381. Mortality with upper gastrointestinal bleeding and perforation: effects of time and NSAID use.
作者: Sebastian Straube.;Martin R Tramèr.;R Andrew Moore.;Sheena Derry.;Henry J McQuay.
来源: BMC Gastroenterol. 2009年9卷41页
Some people who suffer an upper gastrointestinal bleed or perforation die. The mortality rate was estimated at 12% in studies published before 1997, but a systematic survey of more recent data is needed. Better treatment is likely to have reduced mortality. An estimate of mortality is helpful in explaining to patients the risks of therapy, especially with NSAIDs.
382. Meta-analysis shows that prevalence of Epstein-Barr virus-positive gastric cancer differs based on sex and anatomic location.
作者: Gwen Murphy.;Ruth Pfeiffer.;M Constanza Camargo.;Charles S Rabkin.
来源: Gastroenterology. 2009年137卷3期824-33页
Epstein-Barr virus (EBV) has been causally associated with cancer; some gastric carcinomas have a monoclonal EBV genome in every cancer cell, indicating that they arose from a single infected progenitor cell. However, the proportion of EBV-positive gastric carcinomas is uncertain, and the etiologic significance is unknown.
383. Meta-analysis of percutaneous radiofrequency ablation versus ethanol injection in hepatocellular carcinoma.
作者: Carmen Bouza.;Teresa López-Cuadrado.;Raimundo Alcázar.;Zuleika Saz-Parkinson.;José María Amate.
来源: BMC Gastroenterol. 2009年9卷31页
Percutaneous radiofrequency ablation (RFA) has gained popularity in the treatment of hepatocellular carcinoma (HCC). However, its role versus other conventional minimally invasive therapies is still a matter of debate. The purpose of this work is to analyse the efficacy and safety of RFA versus that of ethanol injection (PEI), the percutaneous standard approach to treat nonsurgical HCC.
384. A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome.
作者: Nourieh Hoveyda.;Carl Heneghan.;Kamal R Mahtani.;Rafael Perera.;Nia Roberts.;Paul Glasziou.
来源: BMC Gastroenterol. 2009年9卷15页
Irritable Bowel Syndrome (IBS) is a common chronic gastrointestinal disorder and the evidence for efficacy of most drug therapies in the treatment of IBS is weak. A popular alternative is probiotics, which have been used in several conditions. including IBS. Probiotics are live microbial food supplements.The aim of this systematic review and meta-analysis of randomized trials study was to evaluate the efficacy of probiotics in alleviating symptoms in patients with irritable bowel syndrome. We searched Ovid versions of MEDLINE (1950-2007), EMBASE (1980-2007), CINAHL (1982-2007), AMED (1985-2007), the Cochrane library and hand searched retrieved papers.
385. Meta-analysis of the placebo rates of clinical relapse and severe endoscopic recurrence in postoperative Crohn's disease.
作者: Sara Renna.;Calogero Cammà.;Irene Modesto.;Giuseppe Cabibbo.;Daniela Scimeca.;Giuseppe Civitavecchia.;Filippo Mocciaro.;Ambrogio Orlando.;Marco Enea.;Mario Cottone.
来源: Gastroenterology. 2008年135卷5期1500-9页
The benefit of therapy for prevention of postoperative recurrence of Crohn's disease (CD) is limited. Clinical relapse and severe endoscopic recurrence are the main outcomes in the evaluation of trials on prevention of recurrence. The aim of this meta-analysis was to focus on knowledge of the placebo rates of relapse and recurrence in postoperative CD and to identify factors influencing these rates.
386. Performance of transient elastography for the staging of liver fibrosis: a meta-analysis.
作者: Mireen Friedrich-Rust.;Mei-Fang Ong.;Swantje Martens.;Christoph Sarrazin.;Joerg Bojunga.;Stefan Zeuzem.;Eva Herrmann.
来源: Gastroenterology. 2008年134卷4期960-74页
Transient elastography has been studied in a multitude of liver diseases for the staging of liver fibrosis with variable results. A meta-analysis was performed to assess the overall performance of transient elastography for the diagnosis of liver fibrosis and to analyze factors influencing the diagnostic accuracy.
