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21. Efficacy of a Very-Low-Calorie Weight Loss Diet Plus Exercise Compared With Exercise Alone on Hip Osteoarthritis Pain : A Randomized Controlled Trial.
作者: Michelle Hall.;Rana S Hinman.;Gabrielle Knox.;Libby Spiers.;Fiona McManus.;Anurika P De Silva.;Priya Sumithran.;Anthony Harris.;Nicholas J Murphy.;Flavia Cicuttini.;David J Hunter.;Stephen P Messier.;Kim L Bennell.
来源: Ann Intern Med. 2025年178卷9期1227-1237页
Exercise is recommended to manage hip osteoarthritis, but weight loss recommendations are conflicting.
22. In insulin-treated T2D, automated insulin delivery reduced HbA1c without increasing hypoglycemic events vs. usual care at 13 wk.
GIM/FP/GP: [Formula: see text] Endocrinology: [Formula: see text].
23. High Tibial Osteotomy for Medial Compartment Knee Osteoarthritis : A Randomized Trial With Parallel Preference Arm.
作者: Trevor B Birmingham.;Codie A Primeau.;Rebecca F Moyer.;Dianne M Bryant.;Jinhui Ma.;Kristyn M Leitch.;Wolfgang Wirth.;Ryan Degen.;Alan M Getgood.;Robert B Litchfield.;Kevin R Willits.;Felix Eckstein.;J Robert Giffin.
来源: Ann Intern Med. 2025年178卷9期1238-1248页
Medial opening wedge high tibial osteotomy (HTO) is a limb realignment surgery that aims to preserve joint structure and improve clinical outcomes by redistributing ambulatory loads on the knee among patients with knee osteoarthritis and varus alignment.
24. Rituximab Versus Conventional Therapy for Remission Induction in Eosinophilic Granulomatosis With Polyangiitis : A Randomized Controlled Trial.
作者: Benjamin Terrier.;Grégory Pugnet.;Claire de Moreuil.;Bernard Bonnotte.;Ygal Benhamou.;Dominique Chauveau.;Marie-Charlotte Besse.;Pierre Duffau.;Nicolas Limal.;Antoine Néel.;Geoffrey Urbanski.;Noémie Jourde-Chiche.;Nicolas Martin-Silva.;Julien Campagne.;Arsène Mekinian.;Nicolas Schleinitz.;Felix Ackermann.;Anne-Laure Fauchais.;Antoine Froissart.;Thomas Le Gallou.;Yurdagul Uzunhan.;Jean-François Viallard.;Alice Bérezné.;Laurent Chiche.;Camille Taillé.;Guillaume Direz.;Cécile-Audrey Durel.;Pascal Godmer.;Salim Trad.;Marc Lambert.;Mathilde de Menthon.;Thomas Quéméneur.;Jacques Cadranel.;Pierre Charles.;Antoine Dossier.;Léa Jilet.;Loïc Guillevin.;Hendy Abdoul.;Xavier Puéchal.; .
来源: Ann Intern Med. 2025年178卷9期1249-1257页
Eosinophilic granulomatosis with polyangiitis (EGPA) is an eosinophilic antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Rituximab has emerged as the standard of care in other types of ANCA-associated vasculitis, but controlled studies on its use in EGPA are yet lacking.
25. Vaporized Nicotine Products for Smoking Cessation Among People Experiencing Social Disadvantage : A Randomized Clinical Trial.
作者: Ryan J Courtney.;Bridget C Howard.;Daniel Barker.;Dennis Petrie.;Ron Borland.;Anthony Shakeshaft.;Coral Gartner.;Colin Mendelsohn.;Veronica C Boland.;Alexandra Henderson.;Robyn L Richmond.;Piotr Tutka.;Felix Naughton.;Wayne Hall.;Nicholas Zwar.;Michael Farrell.;Richard P Mattick.;Hayden McRobbie.
来源: Ann Intern Med. 2025年178卷8期1085-1094页
Vaporized nicotine products (VNPs) are more effective than nicotine replacement therapy (NRT) for smoking cessation in general populations, but their effectiveness among low socioeconomic groups is largely unknown.
26. Improvements in Cardiometabolic Risk Factors by Weight Reduction: A Post Hoc Analysis of Adults With Obesity Randomly Assigned to Tirzepatide.
