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401. Patients with obstructive sleep apnea syndrome benefit from acetazolamide during an altitude sojourn: a randomized, placebo-controlled, double-blind trial.
作者: Yvonne Nussbaumer-Ochsner.;Tsogyal D Latshang.;Silvia Ulrich.;Malcolm Kohler.;Robert Thurnheer.;Konrad E Bloch.
来源: Chest. 2012年141卷1期131-138页
Many patients with obstructive sleep apnea syndrome (OSA) are unable or unwilling to use continuous positive airway pressure (CPAP) therapy when traveling to the mountains for work or recreation even though they risk pronounced hypoxemia and exacerbation of sleep apnea. Because the treatment of OSA at altitude has not been established, we tested the hypothesis that acetazolamide improves hypoxemia, sleep, and breathing disturbances in otherwise untreated patients with OSA at altitude.
402. Fluticasone/Salmeterol combination confers benefits in people with asthma who smoke.
作者: Karine L Clearie.;Lorna McKinlay.;Peter A Williamson.;Brian J Lipworth.
来源: Chest. 2012年141卷2期330-338页
Smoking induces airway inflammation and relative resistance to inhaled steroids. The objective of this study was to evaluate the effects on airway hyperresponsiveness of adding salmeterol to fluticasone vs doubling the dose of fluticasone in patients with asthma who smoked and patients with asthma who did not smoke.
403. Noninvasive ventilation in COPD: impact of inspiratory pressure levels on sleep quality.
作者: Michael Dreher.;Emelie Ekkernkamp.;Stephan Walterspacher.;David Walker.;Claudia Schmoor.;Jan H Storre.;Wolfram Windisch.
来源: Chest. 2011年140卷4期939-945页
Although high-intensity noninvasive positive pressure ventilation (HI-NPPV) is superior to low-intensity noninvasive positive pressure ventilation (LI-NPPV) in controlling nocturnal hypoventilation in stable hypercapnic patients with COPD, it produces higher amounts of air leakage, which, in turn, could impair sleep quality. Therefore, the present study assessed the difference in sleep quality during HI-NPPV and LI-NPPV.
404. Long-term treatment with sildenafil citrate in pulmonary arterial hypertension: the SUPER-2 study.
作者: Lewis J Rubin.;David B Badesch.;Thomas R Fleming.;Nazzareno Galiè.;Gerald Simonneau.;Hossein A Ghofrani.;Michael Oakes.;Gary Layton.;Marjana Serdarevic-Pehar.;Vallerie V McLaughlin.;Robyn J Barst.; .
来源: Chest. 2011年140卷5期1274-1283页
The long-term safety and tolerability of sildenafil treatment of pulmonary arterial hypertension (PAH) were assessed.
405. Providing coaching and cotinine results to preteens to reduce their secondhand smoke exposure: a randomized trial.
作者: Melbourne F Hovell.;Dennis R Wahlgren.;Sandy Liles.;Jennifer A Jones.;Suzanne C Hughes.;Georg E Matt.;Ming Ji.;Christina N Lessov-Schlaggar.;Gary E Swan.;Dale Chatfield.;Ding Ding.
来源: Chest. 2011年140卷3期681-689页
Secondhand smoke exposure (SHSe) poses health risks to children living with smokers. Most interventions to protect children from SHSe have coached adult smokers. This trial determined whether coaching and cotinine feedback provided to preteens can reduce their SHSe.
406. Bleeding risk in patients with atrial fibrillation: the AMADEUS study.
作者: Deirdre A Lane.;Pieter W Kamphuisen.;Pascal Minini.;Harry R Büller.;Gregory Y H Lip.
来源: Chest. 2011年140卷1期146-155页
This study aimed to assess the impact of combination antithrombotic therapy on stroke and bleeding risk compared with anticoagulation therapy only in patients with atrial fibrillation (AF).
407. The effect of simulated obstructive apnea and hypopnea on aortic diameter and BP.
作者: Anne-Christin Stöwhas.;Mehdi Namdar.;Patric Biaggi.;Erich W Russi.;Konrad E Bloch.;John R Stradling.;Malcolm Kohler.
