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421. Asthma action plans and patient satisfaction among women with asthma.
作者: Minal R Patel.;Melissa A Valerio.;Georgiana Sanders.;Lara J Thomas.;Noreen M Clark.
来源: Chest. 2012年142卷5期1143-1149页
Asthma action plans (AAPs) are a priority recommendation of the National Asthma Education and Prevention Program and have been shown to positively affect health outcomes. Patient satisfaction is an important clinical outcome, yet little is known about its association with receiving an AAP. This study examined the association between having an AAP and behaviors to keep asthma in control and patient satisfaction with care.
422. Transvenous phrenic nerve stimulation in patients with Cheyne-Stokes respiration and congestive heart failure: a safety and proof-of-concept study.
作者: Xi-Long Zhang.;Ning Ding.;Hong Wang.;Ralph Augostini.;Bing Yang.;Di Xu.;Weizhu Ju.;Xiaofeng Hou.;Xinli Li.;Buqing Ni.;Kejiang Cao.;Isaac George.;Jie Wang.;Shi-Jiang Zhang.
来源: Chest. 2012年142卷4期927-934页
Cheyne-Stokes respiration (CSR), which often occurs in patients with congestive heart failure (CHF), may be a predictor for poor outcome. Phrenic nerve stimulation (PNS) may interrupt CSR in patients with CHF. We report the clinical use of transvenous PNS in patients with CHF and CSR.
423. The role of conventional bronchoscopy in the workup of suspicious CT scan screen-detected pulmonary nodules.
作者: Susan C van 't Westeinde.;Nanda Horeweg.;René M Vernhout.;Harry J M Groen.;Jan-Willem J Lammers.;Carla Weenink.;Kristiaan Nackaerts.;Matthijs Oudkerk.;Willem Mali.;Frederik B Thunnissen.;Harry J de Koning.;Rob J van Klaveren.
来源: Chest. 2012年142卷2期377-384页
Up to 50% of the participants in CT scan lung cancer screening trials have at least one pulmonary nodule. To date, the role of conventional bronchoscopy in the workup of suspicious screen-detected pulmonary nodules is unknown. If a bronchoscopic evaluation could be eliminated, the cost-effectiveness of a screening program could be enhanced and the potential harms of bronchoscopy avoided.
424. Long-term auto-servoventilation or constant positive pressure in heart failure and coexisting central with obstructive sleep apnea.
作者: Winfried J Randerath.;Gregor Nothofer.;Christina Priegnitz.;Norbert Anduleit.;Marcel Treml.;Victoria Kehl.;Wolfgang Galetke.
来源: Chest. 2012年142卷2期440-447页
The coexistence of obstructive sleep apnea (OSA) and central sleep apnea (CSA) and Cheyne-Stokes respiration (CSR) is common in patients with heart failure (HF). While CPAP improves CSA/CSR by about 50%, maximal suppression is crucial in improving clinical outcomes. Auto-servoventilation (ASV) effectively suppresses CSA/CSR in HF, but few trials have been performed in patients with coexisting OSA and CSA/CSR. Our objective was to evaluate a randomized, controlled trial to compare the efficacy of ASV and CPAP in reducing breathing disturbances and improving cardiac parameters in patients with HF and coexisting sleep-disordered breathing.
425. Effect of combined remote ischemic preconditioning and postconditioning on pulmonary function in valvular heart surgery.
作者: Jong-Chan Kim.;Jae-Kwang Shim.;Sak Lee.;Young-Chul Yoo.;So-Young Yang.;Young-Lan Kwak.
来源: Chest. 2012年142卷2期467-475页
The aim of this study was to evaluate the lung-protective effect of combined remote ischemic preconditioning (RIPCpre) and postconditioning (RIPCpost) in patients undergoing complex valvular heart surgery.
426. The efficacy and safety of the novel long-acting β2 agonist vilanterol in patients with COPD: a randomized placebo-controlled trial.
作者: Nicola A Hanania.;Gregory Feldman.;Wolfgang Zachgo.;Jae-Jeong Shim.;Courtney Crim.;Lisa Sanford.;Sally Lettis.;Frank Barnhart.;Brett Haumann.
来源: Chest. 2012年142卷1期119-127页
Vilanterol (GW642444M) (VI) is a novel, inhaled, long-acting β(2) agonist with inherent 24-h activity under development as a once-daily combination therapy with an inhaled corticosteroid for COPD and asthma. This study assessed the dose response, efficacy, and safety of VI at doses of 3 to 50 μg in patients with moderate to severe COPD.
