当前位置: 首页 >> 检索结果
21. Effect of Metagenomic Next-Generation Sequencing on Clinical Outcomes of Patients With Severe Community-Acquired Pneumonia in the ICU: A Multicenter, Randomized Controlled Trial.
作者: Xiaojing Wu.;Ting Sun.;Hangyong He.;Lihua Xing.;Zhenshun Cheng.;Shuang Geng.;Dexiang Xu.;Hong Luo.;Cheng Chen.;Mingyan Jiang.;Guopeng Hou.;Tianshu Zhai.;Ying Cai.;Yijie Liu.;Junlu Li.;Lan Ni.;Xueying Li.;Binbin Qu.;Cheng Lei.;Yang Wang.;Zi Gu.;Peng Zhang.;Xu Huang.;Min Li.;Jingen Xia.;Lian He.;Qingyuan Zhan.
来源: Chest. 2025年167卷2期362-373页
Metagenomic next-generation sequencing (mNGS) was previously established as a method that can increase the pathogen identification rate in patients with severe community-acquired pneumonia (SCAP).
22. Gravity- vs Wall Suction-Driven Large-Volume Thoracentesis: A Randomized Controlled Study.
作者: Samira Shojaee.;Jasleen Pannu.;Lonny Yarmus.;Alberto Fantin.;Christina MacRosty.;Roland Bassett.;Labib Debiane.;Zachary S DePew.;Saadia A Faiz.;Carlos A Jimenez.;Sameer K Avasarala.;Erik Vakil.;Andrew DeMaio.;Lara Bashoura.;Keerthana Keshava.;Travis Ferguson.;Roberto Adachi.;George A Eapen.;David E Ost.;Sami Bashour.;Asad Khan.;Vickie Shannon.;Ajay Sheshadri.;Roberto F Casal.;Scott E Evans.;Krystle Pew.;Nadia Castaldo.;Diwakar D Balachandran.;Vincenzo Patruno.;Robert Lentz.;Cheryl Pai.;Fabien Maldonado.;Lance Roller.;Junsheng Ma.;Jhankruti Zaveri.;Jenna Los.;Luis Vaquero.;Eva Ordonez.;Gulmira Yermakhanova.;Jason Akulian.;Cole Burks.;Roel-Rolando Almario.;Marie Sauve.;Jackson Pettee.;Laila Z Noor.;Muhammad H Arain.;Horiana B Grosu.
来源: Chest. 2024年166卷6期1573-1582页
Prior studies have found no differences in procedural chest discomfort for patients undergoing manual syringe aspiration or drainage with gravity after thoracentesis. However, whether gravity drainage could protect against chest pain due to the larger negative-pressure gradient generated by wall suction has not been investigated.
23. Dexmedetomidine for Reducing Mortality in Patients With Septic Shock: A Randomized Controlled Trial (DecatSepsis).
作者: Ahmed Ragab Ezz Al-Regal.;Eyad Ahmed Ramzy.;Amer Abd Allah Atia.;Moataz Maher Emara.
来源: Chest. 2024年166卷6期1394-1405页
Sepsis, especially septic shock, and its complications have been linked to the hyperadrenergic stress response.
24. Rethinking Blood Eosinophils for Assessing Inhaled Corticosteroids Response in COPD: A Post Hoc Analysis From the FLAME Trial.
作者: Alexander G Mathioudakis.;Sebastian Bate.;Pradeesh Sivapalan.;Jens-Ulrik Stæhr Jensen.;Dave Singh.;Jørgen Vestbo.
来源: Chest. 2024年166卷5期987-997页
The varied treatment response to inhaled corticosteroids (ICS) in patients with COPD and the associated increased risk of pneumonia necessitate a personalized ICS therapeutic approach. This is informed by blood eosinophil count (BEC), which predicts ICS treatment response. However, BEC appears to change in response to ICS treatment.
25. Comparing Bispectral Index Monitoring vs Clinical Assessment for Deep Sedation in the ICU: Effects on Delirium Reduction and Sedative Drug Doses-A Randomized Trial.
