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541. Short term micronutrient-antioxidant supplementation has no impact on a serological marker of gastric atrophy in Zambian adults: retrospective analysis of a randomised controlled trial.
Gastric cancer is a major contributor to cancer deaths in Zambia but, as elsewhere, no preventive strategies have been identified. We set out to investigate the possibility of reducing gastric atrophy, a premalignant lesion, using micronutrient-antioxidant supplementation.
542. Efficacy of immunotherapy with TG4040, peg-interferon, and ribavirin in a Phase 2 study of patients with chronic HCV infection.
作者: Adrian M Di Bisceglie.;Ewa Janczweska-Kazek.;François Habersetzer.;Wlodzimierz Mazur.;Carol Stanciu.;Vicente Carreno.;Coman Tanasescu.;Robert Flisiak.;Manuel Romero-Gomez.;Alexander Fich.;Vincent Bataille.;Myew-Ling Toh.;Marie Hennequi.;Patricia Zerr.;Géraldine Honnet.;Geneviève Inchauspé.;Delphine Agathon.;Jean-Marc Limacher.;Heiner Wedemeyer.
来源: Gastroenterology. 2014年147卷1期119-131.e3页
TG4040 is a modified vaccinia Ankara (MVA) virus that expresses the hepatitis C virus (HCV) proteins NS3, NS4, and NS5B. We performed a phase II open-label study to determine the efficacy, safety, and immunotherapeutic properties of TG4040 in combination with pegylated interferon α-2a and ribavirin (PEG-IFNα/RBV) in patients with chronic HCV infection.
543. Determination of the discriminant score of intestinal microbiota as a biomarker of disease activity in patients with ulcerative colitis.
In recent years, the gut microbiota has been found to provide an important link to the development of inflammatory bowel diseases (IBD) like ulcerative colitis (UC). Accordingly, inter-individual variation in the gut microbial community may be linked to inter-individual variation in the risk of IBD or other diseases. Further, the Terminal Restriction Fragment Length Polymorphism (T-RFLP) is a molecular biology technique for profiling bacterial species in faecal samples. This study was to evaluate a biomarker based on intestinal microbiota.
544. Hepatitis C virus core antigen, an earlier and stronger predictor on sustained virological response in patients with genotype 1 HCV infection.
作者: Bo Feng.;Rui-Feng Yang.;Qing Xie.;Jia Shang.;Fan-Yun Kong.;Hai-Ying Zhang.;Hui-Ying Rao.;Qian Jin.;Xu Cong.;Yun-Ye Liu.;Yi Kang.;Lai Wei.
来源: BMC Gastroenterol. 2014年14卷47页
Earlier kinetics of serum HCV core antigen (HCVcAg) and its predictive value on sustained virological response (SVR) were investigated in patients with genotype 1 HCV infection during antiviral treatment.
545. Simeprevir with peginterferon and ribavirin leads to high rates of SVR in patients with HCV genotype 1 who relapsed after previous therapy: a phase 3 trial.
作者: Xavier Forns.;Eric Lawitz.;Stefan Zeuzem.;Ed Gane.;Jean Pierre Bronowicki.;Pietro Andreone.;Andrzej Horban.;Ashley Brown.;Monika Peeters.;Oliver Lenz.;Sivi Ouwerkerk-Mahadevan.;Jane Scott.;Guy De La Rosa.;Ronald Kalmeijer.;Rekha Sinha.;Maria Beumont-Mauviel.
来源: Gastroenterology. 2014年146卷7期1669-79.e3页
Simeprevir is an oral, once-daily inhibitor of hepatitis c virus (HCV) protease NS3/4A. We investigated the safety and efficacy of simeprevir with peg-interferon α-2a and ribavirin (PR) in a randomized, double-blind, placebo-controlled, phase 3 trial of patients with HCV genotype 1 infection who relapsed after previous interferon-based therapy.
546. Glutenase ALV003 attenuates gluten-induced mucosal injury in patients with celiac disease.
作者: Marja-Leena Lähdeaho.;Katri Kaukinen.;Kaija Laurila.;Pekka Vuotikka.;Olli-Pekka Koivurova.;Tiina Kärjä-Lahdensuu.;Annette Marcantonio.;Daniel C Adelman.;Markku Mäki.
