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4381. Brief report: treatment of insulin-resistant diabetic ketoacidosis with insulin-like growth factor I in an adolescent with insulin-dependent diabetes.
作者: A L Usala.;T Madigan.;B Burguera.;M K Sinha.;J F Caro.;P Cunningham.;J G Powell.;P C Butler.
来源: N Engl J Med. 1992年327卷12期853-7页 4382. Ganciclovir for cytomegalovirus after heart transplantation.
作者: A Laske.;A Gallino.;T Carrel.;M I Turina.
来源: N Engl J Med. 1992年327卷12期892; author reply 892-3页 4383. Ganciclovir for cytomegalovirus after heart transplantation.4385. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. The SAVE Investigators.
作者: M A Pfeffer.;E Braunwald.;L A Moyé.;L Basta.;E J Brown.;T E Cuddy.;B R Davis.;E M Geltman.;S Goldman.;G C Flaker.
来源: N Engl J Med. 1992年327卷10期669-77页
Left ventricular dilatation and dysfunction after myocardial infarction are major predictors of death. In experimental and clinical studies, longterm therapy with the angiotensin-converting--enzyme inhibitor captopril attenuated ventricular dilatation and remodeling. We investigated whether captopril could reduce morbidity and mortality in patients with left ventricular dysfunction after a myocardial infarction.
4387. Early zidovudine and survival in HIV infection. The Veterans Affairs AIDS Cooperative Studies Group.
作者: P M Hartigan.;J D Hamilton.;M S Simberkoff.
来源: N Engl J Med. 1992年327卷11期814-5; author reply 815-6页 4389. Early zidovudine and survival in HIV infection.4390. A comparison of valproate with carbamazepine for the treatment of complex partial seizures and secondarily generalized tonic-clonic seizures in adults. The Department of Veterans Affairs Epilepsy Cooperative Study No. 264 Group.
Valproate is approved for use primarily in patients with absence seizures, but the drug has a broad spectrum of activity against seizures of all types. Partial or secondarily generalized tonic-clonic seizures are often difficult to control adequately with standard treatment, usually carbamazepine or phenytoin.
4391. Central venous catheters and sepsis in patients with quadriplegia.4393. Effects of the early administration of enalapril on mortality in patients with acute myocardial infarction. Results of the Cooperative New Scandinavian Enalapril Survival Study II (CONSENSUS II).
作者: K Swedberg.;P Held.;J Kjekshus.;K Rasmussen.;L Rydén.;H Wedel.
来源: N Engl J Med. 1992年327卷10期678-84页
Long-term administration of angiotensin-converting--enzyme (ACE) inhibitors has been shown to improve survival in patients with symptomatic left ventricular failure and to attenuate left ventricular dilatation in patients with myocardial infarction. We studied whether mortality could be reduced during the 6 months after an acute myocardial infarction with use of the ACE inhibitor enalapril.
4394. Effect of enalapril on mortality and the development of heart failure in asymptomatic patients with reduced left ventricular ejection fractions.
It is not known whether the treatment of patients with asymptomatic left ventricular dysfunction reduces mortality and morbidity. We studied the effect of an angiotensin-converting--enzyme inhibitor, enalapril, on total mortality and mortality from cardiovascular causes, the development of heart failure, and hospitalization for heart failure among patients with ejection fractions of 0.35 or less who were not receiving drug treatment for heart failure.
4397. Prophylactic fluconazole and marrow transplantation.
作者: S L Scholten.;M D Nettleman.;E F Sarrazin.
来源: N Engl J Med. 1992年327卷9期644-5; author reply 645页 4400. Methylprednisolone plus chlorambucil as compared with methylprednisolone alone for the treatment of idiopathic membranous nephropathy. The Italian Idiopathic Membranous Nephropathy Treatment Study Group.
Treatment with methylprednisolone and chlorambucil may protect renal function and increase the chance of remission of the nephrotic syndrome in patients with idiopathic membranous nephropathy. To determine whether similar results might be obtained with methylprednisolone alone, we compared the effects of methylprednisolone and chlorambucil with those of methylprednisolone alone in 92 patients with the nephrotic syndrome caused by idiopathic membranous nephropathy. The patients were randomly assigned to receive either alternating one-month courses of methylprednisolone and then chlorambucil for a total of six months (group 1) or methylprednisolone alone for six months at the same cumulative dosage (group 2).
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