作者: Ivan Huespe.;Diego Giunta.;Katia Acosta.;Debora Avila.;Eduardo Prado.;Devang Sanghavi.;Indalecio Carboni Bisso.;Sergio Giannasi.;Federico C Carini.
来源: Chest. 2024年166卷4期733-742页
Sedative overdoses pose a risk of delirium among patients in the ICU, with potential mitigation through the use of a processed EEG monitor (the bispectral index [BIS]) to guide depth of sedation.
26. Neutrophil-Mediated Inflammatory Plasminogen Degradation, Rather Than High Plasminogen-Activator Inhibitor-1, May Underly Failures and Inefficiencies of Intrapleural Fibrinolysis.
作者: Christopher D Barrett.;Peter K Moore.;Ernest E Moore.;Hunter B Moore.;James G Chandler.;Halima Siddiqui.;Elizabeth R Maginot.;Angela Sauaia.;Angel Augusto Pérez-Calatayud.;Keely Buesing.;Jiashan Wang.;Cesar Davila-Chapa.;Daniel Hershberger.;Ivor Douglas.;Fredric M Pieracci.;Michael B Yaffe.
来源: Chest. 2025年167卷1期67-75页
Complex pleural space infections often require treatment with multiple doses of intrapleural tissue plasminogen activator (tPA) and deoxyribonuclease, with treatment failure frequently necessitating surgery. Pleural infections are rich in neutrophils, and neutrophil elastase degrades plasminogen, the target substrate of tPA, that is required to generate fibrinolysis. We hypothesized that pleural fluid from patients with pleural space infection would show high elastase activity, evidence of inflammatory plasminogen degradation, and low fibrinolytic potential in response to tPA that could be rescued with plasminogen supplementation.
27. Image-Assısted Pleural Needle Biopsy or Medical Thoracoscopy: Which Method for Which Patient? A Randomızed Controlled Trial.
作者: Muzaffer Metintas.;Guntulu Ak.;Huseyin Yildirim.;Emine Dundar.;Nevin Aydin.;Sinan Erginel.;Fusun Alatas.;Senay Yilmaz.;Selma Metintas.
来源: Chest. 2024年166卷2期405-412页
Image-guided or assisted needle biopsies and the increasing use of medical thoracoscopy (MT) have increased the diagnostic accuracy of pleural diseases significantly. However, no consensus exists regarding which patients with pleural effusion should undergo MT and which patients should undergo image-guided or assisted needle biopsy as the first procedure to ensure greater diagnostic accuracy.
28. Effect of Azithromycin on Asthma Remission in Adults With Persistent Uncontrolled Asthma: A Secondary Analysis of a Randomized, Double-Anonymized, Placebo-Controlled Trial.
作者: Dennis Thomas.;Vanessa M McDonald.;Sean Stevens.;Melissa Baraket.;Sandra Hodge.;Alan James.;Christine Jenkins.;Guy B Marks.;Matthew Peters.;Paul N Reynolds.;John W Upham.;Ian A Yang.;Peter G Gibson.
来源: Chest. 2024年166卷2期262-270页
Asthma remission is a potential treatment goal.
29. Noninvasive Electromagnetic Phrenic Nerve Stimulation in Critically Ill Patients: A Feasibility Study.
作者: Alessandro Panelli.;Aline M Grimm.;Sven Krause.;Michael A Verfuß.;Bernhard Ulm.;Julius J Grunow.;Hermann G Bartels.;Niklas M Carbon.;Thomas Niederhauser.;Steffen Weber-Carstens.;Laurent Brochard.;Stefan J Schaller.
来源: Chest. 2024年166卷3期502-510页
Electromagnetic stimulation of the phrenic nerve induces diaphragm contractions, but no coils for clinical use have been available. We recently demonstrated the feasibility of ventilation using bilateral transcutaneous noninvasive electromagnetic phrenic nerve stimulation (NEPNS) before surgery in lung-healthy patients with healthy weight in a dose-dependent manner.
30. CT Imaging Assessment of Response to Treatment in Allergic Bronchopulmonary Aspergillosis in Adults With Bronchial Asthma.