来源: Gastroenterology. 2014年146卷7期1649-58页
Gluten ingestion leads to small intestinal mucosal injury in patients with celiac disease, necessitating strict life-long exclusion of dietary gluten. Despite adherence to a gluten-free diet, many patients remain symptomatic and still have small intestinal inflammation. In this case, nondietary therapies are needed. We investigated the ability of ALV003, a mixture of 2 recombinant gluten-specific proteases given orally, to protect patients with celiac disease from gluten-induced mucosal injury in a phase 2 trial.
547. Sequential algorithm analysis to facilitate selective biliary access for difficult biliary cannulation in ERCP: a prospective clinical study.
作者: Tae Hoon Lee.;Soon Oh Hwang.;Hyun Jong Choi.;Yunho Jung.;Sang Woo Cha.;Il-Kwun Chung.;Jong Ho Moon.;Young Deok Cho.;Sang-Heum Park.;Sun-Joo Kim.
来源: BMC Gastroenterol. 2014年14卷30页
Numerous clinical trials to improve the success rate of biliary access in difficult biliary cannulation (DBC) during ERCP have been reported. However, standard guidelines or sequential protocol analysis according to different methods are limited in place. We planned to investigate a sequential protocol to facilitate selective biliary access for DBC during ERCP.
548. A randomized, double-blind, placebo-controlled, multiple-dose, parallel-group clinical trial to assess the effects of teduglutide on gastric emptying of liquids in healthy subjects.
作者: Jolene Kay Berg.;Eric H Kim.;Benjamin Li.;Bo Joelsson.;Nader N Youssef.
来源: BMC Gastroenterol. 2014年14卷25页
Teduglutide, a recombinant analog of human glucagon-like peptide (GLP)-2, is a novel therapy recently approved for the treatment of adult patients with short bowel syndrome who are dependent on parenteral support. Previous studies assessing the effect of GLP-2 on gastric emptying in humans have yielded inconsistent results, with some studies showing no effect and others documenting a GLP-2-dependent delay in gastric emptying. The primary objective of this study was to assess the effect of teduglutide on gastric emptying of liquids in healthy subjects, as measured by the pharmacokinetics of acetaminophen.
549. Combination therapy with infliximab and azathioprine is superior to monotherapy with either agent in ulcerative colitis.
作者: Remo Panaccione.;Subrata Ghosh.;Stephen Middleton.;Juan R Márquez.;Boyd B Scott.;Laurence Flint.;Hubert J F van Hoogstraten.;Annie C Chen.;Hanzhe Zheng.;Silvio Danese.;Paul Rutgeerts.
来源: Gastroenterology. 2014年146卷2期392-400.e3页
The comparative efficacy and safety of infliximab and azathioprine therapy alone or in combination for ulcerative colitis (UC) have not been evaluated previously.
550. Influence of sucrose ingestion on brainstem and hypothalamic intrinsic oscillations in lean and obese women.
作者: Lisa A Kilpatrick.;Kristen Coveleskie.;Lynn Connolly.;Jennifer S Labus.;Bahar Ebrat.;Jean Stains.;Zhiguo Jiang.;Brandall Y Suyenobu.;Helen E Raybould.;Kirsten Tillisch.;Emeran A Mayer.
来源: Gastroenterology. 2014年146卷5期1212-21页
The study of intrinsic fluctuations in the blood oxygen level-dependent signal of functional magnetic resonance imaging can provide insight into the effect of physiologic states on brain processes. In an effort to better understand the brain-gut communication induced by the absorption and metabolism of nutrients in healthy lean and obese individuals, we investigated whether ingestion of nutritive and non-nutritive sweetened beverages differentially engages the hypothalamus and brainstem vagal pathways in lean and obese women.
551. Effects of tenofovir disoproxil fumarate in hepatitis B e antigen-positive patients with normal levels of alanine aminotransferase and high levels of hepatitis B virus DNA.
作者: Henry L Y Chan.;Chi Kuen Chan.;Aric Josun Hui.;Sing Chan.;Fred Poordad.;Ting-Tsung Chang.;Philippe Mathurin.;John F Flaherty.;Lanjia Lin.;Amy Corsa.;Anuj Gaggar.;G Mani Subramanian.;John G McHutchison.;George Lau.;Sam Lee.;Edward J Gane.
