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421. Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.
作者: Qiong Yang.;Anna Köttgen.;Abbas Dehghan.;Albert V Smith.;Nicole L Glazer.;Ming-Huei Chen.;Daniel I Chasman.;Thor Aspelund.;Gudny Eiriksdottir.;Tamara B Harris.;Lenore Launer.;Michael Nalls.;Dena Hernandez.;Dan E Arking.;Eric Boerwinkle.;Megan L Grove.;Man Li.;W H Linda Kao.;Michel Chonchol.;Talin Haritunians.;Guo Li.;Thomas Lumley.;Bruce M Psaty.;Michael Shlipak.;Shih-Jen Hwang.;Martin G Larson.;Christopher J O'Donnell.;Ashish Upadhyay.;Cornelia M van Duijn.;Albert Hofman.;Fernando Rivadeneira.;Bruno Stricker.;Andre G Uitterlinden.;Guillaume Paré.;Alex N Parker.;Paul M Ridker.;David S Siscovick.;Vilmundur Gudnason.;Jacqueline C Witteman.;Caroline S Fox.;Josef Coresh.
来源: Circ Cardiovasc Genet. 2010年3卷6期523-30页
Elevated serum urate levels can lead to gout and are associated with cardiovascular risk factors. We performed a genome-wide association study to search for genetic susceptibility loci for serum urate and gout and investigated the causal nature of the associations of serum urate with gout and selected cardiovascular risk factors and coronary heart disease (CHD).
422. Ancestry as a determinant of mean population C-reactive protein values: implications for cardiovascular risk prediction.
作者: Tina Shah.;Paul Newcombe.;Liam Smeeth.;Juliet Addo.;Juan P Casas.;John Whittaker.;Michelle A Miller.;Lorna Tinworth.;Steve Jeffery.;Pasquale Strazzullo.;Francesco P Cappuccio.;Aroon D Hingorani.
来源: Circ Cardiovasc Genet. 2010年3卷5期436-44页
Eligibility for rosuvastatin treatment for cardiovascular disease prevention includes a C-reactive protein (CRP) concentration >2 mg/L. Most observational studies of CRP and cardiovascular disease have been in Europeans. We evaluated the influence of ancestry on population CRP concentration to assess the implications for statin targeting in non-Europeans.
423. Association of single nucleotide polymorphisms on chromosome 9p21.3 with platelet reactivity: a potential mechanism for increased vascular disease.
作者: Kiran Musunuru.;Wendy S Post.;William Herzog.;Haiqing Shen.;Jeffrey R O'Connell.;Patrick F McArdle.;Kathleen A Ryan.;Quince Gibson.;Yu-Ching Cheng.;Elizabeth Clearfield.;Andrew D Johnson.;Geoffrey Tofler.;Qiong Yang.;Christopher J O'Donnell.;Diane M Becker.;Lisa R Yanek.;Lewis C Becker.;Nauder Faraday.;Lawrence F Bielak.;Patricia A Peyser.;Alan R Shuldiner.;Braxton D Mitchell.
来源: Circ Cardiovasc Genet. 2010年3卷5期445-53页
Genome-wide association studies have identified a locus on chromosome 9p21.3 to be strongly associated with myocardial infarction/coronary artery disease and ischemic stroke. To gain insights into the mechanisms underlying these associations, we hypothesized that single nucleotide polymorphisms (SNPs) in this region would be associated with platelet reactivity across multiple populations.
424. Body mass index and risk of stroke and myocardial infarction in a relatively lean population: meta-analysis of 16 Japanese cohorts using individual data.
作者: Hiroshi Yatsuya.;Hideaki Toyoshima.;Kazumasa Yamagishi.;Koji Tamakoshi.;Masataka Taguri.;Akiko Harada.;Yasuo Ohashi.;Yoshikuni Kita.;Yoshihiko Naito.;Michiko Yamada.;Naohito Tanabe.;Hiroyasu Iso.;Hirotsugu Ueshima.; .
来源: Circ Cardiovasc Qual Outcomes. 2010年3卷5期498-505页
The association of overweight/obesity with the incidence of cardiovascular diseases, especially stroke, has not been comprehensively examined in relatively lean populations in which stroke is more prevalent than coronary heart disease.
425. Iodixanol versus low-osmolar contrast media for prevention of contrast induced nephropathy: meta-analysis of randomized, controlled trials.
作者: Aaron M From.;Firas J Al Badarin.;Furman S McDonald.;Brian J Bartholmai.;Stephen S Cha.;Charanjit S Rihal.
