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321. Prognostic and therapeutic potential of CXCR6 expression on CD8 + T cells in gastric cancer: a retrospective cohort study.
Gastric cancer (GC) is a pressing global health concern, with prognosis intricately linked to the tumour stage and tumour microenvironment, especially, the presence of immune cells. Notably, CD8 + T cells play a pivotal role in the anti-tumour immune response, prompting investigations into their correlation with GC survival. This study aimed to investigate the intricate interplay between CD8 + T cells, particularly within the context of CXCR6, and survival outcomes in patients with GC.
322. Development and evaluation of a predictive model of upper gastrointestinal bleeding in liver cirrhosis.
作者: Jin Peng.;Huiru Jin.;Ningxin Zhang.;Shiqiu Zheng.;Chengxiao Yu.;Jianzhong Yu.;Longfeng Jiang.
来源: BMC Gastroenterol. 2025年25卷1期142页
Upper gastrointestinal bleeding (UGIB) is a prevalent and severe complication of cirrhosis, often resulting from esophagogastric variceal bleeding (EVB). This condition poses significant life-threatening risks. Once bleeding occurs, the risk of recurrent episodes substantially increases, further compromising liver function and worsening patient outcomes. This study aims to identify risk factors for UGIB in cirrhotic patients using clinical examination data and to develop a non-invasive predictive model to improve diagnostic precision and efficiency.
323. Association between avoidant/restrictive food intake disorder risk, dietary attitudes and behaviors among Chinese patients with inflammatory bowel disease: a cross-sectional study.
作者: Wenjing Tu.;Yiting Li.;Tingting Yin.;Sumin Zhang.;Ping Zhang.;Guihua Xu.
来源: BMC Gastroenterol. 2025年25卷1期144页
Restrictive eating behaviors are common among patients with inflammatory bowel disease (IBD), which may may develop nutritional and/or quality of life impairments into avoidant/restrictive food intake disorder (ARFID). The objective of this study is to estimate the prevalence and characteristics of ARFID in Chinese patients with IBD, and to investigate the current perceptions and dietary behaviors of patients with and without ARFID.
324. Effect of montelukast on remission maintenance in patients with ulcerative colitis: a Randomized, double-blind controlled clinical trial.
作者: Kourosh Masnadi Shirazi.;Mehran Nezam Diba.;Arman Masnadi Shirazinezhad.;Zeinab Nikniaz.
来源: BMC Gastroenterol. 2025年25卷1期145页
Considering the role of leukotrienes in inflammatory pathways, and owing to the anti-leukotrienes effect of montelukast, in the present clinical trial, we aimed to assess the effect of montelukast on remission maintenance in patients with ulcerative colitis (UC).
325. Quality of life, functional impairment and healthcare experiences of patients with irritable bowel syndrome in Norway: an online survey.
作者: Magdy El-Salhy.;Mads Johansson.;Miriam Klevstul.;Jan Gunnar Hatlebakk.
来源: BMC Gastroenterol. 2025年25卷1期143页
The present study is an online survey to determine the quality of life and functional impairment caused by irritable bowel syndrome (IBS) and the healthcare experiences of IBS patients in Norway, which has not been done previously.
326. Treatment outcomes of chronic liver disease and associated factors among patients treated at hospitals in Bahir Dar city, north-west Ethiopia.
作者: Melese Alemnew Ayal.;Yeshiwas Admasu Dessie.;Meskerem Eshetie Nega.;Woynshet Tsegaw Negash.;Senait Mulat Berihun.
来源: BMC Gastroenterol. 2025年25卷1期141页
Chronic liver disease is an on-going loss of liver structure and functions that lasts for at least six months. About 1.5 billion population suffered with this devastating disease worldwide.
327. Phosphatidylserine induce thrombotic tendency and liver damage in obstructive jaundice.
作者: Muxin Yu.;Chuwei Zheng.;Xiaoguang Wang.;Rong Peng.;Guoming Lu.;Jinming Zhang.