387. Meta-analysis of prophylactic corticosteroid use in post-ERCP pancreatitis.
作者: Minghua Zheng.;Jianling Bai.;Bosi Yuan.;Feng Lin.;Jie You.;Mingqin Lu.;Yuewen Gong.;Yongping Chen.
来源: BMC Gastroenterol. 2008年8卷6页
Acute pancreatitis is a common complication of endoscopic retrograde cholangiopancreatography and benefit of pharmacological treatment is unclear. Although prophylactic use of corticosteroid for reduction of pancreatic injury after ERCP has been evaluated, discrepancy about beneficial effect of corticosteroid on pancreatic injury still exists. The aim of current study is to evaluate effectiveness and safety of corticosteroid in prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP).
388. Cigarette smoking and adenomatous polyps: a meta-analysis.
作者: Edoardo Botteri.;Simona Iodice.;Sara Raimondi.;Patrick Maisonneuve.;Albert B Lowenfels.
来源: Gastroenterology. 2008年134卷2期388-95页
Through the past 2 decades, a consistent association between cigarette smoking and colorectal adenomatous polyps, recognized precursor lesions of colorectal cancer, has been shown. We performed a meta-analysis to provide a quantitative pooled risk estimate of the association, focusing on the different characteristics of the study populations, study designs, and clinical feature of the polyps.
389. Meta-analyses of FibroTest diagnostic value in chronic liver disease.
作者: Thierry Poynard.;Rachel Morra.;Philippe Halfon.;Laurent Castera.;Vlad Ratziu.;Françoise Imbert-Bismut.;Sylvie Naveau.;Dominique Thabut.;Didier Lebrec.;Fabien Zoulim.;Marc Bourliere.;Patrice Cacoub.;Djamila Messous.;Mona Munteanu.;Victor de Ledinghen.
来源: BMC Gastroenterol. 2007年7卷40页
FibroTest (FT) is a biomarker of liver fibrosis initially validated in patients with chronic hepatitis C (CHC). The aim was to test two hypotheses, one, that the FT diagnostic value was similar in the three other frequent fibrotic diseases: chronic hepatitis B (CHB), alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD); and the other, that the FT diagnostic value was similar for intermediate and extreme fibrosis stages.
390. Transjugular intrahepatic portosystemic shunt for refractory ascites: a meta-analysis of individual patient data.
作者: Francesco Salerno.;Calogero Cammà.;Marco Enea.;Martin Rössle.;Florence Wong.
来源: Gastroenterology. 2007年133卷3期825-34页
Several randomized controlled trials have compared a transjugular intrahepatic portosystemic shunt (TIPS) with large-volume paracentesis in cirrhotic patients with refractory ascites. Although all agree that TIPS reduces the recurrence rate of ascites, survival is controversial. The aim of this study was to compare the effects of TIPS and large-volume paracentesis in cirrhotic patients with refractory ascites by means of meta-analysis of individual patient data from 4 randomized controlled trials.
391. Coffee consumption and risk of liver cancer: a meta-analysis.
Mounting evidence indicates that coffee drinking may protect against liver injury and lower the risk of liver cancer. We quantitatively assessed the relation between coffee consumption and the risk of liver cancer in a meta-analysis of epidemiologic studies.
392. Gabexate in the prophylaxis of post-ERCP pancreatitis: a meta-analysis of randomized controlled trials.
作者: Minghua Zheng.;Yongping Chen.;Xinjun Yang.;Ji Li.;Youcai Zhang.;Qiqiang Zeng.
来源: BMC Gastroenterol. 2007年7卷6页
Acute pancreatitis is a common complication of endoscopic retrograde cholangiopancreatography and the benefit of its pharmacological treatment is unclear. Although prophylactic use of gabexate for the reduction of pancreatic injury after ERCP has been evaluated, the discrepancy about gabexate's beneficial effect on pancreatic injury still exists. This study aimed to evaluate the effectiveness and safety of gabexate in the prophylaxis of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP).
