当前位置: 首页 >> 检索结果
5427. Improved conception rate after intrauterine insemination of washed spermatozoa from men with poor quality semen.
作者: J F Kerin.;C Kirby.;J Peek.;R Jeffrey.;G M Warnes.;C D Matthews.;L W Cox.
来源: Lancet. 1984年1卷8376期533-5页
The efficacy of high intrauterine insemination of a washed motile fraction of spermatozoa from men with poor quality semen on the day after the luteinising hormone (LH) surge was compared with that of natural intercourse based on symptothermal methods and a single act of intercourse timed on the day after the LH surge in the same 35 couples in a controlled and randomised trial of the three types of cycle. Each couple had been trying to conceive for at least 3 years, the woman being potentially fertile and the only detectable defect related to poor semen quality. After 39 intrauterine insemination cycles, 8 women conceived (all in their first insemination cycle); this procedure was significantly more successful than LH-timed intercourse (0/38; p less than 0.05) and natural intercourse timed by symptothermal methods (1/34; p = 0.022). The technique of intrauterine AIH, with a 'Tomcat' catheter, was simple, painless, and uncomplicated.
5428. Towne-vaccine-induced prevention of cytomegalovirus disease after renal transplants.
作者: S A Plotkin.;M L Smiley.;H M Friedman.;S E Starr.;G R Fleisher.;C Wlodaver.;D C Dafoe.;A D Friedman.;R A Grossman.;C F Barker.
来源: Lancet. 1984年1卷8376期528-30页
91 renal transplant candidates were randomised to receive Towne strain cytomegalovirus (CMV) vaccine or placebo at least 8 weeks before transplantation. The vaccine was well tolerated and there was no vaccine virus excretion. Serological and cellular immune responses developed in most vaccines but were lower in the transplant patients than in healthy volunteers and some of the seronegative patients failed to mount responses. CMV infection occurred in most of the seronegative vaccine-treated or placebo-treated patients who received kidneys from seropositive donors, but the illnesses were less severe in the vaccines than those in similarly exposed placebo-treated patients. Vaccine-treated patients who received kidneys from seronegative donors did not excrete virus, and therefore the vaccine virus was not reactivated from a putative latent state despite immunosuppression at the time of transplantation.
5431. Influenza A prophylaxis with amantadine in a boarding school.
In a boarding school for boys, where routine influenza vaccination is carried out annually, 267 boys were given amantadine (100 mg daily) and 269 received no specific treatment during an influenza A (H1N1) outbreak. 3 boys receiving amantadine and 29 boys receiving no medication had laboratory-proven influenza A. There are circumstances when the prophylactic use of amantadine may be justified for the control of influenza A outbreaks in boarding schools and other institutions where high attack-rates are experienced.
5432. Controlled trial of artificial surfactant to prevent respiratory distress syndrome.
作者: H L Halliday.;G McClure.;M M Reid.;T R Lappin.;C Meban.;P S Thomas.
来源: Lancet. 1984年1卷8375期476-8页
In a randomised, controlled trial of the effectiveness of artificial surfactant therapy 100 babies of less than 34 weeks' gestation were intubated at birth and received manual ventilation. The 49 babies in the treated group also received 30 mg dipalmitoylphosphatidylcholine and 3 mg high-density lipoprotein in a 5 ml suspension. There were no significant differences in mortality or in the incidence or severity of respiratory distress syndrome between the surfactant-treated and control groups as a whole or between subgroups divided on the basis of sex or pulmonary maturity (as assessed by the lecithin-sphingomyelin ratio). However, there appeared to be a trend towards improved survival in treated babies of 27-29 weeks' gestation.
5439. Psychological problems in children with abdominal pain.
The prevalence of psychological problems was investigated in 44 children with abdominal pain of organic origin (Crohn's disease, 24; ulcerative colitis, 20), 16 children with non-organic abdominal pain, and 30 pain-free controls. A self-report battery of five tests was used to measure personal, family, and social adjustment. Compared with controls, all three abdominal-pain groups showed psychological problems. Of significance were depression and low self-esteem in patients with Crohn's disease, depression in those with ulcerative colitis, and low self-esteem in those with non-organic pain. No differences were found between patients with organic and those with non-organic pain. These findings indicate that psychological distress accompanies both organic and non-organic abdominal pain in children and that psychological evaluation may not readily distinguish organic from non-organic cases.
|