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461. Cardiovascular risk factors and venous thromboembolism: a meta-analysis.
作者: Walter Ageno.;Cecilia Becattini.;Timothy Brighton.;Rita Selby.;Pieter W Kamphuisen.
来源: Circulation. 2008年117卷1期93-102页
The concept that venous thromboembolism (VTE) and atherosclerosis are 2 completely distinct entities has recently been challenged because patients with VTE have more asymptomatic atherosclerosis and more cardiovascular events than control subjects. We performed a meta-analysis to assess the association between cardiovascular risk factors and VTE.
462. Quantitative assessment of the effect of angiotensinogen gene polymorphisms on the risk of coronary heart disease.
Angiotensinogen, a key protein in the renin-angiotensin system, plays an important role in cardiovascular hemostasis. Many studies have examined the association between polymorphisms in the angiotensinogen gene and risk of coronary heart disease (CHD), but the results have been inconsistent.
463. Prognostic value of troponins in acute pulmonary embolism: a meta-analysis.
作者: Cecilia Becattini.;Maria Cristina Vedovati.;Giancarlo Agnelli.
来源: Circulation. 2007年116卷4期427-33页
Whether elevated serum troponin levels identify patients with acute pulmonary embolism at high risk of short-term mortality or adverse outcome is undefined.
464. Meta-analysis comparing the effectiveness and adverse outcomes of antifibrinolytic agents in cardiac surgery.
Since the 1980s, antifibrinolytic therapies have assisted surgical teams in reducing the amount of blood loss. To date, however, serious questions remain regarding the safety and effectiveness of these agents.
465. Offsetting impact of thrombosis and restenosis on the occurrence of death and myocardial infarction after paclitaxel-eluting and bare metal stent implantation.
作者: Gregg W Stone.;Stephen G Ellis.;Antonio Colombo.;Keith D Dawkins.;Eberhard Grube.;Donald E Cutlip.;Mark Friedman.;Donald S Baim.;Joerg Koglin.
来源: Circulation. 2007年115卷22期2842-7页
Drug-eluting stents compared with bare metal stents (BMS) may increase late stent thrombosis (ST), although an accompanying increase in the rates of death and myocardial infarction (MI) has not been observed. We hypothesized that the prevention of restenosis-related adverse events by drug-eluting stents might offset some or all of the excess risk from ST.
466. Estrogen receptor alpha polymorphism and risk of cardiovascular disease, cancer, and hip fracture: cross-sectional, cohort, and case-control studies and a meta-analysis.
作者: Alisa D Kjaergaard.;Christina Ellervik.;Anne Tybjaerg-Hansen.;Christen Kirk Axelsson.;Marie-Louise M Grønholdt.;Peer Grande.;Gorm B Jensen.;Børge G Nordestgaard.
来源: Circulation. 2007年115卷7期861-71页
We hypothesized that the estrogen receptor alpha (ESR1) IVS1-397T/C polymorphism affects high-density lipoprotein cholesterol response to hormone replacement therapy and risk of cardiovascular disease (CVD), cancer of reproductive organs, and hip fracture.
467. Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis.
作者: Matthias W Lorenz.;Hugh S Markus.;Michiel L Bots.;Maria Rosvall.;Matthias Sitzer.
来源: Circulation. 2007年115卷4期459-67页
Carotid intima-media thickness (IMT) is increasingly used as a surrogate marker for atherosclerosis. Its use relies on its ability to predict future clinical cardiovascular end points. We performed a systematic review and meta-analysis of data to examine this association.
468. Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies.
作者: Nadeem Sarwar.;John Danesh.;Gudny Eiriksdottir.;Gunnar Sigurdsson.;Nick Wareham.;Sheila Bingham.;S Matthijs Boekholdt.;Kay-Tee Khaw.;Vilmundur Gudnason.
来源: Circulation. 2007年115卷4期450-8页
Many epidemiological studies have reported on associations between serum triglyceride concentrations and the risk of coronary heart disease, but this association has not been reliably quantified. In the present study, we report 2 separate nested case-control comparisons in 2 different prospective, population-based cohorts, plus an updated meta-analysis of 27 additional prospective studies in general Western populations.
469. Adiponectin and coronary heart disease: a prospective study and meta-analysis.
作者: Naveed Sattar.;Goya Wannamethee.;Nadeem Sarwar.;Julia Tchernova.;Lynne Cherry.;A Michael Wallace.;John Danesh.;Peter H Whincup.
来源: Circulation. 2006年114卷7期623-9页
There is uncertainty about the association between circulating concentrations of adiponectin and coronary heart disease (CHD) risk. We report new data from a prospective study in the context of a meta-analysis of previously published prospective studies.
470. Is blood superior to crystalloid cardioplegia? A meta-analysis of randomized clinical trials.
作者: Veena Guru.;John Omura.;Abdullah A Alghamdi.;Richard Weisel.;Stephen E Fremes.
来源: Circulation. 2006年114卷1 Suppl期I331-8页
Many small, randomized, controlled trials have evaluated the effectiveness of blood as compared with crystalloid cardioplegia for myocardial protection during cardiac surgery. Blood cardioplegia provides a closer approximation to normal physiology, which may translate into measurable clinical benefits. This meta-analysis describes the effectiveness of blood cardioplegia in lowering adverse postoperative outcomes.
