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401. Pilot feasibility study to determine the utility of direct access and quantitative magnetic resonance cholangiopancreatography (MRCP) in the assessment of suspected acute biliary or ductal gallstone presentations.
作者: Alex Novak.;Anita Acharya.;Sally Beer.;Alexis Espinosa.;Giles Bond Smith.;Cyrene Saga.;Jane Andrews.;Adam Bailey.;Zahir Soonawalla.;Helen Bungay.;Michael Pavlides.
来源: BMC Gastroenterol. 2025年25卷1期72页
Patients with suspected acute gallstone disease typically undergo abdominal ultrasound. MRCP is often used for patients with abnormal LFTs, potentially making ultrasound unnecessary for this group. Despite high inter-reader variability in MRCP interpretation, new AI technologies may automate and standardize detection and measurement.
402. Global prevalence of Fusobacterium nucleatum and Bacteroides fragilis in patients with colorectal cancer: an overview of case reports/case series and meta-analysis of prevalence studies.
作者: Fatemeh Sameni.;Parisa Abedi Elkhichi.;Ali Dadashi.;Mohammad Sadeghi.;Mehdi Goudarzi.;Maedeh Pourali Eshkalak.;Masoud Dadashi.
来源: BMC Gastroenterol. 2025年25卷1期71页
Colorectal cancer (CRC) is the second deadliest carcinoma across the globe and has been known as a multi-factor induced-disease. Emerging research have demonstrated that bacterial colonization may contribute to the initiation and promotion of the CRC. The presence of Fusobacterium nucleatum (F. nucleatum) and Bacteroides fragilis (B. fragilis) in the gut is associated with the development of CRC. In this study, the prevalence of F. nucleatum and B. fragilis among CRC patients has been assessed worldwide through a systematic review and meta-analysis.
403. Comparative study on different endoscopic submucosal dissection techniques for the treatment of superficial esophageal cancer and precancerous lesions.
作者: Shuanghong Jiang.;Zichen Luo.;Xiuyu Liu.;Haiyang Guo.;Yutong Cui.;Shiqi Liang.;Xinrui Chen.;Ji Zuo.;Xianfei Wang.
来源: BMC Gastroenterol. 2025年25卷1期73页
This study aims to compare the effectiveness and safety of traditional endoscopic submucosal dissection (ESD), endoscopic submucosal tunneling dissection (ESTD), and endoscopic submucosal dissection with C-shaped incision (ESD-C) in the treatment of superficial esophageal cancer and precancerous lesions, providing reference and guidance for the treatment of esophageal cancer.
404. Risk of Gastric Adenocarcinoma After Eradication of Helicobacter pylori.
作者: Anna-Klara Wiklund.;Giola Santoni.;Jane Yan.;Cecilia Radkiewicz.;Shaohua Xie.;Helgi Birgisson.;Eivind Ness-Jensen.;My von Euler-Chelpin.;Joonas H Kauppila.;Jesper Lagergren.
来源: Gastroenterology. 2025年
Helicobacter pylori infection of the stomach is the main risk factor for gastric noncardia adenocarcinoma; however, less is known on how eradication of H pylori influences the risk of this tumor over time, particularly in Western populations. The aim of this study was to delineate how the risk of gastric noncardia adenocarcinoma develops over time after H pylori eradication treatment in a Western population compared with the background population.
405. Early Dietary Fiber Intake Reduces Celiac Disease Risk in Genetically Prone Children: Insights From the TEDDY Study.
作者: Elin M Hård Af Segerstad.;Lazarus K Mramba.;Carin Andrén Aronsson.;Ulla Uusitalo.;Suvi M Virtanen.;Daniel Agardh.; .
来源: Gastroenterology. 2025年168卷6期1185-1188.e2页 406. Risk factors for Clostridioides difficile infection among patients diagnosed with inflammatory intestinal and rheumatological diseases in the biologic era.
作者: Helena Martínez-Lozano.;Paula Saralegui-Gonzalez.;Elena Reigadas.;Pablo Ramón Fueyo-Peláez.;Aurea García-García.;José Miranda-Bautista.;Luis Alcalá.;Juan Carlos Nieto.;María Elena Lobato-Matilla.;Ignacio Marín-Jiménez.;Patricia Muñoz.;Luis Menchén.
