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3441. Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents.
作者: Brian D Lowes.;Edward M Gilbert.;William T Abraham.;Wayne A Minobe.;Patti Larrabee.;Debra Ferguson.;Eugene E Wolfel.;JoAnn Lindenfeld.;Tatiana Tsvetkova.;Alastair D Robertson.;Robert A Quaife.;Michael R Bristow.
来源: N Engl J Med. 2002年346卷18期1357-65页
Beta-blocker therapy may improve cardiac function in patients with idiopathic dilated cardiomyopathy. We tested the hypothesis that beta-blocker therapy produces favorable functional effects in dilated cardiomyopathy by altering the expression of myocardial genes that regulate contractility and pathologic hypertrophy.
3442. Treatment of ankylosing spondylitis by inhibition of tumor necrosis factor alpha.
There are few effective treatments for ankylosing spondylitis, which causes substantial morbidity. Because of the central role of tumor necrosis factor alpha in the spondyloarthritides, we performed a randomized, double-blind, placebo-controlled trial of etanercept, a recombinant human tumor necrosis factor receptor (p75):Fc fusion protein, in patients with ankylosing spondylitis.
3443. Intravascular gamma radiation for in-stent restenosis in saphenous-vein bypass grafts.
作者: Ron Waksman.;Andrew E Ajani.;R Larry White.;Rosanna C Chan.;Lowell F Satler.;Kenneth M Kent.;Augusto D Pichard.;Ellen E Pinnow.;Anh B Bui.;Steven Ramee.;Paul Teirstein.;Joseph Lindsay.
来源: N Engl J Med. 2002年346卷16期1194-9页
Intracoronary radiation therapy is effective in reducing the recurrence of in-stent stenosis in native coronary arteries. We examined the effects of intravascular gamma radiation in patients with in-stent restenosis of saphenous-vein bypass grafts.
3444. Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy.
作者: Salima Hacein-Bey-Abina.;Françoise Le Deist.;Frédérique Carlier.;Cécile Bouneaud.;Christophe Hue.;Jean-Pierre De Villartay.;Adrian J Thrasher.;Nicolas Wulffraat.;Ricardo Sorensen.;Sophie Dupuis-Girod.;Alain Fischer.;E Graham Davies.;Wietse Kuis.;Lilly Leiva.;Marina Cavazzana-Calvo.
来源: N Engl J Med. 2002年346卷16期1185-93页
X-linked severe combined immunodeficiency due to a mutation in the gene encoding the common gamma (gamma(c)) chain is a lethal condition that can be cured by allogeneic stem-cell transplantation. We investigated whether infusion of autologous hematopoietic stem cells that had been transduced in vitro with the gamma(c) gene can restore the immune system in patients with severe combined immunodeficiency.
3445. A controlled trial of valganciclovir as induction therapy for cytomegalovirus retinitis.
作者: Daniel F Martin.;Juan Sierra-Madero.;Sharon Walmsley.;Richard A Wolitz.;Katherine Macey.;Panos Georgiou.;Charles A Robinson.;Mary Jean Stempien.; .
来源: N Engl J Med. 2002年346卷15期1119-26页
Valganciclovir is an orally administered prodrug that is rapidly hydrolyzed to ganciclovir. We compared the effects of oral valganciclovir with those of intravenous ganciclovir as induction therapy for newly diagnosed cytomegalovirus retinitis in 160 patients with the acquired immunodeficiency syndrome (AIDS).
3446. Primary chemoprevention of familial adenomatous polyposis with sulindac.
作者: Francis M Giardiello.;Vincent W Yang.;Linda M Hylind.;Anne J Krush.;Gloria M Petersen.;Jill D Trimbath.;Steven Piantadosi.;Elizabeth Garrett.;Deborah E Geiman.;Walter Hubbard.;G Johan A Offerhaus.;Stanley R Hamilton.
来源: N Engl J Med. 2002年346卷14期1054-9页
Familial adenomatous polyposis is caused by a germ-line mutation in the adenomatous polyposis coli gene and is characterized by the development of hundreds of colorectal adenomas and, eventually, colorectal cancer. Nonsteroidal antiinflammatory drugs can cause regression of adenomas, but whether they can prevent adenomas is unknown.
3447. Clinical responses to undiluted and diluted smallpox vaccine.
作者: Sharon E Frey.;Robert B Couch.;Carol O Tacket.;John J Treanor.;Mark Wolff.;Frances K Newman.;Robert L Atmar.;Robert Edelman.;Carrie M Nolan.;Robert B Belshe.; .
