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481. Association of pan-immune-inflammatory value with metabolic dysfunction-associated steatotic liver disease: findings from NHANES 2017-2020.
作者: Lian-Zhen Huang.;Ze-Bin Ni.;Qi-Rong Yao.;Wei-Feng Huang.;Ji Li.;Yan-Qing Wang.;Jin-Yan Zhang.
来源: BMC Gastroenterol. 2025年25卷1期4页
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease worldwide. The pan-immune-inflammation value (PIV) has been proposed as a biomarker for assessing immune status and inflammation. There is currently no evidence regarding the effect of PIV on the risk of MASLD. This study aimed to investigate the association between PIV and MASLD.
482. Association between the triglyceride-glucose index and liver fibrosis in adults with metabolism-related fatty liver disease in the United States: a cross-sectional study of NHANES 2017-2020.
This study aimed to examine the association between the triglyceride-glucose (TyG) index and liver fibrosis (LF) in U.S. adults with Metabolic Dysfunction-Associated Steatotic Liver Disease (MAFLD).
483. Serum levels of oxidative stress, IL-8, and pepsinogen I/II ratio in Helicobacter pylori and gastric cancer patients: potential diagnostic biomarkers.
作者: Marwa Nasier-Hussain.;Jaleel Najah Samanje.;Khatere Mokhtari.;Mohsen Nabi-Afjadi.;Zeinab Fathi.;Asieh Hoseini.;Elham Bahreini.
来源: BMC Gastroenterol. 2025年25卷1期2页
Helicobacter pylori (H.pylori), a gram-negative bacterial pathogen associated with an increased risk of gastric cancer. This study investigates potential factors in the incidence of gastric cancer in patients with H.pylori, including oxidative stress, inflammatory biomarkers, serum pepsinogens (PG) of I and II, and PG-I/PG-II ratio.
484. Outcomes of percutaneous endoscopic gastrostomy (PEG) in HIV patients.
作者: Nikhitha Mantri.;Haozhe Sun.;Sameer Datta Kandhi.;Nishant Allena.;Muhammad Yasir Anwar.;Vibha Hayagreev.;Shalini Penikilapate.;Ahmed Alemam.;Hassan A Muntazir.;Trishna Acherjee.;Harish Patel.;Jasbir Makker.
来源: BMC Gastroenterol. 2024年24卷1期482页
Percutaneous Endoscopic Gastrostomy (PEG) tube insertion, a routine procedure for long-term enteral nutrition, serves as a crucial intervention for patients who are incapable of tolerating oral intake or meeting adequate nutritional requirements. PEG tube placement carries complications like bleeding and infection. Impact of PEG tubes on the 30-day and long-term mortality in HIV patients is unknown. Despite the ongoing utilization of PEG tubes in HIV patients, a comprehensive exploration of its outcomes is yet to be explored. We intended to study the impact of HIV positive status on post-PEG mortality and review other PEG tube related complications.
485. Superior persistence of ustekinumab compared to anti-TNF in vedolizumab-experienced inflammatory bowel diseases patients: a real-world cohort study.
作者: Horng-Yih Chiu.;Chia-Jung Kuo.;Ming-Wei Lai.;Ren-Chin Wu.;Chien-Ming Chen.;Cheng-Tang Chiu.;Yu-Bin Pan.;Cheng-Hsun Chiu.;Puo-Hsien Le.
来源: BMC Gastroenterol. 2024年24卷1期483页
The increasing use of biologic therapies for moderate to severe inflammatory bowel disease (IBD) highlights the importance of optimal treatment sequencing, particularly after vedolizumab (VDZ) exposure. Studies comparing the effectiveness of ustekinumab (UST) and antitumor necrosis factor (anti-TNF) agents post-VDZ are limited.
486. Predictive modeling to evaluate long-term treatment effectiveness of darvadstrocel in patients with complex perianal fistulas in Crohn's disease.
作者: Chitra Karki.;Gary Hantsbarger.;Erika Turkstra.;Elisabetta Fenu.;Ken Genenz.;Inmaculada Gilaberte.;Julián Panés.
来源: BMC Gastroenterol. 2024年24卷1期479页
Current therapies for complex Crohn's perianal fistulas (CPF) have a limited ability to achieve long-term healing. Darvadstrocel (DVS) is an expanded allogeneic adipose-derived mesenchymal stem cell therapy that has demonstrated efficacy in treating complex CPF in clinical trials. There are, however, limited long-term comparative data with standard of care (SoC). The aim of this study was to combine clinical trial data and real-world evidence using statistical methodologies to predict long-term effectiveness of DVS versus SoC in patients with CPF.
487. Health-care resource use and costs associated with inflammatory bowel disease in northwest London: a retrospective linked database study.
作者: Zia Ui-Haq.;Luiz Causin.;Tahereh Kamalati.;Durgesh Kahol.;Trishan Vaikunthanathan.;Charlotte Wong.;Naila Arebi.
