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4281. Comparison of a standard regimen (CHOP) with three intensive chemotherapy regimens for advanced non-Hodgkin's lymphoma.
作者: R I Fisher.;E R Gaynor.;S Dahlberg.;M M Oken.;T M Grogan.;E M Mize.;J H Glick.;C A Coltman.;T P Miller.
来源: N Engl J Med. 1993年328卷14期1002-6页
CHOP is a first-generation, combination-chemotherapy regimen consisting of cyclophosphamide, doxorubicin, vincristine, and prednisone that has cured approximately 30 percent of patients with advanced stages of intermediate-grade or high-grade non-Hodgkin's lymphoma in national cooperative-group trials. However, studies at single institutions have suggested that 55 to 65 percent of such patients might be cured by third-generation regimens such as ones consisting of low-dose methotrexate with leucovorin rescue, bleomycin, doxorubicin, cyclophosphamide, vincristine, and dexamethasone (m-BACOD); prednisone, doxorubicin, cyclophosphamide, and etoposide, followed by cytarabine, bleomycin, vincristine, and methotrexate with leucovorin rescue (ProMACE-CytaBOM); and methotrexate with leucovorin rescue, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin (MACOP-B).
4282. Single-drug therapy for hypertension in men. A comparison of six antihypertensive agents with placebo. The Department of Veterans Affairs Cooperative Study Group on Antihypertensive Agents.
作者: B J Materson.;D J Reda.;W C Cushman.;B M Massie.;E D Freis.;M S Kochar.;R J Hamburger.;C Fye.;R Lakshman.;J Gottdiener.
来源: N Engl J Med. 1993年328卷13期914-21页
Characteristics such as age and race are often cited as determinants of the response of blood pressure to specific antihypertensive agents, but this clinically important issue has not been examined in sufficiently large trials, involving all standard treatments, to determine the effect of such factors.
4283. Quality of life and antihypertensive therapy in men. A comparison of captopril with enalapril. The Quality-of-Life Hypertension Study Group.
We conducted a multicenter trial comparing two angiotensin-converting-enzyme inhibitors to determine whether effects on quality of life during antihypertensive therapy are uniform within this pharmacologic class of agents, and to relate the effects of the drugs on quality of life to objective adverse events, such as the loss of a job or the death of a spouse.
4284. Randomized comparison of surveillance intervals after colonoscopic removal of newly diagnosed adenomatous polyps. The National Polyp Study Workgroup.
作者: S J Winawer.;A G Zauber.;M J O'Brien.;M N Ho.;L Gottlieb.;S S Sternberg.;J D Waye.;J Bond.;M Schapiro.;E T Stewart.
来源: N Engl J Med. 1993年328卷13期901-6页
The identification and removal of adenomatous polyps and post-polypectomy surveillance are considered to be important for the control of colorectal cancer. In current practice, the intervals between colonoscopies after polypectomy are variable, often a year long, and not based on data from randomized clinical trials. We sought to determine whether follow-up colonoscopy at three years would detect important colonic lesions as well as follow-up colonoscopy at both one and three years.
4286. Effects of stimulus intensity and electrode placement on the efficacy and cognitive effects of electroconvulsive therapy.
作者: H A Sackeim.;J Prudic.;D P Devanand.;J E Kiersky.;L Fitzsimons.;B J Moody.;M C McElhiney.;E A Coleman.;J M Settembrino.
来源: N Engl J Med. 1993年328卷12期839-46页
The efficacy of electroconvulsive therapy in major depression is established, but the importance of the electrical dosage and electrode placement in relation to efficacy and side effects is uncertain.
4287. The effect of varying levels of outdoor-air supply on the symptoms of sick building syndrome.
作者: R Menzies.;R Tamblyn.;J P Farant.;J Hanley.;F Nunes.;R Tamblyn.
来源: N Engl J Med. 1993年328卷12期821-7页
The sick building syndrome is the term given to a constellation of symptoms reported by workers in modern office buildings, hypothesized to occur when the supply of outdoor air is reduced, because of the accumulation of contaminants arising from within the building. We undertook this study to determine the effect of changing the supply of outdoor air in four office buildings on the symptoms reported by workers and their perception of the indoor environment.
4288. Tacrine in Alzheimer's disease.4289. Tacrine in Alzheimer's disease.4291. The effects of treatment with interleukin-1 alpha on platelet recovery after high-dose carboplatin.