来源: Gastroenterology. 2014年146卷5期1240-8页
Little is known about the benefit of antiviral therapy for hepatitis B e antigen (HBeAg)-positive patients with high viral load and normal levels of alanine aminotransferase. We evaluated the effects of single and combination therapies in immune-tolerant patients with chronic hepatitis B.
552. Budesonide is more effective than mesalamine or placebo in short-term treatment of collagenous colitis.
作者: Stephan Miehlke.;Ahmed Madisch.;Limas Kupcinskas.;Dalius Petrauskas.;Günter Böhm.;Hans-Joachim Marks.;Michael Neumeyer.;Torben Nathan.;Fernando Fernández-Bañares.;Roland Greinwald.;Ralf Mohrbacher.;Michael Vieth.;Ole K Bonderup.; .
来源: Gastroenterology. 2014年146卷5期1222-30.e1-2页
Studies reporting that budesonide is effective for the treatment of collagenous colitis have been small and differed in efficacy measures. Mesalamine has been proposed as a treatment option for collagenous colitis, although its efficacy has never been investigated in placebo-controlled trials. We performed a phase 3, placebo-controlled, multicenter study to evaluate budesonide and mesalamine as short-term treatments for collagenous colitis.
553. High dose multiple micronutrient supplementation improves villous morphology in environmental enteropathy without HIV enteropathy: results from a double-blind randomised placebo controlled trial in Zambian adults.
作者: John Louis-Auguste.;Stephen Greenwald.;Michelo Simuyandi.;Rose Soko.;Rose Banda.;Paul Kelly.
来源: BMC Gastroenterol. 2014年14卷15页
Environmental enteropathy (EE) is an asymptomatic abnormality of small bowel structure and function, which may underlie vaccine inefficacy in the developing world. HIV infection co-exists in many of these populations. There is currently no effective treatment. We conducted a secondary analysis of a randomised controlled trial of high dose multiple micronutrient (MM) supplementation on small bowel architecture in EE in participants with or without HIV infection.
554. Detection of drug effects on gastric emptying and contractility using a wireless motility capsule.
作者: Inna Rozov-Ung.;Amjad Mreyoud.;John Moore.;Gregory E Wilding.;Elias Khawam.;Jeffrey M Lackner.;John R Semler.;Michael D Sitrin.
来源: BMC Gastroenterol. 2014年14卷2页
A wireless motility capsule is a new method for ambulatory assessment of transit times and motility throughout the gastrointestinal tract. The objective of this study was to evaluate the ability of a wireless motility capsule to detect drug effects on gastric emptying time (GET) and gastric contractility.
555. Safety and effectiveness using dexmedetomidine versus propofol TCI sedation during oesophagus interventions: a randomized trial.
作者: Susanne Eberl.;Benedikt Preckel.;Jacques J Bergman.;Markus W Hollmann.
来源: BMC Gastroenterol. 2013年13卷176页
Endoscopic treatment of early neoplastic lesions in oesophagus has evolved as a valid and less invasive alternative to surgical resection. These endoscopic interventions are minimal invasive treatment options usually done with sedation on an outpatient basis. The aim of this trial is to determine the safety and effectiveness of dexmedetomidine sedation compared to the standard used propofol TCI sedation during endoscopic oesophageal interventions.
556. Randomized comparison of tenofovir disoproxil fumarate vs emtricitabine and tenofovir disoproxil fumarate in patients with lamivudine-resistant chronic hepatitis B.
作者: Scott Fung.;Peter Kwan.;Milotka Fabri.;Andrzej Horban.;Mijomir Pelemis.;Hie-Won Hann.;Selim Gurel.;Florin A Caruntu.;John F Flaherty.;Benedetta Massetto.;Phillip Dinh.;Amoreena Corsa.;G Mani Subramanian.;John G McHutchison.;Petr Husa.;Edward Gane.
来源: Gastroenterology. 2014年146卷4期980-8页
Tenofovir disoproxil fumarate (TDF) is active against lamivudine-resistant hepatitis B virus (HBV) infection, but data to support its clinical efficacy in this setting are limited.
557. Telaprevir twice daily is noninferior to telaprevir every 8 hours for patients with chronic hepatitis C.
作者: Maria Buti.;Kosh Agarwal.;Yves Horsmans.;William Sievert.;Ewa Janczewska.;Stefan Zeuzem.;Lisa Nyberg.;Robert S Brown.;Christophe Hézode.;Mario Rizzetto.;Raymundo Paraná.;Sandra De Meyer.;Ralph De Masi.;Donghan Luo.;Kirk Bertelsen.;James Witek.
