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441. Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.
作者: Abbas Dehghan.;Qiong Yang.;Annette Peters.;Saonli Basu.;Joshua C Bis.;Alicja R Rudnicka.;Maryam Kavousi.;Ming-Huei Chen.;Jens Baumert.;Gordon D O Lowe.;Barbara McKnight.;Weihong Tang.;Moniek de Maat.;Martin G Larson.;Susana Eyhermendy.;Wendy L McArdle.;Thomas Lumley.;James S Pankow.;Albert Hofman.;Joseph M Massaro.;Fernando Rivadeneira.;Melanie Kolz.;Kent D Taylor.;Cornelia M van Duijn.;Sekar Kathiresan.;Thomas Illig.;Yurii S Aulchenko.;Kelly A Volcik.;Andrew D Johnson.;Andre G Uitterlinden.;Geoffrey H Tofler.;Christian Gieger.; .;Bruce M Psaty.;David J Couper.;Eric Boerwinkle.;Wolfgang Koenig.;Christopher J O'Donnell.;Jacqueline C Witteman.;David P Strachan.;Nicholas L Smith.;Aaron R Folsom.
来源: Circ Cardiovasc Genet. 2009年2卷2期125-33页
Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels.
442. Pulmonary vein isolation for the maintenance of sinus rhythm in patients with atrial fibrillation: a meta-analysis of randomized, controlled trials.
作者: Jonathan P Piccini.;Renato D Lopes.;Melissa H Kong.;Vic Hasselblad.;Kevin Jackson.;Sana M Al-Khatib.
来源: Circ Arrhythm Electrophysiol. 2009年2卷6期626-33页
Catheter ablation is an established yet evolving nonpharmacologic intervention for the maintenance of sinus rhythm in patients with atrial fibrillation (AF). The efficacy and safety of pulmonary vein isolation (PVI) compared with medical therapy remain in question.
443. B-type natriuretic peptides and cardiovascular risk: systematic review and meta-analysis of 40 prospective studies.
作者: Emanuele Di Angelantonio.;Rajiv Chowdhury.;Nadeem Sarwar.;Kausik K Ray.;Reeta Gobin.;Danish Saleheen.;Alexander Thompson.;Vilmundur Gudnason.;Naveed Sattar.;John Danesh.
来源: Circulation. 2009年120卷22期2177-87页
Measurement of B-type natriuretic peptide (BNP) concentration or its precursor (N-terminal fragment [NT-proBNP]) is recommended in patients with symptoms of left ventricular dysfunction and in other settings, but the relevance of these peptides to cardiovascular disease (CVD) in general populations or in patients with stable vascular disease is uncertain.
444. A common variant at 9p21 is associated with sudden and arrhythmic cardiac death.
作者: Christopher Newton-Cheh.;Nancy R Cook.;Martin VanDenburgh.;Eric B Rimm.;Paul M Ridker.;Christine M Albert.
来源: Circulation. 2009年120卷21期2062-8页
Although a heritable basis for sudden cardiac death (SCD) is suggested by the impact of family history on SCD risk, common genetic determinants have been difficult to identify. We hypothesized that a common variant at chromosome 9p21 related to myocardial infarction would influence SCD risk.
445. Major bleeding, mortality, and efficacy of fondaparinux in venous thromboembolism prevention trials.
Bleeding is a strong predictor of death in patients hospitalized for arterial thrombosis who are treated with antithrombotic therapy, but the prognostic importance of bleeding in patients receiving antithrombotic prophylaxis for venous thromboembolism is uncertain.
446. Long-term outcomes after catheter ablation of cavo-tricuspid isthmus dependent atrial flutter: a meta-analysis.
作者: Francisco J Pérez.;Christine M Schubert.;Babar Parvez.;Vishesh Pathak.;Kenneth A Ellenbogen.;Mark A Wood.
来源: Circ Arrhythm Electrophysiol. 2009年2卷4期393-401页
Despite the success of catheter ablation of cavotricuspid isthmus-dependent atrial flutter (AFL), important postablation outcomes are ill-defined. The purpose of our study was to analyze long-term outcomes after catheter ablation of cavotricuspid isthmus-dependent AFL.
447. Treatment of atrial fibrillation with antiarrhythmic drugs or radiofrequency ablation: two systematic literature reviews and meta-analyses.
作者: Hugh Calkins.;Matthew R Reynolds.;Peter Spector.;Manu Sondhi.;Yingxin Xu.;Amber Martin.;Catherine J Williams.;Isabella Sledge.