作者: J W Smith.;D L Longo.;W G Alvord.;J E Janik.;W H Sharfman.;B L Gause.;B D Curti.;S P Creekmore.;J T Holmlund.;R G Fenton.
来源: N Engl J Med. 1993年328卷11期756-61页
Thrombocytopenia is a frequent side effect of cancer chemotherapy and commonly limits attempts to escalate drug doses. To determine whether interleukin-1 alpha could ameliorate carboplatin-induced thrombocytopenia, we combined it with high-dose carboplatin in 43 patients with advanced neoplasms.
4292. Cardioversion from atrial fibrillation without prolonged anticoagulation with use of transesophageal echocardiography to exclude the presence of atrial thrombi.
作者: W J Manning.;D I Silverman.;S P Gordon.;H M Krumholz.;P S Douglas.
来源: N Engl J Med. 1993年328卷11期750-5页
Because atrial thrombi are poorly detected by conventional noninvasive techniques such as transthoracic echocardiography, patients with prolonged atrial fibrillation usually receive several weeks of oral anticoagulation therapy before cardioversion is attempted. We wondered whether transesophageal echocardiography, an accurate method of detecting atrial thrombi, would allow early cardioversion to be performed safely if no thrombi were identified.
4293. A comparison of management patterns after acute myocardial infarction in Canada and the United States. The SAVE investigators.
作者: J L Rouleau.;L A Moyé.;M A Pfeffer.;J M Arnold.;V Bernstein.;T E Cuddy.;G R Dagenais.;E M Geltman.;S Goldman.;D Gordon.
来源: N Engl J Med. 1993年328卷11期779-84页
There are major differences in the organization of the health care systems in Canada and the United States. We hypothesized that these differences may be accompanied by differences in patient care.
4296. Immediate angioplasty compared with the administration of a thrombolytic agent followed by conservative treatment for myocardial infarction. The Mayo Coronary Care Unit and Catheterization Laboratory Groups.
作者: R J Gibbons.;D R Holmes.;G S Reeder.;K R Bailey.;M R Hopfenspirger.;B J Gersh.
来源: N Engl J Med. 1993年328卷10期685-91页
Immediate angioplasty and the administration of a thrombolytic agent followed by conservative treatment are two approaches to the management of acute myocardial infarction, but these methods have not been compared prospectively.
4297. A comparison of immediate coronary angioplasty with intravenous streptokinase in acute myocardial infarction.
作者: F Zijlstra.;M J de Boer.;J C Hoorntje.;S Reiffers.;J H Reiber.;H Suryapranata.
来源: N Engl J Med. 1993年328卷10期680-4页
Despite the widespread use of intravenous thrombolytic therapy and of immediate percutaneous transluminal coronary angioplasty for the treatment of acute myocardial infarction, randomized comparisons of the two approaches to reperfusion are lacking. We report the results of a prospective, randomized trial comparing immediate coronary angioplasty (without previous thrombolytic therapy) with intravenous streptokinase treatment.
4298. A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. The Primary Angioplasty in Myocardial Infarction Study Group.
作者: C L Grines.;K F Browne.;J Marco.;D Rothbaum.;G W Stone.;J O'Keefe.;P Overlie.;B Donohue.;N Chelliah.;G C Timmis.
来源: N Engl J Med. 1993年328卷10期673-9页
The success of thrombolytic therapy for acute myocardial infarction is limited by bleeding complications, the impossibility of reperfusing all occluded coronary arteries, recurrent myocardial ischemia, and the relatively small number of patients who are appropriate candidates for this therapy. We hypothesized that these problems could be overcome by the use of immediate percutaneous transluminal coronary angioplasty (PTCA), without previous thrombolytic therapy.
4299. Effects of walnuts on serum lipid levels and blood pressure in normal men.
作者: J Sabaté.;G E Fraser.;K Burke.;S F Knutsen.;H Bennett.;K D Lindsted.
来源: N Engl J Med. 1993年328卷9期603-7页
In a recent six-year follow-up study, we found that frequent consumption of nuts was associated with a reduced risk of ischemic heart disease. To explore possible explanations for this finding, we studied the effects of nut consumption on serum lipids and blood pressure.
4300. Unrealistic expectations in the diagnosis and treatment of ovarian cancer.
作者: M A Friedman.;B A Chabner.;E L Trimble.;J Adams.;S G Arbuck.
来源: N Engl J Med. 1993年328卷9期664; author reply 664-5页 |