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441. Effect of probiotics combined with immune checkpoint suppressors and chemotherapeutic agents on digestive system function, intestinal immunity and prognosis in patients with metastatic colorectal carcinoma: a quasi-experimental study.
作者: Xiaolei Wang.;Yuxia Huang.;Zhen Yang.;Yang Yang.;Fenfen Wei.;Min Yan.;Fanfan Li.;Chenghao Wang.
来源: BMC Gastroenterol. 2025年25卷1期38页
An exploration of the influence of probiotics combined with immune checkpoint suppressors and chemotherapeutic agents on digestive system function, intestinal immunity and prognosis in patients with metastatic colorectal carcinoma.
442. Effect of KRAS mutation status on clinicopathological characteristics and overall survival in patients with rectal cancer.
作者: Shengbin Zheng.;Zhijie You.;Guodon Guo.;Zhijing Lin.;Siming Wang.;Guohua Yang.
来源: BMC Gastroenterol. 2025年25卷1期37页
KRAS mutations in rectal cancer are associated with a conflict prognosis. This study aimed to compare clinicopathological outcomes of patients and tumor criteria between wKRAS and mKRAS, as well as overall survival in the two groups.
443. Magnitude, patterns, and factors associated with liver disease among clinically suspected clients in Eastern Ethiopia: hidden public health tragedy.
作者: Aliya Nuri.;Sufian Jeilu.;Yared Teklu.;Kadir Abdu.;Ahmed Muhye.;Milkiyas Solomon Getachew.;Imam Dagne.;Muluken Yigezu.;Sewmehon Amsalu Adugna.;Vanisha S Nambiar.;Abdu Oumer.
来源: BMC Gastroenterol. 2025年25卷1期36页
Liver diseases are a public health problem in developing regions, and the majority of them are asymptomatic. Evidence on the current burden of liver disease and associated context-specific risk factors is scarce in the study area, where various risk factors for liver disease, including khat chewing, smoking, and aflatoxin exposure, are common. This study was to assess the magnitude, patterns, and factors associated with liver disease among patients visiting governmental hospitals in eastern Ethiopia.
444. Capecitabine enhances sensitivity to oxaliplatin in advanced gastric cancer and the effects on patients' FOXP1 and GGT levels.
To investigate the effect of capecitabine on the sensitivity of oxaliplatin and on the level of transcription factor forkhead box P1 (FOXP1) and gamma-glutamyl transpeptidase (GGT) in patients with intermediate and advanced gastric cancer.
445. The prognostic value of systemic inflammation response index in digestive system carcinomas: a systematic review and meta-analysis.
作者: Zuo-Hu Niu.;Li Lin.;Hong-Ye Peng.;Xin-Zhuo Zheng.;Mi-Yuan Wang.;Feng-Xia Sun.;Chun-Jun Xu.
来源: BMC Gastroenterol. 2025年25卷1期34页
Digestive system carcinomas (DSC) constitute a significant proportion of solid tumors, with incidence rates rising steadily each year. The systemic inflammation response index (SIRI) has been identified as a potential prognostic marker for survival in various types DSC. This meta-analysis aimed to evaluate the prognostic value of SIRI in patients with DSC.
446. High output stoma after surgery for rectal cancer - a risk factor for low anterior resection syndrome?
作者: Xuena Zhang.;Qingyu Meng.;Jianna Du.;Zhongtao Tian.;Yinju Li.;Bin Yu.;Wenbo Niu.
来源: BMC Gastroenterol. 2025年25卷1期32页
The relationship between high-output stoma (HOS) and low anterior resection syndrome (LARS) was previously unclear. This study investigated the association between HOS and major LARS in rectal cancer patients with preventive stoma.
447. High serum CA19-9 predicts severe cholecystitis in calculous cholecystitis patients.
作者: Shouwen Wang.;Dachen Zhou.;Wanjin Chen.;Qi Guo.;Liujin Hou.;Ruolin Wu.;Wei Wang.;Muhammad Annus Khan.;Muhammad Ahmad.;Fan Huang.;Meijuan Zheng.;Guobin Wang.;Hongchuan Zhao.;Xiaoping Geng.;Xiaojun Yu.