来源: Circ Arrhythm Electrophysiol. 2009年2卷4期349-61页
Although radiofrequency catheter ablation (RFA) has evolved from an experimental procedure to an important treatment option for atrial fibrillation, the relative safety and efficacy of catheter ablation relative to that of antiarrhythmic drug (AAD) therapy has not been established.
448. Safety and efficacy of drug-eluting and bare metal stents: comprehensive meta-analysis of randomized trials and observational studies.
作者: Ajay J Kirtane.;Anuj Gupta.;Srinivas Iyengar.;Jeffrey W Moses.;Martin B Leon.;Robert Applegate.;Bruce Brodie.;Edward Hannan.;Kishore Harjai.;Lisette Okkels Jensen.;Seung-Jung Park.;Raphael Perry.;Michael Racz.;Francesco Saia.;Jack V Tu.;Ron Waksman.;Alexandra J Lansky.;Roxana Mehran.;Gregg W Stone.
来源: Circulation. 2009年119卷25期3198-206页
The safety and efficacy of drug-eluting stents (DES) among more generalized "real-world" patients than those enrolled in pivotal randomized controlled trials (RCTs) are controversial. We sought to perform a meta-analysis of DES studies to estimate the relative impact of DES versus bare metal stents (BMS) on safety and efficacy end points, particularly for non-Food and Drug Administration-labeled indications.
449. Comparison of primary percutaneous coronary intervention and fibrinolytic therapy in ST-segment-elevation myocardial infarction: bayesian hierarchical meta-analyses of randomized controlled trials and observational studies.
作者: Thao Huynh.;Stephane Perron.;Jennifer O'Loughlin.;Lawrence Joseph.;Michel Labrecque.;Jack V Tu.;Pierre Théroux.
来源: Circulation. 2009年119卷24期3101-9页
Published meta-analyses comparing primary percutaneous coronary intervention with fibrinolytic therapy in patients with ST-segment-elevation myocardial infarction include only randomized controlled trials (RCTs). We aim to obviate the limited applicability of RCTs to real-world settings by undertaking meta-analyses of both RCTs and observational studies.
450. Benefits and risks of corticosteroid prophylaxis in adult cardiac surgery: a dose-response meta-analysis.
Cardiopulmonary bypass and cardiac surgery are associated with a significant systemic inflammatory response that may increase postoperative complications. This meta-analysis assessed whether the benefits and risks of corticosteroid use were dose dependent in adult cardiac surgery.
451. The Ross procedure: a systematic review and meta-analysis.
作者: Johanna J M Takkenberg.;Loes M A Klieverik.;Paul H Schoof.;Robert-Jan van Suylen.;Lex A van Herwerden.;Pieter E Zondervan.;Jolien W Roos-Hesselink.;Marinus J C Eijkemans.;Magdi H Yacoub.;Ad J J C Bogers.
来源: Circulation. 2009年119卷2期222-8页
Reports on outcome after the Ross procedure are limited by small study size and show variable durability results. A systematic review of evidence on outcome after the Ross procedure may improve insight into outcome and potential determinants.
452. Mutations in the HFE gene and cardiovascular disease risk: an individual patient data meta-analysis of 53 880 subjects.
作者: Daphne L van der A.;Maroeska M Rovers.;Diederick E Grobbee.;Joannes J M Marx.;Jill Waalen.;Christina Ellervik.;Børge G Nordestgaard.;John K Olynyk.;Peter R Mills.;James Shepherd.;Bernard Grandchamp.;Jolanda M A Boer.;Calogero Caruso.;Marcello Arca.;Beat J Meyer.;Yvonne T van der Schouw.
来源: Circ Cardiovasc Genet. 2008年1卷1期43-50页
Whether mutations in the hemochromatosis (HFE) gene increase cardiovascular disease risk is still undetermined. The main reason is the low frequency of the mutations, in particular of the compound C282Y/H63D genotype. We combined the data of 11 observational studies for an individual patient data meta-analysis.
453. Impact of inherited thrombophilia on venous thromboembolism in children: a systematic review and meta-analysis of observational studies.
作者: Guy Young.;Manuela Albisetti.;Mariana Bonduel.;Leonardo Brandao.;Anthony Chan.;Frauke Friedrichs.;Neil A Goldenberg.;Eric Grabowski.;Christine Heller.;Janna Journeycake.;Gili Kenet.;Anne Krümpel.;Karin Kurnik.;Aaron Lubetsky.;Christoph Male.;Marilyn Manco-Johnson.;Prasad Mathew.;Paul Monagle.;Heleen van Ommen.;Paolo Simioni.;Pavel Svirin.;Daniela Tormene.;Ulrike Nowak-Göttl.