来源: Chest. 2011年140卷3期675-680页
Preliminary evidence supports an association between obstructive sleep apnea (OSA) and thoracic aortic dilatation. The mechanisms through which OSA may promote thoracic aortic dilatation are incompletely understood. Therefore, we studied the acute effects of simulated apnea and hypopnea on aortic diameter and BP in humans.
408. Delay in recognition of pulmonary arterial hypertension: factors identified from the REVEAL Registry.
作者: Lynette M Brown.;Hubert Chen.;Scott Halpern.;Darren Taichman.;Michael D McGoon.;Harrison W Farber.;Adaani E Frost.;Theodore G Liou.;Michelle Turner.;Kathy Feldkircher.;Dave P Miller.;C Gregory Elliott.
来源: Chest. 2011年140卷1期19-26页
Pulmonary arterial hypertension (PAH) is a progressive and fatal disorder. Despite the emergence of effective therapy, PAH is commonly at an advanced stage when recognized. Factors associated with a prolonged symptomatic period before the recognition of PAH have not been fully evaluated.
409. Long-term safety and efficacy of indacaterol, a long-acting β₂-agonist, in subjects with COPD: a randomized, placebo-controlled study.
作者: Kenneth R Chapman.;Stephen I Rennard.;Angeli Dogra.;Roger Owen.;Cheryl Lassen.;Benjamin Kramer.; .
来源: Chest. 2011年140卷1期68-75页
Indacaterol is an inhaled, long-acting β(2)-agonist providing 24-h bronchodilation with once-daily dosing in patients with COPD.
410. Evaluation of the total face mask for noninvasive ventilation to treat acute respiratory failure.
作者: Aylin Ozsancak.;Samy S Sidhom.;Timothy N Liesching.;William Howard.;Nicholas S Hill.
来源: Chest. 2011年139卷5期1034-1041页
We hypothesized that the total face mask (TFM) would be perceived as more comfortable than a standard oronasal mask (ONM) by patients receiving noninvasive mechanical ventilation (NIV) therapy for acute respiratory failure (ARF) and would be quicker to apply by respiratory therapists.
411. Predictors of symptoms are different from predictors of severe exacerbations from asthma in children.
作者: Ann Chen Wu.;Kelan Tantisira.;Lingling Li.;Brooke Schuemann.;Scott T Weiss.;Anne L Fuhlbrigge.; .
来源: Chest. 2011年140卷1期100-107页
Asthma therapy is typically prescribed and titrated based on patient or parent self-report of symptoms. No longitudinal studies have assessed the relationship between symptoms and severe asthma exacerbations in children. The goal of our study was (1) to assess the association of asthma symptoms with severe asthma exacerbations and (2) to compare predictors of persistent asthma symptoms and predictors of severe asthma exacerbations.
412. Comparison of the effect of low-dose ciclesonide and fixed-dose fluticasone propionate and salmeterol combination on long-term asthma control.
Patients with mild persistent asthma constitute about 70% of the asthma population; thus, it is important to know which first-line treatment is best for the management of mild asthma. We compared benefits of first-line treatment with ciclesonide and a combination of fluticasone and salmeterol in patients with mild asthma.
413. COPD and air travel: oxygen equipment and preflight titration of supplemental oxygen.
作者: Aina Akerø.;Anne Edvardsen.;Carl C Christensen.;Jan O Owe.;Morten Ryg.;Ole H Skjønsberg.
来源: Chest. 2011年140卷1期84-90页
Patients with COPD may need supplemental oxygen during air travel to avoid development of severe hypoxemia. The current study evaluated whether the hypoxia-altitude simulation test (HAST), in which patients breathe 15.1% oxygen simulating aircraft conditions, can be used to establish the optimal dose of supplemental oxygen. Also, the various types of oxygen-delivery equipment allowed for air travel were compared.
414. Rapid on-site evaluation of transbronchial aspirates in the diagnosis of hilar and mediastinal adenopathy: a randomized trial.
作者: Rocco Trisolini.;Alessandra Cancellieri.;Carmine Tinelli.;Daniela Paioli.;Luigia Scudeller.;Gian Piero Casadei.;Sergio Forti Parri.;Vanina Livi.;Arrigo Bondi.;Maurizio Boaron.;Marco Patelli.
