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462. High-fat diet promotes liver tumorigenesis via palmitoylation and activation of AKT.
作者: Lang Bu.;Zhengkun Zhang.;Jianwen Chen.;Yizeng Fan.;Jinhe Guo.;Yaqing Su.;Huan Wang.;Xiaomei Zhang.;Xueji Wu.;Qiwei Jiang.;Bing Gao.;Lei Wang.;Kunpeng Hu.;Xiang Zhang.;Wei Xie.;Wenyi Wei.;Ming Kuang.;Jianping Guo.
来源: Gut. 2024年73卷7期1156-1168页
Whether and how the PI3K-AKT pathway, a central node of metabolic homeostasis, is responsible for high-fat-induced non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) remain a mystery. Characterisation of AKT regulation in this setting will provide new strategies to combat HCC.
463. Familial coaggregation of inflammatory bowel disease with cardiovascular disease: a nationwide multigenerational cohort study.
作者: Jiangwei Sun.;Jialu Yao.;Ola Olén.;Jonas Halfvarson.;David Bergman.;Fahim Ebrahimi.;Johan Sundström.;Jonas F Ludvigsson.
来源: Gut. 2024年73卷11期e23页 466. Unveiling 8 years of duodenoscope contamination: insights from a retrospective analysis in a large tertiary care hospital.
作者: Koen van der Ploeg.;Cynthia P Haanappel.;Anne F Voor In 't Holt.;Woutrinus de Groot.;Adriana J C Bulkmans.;Nicole S Erler.;Bibi C G C Mason-Slingerland.;Juliëtte A Severin.;Margreet C Vos.;Marco J Bruno.
来源: Gut. 2024年73卷4期613-621页
Contaminated duodenoscopes caused several hospital outbreaks. Despite efforts to reduce contamination rates, 15% of patient-ready duodenoscopes are still contaminated with gastrointestinal microorganisms. This study aimed to provide an overview of duodenoscope contamination over time, identify risk factors and study the effects of implemented interventions.
467. Positive effects of diet-induced microbiome modification on GDM in mice following human faecal transfer.
作者: Sigal Frishman.;Meital Nuriel-Ohayon.;Sondra Turjeman.;Yishay Pinto.;Or Yariv.;Kinneret Tenenbaum-Gavish.;Yoav Peled.;Eran Poran.;Joseph Pardo.;Rony Chen.;Efrat Muller.;Elhanan Borenstein.;Moshe Hod.;Yoram Louzoun.;Betty Schwartz.;Eran Hadar.;Maria Carmen Collado.;Omry Koren.
来源: Gut. 2024年73卷10期e17页 468. Blood-based colorectal cancer screening in an integrated health system: a randomised trial of patient adherence.
作者: Gloria D Coronado.;Charisma L Jenkins.;Elizabeth Shuster.;Cheryl Johnson.;David Amy.;Jennifer Cook.;Samantha Sahnow.;Jamilyn M Zepp.;Rajasekhara Mummadi.
来源: Gut. 2024年73卷4期622-628页
We evaluated whether people who had not completed a faecal immunochemical test (FIT) for colorectal cancer (CRC) screening would complete a blood-based testing option if offered one during health encounters. Blood-based screening tests for CRC could add to the total number of people screened for CRC by providing another testing alternative.
469. Histone methyltransferase Suv39h1 regulates hepatic stellate cell activation and is targetable in liver fibrosis.
作者: Ming Kong.;Junjing Zhou.;Aoqi Kang.;Yameng Kuai.;Huihui Xu.;Min Li.;Xiulian Miao.;Yan Guo.;Zhiwen Fan.;Yong Xu.;Zilong Li.
来源: Gut. 2024年73卷5期810-824页
Liver fibrosis is a prelude to a host of end-stage liver diseases. Hepatic stellate cells (HSCs), switching from a quiescent state to myofibroblasts, are the major source for excessive production of extracellular matrix proteins. In the present study, we investigated the role of Suv39h1, a lysine methyltransferase, in HSC-myofibroblast transition and the implication in liver fibrosis.
470. ATP citrate lyase (ACLY)-dependent immunometabolism in mucosal T cells drives experimental colitis in vivo.
作者: Anja Schulz-Kuhnt.;Katharina Rühle.;Asal Javidmehr.;Michael Döbrönti.;Jana Biwank.;Selina Knittel.;Peter Neidlinger.;Jannik Leupold.;Li-Juan Liu.;Mark Dedden.;Regina Verena Taudte.;Arne Gessner.;Martin F Fromm.;Dirk Mielenz.;Lucas Kreiss.;Maximilian J Waldner.;Sebastian Schürmann.;Oliver Friedrich.;Barbara Dietel.;Rocío López-Posadas.;Christina Plattner.; .;Sebastian Zundler.;Christoph Becker.;Raja Atreya.;Markus F Neurath.;Imke Atreya.
来源: Gut. 2024年73卷4期601-612页
Mucosal T cells play a major role in inflammatory bowel disease (IBD). However, their immunometabolism during intestinal inflammation is poorly understood. Due to its impact on cellular metabolism and proinflammatory immune cell function, we here focus on the enzyme ATP citrate lyase (ACLY) in mucosal T cell immunometabolism and its relevance for IBD.