来源: Circulation. 2008年118卷13期1373-82页
The aim of the present study was to estimate the impact of inherited thrombophilia (IT) on the risk of venous thromboembolism (VTE) onset and recurrence in children by a meta-analysis of published observational studies.
454. Long-term safety and efficacy of percutaneous coronary intervention with stenting and coronary artery bypass surgery for multivessel coronary artery disease: a meta-analysis with 5-year patient-level data from the ARTS, ERACI-II, MASS-II, and SoS trials.
作者: Joost Daemen.;Eric Boersma.;Marcus Flather.;Jean Booth.;Rod Stables.;Alfredo Rodriguez.;Gaston Rodriguez-Granillo.;Whady A Hueb.;Pedro A Lemos.;Patrick W Serruys.
来源: Circulation. 2008年118卷11期1146-54页
Randomized trials that studied clinical outcomes after percutaneous coronary intervention (PCI) with bare metal stenting versus coronary artery bypass grafting (CABG) are underpowered to properly assess safety end points like death, stroke, and myocardial infarction. Pooling data from randomized controlled trials increases the statistical power and allows better assessment of the treatment effect in high-risk subgroups.
455. Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis.
A large number of studies have examined the tracking of blood pressure (BP) from childhood to adulthood, but the reported findings are inconsistent and few systematic analyses have been conducted.
456. Efficacy of in-hospital multidimensional interventions of secondary prevention after acute coronary syndrome: a systematic review and meta-analysis.
作者: Reto Auer.;Jacques Gaume.;Nicolas Rodondi.;Jacques Cornuz.;William A Ghali.
来源: Circulation. 2008年117卷24期3109-17页
Secondary prevention programs for patients experiencing an acute coronary syndrome have been shown to be effective in the outpatient setting. The efficacy of in-hospital prevention interventions administered soon after acute cardiac events is unclear. We performed a systematic review and meta-analysis to determine whether in-hospital, patient-level interventions targeting multiple cardiovascular risk factors reduce all-cause mortality after an acute coronary syndrome.
458. Independent prognostic importance of a restrictive left ventricular filling pattern after myocardial infarction: an individual patient meta-analysis: Meta-Analysis Research Group in Echocardiography acute myocardial infarction.
作者: .;J E Møller.;G A Whalley.;F L Dini.;R N Doughty.;G D Gamble.;A L Klein.;M Quintana.;C M Yu.
来源: Circulation. 2008年117卷20期2591-8页
Restrictive mitral filling pattern (RFP), the most severe form of diastolic dysfunction, is a predictor of outcome after acute myocardial infarction (AMI). Low power has precluded a definite conclusion on the independent importance of RFP, especially when overall systolic function is preserved. We undertook an individual patient meta-analysis to determine whether RFP is predictive of mortality independently of LV ejection fraction (LVEF), end-systolic volume index, and Killip class in patients after AMI.
459. Repeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease.
作者: Heribert Schunkert.;Anika Götz.;Peter Braund.;Ralph McGinnis.;David-Alexandre Tregouet.;Massimo Mangino.;Patrick Linsel-Nitschke.;Francois Cambien.;Christian Hengstenberg.;Klaus Stark.;Stefan Blankenberg.;Laurence Tiret.;Pierre Ducimetiere.;Andrew Keniry.;Mohammed J R Ghori.;Stefan Schreiber.;Nour Eddine El Mokhtari.;Alistair S Hall.;Richard J Dixon.;Alison H Goodall.;Henrike Liptau.;Helen Pollard.;Daniel F Schwarz.;Ludwig A Hothorn.;H-Erich Wichmann.;Inke R König.;Marcus Fischer.;Christa Meisinger.;Willem Ouwehand.;Panos Deloukas.;John R Thompson.;Jeanette Erdmann.;Andreas Ziegler.;Nilesh J Samani.; .
来源: Circulation. 2008年117卷13期1675-84页
Recently, genome-wide association studies identified variants on chromosome 9p21.3 as affecting the risk of coronary artery disease (CAD). We investigated the association of this locus with CAD in 7 case-control studies and undertook a meta-analysis.
460. Prevalence of angina in women versus men: a systematic review and meta-analysis of international variations across 31 countries.
作者: Harry Hemingway.;Claudia Langenberg.;Jacqueline Damant.;Chris Frost.;Kalevi Pyörälä.;Elizabeth Barrett-Connor.
来源: Circulation. 2008年117卷12期1526-36页
In the absence of previous international comparisons, we sought to systematically evaluate, across time and participant age, the sex ratio in angina prevalence in countries that differ widely in the rate of mortality due to myocardial infarction.
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