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21. Impact of GLA Variant Classification on the Estimated Prevalence of Fabry Disease: A Systematic Review and Meta-Analysis of Screening Studies.
作者: Emanuele Monda.;Gaetano Diana.;Francesca Graziani.;Marta Rubino.;Athanasios Bakalakos.;Ales Linhart.;Dominique P Germain.;Maurizio Scarpa.;Elena Biagini.;Maurizio Pieroni.;Perry Mark Elliott.;Giuseppe Limongelli.
来源: Circ Genom Precis Med. 2023年16卷6期e004252页
The diagnosis of Fabry disease (FD) has relevant implications related to the management. Thus, a clear assignment of GLA variant pathogenicity is crucial. This systematic review and meta-analysis aimed to investigate the prevalence of FD in high-risk populations and newborns and evaluate the impact of different GLA variant classifications on the estimated prevalence of FD.
22. Coronary Computed Tomography Angiography Versus Invasive Coronary Angiography in Stable Chest Pain: A Meta-Analysis of Randomized Controlled Trials.
作者: Marina F Machado.;Nicole Felix.;Pedro H C Melo.;Mateus M Gauza.;Pedro Calomeni.;Giuliano Generoso.;Sourabh Khatri.;Stephan Altmayer.;Ron Blankstein.;Marcio Sommer Bittencourt.;Rhanderson Cardoso.
来源: Circ Cardiovasc Imaging. 2023年16卷11期e015800页
The efficacy of coronary computed tomography angiography (CCTA) versus invasive coronary angiography (ICA) among patients with stable chest pain has been studied in several trials with conflicting results.
23. Direct Oral Anticoagulants for Stroke Prevention in Patients With Device-Detected Atrial Fibrillation: A Study-Level Meta-Analysis of the NOAH-AFNET 6 and ARTESiA Trials.
作者: William F McIntyre.;Alexander P Benz.;Nina Becher.;Jeffrey S Healey.;Christopher B Granger.;Lena Rivard.;A John Camm.;Andreas Goette.;Antonia Zapf.;Marco Alings.;Stuart J Connolly.;Paulus Kirchhof.;Renato D Lopes.
来源: Circulation. 2024年149卷13期981-988页
Device-detected atrial fibrillation (also known as subclinical atrial fibrillation or atrial high-rate episodes) is a common finding in patients with an implanted cardiac rhythm device and is associated with an increased risk of ischemic stroke. Whether oral anticoagulation is effective and safe in this patient population is unclear.
24. Meta-Analysis of Penetrance and Systematic Review on Transition to Disease in Genetic Hypertrophic Cardiomyopathy.
作者: Constantin-Cristian Topriceanu.;Alexandre C Pereira.;James C Moon.;Gabriella Captur.;Carolyn Y Ho.
来源: Circulation. 2024年149卷2期107-123页
Hypertrophic cardiomyopathy (HCM) is characterized by unexplained left ventricular hypertrophy and is classically caused by pathogenic or likely pathogenic variants (P/LP) in genes encoding sarcomere proteins. Not all subclinical variant carriers will manifest clinically overt disease because penetrance (proportion of sarcomere or sarcomere-related P/LP variant carriers who develop disease) is variable, age dependent, and not reliably predicted.
25. Short-Term DAPT and DAPT De-Escalation Strategies for Patients With Acute Coronary Syndromes: A Systematic Review and Network Meta-Analysis.
作者: Toshiki Kuno.;Atsuyuki Watanabe.;Satoshi Shoji.;Tomohiro Fujisaki.;Hiroki Ueyama.;Hisato Takagi.;Pierre Deharo.;Thomas Cuisset.;Sripal Bangalore.;Roxana Mehran.;Gregg W Stone.;Shun Kohsaka.;Deepak L Bhatt.
来源: Circ Cardiovasc Interv. 2023年16卷9期e013242页
Short-term (≤6 months) dual antiplatelet therapy (DAPT) and DAPT de-escalation become attractive for patients with acute coronary syndrome.
