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381. A risk prediction model for nausea and vomiting after TACE: a cross-sectional study.
It was found that 33.8-52.5% of patients experienced nausea and vomiting after Transcatheter Arterial Chemoembolization (TACE) for liver cancer, based on prior literature. But there are no models that predict this risk. In this study, we investigated the factors associated with nausea and vomiting after TACE and developed a predictive model to predict these adverse events.
382. Predictive accuracy of fecal calprotectin in assessing clinical activity and disease severity in patients with Ulcerative Colitis and Crohn's disease.
作者: Ankit V Jain.;Sandeep Gopal.;Anurag J Shetty.;Suresh Shenoy.;B V Tantry.;B Unnikrishnan.;Ramesh Holla.;Rishit Anand.
来源: BMC Gastroenterol. 2025年25卷1期429页
Inflammatory bowel disease (IBD) is an idiopathic disorder characterized by repeated relapses and remissions. Endoscopy, the gold standard for diagnosis and monitoring of these patients is time consuming, expensive, and invasive. Hence, faecal calprotectin (FCP) has been suggested as marker to determine the degree of intestinal inflammation and predict relapse in IBD.
383. Comparative serum imidazole propionate profiling in colorectal adenoma and cancer by UPLC-MS/MS.
作者: Jie Lv.;Qianqian Chen.;Lu Yang.;Jing Guan.;Sheng Wang.;Gen Gui.;Zhaoyun Yang.;Xu Wang.;Bin Sun.
来源: BMC Gastroenterol. 2025年25卷1期426页
The incidence of colorectal cancer (CRC) is increasing with colorectal adenomas recognized as key precancerous lesions. Emerging evidence suggests that Imidazole propionate (ImP), a metabolite of gut microbiota, is elevated in patients, indicating a potential role in tumorigenesis of CRC.
384. Global, regional, and national burden of inflammatory bowel disease in persons aged 60-89 years from 1992 to 2021.
作者: Zhou Zhang.;Na Du.;Chun-Mei Xu.;Wei Chen.; Ting-Ting-Chen.;Yu Xiao.
来源: BMC Gastroenterol. 2025年25卷1期425页
The global burden of inflammatory bowel disease (IBD) is increasing, but detailed data on older adults remain scarce.
385. Trends in incidence and mortality of early-onset gastrointestinal cancers: a comprehensive study.
Early-Onset Gastrointestinal Cancers concerns tumors in people under 50. Accumulating evidence suggests a significant increase in the burden of colorectal cancer in young adults. We investigated the global burden and spatiotemporal trends of the 6 major gastrointestinal (GI) cancers, including colon and rectum cancer (CRC), esophageal cancer (EC), gallbladder and biliary tract cancer (GBTC), liver cancer (LC), pancreatic cancer (PC), and stomach cancer (SC). in young adults, based on cancer-specific incidence and mortality.
386. Development and validation of a nomogram for predicting early recurrence in patients undergoing different courses of postoperative adjuvant transarterial chemoembolisation.
作者: Hongkun Tan.;Yuyan Xu.;Cheng Zhang.;Kaihang Zhong.;Yaohong Wen.;Chunming Wang.;Zhoubin Feng.;Jianan Feng.;Shunjun Fu.;Guolin He.;Lei Cai.;Mingxin Pan.
来源: BMC Gastroenterol. 2025年25卷1期422页
Hepatocellular carcinoma (HCC) is associated with a high rate of postoperative recurrence. Postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE) is effective in preventing recurrence. However, the effect of different courses of PA-TACE on tumor prognosis remains unclear. As such, this study aimed to develop and validate a nomogram that incorporates different courses of PA-TACE to predict early tumor recurrence.
387. Status of short videos as health information sources for chronic pancreatitis in China: a cross-sectional study.
Chronic pancreatitis is a chronic inflammatory disease of the pancreatic tissue caused by genetic or environmental factors; it has a complex etiology and is difficult to diagnose and treat clinically, severely affecting the physical and mental health of patients. Currently, the treatment of chronic pancreatitis often relies on lifelong self-health management by patients. However, the quality of videos related to chronic pancreatitis on short video platforms remains to be determined, and these videos may contain erroneous information that patients cannot recognize. This study aims to assess the quality of information in short videos related to chronic pancreatitis on the Chinese platforms TikTok and Bilibili.
388. Cholesterol-modified prognostic nutritional index as an independent prognostic biomarker in primary biliary cholangitis patients.
作者: Huiling Zhu.;Mengyao Zheng.;Wenbin Li.;Yaqin Huang.;Lili Zhang.;Wenting Yang.;Jinhui Yang.