来源: BMC Gastroenterol. 2025年25卷1期70页
Clostridioides difficile infection (CDI) in inflammatory bowel disease (IBD) has been associated with poor clinical outcomes. The relationship between biologic therapy and CDI is controversial. We aimed to assess whether biologic therapy increases CDI risk among IBD patients, to identify factors associated with increased CDI risk, and to characterize CDI episodes in our population.
408. Efficacy analysis of folic acid in chronic atrophic gastritis with Helicobacter pylori infection: a systematic review and meta-analysis.
Current data indicate that supplements such as folic acid play a significant role in treating chronic atrophic gastritis (CAG). However, no meta-analysis article evaluates its efficacy comprehensively. Therefore, we conducted a meta-analysis to compare the effectiveness and safety of folic acid in the treatment of CAG with Helicobacter pylori (H. pylori) infection.
409. Blood pressure, gallstones, and age at first cholecystectomy in U.S. adults: a cross-sectional study.
Gallstones are a prevalent health issue. Recent studies have revealed that blood pressure (BP) may affect gallstone formation. This study assessed the association between hypertension (HTN) and both the prevalence of gallstones and the age at first cholecystectomy among U.S. adults.
410. The patient perspective on transanal irrigation treatment for low anterior resection syndrome after rectal cancer surgery - a qualitative and quantitative study.
作者: Boglarka Rethy.;Anna Schandl.;Caroline Nordenvall.;Gabriella Jansson Palmer.;Charlotta Bergström.;Maria Williamson.;Emil Pieniowski.;Asif Johar.;Pernilla Lagergren.;Mirna Abraham-Nordling.
来源: BMC Gastroenterol. 2025年25卷1期64页
The aim of the study was to explore long-term experiences of transanal irrigation (TAI) in patients with major low anterior resection syndrome (LARS).
411. Ultrasound radiomics-based logistic regression model for fibrotic NASH.
作者: Fei Xia.;Wei Wei.;Junli Wang.;Yuhe Wang.;Kun Wang.;Chaoxue Zhang.;Qiwei Zhu.
来源: BMC Gastroenterol. 2025年25卷1期66页
Those who have severe fibrosis (F2 ≥ 2 stage) are at the greatest risk for the advancement of the illness among non-alcoholic fatty liver patients. To forecast the non-alcoholic steatohepatitis (NASH) probability accompanied by significant fibrosis, we propose to develop and validate a nomogram liver imaging reporting and data system, providing robust evidence for preventing and treating clinical liver diseases.
412. Therapeutic effects of reduced glutathione on liver function, fibrosis, and HBV DNA clearance in chronic hepatitis B patients.
To evaluate the therapeutic impact of reduced glutathione combined with entecavir on liver function, fibrosis, and HBV-DNA clearance in chronic hepatitis B patients.
413. A comprehensive analysis of percutaneous liver biopsy characteristics and pathological manifestations in a large patient cohort (2009-2024).
This study aimed to analyze the characteristics of patients undergoing percutaneous liver biopsies and investigate the pathological manifestations of four major liver diseases across different age groups.
414. Aberrant SNHG expression predicts poor prognosis in esophageal cancer using meta-analysis and bioinformatics analysis.
作者: Ke Shi.;Li-De Huang.;Dan Li.;Wei-Min Luo.;Hua-Song Liu.;Dong-Xiao Ding.;Qiang Guo.;Yue-Feng Liu.
来源: BMC Gastroenterol. 2025年25卷1期63页
Small nucleolar RNA host gene (SNHG) family were reported involved in various biological processes and may be used as a promising prognostic marker in esophageal cancer (EC). A meta-analysis was performed to investigate the relationship between SNHG expression and prognosis of EC in this study.
415. Clinical risk factors for sarcopenia in acute and chronic pancreatitis.
作者: Mitchell L Ramsey.;Andrew Lu.;Kristyn Gumpper-Fedus.;Stacey Culp.;David Bradley.;Darwin L Conwell.;Zobeida Cruz-Monserrate.;J Royce Groce.;Samuel Han.;Somashekar G Krishna.;Peter Lee.;Thomas Mace.;Georgios I Papachristou.;Kristen M Roberts.;Zarine K Shah.;Phil A Hart.
