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361. Accuracy of point-of-care multiorgan ultrasonography for the diagnosis of pulmonary embolism.
作者: Peiman Nazerian.;Simone Vanni.;Giovanni Volpicelli.;Chiara Gigli.;Maurizio Zanobetti.;Maurizio Bartolucci.;Antonio Ciavattone.;Alessandro Lamorte.;Andrea Veltri.;Andrea Fabbri.;Stefano Grifoni.
来源: Chest. 2014年145卷5期950-957页
Presenting signs and symptoms of pulmonary embolism (PE) are nonspecific, favoring a large use of second-line diagnostic tests such as multidetector CT pulmonary angiography (MCTPA), thus exposing patients to high-dose radiation and to potential serious complications. We investigated the diagnostic performance of multiorgan ultrasonography (lung, heart, and leg vein ultrasonography) and whether multiorgan ultrasonography combined to Wells score and D-dimer could safely reduce MCTPA tests.
362. A validated risk model to predict 90-day VTE events in postsurgical patients.
作者: Christopher J Pannucci.;Sandra Laird.;Justin B Dimick.;Darrell A Campbell.;Peter K Henke.
来源: Chest. 2014年145卷3期567-573页
VTE is the proximate cause of 100,000 deaths in the United States each year. Perioperative VTE risk among surgical patients varies by 20-fold, which highlights the importance of risk stratification to identify high-risk patients, in whom chemoprophylaxis can decrease VTE risk, and low-risk patients, for whom the risk-benefit relationship of prophylaxis may be unfavorable.
363. Hypothalamic-pituitary-adrenal axis effects of mometasone furoate/formoterol fumarate vs fluticasone propionate/salmeterol administered through metered-dose inhaler.
作者: Teddy Kosoglou.;James Hubbell.;David L Cutler.;Amy O Johnson-Levonas.;Danlin Xu.;Bhavna S Kantesaria.;Kenneth Kim.;S David Miller.
来源: Chest. 2013年144卷6期1795-1802页
The effects of mometasone furoate and fluticasone propionate on the hypothalamic-pituitary-adrenal axis were compared when administered from combination metered-dose inhaler (MDI) products.
364. The clinical impact and preventability of ventilator-associated conditions in critically ill patients who are mechanically ventilated.
作者: John Muscedere.;Tasnim Sinuff.;Daren K Heyland.;Peter M Dodek.;Sean P Keenan.;Gordon Wood.;Xuran Jiang.;Andrew G Day.;Denny Laporta.;Michael Klompas.; .
来源: Chest. 2013年144卷5期1453-1460页
Ventilator-associated conditions (VACs) and infection-related ventilator-associated complications (iVACs) are the Centers for Disease Control and Prevention's new surveillance paradigms for patients who are mechanically ventilated. Little is known regarding the clinical impact and preventability of VACs and iVACs and their relationship to ventilator-associated pneumonia (VAP). We evaluated these using data from a large, multicenter, quality-improvement initiative.
365. Development of a novel composite stroke and bleeding risk score in patients with atrial fibrillation: the AMADEUS Study.
作者: Gregory Y H Lip.;Deirdre A Lane.;Harry Buller.;Stavros Apostolakis.
来源: Chest. 2013年144卷6期1839-1847页
The aim of the current analysis was to identify independent predictors of the overall clinical outcome of patients with atrial fibrillation (AF), including both stroke/thromboembolism and/or major bleeding. Given the overlap between stroke and bleeding risk factors, a composite risk-stratification score for stroke/thromboembolism or bleeding could potentially be developed.
366. A randomized controlled trial of balance training during pulmonary rehabilitation for individuals with COPD.
作者: Marla K Beauchamp.;Tania Janaudis-Ferreira.;Verônica Parreira.;Julia M Romano.;Lynda Woon.;Roger S Goldstein.;Dina Brooks.
来源: Chest. 2013年144卷6期1803-1810页
Deficits in balance are increasingly recognized among the important secondary impairments in COPD. The purpose of this study was to investigate the effect of a balance-training program on measures of balance and physical function in patients with COPD enrolled in pulmonary rehabilitation (PR).
367. Albuterol administration is commonly associated with increases in serum lactate in patients with asthma treated for acute exacerbation of asthma.
作者: Lawrence M Lewis.;Ian Ferguson.;Stacey L House.;Kristen Aubuchon.;John Schneider.;Kirk Johnson.;Kazuko Matsuda.
来源: Chest. 2014年145卷1期53-59页
Controversy exists around the incidence and cause of hyperlactatemia during asthma exacerbations. We evaluated the incidence, potential causes, and adverse events of hyperlactatemia in patients with acute asthma exacerbation.
