanism of transcutaneous gastric pacing treatment on gastrointestinal motility recovery and inflammation improvement in early-stage acute pancreatitis patients.
作者: Zhenyu Jia.;Lingchao Kong.;Xiaochun Lu.;Jianying Lu.;Yuying Shen.;Zhenguo Qiao.;Tingting Xia.
来源: BMC Gastroenterol. 2024年24卷1期407页
Acute pancreatitis (AP) is often accompanied by gastrointestinal motility disorders. The purpose of this study was to investigate the efficacy and possible mechanism of transcutaneous gastric pacing (TGP) in early-stage AP patients.
56. Prognostic impact of a 3-week multimodal prehabilitation program on frail elderly patients undergoing elective gastric cancer surgery: a randomized trial.
作者: Jianhui Chen.;Chen Hong.;Rui Chen.;Mengya Zhou.;Senbin Lin.
来源: BMC Gastroenterol. 2024年24卷1期403页
Research indicates that prehabilitation is effective in optimizing physical status before surgery, although this method may be considered "aggressive" for frail elderly patients. This study aimed to evaluate whether multimodal prehabilitation decreases postoperative complications and improves functional recovery in frail elderly patients undergoing gastric cancer surgery, in comparison to usual clinical care.
57. A High-Resolution Microendoscope Improves Esophageal Cancer Screening and Surveillance: Implications for Underserved Global Settings Based on an International Randomized Controlled Trial.
作者: Mimi C Tan.;Zhengqi Li.;Kalpesh K Patel.;Fan Zhang.;Xinying Yu.;Xueshan Wang.;Daniel G Rosen.;Sanford M Dawsey.;Liyan Xue.;Chin Hur.;Richard A Schwarz.;Imran Vohra.;Yubo Tang.;Mengfen Wu.;Tao Wang.;Jennifer Carns.;Hong Xu.;Rebecca R Richards-Kortum.;Guiqi Wang.;Sharmila Anandasabapathy.
来源: Gastroenterology. 2025年168卷3期496-507.e3页
Lugol's chromoendoscopy (LCE)-based detection of esophageal squamous cell neoplasia (ESCN) is limited by low specificity. High-resolution microendoscopy (HRME) was shown to improve specificity and reduce unnecessary biopsies when used by academic endoscopists. In this international randomized controlled trial, we determined the clinical impact, efficiency, and performance of HRME in true global health contexts with a range of providers.
58. Sleep disturbance in patients with cirrhosis and transjugular intrahepatic portosystemic shunt.
作者: Ming Zhao.;Yuling Yan.;Xiaoze Wang.;Bangxi Liu.;Xuefeng Luo.
来源: BMC Gastroenterol. 2024年24卷1期381页
Sleep disturbance (SD) is a common occurrence in individuals with cirrhosis and significantly impacts their quality of life. Datas regarding post transjugular intrahepatic portosystemic shunt (TIPS) SD are scarce. This study aimed to explore the incidence and outcomes of post-TIPS SD.
59. The effect of probiotic supplementation on non-alcoholic fatty liver disease (NAFLD) fibrosis score in patients attending a tertiary hospital clinic in Cairo, Egypt.
作者: Alaa Ahmed Abd El Hamid.;Azza Emam Mohamed.;Manal Sabry Mohamed.;Ghada Essam El-Din Amin.;Hagar Ahmed Ahmed Elessawy.;Mohamed Farouk Allam.
来源: BMC Gastroenterol. 2024年24卷1期354页
Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic fat accumulation (> 5% of liver tissue) in the absence of alcohol abuse or other chronic liver diseases. NAFLD can progress to non-alcoholic steatohepatitis (NASH), fibrosis, cirrhosis, and hepatocellular carcinoma (HCC). This study aimed to assess the efficacy of probiotic (lactobacillus) supplementation on NAFLD fibrosis score.
60. Safety and Tolerability of CP101, a Full-Spectrum, Oral Microbiome Therapeutic for the Prevention of Recurrent Clostridioides difficile Infection: A Phase 2 Randomized Controlled Trial.
作者: Jessica R Allegretti.;Colleen R Kelly.;Thomas Louie.;Monika Fischer.;Susy Hota.;Bharat Misra.;Nick W Van Hise.;Eugene Yen.;Jeffrey S Bullock.;Michael Silverman.;Ian Davis.;Sarah K McGill.;Darrell S Pardi.;Robert Orenstein.;Ari Grinspan.;Najwa El-Nachef.;Paul Feuerstadt.;Thomas J Borody.;Sahil Khanna.;Shrish Budree.;Zain Kassam.
来源: Gastroenterology. 2025年168卷2期357-366.e3页
Recurrent Clostridioides difficile infections (CDIs) remain common. While novel microbiome therapeutics gain approval, the efficacy of a full-spectrum, oral microbiome therapeutic is unknown. This study aimed to determine the safety and efficacy of CP101, an orally administered microbiome therapeutic, to restore a diverse microbiome and prevent recurrent CDI in a broad population.
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