来源: Circ Cardiovasc Interv. 2010年3卷4期351-8页
Contrast-induced nephropathy (CIN) is associated with significant morbidity and mortality. The objective of our meta-analysis was to assess the efficacy of iodixanol compared with low-osmolar contrast media (LOCM) for prevention of CIN.
426. PLA2G7 genotype, lipoprotein-associated phospholipase A2 activity, and coronary heart disease risk in 10 494 cases and 15 624 controls of European Ancestry.
作者: Juan P Casas.;Ewa Ninio.;Andrie Panayiotou.;Jutta Palmen.;Jackie A Cooper.;Sally L Ricketts.;Reecha Sofat.;Andrew N Nicolaides.;James P Corsetti.;F Gerry R Fowkes.;Ioanna Tzoulaki.;Meena Kumari.;Eric J Brunner.;Mika Kivimaki.;Michael G Marmot.;Michael M Hoffmann.;Karl Winkler.;Winfred März.;Shu Ye.;Heide A Stirnadel.;S Matthijs Boekholdt.;Kay-Tee Khaw.;Steve E Humphries.;Manjinder S Sandhu.;Aroon D Hingorani.;Philippa J Talmud.
来源: Circulation. 2010年121卷21期2284-93页
Higher lipoprotein-associated phospholipase A(2)(Lp-PLA2) activity is associated with increased risk of coronary heart disease (CHD), making Lp-PLA2 a potential therapeutic target. PLA2G7 variants associated with Lp-PLA2 activity could evaluate whether this relationship is causal.
427. Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.
作者: Nicholas L Smith.;Janine F Felix.;Alanna C Morrison.;Serkalem Demissie.;Nicole L Glazer.;Laura R Loehr.;L Adrienne Cupples.;Abbas Dehghan.;Thomas Lumley.;Wayne D Rosamond.;Wolfgang Lieb.;Fernando Rivadeneira.;Joshua C Bis.;Aaron R Folsom.;Emelia Benjamin.;Yurii S Aulchenko.;Talin Haritunians.;David Couper.;Joanne Murabito.;Ying A Wang.;Bruno H Stricker.;John S Gottdiener.;Patricia P Chang.;Thomas J Wang.;Kenneth M Rice.;Albert Hofman.;Susan R Heckbert.;Ervin R Fox.;Christopher J O'Donnell.;Andre G Uitterlinden.;Jerome I Rotter.;James T Willerson.;Daniel Levy.;Cornelia M van Duijn.;Bruce M Psaty.;Jacqueline C M Witteman.;Eric Boerwinkle.;Ramachandran S Vasan.
来源: Circ Cardiovasc Genet. 2010年3卷3期256-66页
Although genetic factors contribute to the onset of heart failure (HF), no large-scale genome-wide investigation of HF risk has been published to date. We have investigated the association of 2,478,304 single-nucleotide polymorphisms with incident HF by meta-analyzing data from 4 community-based prospective cohorts: the Atherosclerosis Risk in Communities Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study.
428. Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.
作者: Alanna C Morrison.;Janine F Felix.;L Adrienne Cupples.;Nicole L Glazer.;Laura R Loehr.;Abbas Dehghan.;Serkalem Demissie.;Joshua C Bis.;Wayne D Rosamond.;Yurii S Aulchenko.;Ying A Wang.;Talin Haritunians.;Aaron R Folsom.;Fernando Rivadeneira.;Emelia J Benjamin.;Thomas Lumley.;David Couper.;Bruno H Stricker.;Christopher J O'Donnell.;Kenneth M Rice.;Patricia P Chang.;Albert Hofman.;Daniel Levy.;Jerome I Rotter.;Ervin R Fox.;Andre G Uitterlinden.;Thomas J Wang.;Bruce M Psaty.;James T Willerson.;Cornelia M van Duijn.;Eric Boerwinkle.;Jacqueline C M Witteman.;Ramachandran S Vasan.;Nicholas L Smith.
来源: Circ Cardiovasc Genet. 2010年3卷3期248-55页
Prognosis and survival are significant concerns for individuals with heart failure (HF). To better understand the pathophysiology of HF prognosis, the association between 2,366,858 single-nucleotide polymorphisms (SNPs) and all-cause mortality was evaluated among individuals with incident HF from 4 community-based prospective cohorts: the Atherosclerosis Risk in Communities Study, the Cardiovascular Health Study, the Framingham Heart Study, and the Rotterdam Study.
429. Impact of thrombophilia on risk of arterial ischemic stroke or cerebral sinovenous thrombosis in neonates and children: a systematic review and meta-analysis of observational studies.
