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341. Safety, tolerability, and immunogenicity of the chimpanzee adenovirus type 3-vectored Marburg virus (cAd3-Marburg) vaccine in healthy adults in the USA: a first-in-human, phase 1, open-label, dose-escalation trial.
作者: Melinda J Hamer.;Katherine V Houser.;Amelia R Hofstetter.;Ana M Ortega-Villa.;Christine Lee.;Anne Preston.;Brooke Augustine.;Charla Andrews.;Galina V Yamshchikov.;Somia Hickman.;Steven Schech.;Jack N Hutter.;Paul T Scott.;Paige E Waterman.;Mihret F Amare.;Victoria Kioko.;Casey Storme.;Kayvon Modjarrad.;Melanie D McCauley.;Merlin L Robb.;Martin R Gaudinski.;Ingelise J Gordon.;LaSonji A Holman.;Alicia T Widge.;Larisa Strom.;Myra Happe.;Josephine H Cox.;Sandra Vazquez.;Daphne A Stanley.;Tamar Murray.;Caitlyn N M Dulan.;Ruth Hunegnaw.;Sandeep R Narpala.;Phillip A Swanson.;Manjula Basappa.;Jagada Thillainathan.;Marcelino Padilla.;Britta Flach.;Sarah O'Connell.;Olga Trofymenko.;Patricia Morgan.;Emily E Coates.;Jason G Gall.;Adrian B McDermott.;Richard A Koup.;John R Mascola.;Aurélie Ploquin.;Nancy J Sullivan.;Julie A Ake.;Julie E Ledgerwood.; .
来源: Lancet. 2023年401卷10373期294-302页
WHO has identified Marburg virus as an emerging virus requiring urgent vaccine research and development, particularly due to its recent emergence in Ghana. We report results from a first-in-human clinical trial evaluating a replication-deficient recombinant chimpanzee adenovirus type 3 (cAd3)-vectored vaccine encoding a wild-type Marburg virus Angola glycoprotein (cAd3-Marburg) in healthy adults.
343. Efficacy of pyriproxyfen-pyrethroid long-lasting insecticidal nets (LLINs) and chlorfenapyr-pyrethroid LLINs compared with pyrethroid-only LLINs for malaria control in Benin: a cluster-randomised, superiority trial.
作者: Manfred Accrombessi.;Jackie Cook.;Edouard Dangbenon.;Boulais Yovogan.;Hilaire Akpovi.;Arthur Sovi.;Constantin Adoha.;Landry Assongba.;Aboubacar Sidick.;Bruno Akinro.;Razaki Ossè.;Filémon Tokponnon.;Rock Aïkpon.;Aurore Ogouyemi-Hounto.;Germain Gil Padonou.;Immo Kleinschmidt.;Louisa A Messenger.;Mark Rowland.;Corine Ngufor.;Natacha Protopopoff.;Martin C Akogbeto.
来源: Lancet. 2023年401卷10375期435-446页
New classes of long-lasting insecticidal nets (LLINs) combining mixtures of insecticides with different modes of action could put malaria control back on track after rebounds in transmission across sub-Saharan Africa. We evaluated the relative efficacy of pyriproxyfen-pyrethroid LLINs and chlorfenapyr-pyrethroid LLINs compared with standard LLINs against malaria transmission in an area of high pyrethroid resistance in Benin.
350. Pregnancy outcomes and vaccine effectiveness during the period of omicron as the variant of concern, INTERCOVID-2022: a multinational, observational study.
作者: Jose Villar.;Constanza P Soto Conti.;Robert B Gunier.;Shabina Ariff.;Rachel Craik.;Paolo I Cavoretto.;Stephen Rauch.;Serena Gandino.;Ricardo Nieto.;Adele Winsey.;Camilla Menis.;Gabriel B Rodriguez.;Valeria Savasi.;Niyazi Tug.;Sonia Deantoni.;Marta Fabre.;Begoña Martinez de Tejada.;Maria Jose Rodriguez-Sibaja.;Stefania Livio.;Raffaele Napolitano.;Nerea Maiz.;Helena Sobrero.;Ashley Peterson.;Philippe Deruelle.;Carolina Giudice.;Jagjit S Teji.;Roberto A Casale.;Laurent J Salomon.;Federico Prefumo.;Leila Cheikh Ismail.;Michael G Gravett.;Marynéa Vale.;Valeria Hernández.;Loïc Sentilhes.;Sarah R Easter.;Carola Capelli.;Emily Marler.;Daniela M Cáceres.;Guadalupe Albornoz Crespo.;Ernawati Ernawati.;Michal Lipschuetz.;Ken Takahashi.;Carmen Vecchiarelli.;Teresa Hubka.;Satoru Ikenoue.;Gabriela Tavchioska.;Babagana Bako.;Adejumoke I Ayede.;Brenda Eskenazi.;Jim G Thornton.;Zulfiqar A Bhutta.;Stephen H Kennedy.;Aris T Papageorghiou.; .
