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401. Endoscopic therapy versus medical therapy for bleeding peptic ulcer with adherent clot: a meta-analysis.
作者: Charles J Kahi.;Dennis M Jensen.;Joseph J Y Sung.;Brian L Bleau.;Hye Kyung Jung.;George Eckert.;Thomas F Imperiale.
来源: Gastroenterology. 2005年129卷3期855-62页
The optimal management of bleeding peptic ulcer with adherent clot is controversial and may include endoscopic therapy or medical therapy.
403. Helicobacter pylori "test and treat" or endoscopy for managing dyspepsia: an individual patient data meta-analysis.
作者: Alexander C Ford.;Michelle Qume.;Paul Moayyedi.;Nicolaas L A Arents.;Annmarie T Lassen.;Richard F A Logan.;Kenneth E L McColl.;Paul Myres.;Brendan C Delaney.
来源: Gastroenterology. 2005年128卷7期1838-44页
Helicobacter pylori "test and treat" has been recommended for the management of young dyspeptic patients without alarm symptoms, and trials have suggested that it is as effective as endoscopy. However, none of these trials have had sufficient sample size to confirm that "test and treat" costs less or to detect small differences in effect. A collaborative group has prospectively registered trials comparing prompt endoscopy with a "test and treat" approach, with the aim of performing an individual patient data meta-analysis of both effect and resource utilization data.
404. Are claims of equivalency in digestive diseases trials supported by the evidence?
作者: Jill M Tinmouth.;Leah S Steele.;George Tomlinson.;Richard H Glazier.
来源: Gastroenterology. 2004年126卷7期1700-10页
Traditionally, randomized controlled trials (RCTs) have attempted to show the superiority of one intervention over another. However, when effective treatment already exists, it is sometimes more useful to prove that an intervention is equivalent, or at least not inferior, to the standard of care. Our aim was to determine whether claims of equivalency in digestive diseases trials are supported by the evidence.
405. Fecal DNA testing compared with conventional colorectal cancer screening methods: a decision analysis.
Fecal DNA testing is an emerging tool to detect colorectal cancer (CRC). Our aims were to estimate the clinical and economic consequences of fecal DNA testing vs. conventional CRC screening.
406. A meta-analysis of the placebo rates of remission and response in clinical trials of active Crohn's disease.
作者: Chinyu Su.;Gary R Lichtenstein.;Karen Krok.;Colleen M Brensinger.;James D Lewis.
来源: Gastroenterology. 2004年126卷5期1257-69页
Placebo-controlled, randomized clinical trials (PC-RCTs) are commonly used to assess therapies for Crohn's disease (CD). Knowledge of the placebo rates of remission and response and understanding of design factors that influence these rates is important for designing future clinical trials evaluating pharmacotherapy of CD. The aims of this study were to estimate rates of remission and response in patients with active CD receiving placebo and to identify factors influencing these rates.
407. Addition of a second endoscopic treatment following epinephrine injection improves outcome in high-risk bleeding ulcers.
作者: Xavier Calvet.;Mercedes Vergara.;Enric Brullet.;Javier P Gisbert.;Rafel Campo.
来源: Gastroenterology. 2004年126卷2期441-50页
Endoscopic therapy reduces the rebleeding rate, the need for surgery, and the mortality in patients with peptic ulcer and active bleeding or visible vessel. Injection of epinephrine is the most popular therapeutic method. Guidelines disagree on the need for a second hemostatic procedure immediately after epinephrine; although it seems to reduce further bleeding, its effects on morbidity, surgery rates, and mortality remain unclear. The aim of this study was to perform a systematic review and meta-analysis to determine whether the addition of a second procedure improves hemostatic efficacy and/or patient outcomes after epinephrine injection.
408. Prevalence of hepatitis C virus infection in B-cell non-Hodgkin's lymphoma: systematic review and meta-analysis.
作者: Javier P Gisbert.;Luisa García-Buey.;José María Pajares.;Ricardo Moreno-Otero.
来源: Gastroenterology. 2003年125卷6期1723-32页
The aim of our study was to conduct a systematic review of studies evaluating prevalence of hepatitis C virus (HCV) infection in B-cell non-Hodgkin's lymphoma (B-NHL) and to perform a meta-analysis of case-control studies comparing this prevalence with that of a reference group.
409. Meta-analysis of the relationship between cagA seropositivity and gastric cancer.
作者: Jia Qing Huang.;Ge Fan Zheng.;Katica Sumanac.;E Jan Irvine.;Richard H Hunt.