来源: BMC Gastroenterol. 2025年25卷1期146页
Hypercoagulability contributes to the majority of deaths and organ failure associated with obstructive jaundice (OJ). However, the exact mechanism of the coagulopathy in OJ remains elusive. Our objectives were to demonstrate whether phosphatidylserine (PS) exposure on blood cells (BCs), microparticles (MPs), and endothelial cells (ECs) can account for the hypercoagulability and liver damage in OJ patients.
328. The relationships between depression, inflammation and self-reported disease activity in IBD and their impact on healthcare usage.
作者: Natasha Seaton.;Vari Wileman.;Christine Norton.;Joanna Hudson.;Valeria Mondelli.;Rona Moss-Morris.
来源: BMC Gastroenterol. 2025年25卷1期140页
Depression is common in people living with Inflammatory Bowel Disease (IBD). Depression rates increase with active disease and are linked to poorer clinical outcomes. Previous studies investigating the relationship between contemporaneous IBD disease activity and depression are often poorly controlled, use small samples and/or rely on self-reported measures of disease activity. Depression and self-reported disease activity (SRDA) are linked to increased healthcare usage, however, objective inflammation is rarely statistically controlled. The primary aim was to understand how self-reported disease activity and inflammation are related to depression. Secondary aims included assessing the relative influence of self-reported disease activity, inflammation and depression on healthcare usage.
329. Weight-adjusted waist circumference index with hepatic steatosis and fibrosis in adult females: a cross-sectional, nationally representative study (NHANES 2017-2020).
Obesity is detrimental to liver health. Weight-adjusted waist circumference (WWI) is a new indicator of obesity that is superior to body mass index (BMI) and waist circumference (WC) in predicting obesity. There are limited studies on the relationship between Metabolic Associated Fatty Liver Disease (MASLD) and WWI. Therefore, this study aimed to investigate the association between WWI, Controlled Attenuation Parameters (CAP), and Liver Stiffness Measurement (LSM), with special attention to gender differences.
330. The diagnostic criteria for psychosomatic research-revised (DCPR-R) in a National China multicenter cohort of patients with irritable bowel syndrome and overlapping gastroesophageal reflux disease.
作者: Peicai Li.;Yanping Tang.;Lei Liu.;Lei Yang.;Li Yang.;Zhongmei Sun.;Yanxia Gong.
来源: BMC Gastroenterol. 2025年25卷1期136页
Past studies have shown a substantial overlap between irritable bowel syndrome (IBS) and gastroesophageal reflux disease (GERD). This study investigated the prevalence of DCPR-revised (DCPR-R) syndromes in patients with IBS alone and those with overlapping IBS-GERD. We also explored the relationship of these syndromes with various psychological scales.
331. Choledocholithiasis as a risk factor for cholangiocarcinoma: a nationwide retrospective cohort study.
作者: Jaihwan Kim.;Yoon Suk Lee.;Jong-Chan Lee.;Jin-Hyeok Hwang.
来源: BMC Gastroenterol. 2025年25卷1期138页
Choledocholithiasis has been reported to be associated with the occurrence of cholangiocarcinoma (CCA); however, the association has not yet been sufficiently demonstrated. This study aimed to evaluate the association between choledocholithiasis (common bile duct stones) and CCA.
333. Higher relative fat mass was associated with a higher prevalence of gallstones in US adults.
作者: Shangfen Xie.;Shanni Ma.;Xiaofeng Chen.;Libiao Fang.;Dongen Li.
来源: BMC Gastroenterol. 2025年25卷1期133页
Our study aimed to investigate the association between the relative fat mass (RFM) and gallstones in adults.
334. Preoperative optimization strategy management model applied in gallbladder surgery.
作者: Jie Wang.;HaoFen Xie.; Hong Zhu.;Yue Hu.; Shanshan Mi.; Wang Ying.;QinHong Xu.;Liang Yang.
来源: BMC Gastroenterol. 2025年25卷1期132页
To investigate the impact of implementing a pre-hospitalization optimization strategy on the length of stay and hospital costs for patients undergoing gallbladder surgery at a tertiary hospital, this study aims to analyze patient characteristics relevant to pre-hospitalization gallbladder surgery, focusing on age and underlying medical conditions.