来源: N Engl J Med. 2002年346卷17期1265-74页
To evaluate the potential to increase the supply of smallpox vaccine (vaccinia virus), we compared the response to vaccination with 10(8.1), 10(7.2), and 10(7.0) plaque-forming units (pfu) of vaccinia virus per milliliter.
3448. Dose-related effects of smallpox vaccine.
作者: Sharon E Frey.;Frances K Newman.;John Cruz.;W Brian Shelton.;Janice M Tennant.;Tamara Polach.;Alan L Rothman.;Jeffrey S Kennedy.;Mark Wolff.;Robert B Belshe.;Francis A Ennis.
来源: N Engl J Med. 2002年346卷17期1275-80页
We conducted a double-blind, randomized trial of three dilutions of vaccinia virus vaccine in previously unimmunized adults in order to assess the clinical success rates, humoral responses, and virus-specific activity of cytotoxic T cells and interferon-gamma-producing T cells.
3449. Duration of prophylaxis against venous thromboembolism with enoxaparin after surgery for cancer.
作者: David Bergqvist.;Giancarlo Agnelli.;Alexander T Cohen.;Amiram Eldor.;Paul E Nilsson.;Anne Le Moigne-Amrani.;Flavia Dietrich-Neto.; .
来源: N Engl J Med. 2002年346卷13期975-80页
Abdominal surgery for cancer carries a high risk of venous thromboembolism, but the optimal duration of postoperative thromboprophylaxis is unknown.
3450. Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease.
作者: David M Herrington.;Timothy D Howard.;Gregory A Hawkins.;David M Reboussin.;Jianfeng Xu.;Siqun L Zheng.;K Bridget Brosnihan.;Deborah A Meyers.;Eugene R Bleecker.
来源: N Engl J Med. 2002年346卷13期967-74页
Sequence variants in the gene encoding estrogen receptor alpha (ER-alpha) may modify the effects of hormone-replacement therapy on levels of high-density lipoprotein (HDL) cholesterol and other outcomes related to estrogen treatment in postmenopausal women.
3451. Comparison of angioplasty with stenting, with or without abciximab, in acute myocardial infarction.
作者: Gregg W Stone.;Cindy L Grines.;David A Cox.;Eulogio Garcia.;James E Tcheng.;John J Griffin.;Giulio Guagliumi.;Thomas Stuckey.;Mark Turco.;John D Carroll.;Barry D Rutherford.;Alexandra J Lansky.; .
来源: N Engl J Med. 2002年346卷13期957-66页
As compared with thrombolytic therapy, primary percutaneous transluminal coronary angioplasty (PTCA) in acute myocardial infarction reduces the rates of death, reinfarction, and stroke, but recurrent ischemia, restenosis, and reocclusion of the infarct-related artery remain problematic. When used in combination with PTCA, coronary stenting and platelet glycoprotein IIb/IIIa inhibitors may further improve outcomes.
3453. A controlled trial of inpatient and outpatient geriatric evaluation and management.
作者: Harvey Jay Cohen.;John R Feussner.;Morris Weinberger.;Molly Carnes.;Ronald C Hamdy.;Frank Hsieh.;Ciaran Phibbs.;Donald Courtney.;Kenneth W Lyles.;Conrad May.;Cynthia McMurtry.;Leslye Pennypacker.;David M Smith.;Nina Ainslie.;Thomas Hornick.;Kayla Brodkin.;Philip Lavori.
来源: N Engl J Med. 2002年346卷12期905-12页
Over the past 20 years, both inpatient units and outpatient clinics have developed programs for geriatric evaluation and management. However, the effects of these interventions on survival and functional status remain uncertain.
3454. Bosentan therapy for pulmonary arterial hypertension.
作者: Lewis J Rubin.;David B Badesch.;Robyn J Barst.;Nazzareno Galie.;Carol M Black.;Anne Keogh.;Tomas Pulido.;Adaani Frost.;Sebastien Roux.;Isabelle Leconte.;Michael Landzberg.;Gerald Simonneau.
来源: N Engl J Med. 2002年346卷12期896-903页
Endothelin-1 is a potent vasoconstrictor and smooth-muscle mitogen. In a preliminary study, the orally administered dual endothelin-receptor antagonist bosentan improved exercise capacity and cardiopulmonary hemodynamics in patients with pulmonary arterial hypertension. The present trial investigated the effect of bosentan on exercise capacity in a larger number of patients and compared two doses.
3455. Fluconazole for the treatment of cutaneous leishmaniasis caused by Leishmania major.
作者: Abdulrahman A Alrajhi.;Elfaki A Ibrahim.;Edward B De Vol.;Mohammad Khairat.;Rajab M Faris.;James H Maguire.