26. PRDM16 Deletion Is Associated With Sex-dependent Cardiomyopathy and Cardiac Mortality: A Translational, Multi-Institutional Cohort Study.
作者: Ryan J Kramer.;Amir Nima Fatahian.;Alice Chan.;Jeffery Mortenson.;Jennifer Osher.;Bo Sun.;Lauren E Parker.;Michael B Rosamilia.;Kyra B Potter.;Kaila Moore.;Sage L Atkins.;Jill A Rosenfeld.;Alona Birjiniuk.;Edward Jones.;Taylor S Howard.;Jeffrey J Kim.;Daryl A Scott.;Seema Lalani.;Omid M T Rouzbehani.;Samantha Kaplan.;Marissa A Hathaway.;Jennifer L Cohen.;S Yukiko Asaki.;Hugo R Martinez.;Sihem Boudina.;Andrew P Landstrom.
来源: Circ Genom Precis Med. 2023年16卷4期390-400页
1p36 deletion syndrome can predispose to pediatric-onset cardiomyopathy. Deletion breakpoints are variable and may delete the transcription factor PRDM16. Early studies suggest that deletion of PRDM16 may underlie cardiomyopathy in patients with 1p36 deletion; however, the prognostic impact of PRDM16 loss is unknown.
27. Medicaid Expansion Under the Affordable Care Act and Association With Cardiac Care: A Systematic Review.
作者: Ginger Y Jiang.;John W Urwin.;Jason H Wasfy.
来源: Circ Cardiovasc Qual Outcomes. 2023年16卷6期e009753页
The goal of the Affordable Care Act was to improve health outcomes through expanding insurance, including through Medicaid expansion. We systematically reviewed the available literature on the association of Affordable Care Act Medicaid expansion with cardiac outcomes.
28. Epicardial Adipose Tissue Assessed by Computed Tomography and Echocardiography Are Associated With Adverse Cardiovascular Outcomes: A Systematic Review and Meta-Analysis.
作者: Bryan Chong.;Jayanth Jayabaskaran.;Jitesh Ruban.;Rachel Goh.;Yip Han Chin.;Gwyneth Kong.;Cheng Han Ng.;Chaoxing Lin.;Shaun Loong.;Mark D Muthiah.;Chin Meng Khoo.;Ezman Shariff.;Mark Y Chan.;Fannie Lajeunesse-Trempe.;Andre Tchernof.;Parag Chevli.;Anurag Mehta.;Mamas A Mamas.;Georgios K Dimitriadis.;Nicholas W S Chew.
来源: Circ Cardiovasc Imaging. 2023年16卷5期e015159页
Epicardial adipose tissue (EAT) has garnered attention as a prognostic and risk stratification factor for cardiovascular disease. This study, via meta-analyses, evaluates the associations between EAT and cardiovascular outcomes stratified across imaging modalities, ethnic groups, and study protocols.
29. Characteristics of United States Counties in Which Heart Failure Clinical Trials of Pharmacotherapy Were Conducted.
作者: Elisabeth Cox.;Muath A Alsalloum.;Marin Vander Schaaf.;Abdulaziz S Alfehaid.;Marwah E Alnewais.;Erin R Weeda.
来源: Circ Heart Fail. 2023年16卷7期e010449页 30. Long-Term Effect of Weight Regain Following Behavioral Weight Management Programs on Cardiometabolic Disease Incidence and Risk: Systematic Review and Meta-Analysis.
作者: Jamie Hartmann-Boyce.;Annika Theodoulou.;Jason L Oke.;Ailsa R Butler.;Anastasios Bastounis.;Anna Dunnigan.;Rimu Byadya.;Linda J Cobiac.;Peter Scarborough.;F D Richard Hobbs.;Falko F Sniehotta.;Susan A Jebb.;Paul Aveyard.