来源: BMC Gastroenterol. 2024年24卷1期480页
With 20-40% of patients who have inflammatory bowel disease (IBD) not responding to therapy, resource use and costs can be high. We performed a descriptive analysis of health-care data for IBD management in the National Health Service to explore potential areas for improvement.
488. Fatigue, pain and faecal incontinence in adult inflammatory bowel disease patients and the unmet need: a national cross-sectional survey.
作者: Ailsa Hart.;Laura Miller.;Fionn Cléirigh Büttner.;Thomas Hamborg.;Sonia Saxena.;Richard C G Pollok.;Imogen Stagg.;Vari Wileman.;Qasim Aziz.;Wladyslawa Czuber-Dochan.;Lesley Dibley.;Borislava Mihaylova.;Rona Moss-Morris.;Chris Roukas.;Christine Norton.
来源: BMC Gastroenterol. 2024年24卷1期481页
The co-existence of fatigue, pain and faecal incontinence in people with Inflammatory Bowel Disease (IBD) is unknown. We aimed to determine the presence of and relationship between these symptoms and patients' desire for intervention.
489. Human blood metabolites and gastric cancer: a Mendelian randomization analysis.
作者: Chao Zhang.;Dao Lai Huang.;Kun Zhou.;Jin Tao Cai.;Dang Liu.;Ming Hao Tan.;Guan Yu Zhu.;Xiang Hua Wu.
来源: BMC Gastroenterol. 2024年24卷1期478页
Gastric cancer (GC) remains one of the predominant malignant tumors within the digestive tract, yet its underlying biological mechanisms remain elusive. The primary objective of this study is to delineate the causal relationship between circulating metabolites and GC.
490. Temporal trends in disability adjusted life year and mortality for colorectal cancer attributable to a high red meat diet in China from 1990 to 2021: an analysis of the global burden of disease study 2021.
作者: Yuxin Liu.;Chaofu Zhu.;Haonan Song.;Mengqi Che.;Beijia Xu.;Baiping An.
来源: BMC Gastroenterol. 2024年24卷1期476页
High red meat consumption is a main modifiable risk factor for colorectal cancer mortality (CRC), but its attributable disease burden remains unclear in China. We aimed to analyze the temporal trends in CRC deaths and disability-adjusted life years (DALYs) attributable to high red meat consumption in China from 1990 to 2021 and to predict the disease burden in the next 15 years.
491. Efficiency of laparoscopic retroperitoneal pancreatic necrosectomy for treating infected pancreatic necrosis with duodenal fistula: a single-center retrospective cohort study.
作者: Renrui Wan.;Yanming Hua.;Yifan Tong.;Xin Yu.;Bo Shen.;Hong Yu.
来源: BMC Gastroenterol. 2024年24卷1期477页
Open surgical debridement was the main treatment option for infected pancreatic necrosis (IPN). However, it was associated with significant trauma, leading to a higher mortality rate. With the development of minimally invasive surgery, the step-up treatment principle centered around minimally invasive intervention, significantly reducing the incidence of complications and mortality rates among IPN patients. However, few studies have reported the efficacy of laparoscopic retroperitoneal pancreatic necrosectomy (LRPN), a new minimally invasive debridement technique, in IPN patients with duodenal fistula (DF)-a severe complication of IPN. Therefore, we analyzed the effectiveness and safety of LRPN for treating IPN with DF and discussed the impact of DF on patient prognosis.
492. Human Enteric Glia Diversity in Health and Disease: New Avenues for the Treatment of Hirschsprung Disease.
作者: Jonathan D Windster.;Naomi J M Kakiailatu.;Laura E Kuil.;Agne Antanaviciute.;Andrea Sacchetti.;Katherine C MacKenzie.;Joke Peulen-Zink.;Tsung W Kan.;Eric Bindels.;Emma de Pater.;Michail Doukas.;Thierry P P van den Bosch.;Soheil Yousefi.;Tahsin-Stefan Barakat.;Conny J H M Meeussen.;Pim C E J Sloots.;Rene M H Wijnen.;Kaushal Parikh.;Werend Boesmans.;Veerle Melotte.;Robert M W Hofstra.;Alison Simmons.;Maria M Alves.
来源: Gastroenterology. 2025年168卷5期965-979.e12页
The enteric nervous system (ENS), which is composed of neurons and glia, regulates intestinal motility. Hirschsprung disease (HSCR) results from defects in ENS formation; however, although neuronal aspects have been studied extensively, enteric glia remain disregarded. This study aimed to explore enteric glia diversity in health and disease.
493. Correction: Risk factors and prognostic analysis of microscopic positive esophageal margins after radical surgery for proximal gastric cancer.
作者: Zhenjiang Guo.;Ning Wang.;Guangyuan Zhao.;Chaobo Cui.;Fangzhen Liu.
来源: BMC Gastroenterol. 2024年24卷1期473页 494. Prognostic factors and adjuvant chemotherapy efficacy in stage I gastric cancer patients: a retrospective analysis.
作者: Hua Xiao.;Huiling Li.;Lian Jian.;Zhaodong Ai.;Pingsheng Hu.