368. Objectively measured vs self-reported compliance during oral appliance therapy for sleep-disordered breathing.
作者: Marijke Dieltjens.;Marc J Braem.;Anneclaire V M T Vroegop.;Kristien Wouters.;Johan A Verbraecken.;Wilfried A De Backer.;Paul H Van de Heyning.;Olivier M Vanderveken.
来源: Chest. 2013年144卷5期1495-1502页
Assessment of the overall therapeutic effectiveness of oral appliance therapy can only be realized through objectively measured compliance. The aims of this study were to assess objectively measured compliance during oral appliance therapy at 1-year follow-up and to compare these data with self-reported use.
369. Evaluation of the predictive value of a clinical worsening definition using 2-year outcomes in patients with pulmonary arterial hypertension: a REVEAL Registry analysis.
作者: Adaani E Frost.;David B Badesch.;Dave P Miller.;Raymond L Benza.;Leslie A Meltzer.;Michael D McGoon.
来源: Chest. 2013年144卷5期1521-1529页
Time to clinical worsening has been proposed as a primary end point in clinical trials of pulmonary arterial hypertension (PAH); however, neither standardized nor validated definitions of clinical worsening across PAH trials exist. This study aims to evaluate a proposed definition of clinical worsening within a large prospective, observational registry of patients with PAH with respect to its value as a predictor of proximate (within 1 year) risk for subsequent major events (ie, death, transplantation, or atrial septostomy).
370. Efficacy and safety of fluticasone furoate/vilanterol compared with fluticasone propionate/salmeterol combination in adult and adolescent patients with persistent asthma: a randomized trial.
作者: Ashley Woodcock.;Eugene R Bleecker.;Jan Lötvall.;Paul M O'Byrne.;Eric D Bateman.;Hilary Medley.;Anna Ellsworth.;Loretta Jacques.;William W Busse.
来源: Chest. 2013年144卷4期1222-1229页
The combination of fluticasone furoate (FF), a novel inhaled corticosteroid (ICS), and vilanterol (VI), a long-acting β2 agonist, is under development as a once-daily treatment of asthma and COPD. The aim of this study was to compare the efficacy of FF/VI with fluticasone propionate (FP)/salmeterol (SAL) in patients with persistent asthma uncontrolled on a medium dose of ICS.
371. Baseline regional perfusion impacts exercise response to endobronchial valve therapy in advanced pulmonary emphysema.
作者: Rahul G Argula.;Charlie Strange.;Viswanathan Ramakrishnan.;Jonathan Goldin.
来源: Chest. 2013年144卷5期1578-1586页
Advanced heterogeneous emphysema with hyperinflation impacts exercise tolerance in COPD. Bronchoscopic lung volume reduction using Zephyr endobronchial valves (EBVs) has been shown to improve lung function in patients with heterogeneous emphysema. It is unclear whether the target lobe perfusion of patients receiving EBV therapy impacts exercise tolerance as measured by the 6-min walk test distance (6MWTD).
372. Clinical outcomes of indwelling pleural catheter-related pleural infections: an international multicenter study.
作者: Edward T H Fysh.;Alain Tremblay.;David Feller-Kopman.;Eleanor K Mishra.;Mark Slade.;Luke Garske.;Amelia O Clive.;Carla Lamb.;Rogier Boshuizen.;Benjamin J Ng.;Andrew W Rosenstengel.;Lonny Yarmus.;Najib M Rahman.;Nick A Maskell.;Y C Gary Lee.
来源: Chest. 2013年144卷5期1597-1602页
Indwelling pleural catheters (IPCs) offer effective control of malignant pleural effusions (MPEs). IPC-related infection is uncommon but remains a major concern. Individual IPC centers see few infections, and previous reports lack sufficient numbers and detail. This study combined the experience of 11 centers from North America, Europe, and Australia to describe the incidence, microbiology, management, and clinical outcomes of IPC-related pleural infection.
373. Is it possible to identify exacerbations of mild to moderate COPD that do not require antibiotic treatment?
作者: Marc Miravitlles.;Ana Moragas.;Silvia Hernández.;Carolina Bayona.;Carl Llor.
来源: Chest. 2013年144卷5期1571-1577页
Anthonisen criteria are widely used to guide the use of antibiotics in exacerbations of COPD. We evaluated the best predictors of outcomes in exacerbations of mild to moderate COPD not treated with antibiotics.
374. Thrombocytopenia in critically ill patients receiving thromboprophylaxis: frequency, risk factors, and outcomes.
作者: David R Williamson.;Martin Albert.;Diane Heels-Ansdell.;Donald M Arnold.;François Lauzier.;Ryan Zarychanski.;Mark Crowther.;Theodore E Warkentin.;Peter Dodek.;John Cade.;Olivier Lesur.;Wendy Lim.;Robert Fowler.;Francois Lamontagne.;Stephan Langevin.;Andreas Freitag.;John Muscedere.;Jan O Friedrich.;William Geerts.;Lisa Burry.;Jamal Alhashemi.;Deborah Cook.; .