作者: Bruno Linetzky.;Naveed Sattar.;Subodh Verma.;Harlan M Krumholz.;Cathy Chang Xie.;Hunter T Hoffmann.;Sarah Zimner-Rapuch.;Amelia Torcello-Gómez.;Adam Stefanski.
来源: Ann Intern Med. 2025年178卷8期1095-1105页
Tirzepatide reduced weight and improved cardiometabolic risk factors for participants in the SURMOUNT-1 trial. The changes in cardiometabolic risk factors by degree of tirzepatide-induced weight reduction across a wide spectrum of weight loss have not been reported.
27. Fecal Microbiota Transplantation Versus Vancomycin for Primary Clostridioides difficile Infection : A Randomized Controlled Trial.
作者: Frederik Emil Juul.;Michael Bretthauer.;Peter H Johnsen.;Faye Samy.;Kristian Tonby.;Jan Erik Berdal.;Dag Arne L Hoff.;Eirik H Ofstad.;Awet Abraham.;Birgitte Seip.;Håvard Wiig.;Øyvind Bakken Rognstad.;Ida F Glad.;Jørgen Valeur.;Axel E Nissen-Lie.;Eivind Ness-Jensen.;Kristine M A Lund.;Linn K Skjevling.;Kurt Hanevik.;Hilde Skudal.;Ellen J Melsom.;Raziye Boyar.;Trond J Cooper.;Trond E Ranheim.;Esben M Riise.;Hans-Olov Adami.;Mette Kalager.;Magnus Løberg.;Kjetil K Garborg.
来源: Ann Intern Med. 2025年178卷7期940-947页
Fecal microbiota transplantation (FMT) is recommended for recurrent Clostridioides difficile infection (CDI), but its role in primary CDI is unclear.
28. Effects of a Hypotension-Avoidance Versus a Hypertension-Avoidance Strategy on Neurocognitive Outcomes After Noncardiac Surgery.
作者: Maura Marcucci.;Matthew T V Chan.;Thomas W Painter.;Sergey Efremov.;Hector J Aguado.;Sergey V Astrakov.;Ydo V Kleinlugtenbelt.;Ameen Patel.;Juan P Cata.;Mohammed Amir.;Mikhail Kirov.;Kate Leslie.;Emmanuelle Duceppe.;Flavia K Borges.;Miriam de Nadal.;Vikas Tandon.;Giovanni Landoni.;Valery V Likhvantsev.;Vladimir Lomivorotov.;Daniel I Sessler.;María José Martínez-Zapata.;Denis Xavier.;Edith Fleischmann.;Chew Yin Wang.;Christian S Meyhoff.;Maria Wittmann.;David Torres.;David Highton.;Michael Jacka.;Vishwanath B.;Kelly Zarnke.;Ravinder Singh Sidhu.;Giorgio Oriani.;Sabry Ayad.;Steven Minear.;Tristan E Weaver.;Kurt Ruetzler.;Claudia Brusasco.;Joel L Parlow.;Elizabeth Maxwell.;Scott Miller.;Marko Mrkobrada.;Keyur Suresh Chandra Bhatt.;Prashant Rahate.;Ana Kowark.;Giuseppe De Blasio.;Sandra N Ofori.;David Conen.;Sadeesh Srinathan.;Wojciech Szczeklik.;Raja Jayaram.;Richard K Ellerkmann.;Mona Momeni.;Ingrid Copland.;Jessica Vincent.;Kumar Balasubramanian.;Zhuoru Li.;Michael Ke Wang.;Deyang Li.;Michael H McGillion.;Andrea Kurz.;Mukul Sharma.;Timothy G Short.;P J Devereaux.; .
来源: Ann Intern Med. 2025年178卷7期909-920页
Perioperative hemodynamic abnormalities have been associated with neurocognitive outcomes after noncardiac surgery.
29. High Frequency of Chronic Urticaria Following an Investigational HIV-1 BG505 MD39.3 Trimer mRNA Vaccine in a Phase 1, Randomized, Open-Label Clinical Trial (HVTN 302).
作者: Sharon A Riddler.;Zoe Moodie.;Jesse Clark.;Catherine Yen.;Mary Allen.;Briana D Furch.;Huiyin Lu.;Shannon Grant.;Kajari Mondal.;Maija Anderson.;Janine Maenza.;Maria P Lemos.;Amanda S Woodward Davis.;Stephen R Walsh.;Magdalena E Sobieszczyk.;Ian Frank.;Paul Goepfert.;Kathryn E Stephenson.;Lindsey R Baden.;Hong-Van Tieu.;Michael C Keefer.;M Juliana McElrath.;James G Kublin.;Lawrence Corey.
