Histological remission has emerged as a promising target that may improve long-term outcomes in patients with ulcerative colitis (UC). The aim of this study was to investigate correlations between clinical, endoscopic, and histological remissions and the predictive value of histological remission on long-term outcomes in patients with UC receiving conventional therapy.

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects a quarter of the population. Although multiple studies have investigated the mechanisms underlying steatohepatitis and MASLD progression, little attention has been paid to milder cases, particularly those with normal enzyme levels. Our objective was to evaluate the molecular events in patients with MASLD and normal enzyme levels.

The worldwide increase in acute diverticulitis (AD) prevalence and the resulting growing economic burden on the healthcare system have driven the scientific community towards standardizing a methodological approach to obtain a prompt diagnosis, optimized treatment, and thus containing costs. By the analysis of currently available evidence, this review could provide effective strategies for efficient AD clinical management and highlights possible innovative therapeutic strategies.

Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract, characterized by heterogeneous manifestations with significant morbidities. Diagnosing and managing CD remains challenging due to its variable clinical presentation, complexities in assessing disease extent and activity, and lack of a definitive diagnostic marker. Over the last years, there has been a switch towards a treat-to-target approach in the management of inflammatory bowel disease (IBD). Capsule endoscopy (CE) has emerged as a non-invasive, complementary tool for CD diagnosis and monitoring. CE is patient friendly being wireless and enables direct visualization of the entire small bowel in one sitting. CE plays a role in the diagnostic workup of suspected CD and in cases of in IBD unclassified (IBDU). In established CD, CE plays a role in monitoring mucosal healing, a key therapeutic target linked to improved long-term outcomes. CE findings significantly influence treatment strategies, leading to therapy escalation, adjustment, or avoidance of unnecessary surgical interventions. Moreover, CE disease activity assessment by means of the Lewis score is able to predict disease flares, thus having also a prognostic role. In conclusion, the non-invasive nature of CE, combined with its diagnostic, prognostic, and therapeutic implications, establishes it as an essential tool in the comprehensive management of CD across all disease stages. This review provides a comprehensive update on CE's evolving role in optimizing care of patients with CD.

The gallstone disease is gradually becoming a burden of healthcare systems throughout world. The frequency of gallstone disease in Ethiopia has been the subject of few investigations and to the best of our knowledge, limited evidence of published research has examined the risk factors linked with gallstone disease. The main objective of the current study was to assess the prevalence of gallstone disease and associated factors among patients who visited the surgical department of Debre Birhan Comprehensive Specialization Hospital.

To identify the clinical and molecular factors that effectively predict pathological complete response (pCR) and assess the safety of patients receiving neoadjuvant combination immunotherapy.

Early identification of strangulation in adhesive small bowel obstruction (SBO) is crucial for emergency triage and immediate surgical intervention. This study aimed to explore the predictive value of the immature granulocyte (IG) count in assessing strangulation in adhesive SBO.

Pancreatic cancer (PC) is characterized by an extremely poor prognosis and a high mortality rate, posing a significant burden on society.

Metabolic dysfunction-associated fatty liver disease (MAFLD) affects up to 30% of the global population, yet effective pharmacological treatments remain limited. This systematic review and meta-analysis evaluated the efficacy of GLP-1 receptor agonists and dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) receptor agonists in managing MAFLD.

The traditional TNM staging system fails to explain survival heterogeneity in advanced gastrointestinal cancer, while malnutrition remains an underutilized prognostic modulator. We aimed to establish the prognostic value of dynamic nutritional risk stratification using the Patient-Generated Subjective Global Assessment (PG-SGA).

Although biologics have improved Crohn's disease (CD) management, surgery is still required for severe strictures or penetrating disease. Endoscopic balloon dilatation (EBD) is widely used for postoperative strictures and provides symptom relief; however, its potential preventive effect on surgical recurrence remains unclear. In addition, prognostic factors for surgical recurrence have not been fully established.

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal cancer, with a 5-year survival rate of <13%. Despite advances in diagnostics and treatments, the standard of care for PDAC remains inadequate, and most patients develop resistance to therapy. Targeted approaches, such as Kirsten rat sarcoma (KRAS) inhibition, have shown promise in preclinical models, although clinical application remains challenged by the rapid development of resistance. The phosphatidylinositol-3-kinase (PI3K) signaling pathway is critical for PDAC development and maintenance, yet pharmacologic targeting has failed to yield significant clinical benefits.

This study's goal was to clinically validate the performance of PancreaSure (Immunovia, Inc), a serum biomarker signature composed of tissue inhibitor of metalloproteinase 1, intercellular adhesion molecule 1, cathepsin D, thrombospondin 1, and carbohydrate antigen 19-9 for detection of early-stage pancreatic ductal adenocarcinoma (PDAC) in an independent cohort.

To investigate the influence of health education based on the precede-proceed model (PPM) on the eradication rate and experience of Helicobacter pylori (H. pylori) infection.

We compared the efficacy of four treatment strategies for chronic hepatitis B (CHB): tenofovir disoproxil fumarate (TDF), tenofovir alafenamide (TAF), tenofovir amibufenamide (TMF), and TDF-to-TAF switch strategies strategy. We conducted a network meta-analysis to provide evidence-based clinical guidance.

Given the evidence that poor glycemic control is associated with immunological dysfunction, serum glycosylated hemoglobin A1c (HbA1c), as a useful indicator reflecting blood glucose homeostasis, has potential to predict infectious complications. In this study, we aimed to explore the association between poor glycemic control (HbA1c ≥ 6.5 as an indicator) and infected pancreatic necrosis (IPN) in patients with acute necrotizing pancreatitis (ANP).

Cirrhosis is a major cause of morbidity and mortality worldwide [1]. While serum ferritin is recognized as a marker of liver injury and inflammation, its prognostic value for cirrhosis-related complications is not well established. We investigated whether serum ferritin levels could predict complications in cirrhotic patients.

The acquisition of healthy nutrition habits plays an important role in the solution of gastrointestinal symptoms, and it was recently shown that the cooking skills were the main determinant in the development of these behaviors. Accordingly, this study was planned and conducted with an aim to investigate the relationship between gastrointestinal symptoms and cooking skills.

Gastro-oesophageal reflux disease (GORD) presents with either oesophageal or extra-oesophageal symptoms, or both. The association between symptom subtypes and upper gastrointestinal endoscopy (UGIE) findings has been rarely studied in Nigeria. Our study aimed to determine the pattern of symptom subtypes and UGIE abnormalities, as well as their association in patients with GORD symptoms in Nigeria.

The exact value of cluster of differentiation 47 (CD47), known as the "don't eat me" signal, in colorectal cancer (CRC) has not been clearly revealed. Thus, we investigated the impact of its expression on the overall survival (OS) of CRC patients who underwent colectomy.