来源: BMC Gastroenterol. 2025年25卷1期421页
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by inflammation of the interlobular bile ducts, often associated with malabsorption of fat-soluble vitamins and osteoporosis. Thus, evaluating the nutritional status of patients with PBC and implementing appropriate interventions are significant. But CPNI in determining the nutritional status and forecasting survival outcome among patients with PBC remains unclear.
389. Effectiveness of an app-based walking program for obese patients with inflammatory bowel disease in Korea: a single-blind parallel-group randomized clinical trial.
作者: Young Jin Lee.;Eun Ja Kwon.;Da-In Park.;Sang Hyoung Park.;Sung Wook Hwang.;Byong Duk Ye.
来源: BMC Gastroenterol. 2025年25卷1期417页
Obesity in patients with inflammatory bowel disease (IBD) not only exacerbates symptoms but also interferes with treatment and leads to additional complications. Therefore, managing weight loss and preventing obesity are crucial. This study was designed to develop and implement a 10-week walking exercise program, facilitated by a mobile application, to evaluate its effectiveness in managing weight in obese IBD patients.
390. Helicobacter pylori is associated with less tumor-infiltrating lymphocytes and a poor prognosis in gastric cancer.
作者: Zetian Chen.;Zhijun Zhang.;Hongxin Huang.;Chen Lu.;Qingya Li.;Mengpei Yan.;Chengjun Zhu.;Sen Wang.;Hongda Liu.;Zekuan Xu.;Zheng Li.
来源: BMC Gastroenterol. 2025年25卷1期420页
Helicobacter pylori (H. pylori) is carcinogenic and has the potential to cause progressive gastric lesions and gastric cancer (GC), which also represents one of the essential constituents of the tumor microenvironment (TME) of GC. The infiltration and functional status of tumor-infiltrating lymphocytes (TILs) in the TME affect the anti-tumor function of the body. However, the impact of H. pylori on anti-tumor immunity and prognosis of GC is still unclear.
391. Association between the dietary index of gut microbiota and abnormal bowel symptoms in U.S. adults: a cross-sectional study based on NHANES 2007-2010.
作者: Sicheng Shen.;Huayi Feng.;Chuyue Wang.;Yingqi Yang.;Zhiyang Chen.;Xiaopeng Wang.;Jiacheng Li.
来源: BMC Gastroenterol. 2025年25卷1期419页
The Dietary Index of Gut Microbiota (DI-GM) is a newly developed measure for assessing diet quality in relation to the diversity of the gut microbiome. However, whether it is associated with the risk of chronic constipation and chronic diarrhea remains unclear.
392. A novel inflammatory biomarker in assessing disease activity in ulcerative colitis: gasdermin D.
作者: Osman Cagin Buldukoglu.;Serkan Ocal.;Serdar Akca.;Galip Egemen Atar.;Besir Kaya.;Muhammet Devran Isik.;Ozlem Koca.;Ferda Akbay Harmandar.;Yesim Cekin.;Ayhan Hilmi Cekin.
来源: BMC Gastroenterol. 2025年25卷1期418页
Ulcerative colitis (UC) is a chronic inflammatory disease with a worldwide prevalance of around 5 million patients. Assessment of disease activity is crucial in management of UC patients. Gasdermin D (GSDMD) is a protein which belongs to the gasdermin protein family and plays a role in inflammatory cell death, pyroptosis. GSDMD activation has been shown to be related to inflammatory states in a variety of disorders, including inflammatory bowel diseases. With this study, we aimed to reveal a potential new inflammatory serum marker for assessing disease activity and severity in UC patients in a non-invasive manner.
393. An International Consensus on Appropriate Management of Corticosteroids in Clinical Trials in Inflammatory Bowel Disease.
作者: Jurij Hanžel.;Virginia Solitano.;Sudheer Kumar Vuyyuru.;Remo Panaccione.;Bruce E Sands.;Laurent Peyrin-Biroulet.;Silvio Danese.;Geert R D'Haens.;Raja Atreya.;Matthieu Allez.;Charles N Bernstein.;Peter Bossuyt.;Brian Bressler.;Robert V Bryant.;Benjamin L Cohen.;Jean-Frederic Colombel.;Ferdinando D'Amico.;Axel Dignass.;Marla Dubinsky.;Phillip Fleshner.;Richard B Gearry.;Stephen B Hanauer.;Ailsa L Hart.;Maia Kayal.;Torsten Kucharzik.;Peter L Lakatos.;Edouard Louis.;Fernando Magro.;Neeraj Narula.;Rupert W Leong.;Julián Panés.;Tim Raine.;Zhihua Ran.;Miguel D Regueiro.;Walter Reinisch.;Siddharth Singh.;A Hillary Steinhart.;Simon Travis.;Ryan C Ungaro.;C Janneke van der Woude.;Takayuki Yamamoto.;Vineet Ahuja.;David T Rubin.;Parambir S Dulai.;Linda J Cornfield.;Malcolm Hogan.;William J Sandborn.;Brian G Feagan.;Vipul Jairath.;Christopher Ma.