来源: Ann Intern Med. 2025年178卷7期963-974页
The mRNA platform is under investigation for many vaccines, including HIV-1 vaccines.
30. Comparison of Dose Escalation Versus Switching to Tirzepatide Among People With Type 2 Diabetes Inadequately Controlled on Lower Doses of Dulaglutide : A Randomized Clinical Trial.
作者: Liana K Billings.;Linsey Winne.;Palash Sharma.;Elisa Gomez-Valderas.;K Karthik Chivukula.;Anita Y M Kwan.
来源: Ann Intern Med. 2025年178卷5期609-619页
Tirzepatide, a once-weekly glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist approved for the treatment of adults with type 2 diabetes or obesity, showed clinically meaningful reductions in hemoglobin A1c (HbA1c) and body weight in the SURPASS phase 3 clinical trial program.
31. The Effect of 4:3 Intermittent Fasting on Weight Loss at 12 Months : A Randomized Clinical Trial.
作者: Victoria A Catenacci.;Danielle M Ostendorf.;Zhaoxing Pan.;Laura K Kaizer.;Seth A Creasy.;Adnin Zaman.;Ann E Caldwell.;Jared Dahle.;Bryan Swanson.;Matthew J Breit.;Kristen Bing.;Liza T Wayland.;Shelby L Panter.;Jared J Scorsone.;Daniel H Bessesen.;Paul MacLean.;Edward L Melanson.
来源: Ann Intern Med. 2025年178卷5期634-644页
Long-term (≥12 months) randomized trials evaluating the efficacy of intermittent fasting (IMF) as a dietary weight loss strategy are limited. Furthermore, no studies have compared IMF versus daily caloric restriction (DCR) when both interventions are provided in the context of a guidelines-based behavioral weight loss program.
32. Patient Navigation to Improve Colonoscopy Completion After an Abnormal Stool Test Result : A Randomized Controlled Trial.
作者: Gloria D Coronado.;Amanda F Petrik.;Jamie H Thompson.;Michael C Leo.;Matthew Slaughter.;Priyanka Gautom.;Syed A Hussain.;Leslie Mosso.;Jeffrey Gibbs.;Neha Yadav.;Rajasekhara R Mummadi.;Eric S Johnson.;Ricardo Jimenez.
来源: Ann Intern Med. 2025年178卷5期645-654页
Patient navigation is a recommended practice of the Guide to Community Preventive Services; little is known about whether it improves colonoscopy completion for adults who have received an abnormal stool test result.
33. Effects of Noise and Public Setting on Blood Pressure Readings : A Randomized Crossover Trial.
作者: Junichi Ishigami.;Hairong Liu.;Di Zhao.;Ahmed Sabit.;Chathurangi H Pathiravasan.;Jeanne Charleston.;Edgar R Miller.;Kunihiro Matsushita.;Lawrence J Appel.;Tammy M Brady.
来源: Ann Intern Med. 2025年178卷2期149-156页
Guidelines emphasize quiet settings for blood pressure (BP) measurement.
34. The Effect of the "Safety in Dementia" Online Tool to Assist Decision Making for Caregivers of Persons With Dementia and Access to Firearms : A Randomized Trial.
作者: Marian E Betz.;Jennifer Portz.;Christopher Knoepke.;Megan L Ranney.;Stacy M Fischer.;Ryan A Peterson.;Rachel L Johnson.;Faris Omeragic.;Mirella Castaneda.;Emily Greenway.;Daniel Matlock.
来源: Ann Intern Med. 2024年177卷12期1630-1640页
Caregivers face challenges (including competing desires to prevent injury, respect autonomy, and avoid conflict) when addressing firearm access by community-dwelling persons with Alzheimer disease and related dementias (ADRD).
35. Diabetes Risk Factors in People With HIV Receiving Pitavastatin Versus Placebo for Cardiovascular Disease Prevention : A Randomized Trial.