来源: BMC Gastroenterol. 2025年25卷1期33页
CA19-9 is a classical tumor marker and plays an important role in the diagnosis of biliary and pancreatic cancer. However, a few cases reported that the tumor maker CA19-9 is abnormally elevated in patients with calculous cholecystitis, but the relation between severity of calculous cholecystitis and serum CA19-9 level are still unknown.
448. The clinical value of serum sirtuin-1 concentration in the diagnosis of metabolic dysfunction-associated steatotic liver disease.
作者: Farshad Amirkhizi.;Mahdiyeh Taghizadeh.;Banafshe Khalese-Ranjbar.;Soudabeh Hamedi-Shahraki.;Somayyeh Asghari.
来源: BMC Gastroenterol. 2025年25卷1期27页
Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease and can affect individuals without producing any symptoms. We aimed to explore the value of serum sirtuin-1 (Sirt-1) in the diagnosis of MASLD.
449. Potential alternative and novel biomarkers for paediatric MAFLD: exploratory evidence from a Chinese cohort.
作者: Fan Yang.;Mengyuan Hu.;Lulian Xu.;Xiaowei Zheng.;Lihong Zhu.;Le Zhang.;Haoyang Zhang.
来源: BMC Gastroenterol. 2025年25卷1期28页
While the associations between pediatric non-obese metabolic dysfunction-associated fatty liver disease (MAFLD) and multiple diagnostic biomarkers are well-established, the role of a broader range of blood-based, urine-based, and body composition-based biomarkers for monitoring MAFLD are needed.
450. The association between oxidative balance score with constipation and diarrhea in US adults: a cross-sectional analysis of NHANES 2007-2010.
Oxidative stress is associated with functional bowel disorders. The Oxidative Balance Score (OBS) is used to represent the overall level of oxidative stress experienced by an individual. Sex differences are exhibited in the occurrence of constipation and diarrhea. This population-based study aimed to examine the association between the OBS, constipation, and diarrhea, among adults in the United States (US), stratified by sex.
451. Association of anxiety status and anxiety duration with constipation in adult Americans: a cross-sectional study using data from the NHANES 2007-2010.
作者: Xinran Li.;Conghui Bian.;Hui Dai.;Xingrui Chen.;Haihua Qian.;Dan Zhang.
来源: BMC Gastroenterol. 2025年25卷1期31页
Constipated patients may exhibit anxious behaviors, but the relationship between the two remains unclear. This population-based study aims to investigate the relationships of anxiety status and anxiety duration with constipation among U.S. adults.
452. The role of exercise-based prehabilitation in enhancing surgical outcomes for patients with digestive system cancers: a meta-analysis.
作者: Shasha Xu.;Rong Yin.;Haiou Zhu.;Yin Gong.;Jing Zhu.;Changxian Li.;Qin Xu.
来源: BMC Gastroenterol. 2025年25卷1期26页
Prehabilitation is a crucial component of tumor rehabilitation that attempts to improve patients' preoperative health, although its efficacy in treating patients with cancers of the digestive system is still up for debate.
453. Structural equation modeling of the impact of disease activity on inflammatory bowel disease control: the mediating roles of self-efficacy and self-management behaviors.
作者: Yongli Zhu.;Ke Liu.;Jinfeng Jiang.;Xin Cheng.;Hao Wang.;Feiyang Long.;Kang Li.;Changping Mu.;Lijun Cui.
来源: BMC Gastroenterol. 2025年25卷1期30页
Maintaining effective disease control in patients with inflammatory bowel disease (IBD) is both a significant goal and challenge. Drawing on the Common-Sense Model of Self-Regulation (CSM) and related research, this study investigates how IBD activity status influences disease control through both direct and indirect pathways.
454. Association between non-insulin-based insulin resistance surrogate makers and Helicobacter pylori infection: a population-based study.
作者: Jiayu Qiu.;Yueming Yu.;Dingwei Liu.;Sihai Chen.;Youhua Wang.;Jianxiang Peng.;Jinliang Xie.;Chengyun Wu.;Feng Zhou.;Hui Fang.;Qirui Lai.;Yong Xie.