来源: Chest. 2011年139卷2期395-401页
Rapid on-site evaluation (ROSE) of transbronchial needle aspirates has long been used during flexible bronchoscopy, but its usefulness in the diagnosis of hilar and mediastinal adenopathy is controversial. The aim of the present study was to evaluate the extent to which ROSE can be valuable in patients undergoing transbronchial needle aspiration (TBNA) for the diagnosis of hilar and mediastinal adenopathy.
415. The effect of supplemental oxygen on hypercapnia in subjects with obesity-associated hypoventilation: a randomized, crossover, clinical study.
作者: Meme Wijesinghe.;Mathew Williams.;Kyle Perrin.;Mark Weatherall.;Richard Beasley.
来源: Chest. 2011年139卷5期1018-1024页
It is unknown whether oxygen therapy causes worsening hypercapnia in patients with obesity-associated hypoventilation (OAH), similar to the response observed in COPD. The objectives of this study were to investigate whether breathing 100% oxygen results in an increase in hypercapnia in patients with OAH and the mechanisms of any effect.
416. Effects of varenicline on smoking cessation in patients with mild to moderate COPD: a randomized controlled trial.
作者: Donald P Tashkin.;Stephen Rennard.;J Taylor Hays.;Wendy Ma.;David Lawrence.;Theodore C Lee.
来源: Chest. 2011年139卷3期591-599页
Smoking is the most important risk factor for COPD and accelerates its progression. Despite the health implications, a large proportion of patients with COPD continue to smoke, so finding effective smoking cessation interventions for this population is paramount. To our knowledge, this is the first randomized clinical trial to compare the efficacy and safety of varenicline tartrate vs placebo in smokers with mild to moderate COPD.
417. A randomized trial of parental behavioral counseling and cotinine feedback for lowering environmental tobacco smoke exposure in children with asthma: results of the LET'S Manage Asthma trial.
作者: Sandra R Wilson.;Harold J Farber.;Sarah B Knowles.;Philip W Lavori.
来源: Chest. 2011年139卷3期581-590页
Secondhand tobacco smoke exposure impairs the control of pediatric asthma. Evidence of the efficacy of interventions to reduce children's exposure and improve disease outcomes has been inconclusive.
418. Does a protective ventilation strategy reduce the risk of pulmonary complications after lung cancer surgery?: a randomized controlled trial.
作者: Mikyung Yang.;Hyun Joo Ahn.;Kwhanmien Kim.;Jie Ae Kim.;Chin A Yi.;Myung Joo Kim.;Hyo Jin Kim.
来源: Chest. 2011年139卷3期530-537页
Protective ventilation strategy has been shown to reduce ventilator-induced lung injury in patients with ARDS. In this study, we questioned whether protective ventilatory settings would attenuate lung impairment during one-lung ventilation (OLV) compared with conventional ventilation in patients undergoing lung resection surgery.
419. Number of lymph nodes harvested from a mediastinal lymphadenectomy: results of the randomized, prospective American College of Surgeons Oncology Group Z0030 trial.
作者: Gail E Darling.;Mark S Allen.;Paul A Decker.;Karla Ballman.;Richard A Malthaner.;Richard I Inculet.;David R Jones.;Robert J McKenna.;Rodney J Landreneau.;Joe B Putnam.
来源: Chest. 2011年139卷5期1124-1129页
Lymph node status is a major determinant of stage and survival in patients with lung cancer; however, little information is available about the expected yield of a mediastinal lymphadenectomy.
420. Effects of exercise on respiratory flow and sputum properties in patients with cystic fibrosis.
作者: Tiffany J Dwyer.;Jennifer A Alison.;Zoe J McKeough.;Evangelia Daviskas.;Peter T P Bye.
来源: Chest. 2011年139卷4期870-877页
The physiologic mechanisms by which exercise may clear secretions in subjects with cystic fibrosis (CF) are unknown. The purpose of this study was to compare ventilation, respiratory flow, and sputum properties following treadmill and cycle exercise with resting breathing (referred to as "control").
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