作者: Gili Kenet.;Lisa K Lütkhoff.;Manuela Albisetti.;Timothy Bernard.;Mariana Bonduel.;Leonardo Brandao.;Stephane Chabrier.;Anthony Chan.;Gabrielle deVeber.;Barbara Fiedler.;Heather J Fullerton.;Neil A Goldenberg.;Eric Grabowski.;Gudrun Günther.;Christine Heller.;Susanne Holzhauer.;Alfonso Iorio.;Janna Journeycake.;Ralf Junker.;Fenella J Kirkham.;Karin Kurnik.;John K Lynch.;Christoph Male.;Marilyn Manco-Johnson.;Rolf Mesters.;Paul Monagle.;C Heleen van Ommen.;Leslie Raffini.;Kevin Rostásy.;Paolo Simioni.;Ronald D Sträter.;Guy Young.;Ulrike Nowak-Göttl.
来源: Circulation. 2010年121卷16期1838-47页
The aim of this study was to estimate the impact of thrombophilia on risk of first childhood stroke through a meta-analysis of published observational studies.
430. Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium.
作者: Nicholas L Smith.;Ming-Huei Chen.;Abbas Dehghan.;David P Strachan.;Saonli Basu.;Nicole Soranzo.;Caroline Hayward.;Igor Rudan.;Maria Sabater-Lleal.;Joshua C Bis.;Moniek P M de Maat.;Ann Rumley.;Xiaoxiao Kong.;Qiong Yang.;Frances M K Williams.;Veronique Vitart.;Harry Campbell.;Anders Mälarstig.;Kerri L Wiggins.;Cornelia M Van Duijn.;Wendy L McArdle.;James S Pankow.;Andrew D Johnson.;Angela Silveira.;Barbara McKnight.;Andre G Uitterlinden.; .;Nena Aleksic.;James B Meigs.;Annette Peters.;Wolfgang Koenig.;Mary Cushman.;Sekar Kathiresan.;Jerome I Rotter.;Edwin G Bovill.;Albert Hofman.;Eric Boerwinkle.;Geoffrey H Tofler.;John F Peden.;Bruce M Psaty.;Frank Leebeek.;Aaron R Folsom.;Martin G Larson.;Timothy D Spector.;Alan F Wright.;James F Wilson.;Anders Hamsten.;Thomas Lumley.;Jacqueline C M Witteman.;Weihong Tang.;Christopher J O'Donnell.
来源: Circulation. 2010年121卷12期1382-92页
Plasma levels of coagulation factors VII (FVII), VIII (FVIII), and von Willebrand factor (vWF) influence risk of hemorrhage and thrombosis. We conducted genome-wide association studies to identify new loci associated with plasma levels.
431. Meta-analyses of septal reduction therapies for obstructive hypertrophic cardiomyopathy: comparative rates of overall mortality and sudden cardiac death after treatment.
作者: Robert A Leonardi.;Evan P Kransdorf.;David L Simel.;Andrew Wang.
来源: Circ Cardiovasc Interv. 2010年3卷2期97-104页
Septal reduction for obstructive hypertrophic cardiomyopathy may be performed by surgical myectomy or alcohol septal ablation (ASA). Unlike surgical myectomy, ASA creates an intramyocardial scar that may potentiate the risk of ventricular arrhythmias and sudden cardiac death (SCD).
432. Statins for the primary prevention of cardiovascular events in women with elevated high-sensitivity C-reactive protein or dyslipidemia: results from the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) and meta-analysis of women from primary prevention trials.
作者: Samia Mora.;Robert J Glynn.;Judith Hsia.;Jean G MacFadyen.;Jacques Genest.;Paul M Ridker.
来源: Circulation. 2010年121卷9期1069-77页
Statin therapy in women without cardiovascular disease (CVD) is controversial, given the insufficient evidence of benefit. We analyzed sex-specific outcomes in the Justification for the Use of Statins in Prevention: An Intervention Trial Evaluating Rosuvastatin (JUPITER) and synthesized the results with prior trials.
433. Genetic effects on carotid intima-media thickness: systematic assessment and meta-analyses of candidate gene polymorphisms studied in more than 5000 subjects.
作者: Lavinia Paternoster.;Nahara A Martinez-Gonzalez.;Rebecca Charleton.;Mabel Chung.;Steff Lewis.;Cathie L M Sudlow.
来源: Circ Cardiovasc Genet. 2010年3卷1期15-21页
Carotid intima-media thickness (CIMT) is highly heritable and associated with stroke and myocardial infarction, making it a promising quantitative intermediate phenotype for genetic studies of vascular disease. There have been many CIMT candidate gene association studies, but no systematic review to identify consistent, reliable findings.
