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3567. The pulmonary response to fiberglass dust. Report of the Committee on Environmental Health. American College of Chest Physicians.
来源: Chest. 1976年69卷2期216-9页
Fiberglass inhalation seems to produce a minimal tissue response in the lungs, and the reaction is one of macrophagic mobilization and is characteristic of the pulmonary response to those nonfibrogenic dusts classified as nuisance dusts. In order to merit the designation of a nuisance dust, the pulmonary response must fulfill the following three requisites:31(p5) (1) The alveolar architecture must remain intact. (2) The stromal proliferation is minimal and consists mainly of reticulin. (3) The tissue reaction is potentially reversible. Inasmuch as the pulmonary reaction to the dusts of fiber glass fulfills all of these requirements, it should be classified as a nuisance dust. 31(p5) There is no evidence to indicate that inhaling fiber glass is associated with either permanent respiratory impairment or carcinogenesis; however, the final verdict as far as the latter is concerned must await the findings of long-term mortality studies.
3570. The current status of prostaglandins and the lungs.
The prostaglandins are a group of pharmacologically potent lipid compounds whose role in pulmonary pathophysiology remains to be defined. There is not question that these compounds can induce constriction (PGF) or relaxation (PGE) of the smooth muscle in bronchi and pulmonary vessels. There is no question that the lungs are a major site of both the synthesis and degradation. These facts make speculation about the role of the prostaglandins in pulmonary disorders a tempting exercise. However, the current paucity of clinical data prevents any valid assessment of such speculation at this time and emphasizes the need for continued investigation of the role of prostaglandins in patients with lung disease.
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