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561. Estimating a minimally important difference in pulmonary arterial hypertension following treatment with sildenafil.
作者: Claire Gilbert.;Martin C J Brown.;Joseph C Cappelleri.;Martin Carlsson.;Stephen P McKenna.
来源: Chest. 2009年135卷1期137-142页
No guidelines exist to help physicians determine whether functional and health-related quality of life (HRQoL) changes observed following treatment of patients with pulmonary arterial hypertension (PAH) represent important benefits. These analyses were undertaken to help define a minimally important difference (MID) in exercise capacity, measured by the 6-min walk distance (6MWD), and HRQoL, measured by the Short Form-36 (SF-36) questionnaire in patients with PAH.
562. Endobronchial ultrasonography-guided transbronchial needle aspiration increases the diagnostic yield of peripheral pulmonary lesions: a randomized trial.
作者: Tung-Ying Chao.;Min-Te Chien.;Chien-Hao Lie.;Yu-Hsiu Chung.;Jui-Long Wang.;Meng-Chih Lin.
来源: Chest. 2009年136卷1期229-236页
The diagnostic yield of endobronchial ultrasonography (EBUS)-guided transbronchial needle aspiration (TBNA) for peripheral pulmonary lesions (PPLs) has not been evaluated. The diagnostic impact of TBNA when the EBUS probe is adjacent to lesions remains to be determined.
563. Ambrisentan therapy in patients with pulmonary arterial hypertension who discontinued bosentan or sitaxsentan due to liver function test abnormalities.
作者: Michael D McGoon.;Adaani E Frost.;Ronald J Oudiz.;David B Badesch.;Nazzareno Galie.;Horst Olschewski.;Vallerie V McLaughlin.;Michael J Gerber.;Chris Dufton.;Darrin J Despain.;Lewis J Rubin.
来源: Chest. 2009年135卷1期122-129页
Some endothelin receptor antagonists (ERAs) are associated with liver function test (LFT) result abnormalities. However, ambrisentan has an incidence of serum aminotransferase levels more than three times the upper limit of normal (ULN), similar to that observed in PAH patients who are not receiving ERAs. Because ambrisentan may provide benefits in PAH patients who have discontinued ERA therapy due to LFT abnormalities, we evaluated the safety and efficacy of ambrisentan in this patient population.
564. Morphine with adjuvant ketamine vs higher dose of morphine alone for immediate postthoracotomy analgesia.
作者: Nachum Nesher.;Margaret P Ekstein.;Yoseph Paz.;Nissim Marouani.;Shoshana Chazan.;Avi A Weinbroum.
来源: Chest. 2009年136卷1期245-252页
Thoracotomy is associated with severe pain. We hypothesized that the concomitant use of a subanesthetic dose of ketamine plus a two-third-standard morphine dose might provide more effective analgesia with fewer side effects than a standard morphine dose for early pain control.
565. 8-Isoprostane in exhaled breath condensate and exercise-induced bronchoconstriction in asthmatic children and adolescents.
作者: Mario Barreto.;Maria Pia Villa.;Carla Olita.;Susy Martella.;Giovanni Ciabattoni.;Paolo Montuschi.
来源: Chest. 2009年135卷1期66-73页
Exercise-induced bronchoconstriction (EIB) in the asthmatic child is associated with persistent airway inflammation and poor disease control. EIB could arise partly from airway oxidative stress. Exhaled breath condensate (EBC) levels of 8-isoprostane (IsoP), which is a known marker of oxidative stress, might therefore be helpful for monitoring asthma noninvasively.
566. Early microbiological response to linezolid vs vancomycin in ventilator-associated pneumonia due to methicillin-resistant Staphylococcus aureus.
作者: Richard G Wunderink.;Meryl H Mendelson.;Michael S Somero.;Timothy C Fabian.;Addison K May.;Helen Bhattacharyya.;Kenneth V Leeper.;Joseph S Solomkin.
来源: Chest. 2008年134卷6期1200-1207页
Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of ventilator-associated pneumonia (VAP). This prospective, open-label, multicenter clinical trial compared the early microbiological efficacy of linezolid (LZD) therapy with that of vancomycin (VAN) therapy in patients with MRSA VAP.
567. Effects of aminoguanidine, an inhibitor of inducible nitric oxide synthase, on nitric oxide production and its metabolites in healthy control subjects, healthy smokers, and COPD patients.
作者: Caterina Brindicci.;Kazuhiro Ito.;Olga Torre.;Peter J Barnes.;Sergei A Kharitonov.