来源: Gastroenterology. 2025年169卷6期1282-1293页
Approval of new therapies for inflammatory bowel disease (IBD) requires rigorously designed and well-executed randomized controlled trials (RCTs). Corticosteroids remain a cornerstone of IBD induction therapy, and many patients in trials are enrolled while taking corticosteroids. Despite this, approaches to corticosteroid management in RCTs have been highly heterogeneous, often differing from clinical practice. This negatively impacts patients' willingness to participate due to prolonged corticosteroid exposure and may potentially bias outcomes in the clinical trial. Our aim is to provide comprehensive standardized recommendations on key aspects of corticosteroid use in IBD clinical trials through a multiphase, international expert consensus, with a goal to help inform and standardize practice in future RCTs.
395. Neoadjuvant chemotherapy with or without PD-1/PD-L1 inhibitors in resectable esophageal squamous cell carcinoma: a meta-analysis based on randomized controlled trials.
作者: Ye Zhang.;Jie Chen.;Fenglian Yu.;Wenxiong Zhang.;Yingmei Zhong.
来源: BMC Gastroenterol. 2025年25卷1期416页
Neoadjuvant chemotherapy (NC) is a cornerstone in the management of resectable esophageal squamous cell carcinoma (ESCC). The integration of PD-1/PD-L1 inhibitors into NC (NIC) regimens has shown promise; however, its efficacy and safety remain uncertain. This meta-analysis aims to compare the potential risks and clinical benefits of NIC versus NC in patients with resectable ESCC based on randomized controlled trials (RCTs).
396. Association between C-reactive protein to lymphocyte ratio and gallstones: a cross-sectional study.
作者: Xiaoyang Sun.;Jie Lin.;Zhenao Wang.;Chenfang Zhang.;Kai Zhao.;Xuewen Zhang.;Jiyao Sheng.
来源: BMC Gastroenterol. 2025年25卷1期415页
Inflammation plays a key role in the development of gallstones, and the C-reactive protein to lymphocyte ratio (CLR) has been introduced as a promising biomarker for evaluating inflammatory processes. Nonetheless, its correlation with gallstone prevalence remains ambiguous. This study aims to evaluate the potential link between CLR levels and gallstone prevalence.
397. Association between the immune-inflammation index and the severity and clinical outcomes of patients with inflammatory bowel disease: a systematic review and meta-analysis.
作者: Peiji Li.;Yilin Wu.;Wei Xiong.;Jiahui Cao.;Mengyun Chen.;Zhaowei Yuan.;Wenxin Guo.;Bing Yang.
来源: BMC Gastroenterol. 2025年25卷1期414页
Existing studies have explored the association between immune-inflammatory indices and inflammatory bowel disease (IBD), but there is a lack of comprehensive evidence. This meta-analysis and systematic review seeks to synthesize the data of available clinical research and offer the latest and comprehensive evidence-based conclusions regarding whether these immune-inflammatory indices can effectively predict the severity, activity, and prognosis of IBD.
398. A preliminary exploration of a predictive model and nomogram for the efficacy of compound digestive enzyme therapy based on serum (PGI, PGII, VIP, and PRDX1) in patients with functional dyspepsia.
This study aimed to explore the feasibility of constructing compound digestive enzyme therapeutic effect prediction model based on serum pepsinogen I (PGI), pepsinogen II (PGII), vasoactive intestinal peptide (VIP), and peroxidase 1 (PRDX1) in patients with functional dyspepsia (FD), and draw nomograms, to provide reference for the selection of clinical treatment.
399. A cooling off period: decline in the use of hot biopsy forceps technique in colonoscopy in the U.S. Medicare population 2000-2019.
作者: Andrew J Read.;Jacob E Kurlander.;Akbar K Waljee.;Sameer D Saini.
来源: BMC Gastroenterol. 2025年25卷1期411页
The use of hot biopsy forceps (with electrocautery) is no longer routinely recommended given increased complications compared to cold biopsy forceps (without electrocautery). It is unknown how often the technique is currently used in the United States (U.S.) or how its usage has changed over time.
400. Comparative efficacy of gelatin sponge, microcoils, and nbca in arterial gastrointestinal bleeding: a retrospective study.
Arterial gastrointestinal bleeding poses a serious threat to life that requires timely and effective intervention. This study evaluated the effectiveness of three different embolization strategies: the use of gelatin sponge alone, in combination with microcoils, and in combination with n-butyl cyanoacrylate (NBCA).
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