来源: Chest. 2013年144卷4期1207-1215页
Thrombocytopenia is the most common hemostatic disorder in critically ill patients. The objective of this study was to describe the incidence, risk factors, and outcomes of thrombocytopenia in patients admitted to medical-surgical ICUs.
375. Incidence and risk factors of Legionella pneumophila pneumonia during anti-tumor necrosis factor therapy: a prospective French study.
作者: Fanny Lanternier.;Florence Tubach.;Philppe Ravaud.;Dominique Salmon.;Pierre Dellamonica.;Stephane Bretagne.;Marie Couret.;Beatrice Bouvard.;Michel Debandt.;Isabelle Gueit.;Jean-Pierre Gendre.;Jean Leone.;Nathalie Nicolas.;Dider Che.;Xavier Mariette.;Olivier Lortholary.; .
来源: Chest. 2013年144卷3期990-998页
Our objective was to describe the incidence and risk factors of legionellosis associated with tumor necrosis factor (TNF)-α antagonist use.
376. Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis and septic shock.
作者: Michael A Puskarich.;Stephen Trzeciak.;Nathan I Shapiro.;Andrew B Albers.;Alan C Heffner.;Jeffrey A Kline.;Alan E Jones.
来源: Chest. 2013年143卷6期1548-1553页
We sought to compare the association of whole-blood lactate kinetics with survival in patients with septic shock undergoing early quantitative resuscitation.
377. Sildenafil preserves exercise capacity in patients with idiopathic pulmonary fibrosis and right-sided ventricular dysfunction.
作者: MeiLan K Han.;David S Bach.;Peter G Hagan.;Eric Yow.;Kevin R Flaherty.;Galen B Toews.;Kevin J Anstrom.;Fernando J Martinez.; .
来源: Chest. 2013年143卷6期1699-1708页
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with pulmonary vasculopathy.
378. Heparin-induced thrombocytopenia in medical surgical critical illness.
作者: Theodore E Warkentin.;Jo-Ann I Sheppard.;Diane Heels-Ansdell.;John C Marshall.;Lauralyn McIntyre.;Marcelo G Rocha.;Sangeeta Mehta.;Andrew R Davies.;Andrew D Bersten.;Tim M Crozier.;David Ernest.;Nicholas E Vlahakis.;Richard I Hall.;Gordon G Wood.;Germain Poirier.;Mark A Crowther.;Deborah J Cook.; .
来源: Chest. 2013年144卷3期848-858页
In a recent multicenter randomized trial comparing unfractionated heparin (UFH) with low-molecular-weight heparin (dalteparin) for thromboprophylaxis in 3,746 critically ill patients, 17 patients (0.5%) developed heparin-induced thrombocytopenia (HIT) based on serotonin-release assay-positive (SRA+) status. A trend to a lower frequency of HIT with dalteparin vs UFH was observed in the intention-to-treat analysis (five vs 12 patients, P = .14), which was statistically significant (three vs 12 patients, P = .046) in a prespecified per-protocol analysis that excluded patients with DVT at study entry. We sought to characterize HIT outcomes and to determine how dalteparin thromboprophylaxis may reduce HIT frequency in patients in the ICU.
379. Effect of increased blood levels of β-endorphin on perception of breathlessness.
作者: Donald A Mahler.;Alex H Gifford.;Laurie A Waterman.;Joseph Ward.;William J Kraemer.;Brian R Kupchak.;Andrew Harver.
来源: Chest. 2013年143卷5期1378-1385页
Although opioid receptors are expressed broadly in the CNS and in peripheral sensory nerve endings including bronchioles and alveolar walls of the respiratory tract, it is unknown whether the modulatory effect of endogenous opioids on breathlessness occurs in the CNS or in the peripheral nervous system. The purpose of this investigation was to examine whether increased blood levels of β-endorphin modify breathlessness by a putative effect of binding to peripheral opioid receptors in the respiratory tract.
380. CPAP improves endothelial function in patients with minimally symptomatic OSA: results from a subset study of the MOSAIC trial.
作者: Malcolm Kohler.;Sonya Craig.;Justin C T Pepperell.;Debby Nicoll.;Daniel J Bratton.;Andrew J Nunn.;Paul Leeson.;John R Stradling.
来源: Chest. 2013年144卷3期896-902页
Minimally symptomatic OSA is a highly prevalent disorder, and the effects of CPAP on vascular function in these patients are unknown. This trial aimed to investigate whether CPAP improves vascular function in minimally symptomatic OSA.
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