来源: Chest. 2009年135卷2期353-367页
Nitric oxide (NO) is produced by resident and inflammatory cells in the respiratory tract by the enzyme NO synthase (NOS), which exists in three isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS. NO production is increased in patients with COPD, and the production of NO under oxidative stress conditions generates reactive nitrogen species that may amplify the inflammatory response in COPD.
568. Increasing doses of inhaled corticosteroids compared to adding long-acting inhaled beta2-agonists in achieving asthma control.
作者: Paul M O'Byrne.;Ian P Naya.;Anders Kallen.;Dirkje S Postma.;Peter J Barnes.
来源: Chest. 2008年134卷6期1192-1199页
Combination therapy with inhaled corticosteroids (ICSs) and long-acting beta(2)-agonists (LABAs), or treatment with high doses of ICSs alone improves asthma control when therapy with low-dose ICSs is not sufficient. However, it is not known which of these treatment options is more effective in sustaining asthma control.
569. Obesity and persisting sleep apnea after adenotonsillectomy in Greek children.
作者: Maria T Apostolidou.;Emmanouel I Alexopoulos.;Konstantinos Chaidas.;Georgia Ntamagka.;Anastasia Karathanasi.;Theoharis I Apostolidis.;Konstantinos Gourgoulianis.;Athanasios G Kaditis.
来源: Chest. 2008年134卷6期1149-1155页
The relative importance of obesity and adenotonsillar hypertrophy in the pathogenesis of obstructive sleep-disordered breathing (SDB) in childhood is unclear. Adenotonsillectomy (AT) for SDB is not always curative, and obese children are at increased risk for residual disease postoperatively.
570. Airway remodeling measured by multidetector CT is increased in severe asthma and correlates with pathology.
作者: Ravi S Aysola.;Eric A Hoffman.;David Gierada.;Sally Wenzel.;Janice Cook-Granroth.;Jaime Tarsi.;Jie Zheng.;Kenneth B Schechtman.;Thiruvamoor P Ramkumar.;Rebecca Cochran.;E Xueping.;Chandrika Christie.;John Newell.;Sean Fain.;Talissa A Altes.;Mario Castro.
来源: Chest. 2008年134卷6期1183-1191页
To prospectively apply an automated, quantitative three-dimensional approach to imaging and airway analysis to assess airway remodeling in asthma patients.
571. Relationship between pulmonary emphysema and osteoporosis assessed by CT in patients with COPD.
作者: Tadashi Ohara.;Toyohiro Hirai.;Shigeo Muro.;Akane Haruna.;Kunihiko Terada.;Daisuke Kinose.;Satoshi Marumo.;Emiko Ogawa.;Yuma Hoshino.;Akio Niimi.;Kazuo Chin.;Michiaki Mishima.
来源: Chest. 2008年134卷6期1244-1249页
Osteoporosis is one of the important systemic features of COPD. Although COPD itself is regarded as one risk factor for osteoporosis, the relationship between the extent of emphysema and reduced bone density is still unclear. Our first aim was therefore to measure vertebral bone density and the percentage of low-attenuation area (LAA%) in the lungs using chest CT scans in COPD patients. Our second aim was to investigate the relationships among CT scan measurements, anthropometric parameters, and pulmonary function.
572. Continuous aspiration of subglottic secretions in the prevention of ventilator-associated pneumonia in the postoperative period of major heart surgery.
作者: Emilio Bouza.;María Jesús Pérez.;Patricia Muñoz.;Cristina Rincón.;José María Barrio.;Javier Hortal.
来源: Chest. 2008年134卷5期938-946页
Aspiration of endotracheal secretions is a major step in the prevention of ventilator-associated pneumonia (VAP). We compared conventional and continuous aspiration of subglottic secretions (CASS) procedures in ventilated patients after major heart surgery (MHS).
573. Cardiac effects of continuous and bilevel positive airway pressure for patients with heart failure and obstructive sleep apnea: a pilot study.
作者: Rami N Khayat.;William T Abraham.;Brian Patt.;Monica Roy.;Keding Hua.;David Jarjoura.
来源: Chest. 2008年134卷6期1162-1168页
Obstructive sleep apnea (OSA) is prevalent in patients with heart failure. Treatment with continuous positive airway pressure (CPAP) improves systolic function in patients with heart failure. Bilevel positive airway pressure (PAP) is another treatment modality for OSA. The intermediate-term effect of bilevel PAP on left ventricular ejection fraction (LVEF) in patients with stable heart failure and OSA has not been compared to the effect of CPAP.