393. A meta-analysis of the placebo rates of remission and response in clinical trials of active ulcerative colitis.
作者: Chinyu Su.;James D Lewis.;Brittany Goldberg.;Colleen Brensinger.;Gary R Lichtenstein.
来源: Gastroenterology. 2007年132卷2期516-26页
Knowledge of the placebo outcomes and understanding specific study features that influence these outcomes is important for designing future clinical trials evaluating therapy of ulcerative colitis (UC). The aims of this study were to estimate the placebo rates of remission and response in placebo-controlled, randomized clinical trials for active UC and to identify factors influencing these rates.
394. Folate intake, MTHFR polymorphisms, and risk of esophageal, gastric, and pancreatic cancer: a meta-analysis.
Increasing evidence suggests that a low folate intake and impaired folate metabolism may be implicated in the development of gastrointestinal cancers. We conducted a systematic review with meta-analysis of epidemiologic studies evaluating the association of folate intake or genetic polymorphisms in 5,10-methylenetetrahydrofolate reductase (MTHFR), a central enzyme in folate metabolism, with risk of esophageal, gastric, or pancreatic cancer.
395. Limited value of alarm features in the diagnosis of upper gastrointestinal malignancy: systematic review and meta-analysis.
作者: Nimish Vakil.;Paul Moayyedi.;M Brian Fennerty.;Nicholas J Talley.
来源: Gastroenterology. 2006年131卷2期390-401; quiz 659-60页
Alarm features such as dysphagia, weight loss, or anemia raise concern of an upper gastrointestinal malignancy in patients with dyspepsia. The aim of this study was to determine the diagnostic accuracy of alarm features in predicting malignancy by performing a metaanalysis based on the published literature.
398. Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data.
作者: Gioacchino Leandro.;Alessandra Mangia.;Jason Hui.;Paolo Fabris.;Laura Rubbia-Brandt.;Guido Colloredo.;Luigi E Adinolfi.;Tarik Asselah.;Julie R Jonsson.;Antonina Smedile.;Norah Terrault.;Valerio Pazienza.;Maria Teresa Giordani.;Emiliano Giostra.;Aurelio Sonzogni.;Giuseppe Ruggiero.;Patrick Marcellin.;Elizabeth E Powell.;Jacob George.;Francesco Negro.; .
来源: Gastroenterology. 2006年130卷6期1636-42页
Steatosis is a frequent histologic finding in chronic hepatitis C (CHC), but it is unclear whether steatosis is an independent predictor for liver fibrosis. We evaluated the association between steatosis and fibrosis and their common correlates in persons with CHC and in subgroup analyses according to hepatitis C virus (HCV) genotype and body mass index.
399. Association of 6-thioguanine nucleotide levels and inflammatory bowel disease activity: a meta-analysis.
作者: Mark T Osterman.;Rabi Kundu.;Gary R Lichtenstein.;James D Lewis.
来源: Gastroenterology. 2006年130卷4期1047-53页
6-Thioguanine nucleotide (6-TGN) levels have been proposed to correlate with inflammatory bowel disease (IBD) activity among patients treated with azathioprine or 6-mercaptopurine (6-MP). Previous studies, most with small sample sizes, yielded conflicting conclusions. Our aim was to pool the available data to provide a more precise estimate of the association between 6-TGN levels and IBD activity.
400. Uncovered transjugular intrahepatic portosystemic shunt for refractory ascites: a meta-analysis.
作者: Gennaro D'Amico.;Angelo Luca.;Alberto Morabito.;Roberto Miraglia.;Mario D'Amico.
来源: Gastroenterology. 2005年129卷4期1282-93页
Several trials showed that uncovered transjugular intrahepatic portosystemic shunt (TIPS) is superior to paracentesis for the control of refractory ascites. However, the results for encephalopathy and mortality were not consistent across trials. We performed a systematic review of randomized controlled trials of TIPS for refractory ascites to assess the overall treatment effects and to explore potential reasons of heterogeneity.
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