来源: BMC Gastroenterol. 2025年25卷1期60页
Sarcopenia is common in chronic pancreatitis (CP) and has been associated with unfavorable outcomes; however, it is not well studied in acute pancreatitis (AP).
416. Machine learning-based plasma metabolomics for improved cirrhosis risk stratification.
作者: Jingru Song.;Ziwei Gao.;Liqun Lai.;Jie Zhang.;Binbin Liu.;Yi Sang.;Siqi Chen.;Jiachen Qi.;Yujun Zhang.;Huang Kai.;Wei Ye.
来源: BMC Gastroenterol. 2025年25卷1期61页
Cirrhosis is a leading cause of mortality in patients with chronic liver disease (CLD). The rapid development of metabolomic technologies has enabled the capture of metabolic changes related to the progression of cirrhosis.
417. The serum hepcidin and the hepcidin/ferritin ratio in NAFLD: a systematic review and meta-analysis.
作者: Jingmin Song.;Heqing Wang.;Xiaolian Gao.;Fen Yang.;Xinhong Zhu.;Guiyuan Qiao.;Ting Gan.;Junxiu Tao.
来源: BMC Gastroenterol. 2025年25卷1期62页
Non-alcoholic fatty liver disease (NAFLD) is a spectrum of chronic liver diseases characterized by hepatic steatosis exceeding 5% in the absence of alcohol and other liver-damaging factors. Clinical studies have identified a potential link between abnormal iron metabolism and the high incidence of NAFLD; however, the results from clinical trials remain inconsistent. This meta-analysis aims to compare serum hepcidin levels and the hepcidin/ferritin ratio between adults with NAFLD and those without to explore their potential relationship with NAFLD.
418. Short-term endoscopic alterations of early gastric cancer after successful eradication of Helicobacter pylori.
作者: Xiaohan Yan.;Jingze Li.;Zehua Zhang.;Bensong Duan.;Meidong Xu.;Qinwei Xu.
来源: BMC Gastroenterol. 2025年25卷1期59页
Detecting and demarcating early gastric cancers (EGC) after eradication therapy of Helicobacter pylori (H. pylori) is a challenging task due to the fact that the lesion's surface is covered with gastritis-like tissue (non-neoplastic epithelium covering the cancerous tissue). However, our study aimed to investigate the endoscopic alterations of EGC within 3 months after eradication, which has not been reported clearly yet.
419. A foundation systematic review of natural language processing applied to gastroenterology & hepatology.
作者: Matthew Stammers.;Balasubramanian Ramgopal.;Abigail Owusu Nimako.;Anand Vyas.;Reza Nouraei.;Cheryl Metcalf.;James Batchelor.;Jonathan Shepherd.;Markus Gwiggner.
来源: BMC Gastroenterol. 2025年25卷1期58页
This review assesses the progress of NLP in gastroenterology to date, grades the robustness of the methodology, exposes the field to a new generation of authors, and highlights opportunities for future research.
420. Emodin protects against severe acute pancreatitis-associated acute lung injury by activating Nrf2/HO-1/GPX4 signal and inhibiting ferroptosis in vivo and in vitro.
作者: Gang Shen.;Haiyun Wen.;Huijuan Li.;Xuetao Zhang.;Bowen Lan.;Xuanchi Dong.;Peng Ge.;Yalan Luo.;Hailong Chen.
来源: BMC Gastroenterol. 2025年25卷1期57页
Severe acute pancreatitis (SAP) has high morbidity, a complicated and dangerous course, and many complications, including severe pulmonary complications. SAP-associated acute lung injury (SAP-ALI) is still a significant challenge for surgeons because of its high mortality. Therefore, more effective treatment methods are urgently needed. Emodin (EMO) has shown tremendous potential in treating many refractory diseases. However, its protection mechanism in SAP-ALI needs to be further clarified. This study was undertaken to investigate the protective effects of EMO against lung injury in SAP rats and alveolar epithelial cells, with a particular focus on the classical ferroptosis pathway.
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