427. The association between a Darc gene polymorphism and clinical outcomes in African American patients with acute lung injury.
作者: Kirsten Neudoerffer Kangelaris.;Anil Sapru.;Carolyn S Calfee.;Kathleen D Liu.;Ludmila Pawlikowska.;John S Witte.;Eric Vittinghoff.;Hanjing Zhuo.;Andrew D Auerbach.;Elad Ziv.;Michael A Matthay.; .
来源: Chest. 2012年141卷5期1160-1169页
Acute lung injury (ALI) mortality is increased among African Americans compared with Americans of European descent, and genetic factors may be involved. A functional T-46C polymorphism (rs2814778) in the promoter region of Duffy antigen/receptor for chemokines (Darc) gene, present almost exclusively in people of African descent, results in isolated erythrocyte DARC deficiency and has been implicated in ALI pathogenesis in preclinical and murine models, possibly because of an increase in circulating Duffy-binding, proinflammatory chemokines like IL-8. We sought to determine the effect of the functional rs2814778 polymorphism, C/C genotype (Duffy null state), on clinical outcomes in African Americans with acute lung injury.
428. Questionnaires and pocket spirometers provide an alternative approach for COPD screening in the general population.
作者: Steven B Nelson.;Lisa M LaVange.;Yonghong Nie.;John W Walsh.;Paul L Enright.;Fernando J Martinez.;David M Mannino.;Byron M Thomashow.
来源: Chest. 2012年142卷2期358-366页
In response to the Agency for Healthcare Research and Quality statement questioning the usefulness of “screening spirometry,” the National Heart, Lung, and Blood Institute and the COPD Foundation held a consensus conference in June 2008 to establish a procedure to detect cases of COPD in the general population. Conference participants developed a three-stage approach, using a brief questionnaire, peak flow measurement with a pocket spirometer, and diagnostic quality spirometry. The overall objective of this study was to examine the usefulness of a simple questionnaire and peak flow measurement in screening for COPD in a self-selected population. We hypothesized that this combination would efficiently screen for clinically relevant COPD.
429. Randomized clinical trial of endobronchial ultrasound needle biopsy with and without aspiration.
作者: Roberto F Casal.;Gregg A Staerkel.;David Ost.;Francisco A Almeida.;Mateen H Uzbeck.;George A Eapen.;Carlos A Jimenez.;Graciela M Nogueras-Gonzalez.;Mona Sarkiss.;Rodolfo C Morice.
来源: Chest. 2012年142卷3期568-573页
Endobronchial ultrasound (EBUS)-guided transbronchial needle aspiration (EBUS-TBNA) is performed with a dedicated 22- or 21-gauge needle while suction is applied. Fine-needle sampling without suction (capillary sampling) has been studied for endoscopic ultrasound and for biopsies at various body sites and has resulted in similar diagnostic yield and fewer traumatic samples. However, the role of EBUS-guided transbronchial needle capillary sampling (EBUS-TBNCS) is still to be determined.
430. Correlation of cough with disease activity and treatment with cyclophosphamide in scleroderma interstitial lung disease: findings from the Scleroderma Lung Study.
作者: Arthur C Theodore.;Chi-Hong Tseng.;Ning Li.;Robert M Elashoff.;Donald P Tashkin.
来源: Chest. 2012年142卷3期614-621页
Cough is a significant symptom in patients with scleroderma interstitial lung disease (SSc-ILD), affecting 73% of the 158 patients enrolled in the Scleroderma Lung Study (SLS), a multicenter randomized trial of oral cyclophosphamide (CYC) vs placebo (PLA) in patients with active interstitial lung disease.
431. Macrolide antibiotics and survival in patients with acute lung injury.
Animal models suggest that immunomodulatory properties of macrolide antibiotics have therapeutic value for patients with acute lung injury (ALI). We investigated the association between receipt of macrolide antibiotics and clinical outcomes in patients with ALI.
432. The effects of a "new" walking aid on exercise performance in patients with COPD: a randomized crossover trial.
作者: Anouk W Vaes.;Janneke Annegarn.;Kenneth Meijer.;Martijn W J Cuijpers.;Frits M E Franssen.;Jozé Wiechert.;Emiel F M Wouters.;Martijn A Spruit.
来源: Chest. 2012年141卷5期1224-1232页
Generally, the use of a rollator improves mobility in patients with COPD. Nevertheless, not all patients benefit from its use, and many patients feel embarrassed about using it. Therefore, other walking aids are worthwhile to consider. We compared the direct effects of a "new" ambulation aid (a modern draisine) with the effects of a rollator on 6-min walk distance (6MWD) in patients with COPD.