来源: Circ Cardiovasc Qual Outcomes. 2023年16卷4期e009348页
Behavioral weight management programs (BWMPs) enhance weight loss in the short term, but longer term cardiometabolic effects are uncertain as weight is commonly regained. We assessed the impact of weight regain after BWMPs on cardiovascular risk factors, diabetes, and cardiovascular disease.
31. Response by Zhao et al to Letter Regarding Article, "Associations of Dietary Cholesterol, Serum Cholesterol, and Egg Consumption With Overall and Cause-Specific Mortality: Systematic Review and Updated Meta-Analysis".32. Sodium Restriction in Patients With Heart Failure: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
作者: Eloisa Colin-Ramirez.;Nariman Sepehrvand.;Sarah Rathwell.;Heather Ross.;Jorge Escobedo.;Peter Macdonald.;Richard Troughton.;Clara Saldarriaga.;Fernando Lanas.;Robert Doughty.;Finlay A McAlister.;Justin A Ezekowitz.
来源: Circ Heart Fail. 2023年16卷1期e009879页
Sodium restriction is a nonpharmacologic treatment suggested by practice guidelines for the management of patients with heart failure (HF). In this study, we synthesized the data from randomized controlled trials (RCTs) evaluating the effects of sodium restriction on clinical outcomes in patients with HF.
33. Comparison of Unguided De-Escalation Versus Guided Selection of Dual Antiplatelet Therapy After Acute Coronary Syndrome: A Systematic Review and Network Meta-Analysis.
作者: Toshiki Kuno.;Tomohiro Fujisaki.;Satoshi Shoji.;Yuki Sahashi.;Yusuke Tsugawa.;Masao Iwagami.;Hisato Takagi.;Alexandros Briasoulis.;Pierre Deharo.;Thomas Cuisset.;Azeem Latib.;Shun Kohsaka.;Deepak L Bhatt.
来源: Circ Cardiovasc Interv. 2022年15卷8期e011990页
The benefit of dual antiplatelet therapy (DAPT) for reducing ischemic events is greatest in the early period of acute coronary syndrome, and recent randomized controlled trials have investigated the unguided de-escalation strategy of changing potent P2Y12 inhibitors to less potent or reduced-dose P2Y12 inhibitors 1 month after acute coronary syndrome. However, it remains unclear which strategy is more effective and safer: the uniform unguided de-escalation strategy versus the personalized guided selection of DAPT with genotype or platelet function tests.
34. Assessment of Clinical Worsening End Points as a Surrogate for Mortality in Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
作者: Élodie Tremblay.;Camille Gosselin.;Vicky Mai.;Annie C Lajoie.;Roubi Kilo.;Jason Weatherald.;Yves Lacasse.;Sebastien Bonnet.;Jean-Christophe Lega.;Steeve Provencher.
来源: Circulation. 2022年146卷8期597-612页
Clinical worsening (CW) is a composite end point commonly used in pulmonary arterial hypertension (PAH) trials. We aimed to assess the trial-level surrogacy of CW for mortality in PAH trials, and whether the various CW components were similar in terms of frequency of occurrence, treatment-related relative risk (RR) reduction, and importance to patients.
35. Arrhythmogenic Right Ventricular Cardiomyopathy Prevalence and Arrhythmic Outcomes in At-Risk Family Members: A Systematic Review and Meta-Analysis.
作者: Apurva Sharma.;Laurens P Bosman.;Crystal Tichnell.;Julie Nanavati.;Brittney Murray.;Bareng A S Nonyane.;Harikrishna Tandri.;Hugh Calkins.;Cynthia A James.
来源: Circ Genom Precis Med. 2022年15卷3期e003530页
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a complex cardiomyopathy with autosomal dominant inheritance and age-related incomplete penetrance, characterized by a high risk of sudden cardiac death. Recent professional consensus guidelines recommend clinical cardiac lifelong serial screening for at-risk family members refined only by age, but family genotype might influence necessary screening. Although numerous studies report prevalence of disease and arrhythmia in family members and explore predictors of penetrance and arrhythmic risk, a systematic review consolidating this evidence is lacking.