来源: N Engl J Med. 2002年346卷12期891-5页
Whereas certain oral antifungal azoles are well documented to have activity against leishmania, data on the efficacy of fluconazole for leishmaniasis are limited. We conducted a controlled trial in Saudi Arabia of fluconazole for the treatment of cutaneous leishmaniasis caused by Leishmania major.
3456. Amiodarone as compared with lidocaine for shock-resistant ventricular fibrillation.
作者: Paul Dorian.;Dan Cass.;Brian Schwartz.;Richard Cooper.;Robert Gelaznikas.;Aiala Barr.
来源: N Engl J Med. 2002年346卷12期884-90页
Lidocaine has been the initial antiarrhythmic drug treatment recommended for patients with ventricular fibrillation that is resistant to conversion by defibrillator shocks. We performed a randomized trial comparing intravenous lidocaine with intravenous amiodarone as an adjunct to defibrillation in victims of out-of-hospital cardiac arrest.
3457. Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction.
作者: Arthur J Moss.;Wojciech Zareba.;W Jackson Hall.;Helmut Klein.;David J Wilber.;David S Cannom.;James P Daubert.;Steven L Higgins.;Mary W Brown.;Mark L Andrews.; .
来源: N Engl J Med. 2002年346卷12期877-83页
Patients with reduced left ventricular function after myocardial infarction are at risk for life-threatening ventricular arrhythmias. This randomized trial was designed to evaluate the effect of an implantable defibrillator on survival in such patients.
3458. Intravenous zoledronic acid in postmenopausal women with low bone mineral density.
作者: Ian R Reid.;Jacques P Brown.;Peter Burckhardt.;Zebulun Horowitz.;Peter Richardson.;Ulrich Trechsel.;Albert Widmer.;Jean-Pierre Devogelaer.;Jean-Marc Kaufman.;Philippe Jaeger.;Jean-Jacques Body.;Maria Luisa Brandi.;Johann Broell.;Raffaele Di Micco.;Andrea Riccardo Genazzani.;Dieter Felsenberg.;Joachim Happ.;Michael J Hooper.;Jochen Ittner.;Georg Leb.;Hans Mallmin.;Timothy Murray.;Sergio Ortolani.;Alessandro Rubinacci.;Maria Saaf.;Goran Samsioe.;Leon Verbruggen.;Pierre J Meunier.
来源: N Engl J Med. 2002年346卷9期653-61页
Bisphosphonates are effective agents for the management of osteoporosis. Their low bioavailability and low potency necessitate frequent administration on an empty stomach, which may reduce compliance. Gastrointestinal intolerance limits maximal dosing. Although intermittent intravenous treatments have been used, the optimal doses and dosing interval have not been systematically explored.
3459. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia.
作者: Hagop Kantarjian.;Charles Sawyers.;Andreas Hochhaus.;Francois Guilhot.;Charles Schiffer.;Carlo Gambacorti-Passerini.;Dietger Niederwieser.;Debra Resta.;Renaud Capdeville.;Ulrike Zoellner.;Moshe Talpaz.;Brian Druker.;John Goldman.;Stephen G O'Brien.;Nigel Russell.;Thomas Fischer.;Oliver Ottmann.;Pascale Cony-Makhoul.;Thierry Facon.;Richard Stone.;Carole Miller.;Martin Tallman.;Randy Brown.;Michael Schuster.;Thomas Loughran.;Alois Gratwohl.;Franco Mandelli.;Giuseppe Saglio.;Mario Lazzarino.;Domenico Russo.;Michele Baccarani.;Enrica Morra.; .
来源: N Engl J Med. 2002年346卷9期645-52页
Chronic myelogenous leukemia (CML) is caused by the BCR-ABL tyrosine kinase, the product of the Philadelphia chromosome. Imatinib mesylate, formerly STI571, is a selective inhibitor of this kinase.
3460. Leptin-replacement therapy for lipodystrophy.
作者: Elif Arioglu Oral.;Vinaya Simha.;Elaine Ruiz.;Alexa Andewelt.;Ahalya Premkumar.;Peter Snell.;Anthony J Wagner.;Alex M DePaoli.;Marc L Reitman.;Simeon I Taylor.;Phillip Gorden.;Abhimanyu Garg.
来源: N Engl J Med. 2002年346卷8期570-8页
The adipocyte hormone leptin is important in regulating energy homeostasis. Since severe lipodystrophy is associated with leptin deficiency, insulin resistance, hypertriglyceridemia, and hepatic steatosis, we assessed whether leptin replacement would ameliorate this condition.
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