335. The causal impact of genetically predicted inflammatory bowel disease on extraintestinal manifestations: a mendelian randomization study.
作者: Xingcan Fan.;Anqi He.;Kaiyu Li.;Maorun Zhang.;Qi Zhang.;Wanyi Xiao.;Gang Liu.
来源: BMC Gastroenterol. 2025年25卷1期135页
Extraintestinal manifestations (EIMs) significantly affect the life quality of people with inflammatory bowel disease (IBD) and are crucial factors impacting occurrence rates and mortality among IBD patients. This study performed a Mendelian randomization (MR) analysis to investigate the causal relationships between genetically predicted IBD and the development of EIMs, including erythema nodosum (EN), episcleritis, scleritis, uveitis, primary sclerosing cholangitis (PSC), and spondyloarthritis. To further investigate differences between subtypes, separate analyses were conducted for ulcerative colitis (UC) and Crohn's disease (CD).
336. Comparison of short-term efficacy of laparoscopic proximal gastrectomy with modified side overlap anastomosis and laparoscopic total gastrectomy with Roux-en-Y anastomosis.
To investigate the short-term efficacy of laparoscopic proximal gastrectomy (LPG) with modified side overlap anastomosis in comparison with laparoscopic total gastrectomy (LTG) with Roux-en-Y anastomosis.
337. Safety and efficacy of ciprofol versus propofol for gastrointestinal endoscopy: a meta-analysis.
作者: Xi Cheng.;Pengyu Zhang.;Dan Jiang.;Baoxia Fang.;Fuchao Chen.
来源: BMC Gastroenterol. 2025年25卷1期130页
The role of ciprofol as a novel anesthetic in gastrointestinal endoscopic surgery is unclear. We conducted a systematic review and meta-analysis to evaluate the efficacy and safety of ciprofol for gastrointestinal endoscopy in patients aged over 65 years and under 65 years, aiming to provide evidence-based information for clinical decision-making.
338. Persistence of anemia in patients with Celiac disease despite a gluten free diet: a retrospective study.
作者: Marco Valvano.;Chiara Giansante.;Antonio Vinci.;Massimo Maurici.;Stefano Fabiani.;Gianpiero Stefanelli.;Nicola Cesaro.;Angelo Viscido.;Claudia Caloisi.;Giovanni Latella.
来源: BMC Gastroenterol. 2025年25卷1期128页
The main treatment for Celiac Disease (CD) is the gluten-free diet (GFD). However, in some CD patients, iron deficiency anemia can be persistent despite a GFD.
339. Explainable machine learning model for predicting acute pancreatitis mortality in the intensive care unit.
Current prediction models are suboptimal for determining mortality risk in patients with acute pancreatitis (AP); this might be improved by using a machine learning (ML) model. In this study, we aimed to construct an explainable ML model to calculate the risk of mortality in patients with AP admitted in intensive care unit (ICU) and compared it with existing scoring systems.
340. Diagnostic value of peripheral blood inflammatory indices for clinicopathological profile of colorectal cancer: a retrospective observational study.
作者: Mohammad Rezazadeh.;Amirreza Kamyabi.;Ramtin Ghamkhari Pisheh.;Sahar Noroozie.;Bahareh Shateri Amiri.;Alireza Negahi.;Hanieh Radkhah.
来源: BMC Gastroenterol. 2025年25卷1期127页
Colorectal cancer (CRC) ranks as the third most prevalent cancer globally and the second leading cause of cancer-related mortality. This study investigates the diagnostic value of peripheral blood inflammatory indices, including the Cancer-Inflammation Prognostic Index (CIPI), Systemic Inflammation Response Index (SIRI), Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) index, Neutrophil-to-Lymphocyte Ratio (NLR), and Platelet-to-Lymphocyte Ratio (PLR), in the early diagnosis of clinicopathological characteristics of CRC.
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