574. Alendronate once weekly for the prevention and treatment of bone loss in Canadian adult cystic fibrosis patients (CFOS trial).
作者: Alexandra Papaioannou.;Courtney C Kennedy.;Andreas Freitag.;George Ioannidis.;John O'Neill.;Colin Webber.;Margaret Pui.;Yves Berthiaume.;Harvey R Rabin.;Nigel Paterson.;Alphonse Jeanneret.;Elias Matouk.;Josee Villeneuve.;Madeline Nixon.;Jonathan D Adachi.
来源: Chest. 2008年134卷4期794-800页
Patients with cystic fibrosis (CF) are at risk for early bone loss, and demonstrate increased risks for vertebral fractures and kyphosis. A multicenter, randomized, controlled trial was conducted to assess the efficacy, tolerability, and safety of therapy with oral alendronate (FOSAMAX; Merck; Whitehouse Station, NJ) in adults with CF and low bone mass.
575. A phase 3, randomized, double-blind study to assess the efficacy and safety of fospropofol disodium injection for moderate sedation in patients undergoing flexible bronchoscopy.
作者: Gerard A Silvestri.;Brad D Vincent.;Momen M Wahidi.;Emory Robinette.;James R Hansbrough.;Gordon H Downie.
来源: Chest. 2009年135卷1期41-47页
Fospropofol disodium is a water-soluble prodrug of propofol with unique pharmacokinetic/pharmacodynamic properties. This randomized, double-blind, multicenter study evaluated the use of fospropofol in patients undergoing flexible bronchoscopy.
576. High-resolution CT scan findings in patients with symptomatic scleroderma-related interstitial lung disease.
作者: Jonathan G Goldin.;David A Lynch.;Diane C Strollo.;Robert D Suh.;Dean E Schraufnagel.;Philip J Clements.;Robert M Elashoff.;Daniel E Furst.;Sarinnapha Vasunilashorn.;Michael F McNitt-Gray.;Mathew S Brown.;Michael D Roth.;Donald P Tashkin.; .
来源: Chest. 2008年134卷2期358-367页
Lung disease has become the leading cause of mortality and morbidity in scleroderma (SSc) patients. The frequency, nature, and progression of interstitial lung disease seen on high-resolution CT (HRCT) scans in patients with diffuse SSc (dcSSc) compared with those with limited SSc (lcSSc) has not been well characterized.
577. A randomized trial of CT fluoroscopic-guided bronchoscopy vs conventional bronchoscopy in patients with suspected lung cancer.
作者: David Ost.;Rakesh Shah.;Edward Anasco.;Lisa Lusardi.;Jacqueline Doyle.;Christine Austin.;Alan Fein.
来源: Chest. 2008年134卷3期507-513页
Prior case series have shown promising diagnostic sensitivity for CT scan-guided bronchoscopy.
578. Sitaxsentan for the treatment of pulmonary arterial hypertension: a 1-year, prospective, open-label observation of outcome and survival.
作者: Raymond L Benza.;Robyn J Barst.;Nazzareno Galie.;Adaani Frost.;Reda E Girgis.;Kristin B Highland.;Charlie Strange.;Carol M Black.;David B Badesch.;Lewis Rubin.;Thomas R Fleming.;Robert Naeije.
来源: Chest. 2008年134卷4期775-782页
Despite advances in the management of pulmonary arterial hypertension (PAH), the mortality rate remains excessive. Long-term efficacy evaluations are needed to guide therapeutic management. The purpose of this study is to present 1-year observational data with two endothelin antagonists, sitaxsentan and bosentan, in a prospective, open-label study.
579. Patterns of domestic activity and ambulatory oxygen usage in COPD.
The aim of this study was to examine patterns of domestic activity and ambulatory oxygen usage in patients with COPD in their domestic environment.
580. A possible association between suspected restrictive pattern as assessed by ordinary pulmonary function test and the metabolic syndrome.
作者: Kei Nakajima.;Yoichi Kubouchi.;Toshitaka Muneyuki.;Midori Ebata.;Satoko Eguchi.;Hiromi Munakata.
来源: Chest. 2008年134卷4期712-718页
Impaired restrictive pulmonary function has been reported to be associated with insulin resistance and metabolic abnormalities. However, the possible association of restrictive pulmonary defect with metabolic syndrome (MetS) is not well understood. We examined the association in comparison with C-reactive protein (CRP), which is a predictor for MetS.
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