433. Functional and muscular effects of neuromuscular electrical stimulation in patients with severe COPD: a randomized clinical trial.
作者: Isabelle Vivodtzev.;Richard Debigaré.;Philippe Gagnon.;Vincent Mainguy.;Didier Saey.;Annie Dubé.;Marie-Ève Paré.;Marthe Bélanger.;François Maltais.
来源: Chest. 2012年141卷3期716-725页
The mechanisms through which neuromuscular electrical stimulation (NMES) training may improve limb muscle function and exercise tolerance in COPD are poorly understood. We investigated the functional and muscular effects of NMES in advanced COPD.
434. Oxygen uptake efficiency plateau best predicts early death in heart failure.
The responses of oxygen uptake efficiency (ie, oxygen uptake/ventilation = VO(2)/VE) and its highest plateau (OUEP) during incremental cardiopulmonary exercise testing (CPET) in patients with chronic left heart failure (HF) have not been previously reported. We planned to test the hypothesis that OUEP during CPET is the best single predictor of early death in HF.
435. A randomized primary care trial of steroid titration against mannitol in persistent asthma: STAMINA trial.
作者: Brian J Lipworth.;Philip M Short.;Peter A Williamson.;Karine L Clearie.;Thomas C Fardon.;Cathy M Jackson.
来源: Chest. 2012年141卷3期607-615页
We compared titrating inhaled corticosteroid (ICS) against mannitol airway hyperresponsiveness (AHR) or a reference strategy (control) based on symptoms, reliever use, and lung function in primary care.
436. Acute effects of salmeterol and fluticasone propionate alone and in combination on airway blood flow in patients with asthma.
The airway contains airway smooth muscle and airway vascular smooth muscle. The acute effects of inhaled long-acting β(2)-adrenergic agonists (LABAs) alone, or in combination with an inhaled glucocorticoid (ICS), on airway smooth muscle tone in asthma are known; however, to the best of our knowledge, their effect on airway vascular smooth muscle tone has not been investigated previously. The objective of this study was to investigate the immediate effects of a LABA and an ICS alone and in combination on airway blood flow (Qaw) as an index of airway vascular smooth muscle tone in patients with stable asthma.
437. Effects of nebulized bronchodilator therapy on heart rate and arrhythmias in critically ill adult patients.
作者: Fahim M Khorfan.;Patricia Smith.;Sandra Watt.;Kimberly R Barber.
来源: Chest. 2011年140卷6期1466-1472页
Tachycardia and tachyarrhythmias are associated with increased morbidity and mortality in adult patients in the ICU. This study examines the effects of nebulized bronchodilator therapy (albuterol and ipratropium) on heart rate and arrhythmias in this population and tests the proposition that levalbuterol is safer than albuterol in that regard.
438. Race and sex differences in response to endothelin receptor antagonists for pulmonary arterial hypertension.
作者: Nicole B Gabler.;Benjamin French.;Brian L Strom.;Ziyue Liu.;Harold I Palevsky.;Darren B Taichman.;Steven M Kawut.;Scott D Halpern.
来源: Chest. 2012年141卷1期20-26页
Recently studied therapies for pulmonary arterial hypertension (PAH) have improved outcomes among populations of patients, but little is known about which patients are most likely to respond to specific treatments. Differences in endothelin-1 biology between sexes and between whites and blacks may lead to differences in patients' responses to treatment with endothelin receptor antagonists (ERAs).
439. A randomized trial to improve communication about end-of-life care among patients with COPD.
作者: David H Au.;Edmunds M Udris.;Ruth A Engelberg.;Paula H Diehr.;Christopher L Bryson.;Lynn F Reinke.;J Randall Curtis.
来源: Chest. 2012年141卷3期726-735页
Patients with COPD consistently express a desire to discuss end-of-life care with clinicians, but these discussions rarely occur. We assessed whether an intervention using patient-specific feedback about preferences for discussing end-of-life care would improve the occurrence and quality of communication between patients with COPD and their clinicians.
440. Efficacy of aclidinium bromide 400 μg twice daily compared with placebo and tiotropium in patients with moderate to severe COPD.
作者: Rainard Fuhr.;Helgo Magnussen.;Kristina Sarem.;Anna Ribera Llovera.;Anne-Marie Kirsten.;Meritxell Falqués.;Cynthia F Caracta.;Esther Garcia Gil.
来源: Chest. 2012年141卷3期745-752页
The efficacy and safety of aclidinium bromide bid, a novel, long-acting, muscarinic antagonist, was assessed in patients with moderate to severe COPD.
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