来源: Gastroenterology. 2003年125卷6期1636-44页
Reports in the literature regarding the relationship of infection with cagA -positive strains of Helicobacter pylori to gastric cancer over and above H. pylori infection alone are conflicting. The aim of this study was to estimate the magnitude of the risk for gastric cancer associated with cagA seropositivity and to identify any sources of heterogeneity between studies.
410. Emergency sclerotherapy versus vasoactive drugs for variceal bleeding in cirrhosis: a Cochrane meta-analysis.
作者: Gennaro D'Amico.;Giada Pietrosi.;Ilaria Tarantino.;Luigi Pagliaro.
来源: Gastroenterology. 2003年124卷5期1277-91页
Emergency sclerotherapy is used as a first-line therapy for variceal bleeding in cirrhosis, although pharmacologic treatment stops bleeding in most patients. We performed a meta-analysis comparing emergency sclerotherapy with pharmacologic treatment.
411. Protective association of aspirin/NSAIDs and esophageal cancer: a systematic review and meta-analysis.
作者: Douglas A Corley.;Karla Kerlikowske.;Rajiv Verma.;Patricia Buffler.
来源: Gastroenterology. 2003年124卷1期47-56页
Esophageal carcinomas have high fatality rates, making chemoprevention agents desirable. We performed a systematic review with meta-analysis of observational studies evaluating the association of aspirin/nonsteroidal anti-inflammatory drug (NSAID) use and esophageal cancer.
412. Are proton pump inhibitors the first choice for acute treatment of gastric ulcers? A meta analysis of randomized clinical trials.
Gastric ulcers are a frequent problem in the United States. Proton pump inhibitors have been shown to increase healing rates and improve clinical symptoms. The objective of this study is to compare gastric ulcer healing rates for patients treated with a proton pump inhibitor (PPI) (omeprazole, rabeprazole, pantoprazole, or lansoprazole), an histamine 2- receptor antagonist (ranitidine) or placebo.
413. Validity of randomized clinical trials in gastroenterology from 1964-2000.
作者: Lise L Kjaergard.;Sarah L Frederiksen.;Christian Gluud.
来源: Gastroenterology. 2002年122卷4期1157-60页
The internal validity of clinical trials depends on the adequacy of the reported methodological quality. We assessed the methodological quality of all 383 randomized clinical trials published in GASTROENTEROLOGY as original articles from 1964 to 2000.
414. Polymorphisms and colorectal tumor risk.
Increasingly, studies of the relationship between common genetic variants and colorectal tumor risk are being proposed. To assess the evidence that any of these confers a risk, a systematic review and meta-analysis of published studies was undertaken.
415. Octreotide for acute esophageal variceal bleeding: a meta-analysis.
作者: D A Corley.;J P Cello.;W Adkisson.;W F Ko.;K Kerlikowske.
来源: Gastroenterology. 2001年120卷4期946-54页
Studies of octreotide have not demonstrated a consistent benefit in efficacy or safety compared with conventional therapies. This study statistically pooled existing trials to evaluate the safety and efficacy of octreotide for esophageal variceal hemorrhage.
416. Very high risk of cancer in familial Peutz-Jeghers syndrome.
作者: F M Giardiello.;J D Brensinger.;A C Tersmette.;S N Goodman.;G M Petersen.;S V Booker.;M Cruz-Correa.;J A Offerhaus.
来源: Gastroenterology. 2000年119卷6期1447-53页
The Peutz-Jeghers syndrome (PJS) is an autosomal dominant polyposis disorder with increased risk of multiple cancers, but literature estimates of risk vary.
418. Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer.
Reports in the literature regarding the relationship of Helicobacter pylori infection to gastric cancer are conflicting. The aim of this study was to identify the source of heterogeneity between studies.
419. Mesalamine in the maintenance treatment of Crohn's disease: a meta-analysis adjusted for confounding variables.
The benefit of mesalamine for maintenance of remission in Crohn's disease is controversial. The aim of this study was to assess the effectiveness of mesalamine in maintaining remission of quiescent Crohn's disease.
420. Speed of healing and symptom relief in grade II to IV gastroesophageal reflux disease: a meta-analysis.
Esophagitis healing proportions are often incorrectly called the healing rate. The aim of this study was to compare different drug classes by expressing the speed of healing and symptom relief through a new approach.
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