472. Comparison of OLGA and OLGIM as predictors of gastric cancer in a Latin American population: the ECHOS Study.
作者: Gonzalo Latorre.;Felipe Silva.;Isabella Montero.;Miguel Bustamante.;Eitan Dukes.;Javier Uribe.;Oscar Corsi Sotelo.;Diego Reyes.;Eduardo Fuentes-López.;Margarita Pizarro.;Patricio Medel.;Javiera Torres.;Juan Carlos Roa.;Sebastián Pizarro.;Pablo Achurra.;Andrés Donoso.;Ignacio Wichmann.;Alejandro H Corvalán.;Javier Chahuan.;Roberto Candia.;Carlos Agüero.;Robinson Gonzalez.;Jose Ignacio Vargas.;Alberto Espino.;M Constanza Camargo.;Shailja C Shah.;Arnoldo Riquelme.
来源: Gut. 2024年73卷10期e18页 474. Gut microbiota predicts severity and reveals novel metabolic signatures in acute pancreatitis.
作者: Christoph Ammer-Herrmenau.;Kai L Antweiler.;Thomas Asendorf.;Georg Beyer.;Soeren M Buchholz.;Silke Cameron.;Gabriele Capurso.;Marko Damm.;Linh Dang.;Fabian Frost.;Antonio Gomes.;Jacob Hamm.;Robert Henker.;Albrecht Hoffmeister.;Christian Meinhardt.;Lukasz Nawacki.;Vitor Nunes.;Arpad Panyko.;Cesareo Pardo.;Veit Phillip.;Aldis Pukitis.;Sebastian Rasch.;Diana Riekstina.;Ecaterina Rinja.;María Lourdes Ruiz-Rebollo.;Simon Sirtl.;Mark Weingarten.;Vasile Sandru.;Julia Woitalla.;Volker Ellenrieder.;Albrecht Neesse.
来源: Gut. 2024年73卷3期485-495页
Early disease prediction is challenging in acute pancreatitis (AP). Here, we prospectively investigate whether the microbiome predicts severity of AP (Pancreatitis-Microbiome As Predictor of Severity; P-MAPS) early at hospital admission.
476. ForePass endoscopic bypass device for obesity and insulin resistance-metabolic treatment in a swine model.
作者: Giulia Angelini.;Manoel Galvao Neto.;Ivo Boskoski.;Maria Emiliana Caristo.;Sara Russo.;Luca Proto.;Elena Previti.;Lisa Olsson.;Hobby Aggarwal.;Samantha Pezzica.;Elisa Ferrari.;Vincenzo Bove.;Alfredo Genco.;Stefan Bornstein.;Valentina Tremaroli.;Amalia Gastaldelli.;Geltrude Mingrone.
来源: Gut. 2024年73卷4期568-572页 477. Dominant-negative effect of lactase missense variants: hetero-complex assembly with the wild-type enzyme impairs intracellular trafficking and digestive function.
作者: Dalanda Wanes.;Tammy Stellbrinck.;Lara M Marten.;René Santer.;Hassan Y Naim.
来源: Gut. 2024年73卷10期e16页 478. Protein biomarkers and alternatively methylated cell-free DNA detect early stage pancreatic cancer.
作者: Roni Ben-Ami.;Qiao-Li Wang.;Jinming Zhang.;Julianna G Supplee.;Johannes F Fahrmann.;Roni Lehmann-Werman.;Lauren K Brais.;Jonathan Nowak.;Chen Yuan.;Maureen Loftus.;Ana Babic.;Ehsan Irajizad.;Tal Davidi.;Aviad Zick.;Ayala Hubert.;Daniel Neiman.;Sheina Piyanzin.;Ofer Gal-Rosenberg.;Amit Horn.;Ruth Shemer.;Benjamin Glaser.;Natalia Boos.;Kunal Jajoo.;Linda Lee.;Thomas E Clancy.;Douglas A Rubinson.;Kimmie Ng.;John A Chabot.;Fay Kastrinos.;Michael Kluger.;Andrew J Aguirre.;Pasi A Jänne.;Nabeel Bardeesy.;Ben Stanger.;Mark H O'Hara.;Jacob Till.;Anirban Maitra.;Erica L Carpenter.;Andrea J Bullock.;Jeanine Genkinger.;Samir M Hanash.;Cloud P Paweletz.;Yuval Dor.;Brian M Wolpin.
来源: Gut. 2024年73卷4期639-648页
Pancreatic ductal adenocarcinoma (PDAC) is commonly diagnosed at an advanced stage. Liquid biopsy approaches may facilitate detection of early stage PDAC when curative treatments can be employed.
479. Endoscopic variceal ligation versus propranolol for the primary prevention of oesophageal variceal bleeding in patients with hepatocellular carcinoma: an open-label, two-centre, randomised controlled trial.
作者: Tsung-Chieh Yang.;Wen-Chi Chen.;Ming-Chih Hou.;Ping-Hsien Chen.;Pei-Chang Lee.;Chung-Yu Chang.;Hsiao-Sheng Lu.;Yu-Jen Chen.;Shao-Jung Hsu.;Hui-Chun Huang.;Jiing-Chyuan Luo.;Yi-Hsiang Huang.;Fa-Yauh Lee.
来源: Gut. 2024年73卷4期682-690页
This randomised trial aimed to address whether endoscopic variceal ligation (EVL) or propranolol (PPL) is more effective at preventing initial oesophageal variceal bleeding (EVB) in patients with hepatocellular carcinoma (HCC).
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