36. Comparative Efficacy of 5 Exercise Types on Cardiometabolic Health in Overweight and Obese Adults: A Systematic Review and Network Meta-Analysis of 81 Randomized Controlled Trials.
作者: Alexios Batrakoulis.;Athanasios Z Jamurtas.;Georgios S Metsios.;Konstantinos Perivoliotis.;Gary Liguori.;Yuri Feito.;Deborah Riebe.;Walter R Thompson.;Theodore J Angelopoulos.;Peter Krustrup.;Magni Mohr.;Dimitrios Draganidis.;Athanasios Poulios.;Ioannis G Fatouros.
来源: Circ Cardiovasc Qual Outcomes. 2022年15卷6期e008243页
Although regular exercise is recommended for preventing and treating overweight/obesity, the most effective exercise type for improving cardiometabolic health in individuals with overweight/obesity remains largely undecided. This network meta-analysis aimed to evaluate and rank the comparative efficacy of 5 exercise modalities on cardiometabolic health measures in individuals with overweight/obesity.
37. Compounding Benefits of Cholesterol-Lowering Therapy for the Reduction of Major Cardiovascular Events: Systematic Review and Meta-Analysis.
作者: Nelson Wang.;Mark Woodward.;Mark D Huffman.;Anthony Rodgers.
来源: Circ Cardiovasc Qual Outcomes. 2022年15卷6期e008552页
Mendelian randomization studies use genetic variants as natural experiments to provide evidence about causal relations between modifiable risk factors and disease. Recent Mendelian randomization studies suggest each mmol/L reduction in low-density lipoprotein cholesterol (LDL-C) sustained over a lifetime can reduce the risk of cardiovascular disease by more than half. However, these findings have not been replicated in randomized clinical trials, and the effect of treatment duration on the magnitude of risk reduction remains uncertain. The aim of this article was to evaluate the relationship between lipid-lowering drug exposure time and relative risk reduction of major cardiovascular events in randomized clinical trials.
38. Associations of Dietary Cholesterol, Serum Cholesterol, and Egg Consumption With Overall and Cause-Specific Mortality: Systematic Review and Updated Meta-Analysis.
作者: Bin Zhao.;Lu Gan.;Barry I Graubard.;Satu Männistö.;Demetrius Albanes.;Jiaqi Huang.
来源: Circulation. 2022年145卷20期1506-1520页
Despite substantial research highlighting the importance of exogenous dietary cholesterol intake and endogenous serum cholesterol level in human health, a thorough evaluation of the associations is lacking. Our study objective was to examine overall and cause-specific mortality in relation to dietary and serum cholesterol, as well as egg consumption, and conduct an updated meta-regression analysis of cohort studies.
39. Arrhythmic Phenotypes Are a Defining Feature of Dilated Cardiomyopathy-Associated SCN5A Variants: A Systematic Review.
作者: Stacey Peters.;Bryony A Thompson.;Mark Perrin.;Paul James.;Dominica Zentner.;Jonathan M Kalman.;Jamie I Vandenberg.;Diane Fatkin.
来源: Circ Genom Precis Med. 2022年15卷1期e003432页
Variants in the SCN5A gene, that encodes the cardiac sodium channel, Nav1.5, are associated with a highly arrhythmogenic form of dilated cardiomyopathy (DCM). Our aim was to review the phenotypes, natural history, functional effects, and treatment outcomes of DCM-associated rare SCN5A variants.
40. Early Termination of Acute Stroke Randomized Controlled Trials Published Between 2013 and 2020: A Systematic Review.
作者: Brent Strong.;J Adam Oostema.;Nadia Nikroo.;Murtaza Hussain.;Mathew J Reeves.
来源: Circ Cardiovasc Qual Outcomes. 2021年14卷12期e007995页
Termination of a clinical trial before the maximum planned sample size is accrued can occur for multiple valid reasons but has implications for the interpretation of results. We undertook a systematic review of contemporary acute stroke trials to document the prevalence of and reasons for early termination.
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