来源: Lancet. 2023年401卷10375期447-457页
In 2021, we showed an increased risk associated with COVID-19 in pregnancy. Since then, the SARS-CoV-2 virus has undergone genetic mutations. We aimed to examine the effects on maternal and perinatal outcomes of COVID-19 during pregnancy, and evaluate vaccine effectiveness, when omicron (B.1.1.529) was the variant of concern.
352. Stopping epidemics when and where they occur.
作者: Els Torreele.;Michel Kazatchkine.;Joanne Liu.;Mark Dybul.;Mauricio Cárdenas.;Sudhvir Singh.;Helena Legido Quigley.;Christine McNab.;Ellen Johnson Sirleaf.;Mariana Mazzucato.;Helen Clark.
来源: Lancet. 2023年401卷10374期324-328页 357. Molnupiravir plus usual care versus usual care alone as early treatment for adults with COVID-19 at increased risk of adverse outcomes (PANORAMIC): an open-label, platform-adaptive randomised controlled trial.
作者: Christopher C Butler.;F D Richard Hobbs.;Oghenekome A Gbinigie.;Najib M Rahman.;Gail Hayward.;Duncan B Richards.;Jienchi Dorward.;David M Lowe.;Joseph F Standing.;Judith Breuer.;Saye Khoo.;Stavros Petrou.;Kerenza Hood.;Jonathan S Nguyen-Van-Tam.;Mahendra G Patel.;Benjamin R Saville.;Joe Marion.;Emma Ogburn.;Julie Allen.;Heather Rutter.;Nick Francis.;Nicholas P B Thomas.;Philip Evans.;Melissa Dobson.;Tracie-Ann Madden.;Jane Holmes.;Victoria Harris.;May Ee Png.;Mark Lown.;Oliver van Hecke.;Michelle A Detry.;Christina T Saunders.;Mark Fitzgerald.;Nicholas S Berry.;Lazaro Mwandigha.;Ushma Galal.;Sam Mort.;Bhautesh D Jani.;Nigel D Hart.;Haroon Ahmed.;Daniel Butler.;Micheal McKenna.;Jem Chalk.;Layla Lavallee.;Elizabeth Hadley.;Lucy Cureton.;Magdalena Benysek.;Monique Andersson.;Maria Coates.;Sarah Barrett.;Clare Bateman.;Jennifer C Davies.;Ivy Raymundo-Wood.;Andrew Ustianowski.;Andrew Carson-Stevens.;Ly-Mee Yu.;Paul Little.; .
来源: Lancet. 2023年401卷10373期281-293页
The safety, effectiveness, and cost-effectiveness of molnupiravir, an oral antiviral medication for SARS-CoV-2, has not been established in vaccinated patients in the community at increased risk of morbidity and mortality from COVID-19. We aimed to establish whether the addition of molnupiravir to usual care reduced hospital admissions and deaths associated with COVID-19 in this population.
358. Machine learning-based marker for coronary artery disease: derivation and validation in two longitudinal cohorts.
作者: Iain S Forrest.;Ben O Petrazzini.;Áine Duffy.;Joshua K Park.;Carla Marquez-Luna.;Daniel M Jordan.;Ghislain Rocheleau.;Judy H Cho.;Robert S Rosenson.;Jagat Narula.;Girish N Nadkarni.;Ron Do.
来源: Lancet. 2023年401卷10372期215-225页
Binary diagnosis of coronary artery disease does not preserve the complexity of disease or quantify its severity or its associated risk with death; hence, a quantitative marker of coronary artery disease is warranted. We evaluated a quantitative marker of coronary artery disease derived from probabilities of a machine learning model.
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