作者: Cendrine Godet.;Anne-Laure Brun.;Francis Couturaud.;François Laurent.;Jean-Pierre Frat.;Sylvain Marchand-Adam.;Frédéric Gagnadoux.;Elodie Blanchard.;Camille Taillé.;Bruno Philippe.;Sandrine Hirschi.;Claire Andréjak.;Arnaud Bourdin.;Cécile Chenivesse.;Stéphane Dominique.;Gilles Mangiapan.;Marlène Murris-Espin.;Frédéric Rivière.;Gilles Garcia.;François-Xavier Blanc.;François Goupil.;Anne Bergeron.;Thomas Flament.;Pascaline Priou.;Hervé Mal.;Joe de Keizer.;Stéphanie Ragot.;Jacques Cadranel.; .
来源: Chest. 2024年165卷6期1307-1318页
One of the major challenges in managing allergic bronchopulmonary aspergillosis remains consistent and reproducible assessment of response to treatment.
31. Automatic Mechanical Ventilation vs Manual Bag Ventilation During CPR: A Pilot Randomized Controlled Trial.
作者: Jonghwan Shin.;Hui Jai Lee.;Kwang Nam Jin.;Jung Ho Shin.;Kyoung Min You.;Stephen Gyung Won Lee.;Jin Hee Jung.;Kyoung Jun Song.;Jieun Pak.;Tae Yun Park.;Chang Je Park.;Gi Tak Bae.
来源: Chest. 2024年166卷2期311-320页
There is insufficient evidence supporting the theory that mechanical ventilation can replace the manual ventilation method during CPR.
32. The Association Between Malnutrition and High Protein Treatment on Outcomes in Critically Ill Patients: A Post Hoc Analysis of the EFFORT Protein Randomized Trial.
作者: Charles Chin Han Lew.;Zheng-Yii Lee.;Andrew G Day.;Xuran Jiang.;Danielle Bear.;Gordon L Jensen.;Pauline Y Ng.;Lauren Tweel.;Angela Parillo.;Daren K Heyland.;Charlene Compher.
来源: Chest. 2024年165卷6期1380-1391页
Preexisting malnutrition in critically ill patients is associated with adverse clinical outcomes. Malnutrition can be diagnosed with the Global Leadership Initiative on Malnutrition using parameters such as weight loss, muscle wasting, and BMI. International critical care nutrition guidelines recommend high protein treatment to improve clinical outcomes in critically ill patients diagnosed with preexisting malnutrition. However, this recommendation is based on expert opinion.
33. High vs Low PEEP in Patients With ARDS Exhibiting Intense Inspiratory Effort During Assisted Ventilation: A Randomized Crossover Trial.
作者: Giuseppe Bello.;Valentina Giammatteo.;Alessandra Bisanti.;Luca Delle Cese.;Tommaso Rosà.;Luca S Menga.;Luca Montini.;Teresa Michi.;Giorgia Spinazzola.;Gennaro De Pascale.;Mariano Alberto Pennisi.;Roberta Ribeiro De Santis Santiago.;Lorenzo Berra.;Massimo Antonelli.;Domenico Luca Grieco.
来源: Chest. 2024年165卷6期1392-1405页
Positive end-expiratory pressure (PEEP) can potentially modulate inspiratory effort (ΔPes), which is the major determinant of self-inflicted lung injury.
34. Physiologic Effects of Reconnection to the Ventilator for 1 Hour Following a Successful Spontaneous Breathing Trial.
作者: Rémi Coudroy.;Alice Lejars.;Maeva Rodriguez.;Jean-Pierre Frat.;Christophe Rault.;François Arrivé.;Sylvain Le Pape.;Arnaud W Thille.
来源: Chest. 2024年165卷6期1406-1414页
Reconnection to the ventilator for 1 h following a successful spontaneous breathing trial (SBT) may reduce reintubation rates compared with direct extubation. However, the physiologic mechanisms leading to this effect are unclear.
35. Prophylactic Minocycline for Delirium in Critically Ill Patients: A Randomized Controlled Trial.
作者: Felipe Dal-Pizzol.;André Coelho.;Carla S Simon.;Monique Michels.;Emily Corneo.;Aline Jeremias.;Danusa Damásio.;Cristiane Ritter.