434. Predictors of survival from out-of-hospital cardiac arrest: a systematic review and meta-analysis.
作者: Comilla Sasson.;Mary A M Rogers.;Jason Dahl.;Arthur L Kellermann.
来源: Circ Cardiovasc Qual Outcomes. 2010年3卷1期63-81页
Prior studies have identified key predictors of out-of-hospital cardiac arrest (OHCA), but differences exist in the magnitude of these findings. In this meta-analysis, we evaluated the strength of associations between OHCA and key factors (event witnessed by a bystander or emergency medical services [EMS], provision of bystander cardiopulmonary resuscitation [CPR], initial cardiac rhythm, or the return of spontaneous circulation). We also examined trends in OHCA survival over time.
435. Adjunctive thrombectomy for acute myocardial infarction: A bayesian meta-analysis.
作者: François-Pierre Mongeon.;Patrick Bélisle.;Lawrence Joseph.;Mark J Eisenberg.;Stéphane Rinfret.
来源: Circ Cardiovasc Interv. 2010年3卷1期6-16页
In available trials and meta-analyses, adjunctive thrombectomy in acute myocardial infarction (MI) improves markers of myocardial reperfusion but has limited effects on clinical outcomes. Thrombectomy devices simply aspirate thrombus or mechanically fragment it before aspiration. Simple aspiration thrombectomy may offer a distinct advantage.
436. Complication rates after left- versus right-sided carotid endarterectomy.
作者: Louis-Philippe Girard.;Thomas E Feasby.;Michael Eliasziw.;Hude Quan.;James Kennedy.;Henry J M Barnett.;William A Ghali.
来源: Circ Cardiovasc Qual Outcomes. 2009年2卷6期642-7页
Studies suggest that the side of carotid endarterectomy (CE) may influence the rate of postoperative complications. We sought to clarify this by (1) analysis of individual-level data from 3 large studies and (2) systematic review and meta-analysis of additional published descriptions of outcomes by side.
437. Double versus single stenting for coronary bifurcation lesions: a meta-analysis.
作者: Demosthenes G Katritsis.;George C M Siontis.;John P A Ioannidis.
来源: Circ Cardiovasc Interv. 2009年2卷5期409-15页
Several trials have addressed whether bifurcation lesions require stenting of both the main vessel and side branch, but uncertainty remains on the benefits of such double versus single stenting of the main vessel only.
438. A comparison of abciximab and small-molecule glycoprotein IIb/IIIa inhibitors in patients undergoing primary percutaneous coronary intervention: a meta-analysis of contemporary randomized controlled trials.
作者: Hitinder S Gurm.;Umesh Tamhane.;Pascal Meier.;P Michael Grossman.;Stanley Chetcuti.;Eric R Bates.
来源: Circ Cardiovasc Interv. 2009年2卷3期230-6页
Current guidelines recommend abciximab as the preferred agent for patients undergoing primary percutaneous coronary intervention, yet small-molecule glycoprotein IIb/IIIa inhibitors are more commonly used in clinical practice. The objective of our meta-analysis was to evaluate for differences in clinical outcome between small-molecule glycoprotein IIb/IIIa inhibitors and abciximab in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.
439. A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.
作者: Fabio Marroni.;Arne Pfeufer.;Yurii S Aulchenko.;Christopher S Franklin.;Aaron Isaacs.;Irene Pichler.;Sarah H Wild.;Ben A Oostra.;Alan F Wright.;Harry Campbell.;Jacqueline C Witteman.;Stefan Kääb.;Andrew A Hicks.;Ulf Gyllensten.;Igor Rudan.;Thomas Meitinger.;Cristian Pattaro.;Cornelia M van Duijn.;James F Wilson.;Peter P Pramstaller.; .
来源: Circ Cardiovasc Genet. 2009年2卷4期322-8页
We set out to identify common genetic determinants of the length of the RR and QT intervals in 2325 individuals from isolated European populations.
440. Association of blood lipids with common DNA sequence variants at 19 genetic loci in the multiethnic United States National Health and Nutrition Examination Survey III.
作者: Mary E Keebler.;Christopher L Sanders.;Aarti Surti.;Candace Guiducci.;Noel P Burtt.;Sekar Kathiresan.
来源: Circ Cardiovasc Genet. 2009年2卷3期238-43页
Using the genome-wide association approach in individuals of European ancestry, we and others recently identified single-nucleotide polymorphisms (SNPs) at 19 loci as associated with blood lipids; 8 of these loci were novel. Whether these same SNPs associate with lipids in a broader range of ethnicities is unknown.
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