来源: Gastroenterology. 2014年146卷3期744-753.e3页
We performed an open-label, multicenter, phase 3 study of the safety and efficacy of twice-daily telaprevir in treatment-naive patients with chronic hepatitis C virus (HCV) genotype 1 infection, including those with cirrhosis.
558. Transluminal endoscopic step-up approach versus minimally invasive surgical step-up approach in patients with infected necrotising pancreatitis (TENSION trial): design and rationale of a randomised controlled multicenter trial [ISRCTN09186711].
作者: Sandra van Brunschot.;Janneke van Grinsven.;Rogier P Voermans.;Olaf J Bakker.;Marc G H Besselink.;Marja A Boermeester.;Thomas L Bollen.;Koop Bosscha.;Stefan A Bouwense.;Marco J Bruno.;Vincent C Cappendijk.;Esther C Consten.;Cornelis H Dejong.;Marcel G W Dijkgraaf.;Casper H van Eijck.;G Willemien Erkelens.;Harry van Goor.;Mohammed Hadithi.;Jan-Willem Haveman.;Sijbrand H Hofker.;Jeroen J M Jansen.;Johan S Laméris.;Krijn P van Lienden.;Eric R Manusama.;Maarten A Meijssen.;Chris J Mulder.;Vincent B Nieuwenhuis.;Jan-Werner Poley.;Rogier J de Ridder.;Camiel Rosman.;Alexander F Schaapherder.;Joris J Scheepers.;Erik J Schoon.;Tom Seerden.;B W Marcel Spanier.;Jan Willem A Straathof.;Robin Timmer.;Niels G Venneman.;Frank P Vleggaar.;Ben J Witteman.;Hein G Gooszen.;Hjalmar C van Santvoort.;Paul Fockens.; .
来源: BMC Gastroenterol. 2013年13卷161页
Infected necrotising pancreatitis is a potentially lethal disease that nearly always requires intervention. Traditionally, primary open necrosectomy has been the treatment of choice. In recent years, the surgical step-up approach, consisting of percutaneous catheter drainage followed, if necessary, by (minimally invasive) surgical necrosectomy has become the standard of care. A promising minimally invasive alternative is the endoscopic transluminal step-up approach. This approach consists of endoscopic transluminal drainage followed, if necessary, by endoscopic transluminal necrosectomy. We hypothesise that the less invasive endoscopic step-up approach is superior to the surgical step-up approach in terms of clinical and economic outcomes.
559. Methotrexate in combination with infliximab is no more effective than infliximab alone in patients with Crohn's disease.
作者: Brian G Feagan.;John W D McDonald.;Remo Panaccione.;Robert A Enns.;Charles N Bernstein.;Terry P Ponich.;Raymond Bourdages.;Donald G Macintosh.;Chrystian Dallaire.;Albert Cohen.;Richard N Fedorak.;Pierre Paré.;Alain Bitton.;Fred Saibil.;Frank Anderson.;Allan Donner.;Cindy J Wong.;Guangyong Zou.;Margaret K Vandervoort.;Marybeth Hopkins.;Gordon R Greenberg.
来源: Gastroenterology. 2014年146卷3期681-688.e1页
Methotrexate and infliximab are effective therapies for Crohn's disease (CD). In the combination of maintenance methotrexate-infliximab trial, we evaluated the potential superiority of combination therapy over infliximab alone.
560. Efficacy of nucleotide polymerase inhibitor sofosbuvir plus the NS5A inhibitor ledipasvir or the NS5B non-nucleoside inhibitor GS-9669 against HCV genotype 1 infection.
作者: Edward J Gane.;Catherine A Stedman.;Robert H Hyland.;Xiao Ding.;Evguenia Svarovskaia.;G Mani Subramanian.;William T Symonds.;John G McHutchison.;Phillip S Pang.
来源: Gastroenterology. 2014年146卷3期736-743.e1页
We evaluated an all-oral regimen comprising the nucleotide polymerase inhibitor sofosbuvir (SOF) with the NS5A inhibitor ledipasvir (LDV) or the NS5B non-nucleoside inhibitor GS-9669 in patients with genotype 1 hepatitis C virus (HCV) infection.
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