来源: Chest. 2024年165卷5期1129-1138页
Delirium is a potentially severe form of acute encephalopathy. Minocycline has neuroprotective effects in animal models of neurologic diseases; however, data from human studies remain scarce.
36. Safety and Efficacy of Clofazimine as an Alternative for Rifampicin in Mycobacterium avium Complex Pulmonary Disease Treatment: Outcomes of a Randomized Trial.
作者: Sanne M H Zweijpfenning.;Rob Aarnoutse.;Martin J Boeree.;Cecile Magis-Escurra.;Ralf Stemkens.;Bram Geurts.;Jakko van Ingen.;Wouter Hoefsloot.
来源: Chest. 2024年165卷5期1082-1092页
Results of retrospective studies have suggested clofazimine as an alternative for rifampicin in the treatment of Mycobacterium avium complex pulmonary disease (MAC-PD).
37. Comparison of Pirfenidone and Nintedanib: Post Hoc Analysis of the CleanUP-IPF Study.
作者: John S Kim.;Susan Murray.;Eric Yow.;Kevin J Anstrom.;Hyun J Kim.;Kevin R Flaherty.;Fernando J Martinez.;Imre Noth.
来源: Chest. 2024年165卷5期1163-1173页
Antifibrotics are effective in slowing FVC decline in idiopathic pulmonary fibrosis (IPF). However, whether antifibrotic type is differentially associated with FVC decline remains inconclusive.
38. Symptoms and Impaired Quality of Life After COVID-19 Hospitalization: Effect of Therapeutic Heparin in Non-ICU Patients in the Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 Acute Trial: Effect on 3-Month Symptoms and Quality of Life.
作者: Yonatan Y Greenstein.;Kinsley Hubel.;Joshua Froess.;Stephen R Wisniewski.;Vidya Venugopal.;Yu-Hsuan Lai.;Jeff S Berger.;Steven Y Chang.;Christos Colovos.;Faraaz Shah.;Lucy Z Kornblith.;Patrick R Lawler.;Manila Gaddh.;Raquel Morillo Guerrero.;William Nkemdirim.;Renato D Lopes.;Harmony R Reynolds.;Jose Seijas Amigo.;Lana Wahid.;Ajani Zahra.;Ewan C Goligher.;Ryan Zarychanski.;Eric Leifer.;David T Huang.;Matthew D Neal.;Judith S Hochman.;Mary Cushman.;Michelle N Gong.
来源: Chest. 2024年165卷4期785-799页
Therapeutic-dose heparin decreased days requiring organ support in noncritically ill patients hospitalized for COVID-19, but its impact on persistent symptoms or quality of life (QOL) is unclear.
39. Ozanimod Therapy in Patients With COVID-19 Requiring Oxygen Support: A Randomized Open-Label Pilot Trial.
作者: François Lellouche.;Pascale Blais-Lecours.;François Maltais.;Jean-François Sarrazin.;Philippe Rola.;Tuyen Nguyen.;Nathalie Châteauvert.;David Marsolais.
来源: Chest. 2024年165卷4期810-819页
Sphingosine-1-phosphate receptor ligands (SRLs) dampen immunopathologic damages in models of viral pneumonia.
40. The Effect of Pressure Changes During Mechanical Insufflation-Exsufflation on Respiratory and Airway Physiology.
作者: Neeraj M Shah.;Chloe Apps.;Georgios Kaltsakas.;Sophie Madden-Scott.;Eui-Sik Suh.;Rebecca F D'Cruz.;Gill Arbane.;Maxime Patout.;Elodie Lhuillier.;Nicholas Hart.;Patrick B Murphy.
来源: Chest. 2024年165卷4期929-941页
Respiratory muscle weakness can impair cough function, leading to lower respiratory tract infections. These infections are an important contributor to morbidity and mortality in patients with neuromuscular disease. Mechanical insufflation-exsufflation (MIE) is used to augment cough function in these patients. Although MIE is widely used, there are few data to advise on the optimal technique. Since the introduction of MIE, the recommended pressures to be delivered have increased. There are concerns regarding the use of higher pressures and their potential to cause lung derecruitment and upper airway closure.
|