471. Cardiovascular outcomes with atrial-based pacing compared with ventricular pacing: meta-analysis of randomized trials, using individual patient data.
作者: Jeffrey S Healey.;William D Toff.;Gervasio A Lamas.;Henning R Andersen.;Kevin E Thorpe.;Kenneth A Ellenbogen.;Kerry L Lee.;Allan M Skene.;Eleanor B Schron.;J Douglas Skehan.;Lee Goldman.;Robin S Roberts.;A John Camm.;Salim Yusuf.;Stuart J Connolly.
来源: Circulation. 2006年114卷1期11-7页
Several randomized trials have compared atrial-based (dual-chamber or atrial) pacing with ventricular pacing in patients with bradycardia. No trial has shown a mortality reduction, and only 1 small trial suggested a reduction in stroke. The goal of this review was to determine whether atrial-based pacing prevents major cardiovascular events.
472. Unfractionated and low-molecular-weight heparin as adjuncts to thrombolysis in aspirin-treated patients with ST-elevation acute myocardial infarction: a meta-analysis of the randomized trials.
作者: John W Eikelboom.;Daniel J Quinlan.;Shamir R Mehta.;Alexander G Turpie.;Ian B Menown.;Salim Yusuf.
来源: Circulation. 2005年112卷25期3855-67页
There is uncertainty about the role of intravenous unfractionated heparin (UFH) and low-molecular-weight heparin (LMWH) in patients with ST-elevation myocardial infarction (STEMI) treated with aspirin and thrombolysis.
473. Prognostic value of troponin T and I among asymptomatic patients with end-stage renal disease: a meta-analysis.
作者: Nadia A Khan.;Brenda R Hemmelgarn.;Marcello Tonelli.;Christopher R Thompson.;Adeera Levin.
来源: Circulation. 2005年112卷20期3088-96页
The prognostic usefulness of troponin enzymes in end-stage renal disease (ESRD) patients is controversial. To resolve this uncertainty of troponin as a prognostic tool, we conducted a systematic review to quantify the association between elevated troponin I or T and long-term total mortality among ESRD patients not suspected of having acute coronary syndrome.
474. Headaches and the treatment of blood pressure: results from a meta-analysis of 94 randomized placebo-controlled trials with 24,000 participants.
Uncertainty exists over whether blood pressure-lowering drugs prevent headache.
475. Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials.
作者: Dariush Mozaffarian.;Anouk Geelen.;Ingeborg A Brouwer.;Johanna M Geleijnse.;Peter L Zock.;Martijn B Katan.
来源: Circulation. 2005年112卷13期1945-52页
The effect of fish oil on heart rate (HR), a major risk factor for sudden death, is not well established. We calculated this effect in a meta-analysis of randomized, double-blind, placebo-controlled trials in humans.
476. Effect of pravastatin on rate of kidney function loss in people with or at risk for coronary disease.
作者: Marcello Tonelli.;Chris Isles.;Timothy Craven.;Andrew Tonkin.;Marc A Pfeffer.;James Shepherd.;Frank M Sacks.;Curt Furberg.;Stuart M Cobbe.;John Simes.;Malcolm West.;Chris Packard.;Gary C Curhan.
来源: Circulation. 2005年112卷2期171-8页
Limited data suggest that HMG-CoA reductase inhibitors (statins) reduce rates of kidney function loss. We performed this analysis to determine whether pravastatin reduced the rate of kidney function loss over approximately 5 years in people with or at high risk for coronary disease.
477. Late loss in lumen diameter and binary restenosis for drug-eluting stent comparison.
Published rates of coronary restenosis have fallen below 10% in drug-eluting stent trials. Early evaluations of new stents have used continuous end points that are presumed surrogates for restenosis, but the generalizability and power of such end points have not been examined systematically.
478. Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial function.
作者: Marie S O'Neill.;Aristidis Veves.;Antonella Zanobetti.;Jeremy A Sarnat.;Diane R Gold.;Panayiotis A Economides.;Edward S Horton.;Joel Schwartz.
来源: Circulation. 2005年111卷22期2913-20页
Epidemiological studies suggest that people with diabetes are vulnerable to cardiovascular health effects associated with exposure to particle air pollution. Endothelial and vascular function is impaired in diabetes and may be related to increased cardiovascular risk. We examined whether endothelium-dependent and -independent vascular reactivity was associated with particle exposure in individuals with and without diabetes.
479. Percutaneous coronary intervention versus conservative therapy in nonacute coronary artery disease: a meta-analysis.
Percutaneous coronary intervention (PCI) has been shown to improve symptoms compared with conservative medical treatment in patients with stable coronary artery disease (CAD); however, there is limited evidence on the effect of PCI on the risk of death, myocardial infarction, and subsequent revascularization. Therefore, we performed a meta-analysis of 11 randomized trials comparing PCI to conservative treatment in patients with stable CAD.
480. Risk of worsening renal function with nesiritide in patients with acutely decompensated heart failure.
作者: Jonathan D Sackner-Bernstein.;Hal A Skopicki.;Keith D Aaronson.
来源: Circulation. 2005年111卷12期1487-91页
Renal function is an important prognostic factor for patients with acutely decompensated heart failure (ADHF). We investigated the renal effects of nesiritide as treatment for ADHF.
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