来源: BMC Gastroenterol. 2025年25卷1期25页
Current evidence on the associations between insulin resistance (IR) and Helicobacter pylori (H. pylori) infection remains limited. This study aimed to investigate the association between non-insulin-based surrogate markers of IR, including the triglyceride glucose (TyG) index, triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, and the metabolic score for IR (METS-IR), and H. pylori infection in U.S.
455. Deep learning-based CT radiomics predicts prognosis of unresectable hepatocellular carcinoma treated with TACE-HAIC combined with PD-1 inhibitors and tyrosine kinase inhibitors.
To develop and validate a computed tomography (CT)-based deep learning radiomics model to predict treatment response and progression-free survival (PFS) in patients with unresectable hepatocellular carcinoma (uHCC) treated with transarterial chemoembolization (TACE)-hepatic arterial infusion chemotherapy (HAIC) combined with PD-1 inhibitors and tyrosine kinase inhibitors (TKIs).
456. Correlation and diagnostic significance of CD4 T cell subsets and NLRP3 inflammasome in ulcerative colitis: the role of the NLRP3/T-bet/GATA3 axis.
作者: Yingnan Hu.;Jingyi Tang.;Dian Yu.;Shuo Su.;Jintao Fang.;Linying Xia.;Wenjun Xu.;Weihan Zhu.;Ninping Song.;Fengyong Wang.;Dechang Diao.;Wei Zhang.
来源: BMC Gastroenterol. 2025年25卷1期23页
Ulcerative colitis (UC) is characterized by complex immunological interactions involving CD4 T cell subsets and the NLRP3 inflammasome, which influence inflammatory responses. This investigation focused on delineating the activation profiles of these components and their correlation with disease severity and activity, assessing their diagnostic implications in UC.
457. PPARγ activation attenuates neonatal CRD-induced visceral pain sensitization and anxiety in male rats by alleviating oxidative stress.
作者: Minjie Li.;Xiyu Zhuo.;Yongxiao Liu.;Jinchao You.;Jianqing Lin.
来源: BMC Gastroenterol. 2025年25卷1期22页
Visceral pain sensitization and emotional reactions due to irritable bowel syndrome (IBS) occur frequently in the general population. Oxidative stress plays a crucial role in the pathogenesis of IBS. Previous studies have demonstrated that activation of peroxisome proliferator-activated receptor gamma (PPARγ) has analgesic effects. Therefore, we aimed to determine whether PPARγ activation ameliorates oxidative stress and affects thus nociceptive sensitization and emotional responses in IBS.
458. Association between neutrophil-albumin ratio and ultrasound-defined metabolic dysfunction-associated fatty liver disease in U.S. adults: evidence from NHANES 2017-2018.
Metabolic dysfunction-associated fatty liver disease (MAFLD) is increasingly prevalent, and systemic inflammation markers may play a role in its pathogenesis. This study aimed to investigate the relationship between neutrophil-albumin ratio (NAR) and MAFLD.
459. Association of daily step counts and step intensity with mortality among US adults: a cross-sectional study of NHANES 2005-2006.
作者: Tianzhou Peng.;Changhao Liu.;Ti Yang.;Leyi Liao.;Qingping Li.;Hanbiao Liang.;Jiapeng Zhang.;Chen Xie.;Kai Wang.;Chuanjiang Li.
来源: BMC Gastroenterol. 2025年25卷1期21页
We aimed to describe the dose-response relationship between daily step counts and intensity with respect to all-cause mortality among US adults diagnosed with metabolic dysfunction-associated steatotic liver disease (MASLD).
460. Eradication Therapy to Prevent Gastric Cancer in Helicobacterpylori-Positive Individuals: Systematic Review and Meta-Analysis of Randomized Controlled Trials and Observational Studies.
作者: Alexander C Ford.;Yuhong Yuan.;Jin Young Park.;David Forman.;Paul Moayyedi.
来源: Gastroenterology. 2025年
Screening for, and treating, Helicobacter pylori in the general population or patients with early gastric neoplasia could reduce incidence of, and mortality from, gastric cancer. We updated a meta-analysis of randomized controlled trials (RCTs) examining this issue.
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