来源: BMC Gastroenterol. 2024年24卷1期474页
Although stage I gastric cancer (GC) presents a favorable survival rate, outcomes for patients experiencing recurrence remain poor. This research focuses on assessing the prognosis and identifying risk factors for stage I GC patients, further assessing the necessity of adjuvant chemotherapy (AC).
495. Associations of C-reactive protein to lymphocyte ratio and metabolic-dysfunction-associated steatotic liver disease: evidence from NHANES 2017-2018.
作者: Bowen Liu.;Xiaomei Sun.;Xiaobin Li.;Fenping Lu.;Guangyan Xing.;Guiping Ma.;Yun Ran.;Shi Ping Hu.
来源: BMC Gastroenterol. 2024年24卷1期475页
This study aimed to investigate the association between Metabolic-dysfunction-associated steatotic liver disease(MASLD)and C-reactive protein/lymphocyte ratio (CLR).
496. Efficacy of probiotic, prebiotic, and synbiotics supplements in individuals with anemia: a systematic review and meta-analysis of randomized controlled trials.
作者: Qian Hu.;Ying Liu.;Youmei Fei.;Jingping Zhang.;Shao Yin.;Hui Zou.;Fengya Zhu.
来源: BMC Gastroenterol. 2024年24卷1期472页
Anemia is a common global health problem, particularly in impoverished regions, with a high incidence rate. The condition is multifactorial, with iron deficiency being one of the most prevalent causes. Current treatment for anemia often relies on iron supplements or erythropoiesis-stimulating agents, although these therapies may show limited efficacy for some patients. Recent evidence suggests that probiotics, prebiotics, and synbiotics, as microbiome modulators, hold significant potential in the treatment of anemia. These interventions may enhance iron absorption and improve overall blood health through their impact on gut microbiota, thus providing an alternative or complementary approach to conventional treatments.
497. Association between the lymphocyte-to-high-density lipoprotein ratio and metabolic dysfunction-associated steatotic liver disease among US adults: a cross-sectional study from NHANES 2017 to 2020.
作者: Chuanzhi Tang.;Dadi Peng.;Kezhen Zong.;Zhongjun Wu.;Miao Gong.;Hui Li.;Zuotian Huang.;Shanshan Li.
来源: BMC Gastroenterol. 2024年24卷1期470页
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a liver disease that is strongly associated with chronic low-grade inflammation. Stage 3 of MASLD is characterized by excessive formation of connective tissues, commonly referred to as liver fibrosis. Although numerous inflammatory markers have been identified and extensively studied, including the tumor necrosis factor-α and interleukin-6 have been studied [Byrne CD, Targher G. NAFLD: a multisystem disease. J Hepatol. 2015;62(1 Suppl):S47-64], the lymphocyte-to-high-density lipoprotein ratio (LHR) as a new biomarker that has not been sufficiently studied. This study aims to investigate the relationship between LHR levels and MASLD, determine its potential as a predictive marker for steatosis and fibrosis stages.
498. Construction and validation of a predictive model for the risk of rebleeding in patients with esophageal and gastric varices hemorrhage.
Esophageal and gastric varices hemorrhage (EGVH) is a life-threatening condition with the 6-week mortality rate of 15-25%. Up to 60% of patients with EGVH may experience rebleeding with a mortality rate of 33%. The existing scoring systems, such as RS scoring system (Rockall score, RS) and GBS scoring system (Glasgow-Blatchford score, GBS), have limitations in predicting the risk of rebleeding. Our study was to construct and validate a novel predictive model for the risk of rebleeding in patients with EGVH and to compare the predictive power of the predictive model with GBS and pRS.
499. Correlation of serum cotinine with fatty liver index in adults: data from the NHANES March 2017 and 2018.
作者: Guangwen Chen.;Nan Chen.;Lijian Liu.;Xiaoyan Huang.;Jianfeng Li.;Jinxiu Wei.;Yuqing Wang.;Chengning Yang.;Sheng Xie.
来源: BMC Gastroenterol. 2024年24卷1期469页
The correlation between serum cotinine and fatty liver index (FLI) needs further investigation for the early identification, prevention, and treatment of metabolic dysfunction-associated steatotic liver disease (MASLD).
500. Glepaglutide, a Long-Acting Glucagon-like Peptide-2 Analogue, Reduces Parenteral Support in Patients With Short Bowel Syndrome: A Phase 3 Randomized Controlled Trial.
作者: Palle B Jeppesen.;Tim Vanuytsel.;Sukanya Subramanian.;Francisca Joly.;Geert Wanten.;Georg Lamprecht.;Marek Kunecki.;Farooq Rahman.;Thor S S Nielsen.;Mark Berner-Hansen.;Ulrich-Frank Pape.;David F Mercer.
来源: Gastroenterology. 2025年168卷4期701-713.e6页
Glepaglutide is a long-acting glucagon-like peptide (GLP)-2 analogue developed to improve intestinal absorption in patients with short bowel syndrome (SBS). The authors conducted a trial to establish the efficacy and safety of glepaglutide in reducing parenteral support (PS) needs in patients with SBS with intestinal failure.
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