作者: Kathleen V Fitch.;Markella V Zanni.;Jennifer Manne-Goehler.;Marissa R Diggs.;Arijeet K Gattu.;Judith S Currier.;Gerald S Bloomfield.;Chiu-Bin Hsiao.;Samir K Gupta.;Judith A Aberg.;Carlos D Malvestutto.;Carl J Fichtenbaum.;Michael T Lu.;Pamela S Douglas.;Heather J Ribaudo.;Steven K Grinspoon.
来源: Ann Intern Med. 2024年177卷11期1449-1461页
REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) led to new guidelines for statin use among people with HIV (PWH) with low to moderate risk for atherosclerotic cardiovascular disease (ASCVD). Little is known about the natural history of diabetes mellitus (DM) or mechanisms contributing to statin effects on DM among this population.
36. Effect of Four Hemoglobin Transfusion Threshold Strategies in Patients With Acute Myocardial Infarction and Anemia : A Target Trial Emulation Using MINT Trial Data.
作者: Gerard T Portela.;Jeffrey L Carson.;Sonja A Swanson.;John H Alexander.;Paul C Hébert.;Shaun G Goodman.;Philippe Gabriel Steg.;Marnie Bertolet.;Jordan B Strom.;Dean A Fergusson.;Tabassome Simon.;Harvey D White.;Howard A Cooper.;J Dawn Abbott.;Sunil V Rao.;Bernard R Chaitman.;Christopher B Fordyce.;Renato D Lopes.;Benoit Daneault.;Maria M Brooks.; .
来源: Ann Intern Med. 2024年177卷11期1489-1498页
The optimal hemoglobin threshold to guide red blood cell (RBC) transfusion for patients with acute myocardial infarction (MI) and anemia is uncertain.
37. Effectiveness of Integrating Suicide Care in Primary Care : Secondary Analysis of a Stepped-Wedge, Cluster Randomized Implementation Trial.
作者: Julie Angerhofer Richards.;Maricela Cruz.;Christine Stewart.;Amy K Lee.;Taylor C Ryan.;Brian K Ahmedani.;Gregory E Simon.
来源: Ann Intern Med. 2024年177卷11期1471-1481页
Primary care encounters are common among patients at risk for suicide.
38. Time-Restricted Eating in Adults With Metabolic Syndrome : A Randomized Controlled Trial.
作者: Emily N C Manoogian.;Michael J Wilkinson.;Monica O'Neal.;Kyla Laing.;Justina Nguyen.;David Van.;Ashley Rosander.;Aryana Pazargadi.;Nikko R Gutierrez.;Jason G Fleischer.;Shahrokh Golshan.;Satchidananda Panda.;Pam R Taub.
来源: Ann Intern Med. 2024年177卷11期1462-1470页
Time-restricted eating (TRE), limiting daily dietary intake to a consistent 8 to 10 hours without mandating calorie reduction, may provide cardiometabolic benefits.
39. Long-Term Effects of Individualized Acupuncture for Chronic Neck Pain : A Randomized Controlled Trial.
作者: Ling Zhao.;Mingsheng Sun.;Zihan Yin.;Jin Cui.;Ruihui Wang.;Laixi Ji.;Guoyan Geng.;Jiao Chen.;Dingjun Cai.;Qi Liu.;Hui Zheng.;Fanrong Liang.
来源: Ann Intern Med. 2024年177卷10期1330-1338页
Long-term effects of individualized acupuncture in persons with chronic neck pain (CNP) remain unknown.
40. Endoscopic Ultrasound-Guided Rendezvous Technique Versus Precut Sphincterotomy as Salvage Technique in Patients With Benign Biliary Disease and Difficult Biliary Cannulation : A Randomized Controlled Trial.
作者: Arup Choudhury.;Jayanta Samanta.;Gaurav Muktesh.;Jahnvi Dhar.;Antriksh Kumar.;Jimil Shah.;Marco Spadaccini.;Pankaj Gupta.;Alessandro Fugazza.;Vikas Gupta.;Thakur Deen Yadav.;Rakesh Kochhar.;Cesare Hassan.;Alessandro Repici.;Antonio Facciorusso.
来源: Ann Intern Med. 2024年177卷10期1361-1369页
The standard salvage technique used for difficult bile duct cannulation is precut sphincterotomy, whereas endoscopic ultrasound-guided rendezvous technique (EUS-RV) is a relatively newer method. Prospective comparative data between these 2 techniques as salvage for biliary access in patients with benign biliary disease and difficult bile duct cannulation is lacking.
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