521. Platelet-Targeted Gene Therapy for Hemophilia A with Inhibitor History.
作者: Mary Eapen.;Lynn M Malec.;Myriam A Armant.;Bryon D Johnson.;Qizhen Shi.;Huiqing Xu.;Lily M Du.;James H Jerkins.;Lisa J Duffy.;Frederic D Bushman.;Carole Lee.;Angelina Petrichenko.;Peiman Hematti.;Ruta Brazauskas.;Shawn M Jobe.;Parameswaran N Hari.;David A Wilcox.
来源: N Engl J Med. 2025年392卷4期412-414页 528. Abelacimab versus Rivaroxaban in Patients with Atrial Fibrillation.
作者: Christian T Ruff.;Siddharth M Patel.;Robert P Giugliano.;David A Morrow.;Bruce Hug.;Julia F Kuder.;Erica L Goodrich.;Shih-Ann Chen.;Shaun G Goodman.;Boyoung Joung.;Robert G Kiss.;Jindrich Spinar.;Wojciech Wojakowski.;Jeffrey I Weitz.;Sabina A Murphy.;Stephen D Wiviott.;Sanobar Parkar.;Daniel Bloomfield.;Marc S Sabatine.; .
来源: N Engl J Med. 2025年392卷4期361-371页
Abelacimab is a fully human monoclonal antibody that binds to the inactive form of factor XI and blocks its activation. The safety of abelacimab as compared with a direct oral anticoagulant in patients with atrial fibrillation is unknown.
529. Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Esophageal Cancer.
作者: Jens Hoeppner.;Thomas Brunner.;Claudia Schmoor.;Peter Bronsert.;Birte Kulemann.;Rainer Claus.;Stefan Utzolino.;Jakob Robert Izbicki.;Ines Gockel.;Berthold Gerdes.;Michael Ghadimi.;Benedikt Reichert.;Johan F Lock.;Christiane Bruns.;Ernst Reitsamer.;Maximillian Schmeding.;Frank Benedix.;Tobias Keck.;Gunnar Folprecht.;Peter Thuss-Patience.;Ulf Peter Neumann.;Andreas Pascher.;Detlef Imhof.;Severin Daum.;Tanja Strieder.;Christian Krautz.;Simone Zimmermann.;Jens Werner.;Rolf Mahlberg.;Gerald Illerhaus.;Peter Grimminger.;Florian Lordick.
来源: N Engl J Med. 2025年392卷4期323-335页
The best multimodal approach for resectable locally advanced esophageal adenocarcinoma is unclear. An important question is whether perioperative chemotherapy is preferable to preoperative chemoradiotherapy.
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